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  1. Article ; Online: Evaluation of the 3-minute chair rise test as part of preoperative evaluation for patients with non-small cell lung cancer.

    Azzi, Mathilde / Debeaumont, David / Bonnevie, Tristan / Aguilaniu, Bernard / Cerasuolo, Damiano / Boujibar, Fairuz / Cuvelier, Antoine / Gravier, Francis-Edouard

    Thoracic cancer

    2020  Volume 11, Issue 9, Page(s) 2431–2439

    Abstract: Background: Peak oxygen uptake ( : Methods: Retrospective data from CPX and 3CRT carried out in 36 patients with NSCLC between March 2018 and February 2019 were included. A multivariate analysis was undertaken to derive a predictive : Results: The ...

    Abstract Background: Peak oxygen uptake (
    Methods: Retrospective data from CPX and 3CRT carried out in 36 patients with NSCLC between March 2018 and February 2019 were included. A multivariate analysis was undertaken to derive a predictive
    Results: The following equation was obtained:
    Conclusions: The level of error in the prediction of
    Key points: SIGNIFICANT FINDINGS OF THE STUDY: Cardiopulmonary exercise tests can stratify the surgical risk. Prediction of the peak oxygen uptake (
    What this study adds: The 3CRT is a useful screening tool to determine the necessity for a comprehensive cardiopulmonary exercise test, whose access is limited in clinical practice. It could also allow early screening of patients requiring specific prehabilitation programs.
    MeSH term(s) Carcinoma, Non-Small-Cell Lung/diagnosis ; Carcinoma, Non-Small-Cell Lung/pathology ; Exercise Test/methods ; Female ; Humans ; Lung Neoplasms/diagnosis ; Lung Neoplasms/pathology ; Male ; Preoperative Care/methods ; Retrospective Studies
    Language English
    Publishing date 2020-07-08
    Publishing country Singapore
    Document type Journal Article
    ZDB-ID 2625856-0
    ISSN 1759-7714 ; 1759-7706
    ISSN (online) 1759-7714
    ISSN 1759-7706
    DOI 10.1111/1759-7714.13548
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Extracorporeal CO

    Azzi, Mathilde / Aboab, Jerome / Alviset, Sophie / Ushmorova, Daria / Ferreira, Luis / Ioos, Vincent / Memain, Nathalie / Issoufaly, Tazime / Lermuzeaux, Mathilde / Laine, Laurent / Serbouti, Rita / Silva, Daniel

    BMJ open respiratory research

    2021  Volume 8, Issue 1

    Abstract: Background: The gold-standard treatment for acute exacerbation of chronic obstructive pulmonary disease (ae-COPD) is non-invasive ventilation (NIV). However, NIV failures may be observed, and invasive mechanical ventilation (IMV) is required. ... ...

    Abstract Background: The gold-standard treatment for acute exacerbation of chronic obstructive pulmonary disease (ae-COPD) is non-invasive ventilation (NIV). However, NIV failures may be observed, and invasive mechanical ventilation (IMV) is required. Extracorporeal CO₂ removal (ECCO₂R) devices can be an alternative to intubation. The aim of the study was to assess ECCO₂R effectiveness and safety.
    Methods: Patients with consecutive ae-COPD who experienced NIV failure were retrospectively assessed over two periods of time: before and after ECCO₂R device implementation in our ICU in 2015 (Xenios AG).
    Results: Both groups (ECCO₂R: n=26, control group: n=25) were comparable at baseline, except for BMI, which was significantly higher in the ECCO₂R group (30 kg/m² vs 25 kg/m²). pH and PaCO₂ significantly improved in both groups. The mean time on ECCO₂R was 5.4 days versus 27 days for IMV in the control group. Four patients required IMV in the ECCO₂R group, of whom three received IMV after ECCO₂R weaning. Seven major bleeding events were observed with ECCO₂R, but only three led to premature discontinuation of ECCO₂R. Eight cases of ventilator-associated pneumonia were observed in the control group. Mean time spent in the ICU and mean hospital stay in the ECCO₂R and control groups were, respectively, 18 vs 30 days, 29 vs 49 days, and the 90-day mortality rates were 15% vs 28%.
    Conclusions: ECCO₂R was associated with significant improvement of pH and PaCO₂ in patients with ae-COPD failing NIV therapy. It also led to avoiding intubation in 85% of cases, with low complication rates.
    Trial registration number: ClinicalTrials.gov, NCT04882410. Date of registration 12 May 2021, retrospectively registered.https://www.clinicaltrials.gov/ct2/show/NCT04882410.
    MeSH term(s) Carbon Dioxide ; Humans ; Length of Stay ; Noninvasive Ventilation ; Pulmonary Disease, Chronic Obstructive/therapy ; Respiration, Artificial
    Chemical Substances Carbon Dioxide (142M471B3J)
    Language English
    Publishing date 2021-12-10
    Publishing country England
    Document type Journal Article
    ZDB-ID 2736454-9
    ISSN 2052-4439 ; 2052-4439
    ISSN (online) 2052-4439
    ISSN 2052-4439
    DOI 10.1136/bmjresp-2021-001089
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Continuous Positive Airway Pressure (CPAP) face-mask ventilation is an easy and cheap option to manage a massive influx of patients presenting acute respiratory failure during the SARS-CoV-2 outbreak: A retrospective cohort study.

    Alviset, Sophie / Riller, Quentin / Aboab, Jérôme / Dilworth, Kelly / Billy, Pierre-Antoine / Lombardi, Yannis / Azzi, Mathilde / Ferreira Vargas, Luis / Laine, Laurent / Lermuzeaux, Mathilde / Mémain, Nathalie / Silva, Daniel / Tchoubou, Tona / Ushmorova, Daria / Dabbagh, Hanane / Escoda, Simon / Lefrançois, Rémi / Nardi, Annelyse / Ngima, Armand /
    Ioos, Vincent

    PloS one

    2020  Volume 15, Issue 10, Page(s) e0240645

    Abstract: Introduction: Because of the COVID-19 pandemic, intensive care units (ICU) can be overwhelmed by the number of hypoxemic patients.: Material and methods: This single centre retrospective observational cohort study took place in a French hospital ... ...

    Abstract Introduction: Because of the COVID-19 pandemic, intensive care units (ICU) can be overwhelmed by the number of hypoxemic patients.
    Material and methods: This single centre retrospective observational cohort study took place in a French hospital where the number of patients exceeded the ICU capacity despite an increase from 18 to 32 beds. Because of this, 59 (37%) of the 159 patients requiring ICU care were referred to other hospitals. From 27th March to 23rd April, consecutive patients who had respiratory failure or were unable to maintain an SpO2 > 90%, despite receiving 10-15 l/min of oxygen with a non-rebreather mask, were treated by continuous positive airway pressure (CPAP) unless the ICU physician judged that immediate intubation was indicated. We describe the characteristics, clinical course, and outcomes of these patients. The main outcome under study was CPAP discontinuation.
    Results: CPAP was initiated in 49 patients and performed out of ICU in 41 (84%). Median age was 65 years (IQR = 54-71) and 36 (73%) were men. Median respiratory rate before CPAP was 36 (30-40) and median SpO2 was 92% (90-95) under 10 to 15 L/min oxygen flow. Median duration of CPAP was 3 days (IQR = 1-5). Reasons for discontinuation of CPAP were: intubation in 25 (51%), improvement in 16 (33%), poor tolerance in 6 (12%) and death in 2 (4%) patients. A decision not to intubate had been taken for 8 patients, including the 2 who died while on CPAP. Two patients underwent less than one hour CPAP for poor tolerance. In the end, 15 (38%) out of 39 evaluable patients recovered with only CPAP whereas 24 (62%) were intubated.
    Conclusions: CPAP is feasible in a non-ICU environment in the context of massive influx of patients. In our cohort up to 1/3 of the patients presenting with acute respiratory failure recovered without intubation.
    MeSH term(s) Aged ; COVID-19 ; Continuous Positive Airway Pressure/economics ; Continuous Positive Airway Pressure/instrumentation ; Continuous Positive Airway Pressure/methods ; Coronavirus Infections/economics ; Coronavirus Infections/epidemiology ; Coronavirus Infections/therapy ; Costs and Cost Analysis ; Female ; France ; Hospital Bed Capacity/statistics & numerical data ; Humans ; Intensive Care Units/statistics & numerical data ; Male ; Middle Aged ; Pandemics/economics ; Patient Admission/statistics & numerical data ; Pneumonia, Viral/economics ; Pneumonia, Viral/epidemiology ; Pneumonia, Viral/therapy
    Keywords covid19
    Language English
    Publishing date 2020-10-14
    Publishing country United States
    Document type Journal Article ; Observational Study
    ZDB-ID 2267670-3
    ISSN 1932-6203 ; 1932-6203
    ISSN (online) 1932-6203
    ISSN 1932-6203
    DOI 10.1371/journal.pone.0240645
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Continuous Positive Airway Pressure (CPAP) face-mask ventilation is an easy and cheap option to manage a massive influx of patients presenting acute respiratory failure during the SARS-CoV-2 outbreak: A retrospective cohort study

    Alviset, Sophie / Riller, Quentin / Aboab, Jérôme / Dilworth, Kelly / Billy, Pierre-Antoine / Lombardi, Yannis / Azzi, Mathilde / Ferreira Vargas, Luis / Laine, Laurent / Lermuzeaux, Mathilde / Mémain, Nathalie / Silva, Daniel / Tchoubou, Tona / Ushmorova, Daria / Dabbagh, Hanane / Escoda, Simon / Lefrançois, Rémi / Nardi, Annelyse / Ngima, Armand /
    Ioos, Vincent

    PLoS One

    Abstract: INTRODUCTION: Because of the COVID-19 pandemic, intensive care units (ICU) can be overwhelmed by the number of hypoxemic patients. MATERIAL AND METHODS: This single centre retrospective observational cohort study took place in a French hospital where the ...

    Abstract INTRODUCTION: Because of the COVID-19 pandemic, intensive care units (ICU) can be overwhelmed by the number of hypoxemic patients. MATERIAL AND METHODS: This single centre retrospective observational cohort study took place in a French hospital where the number of patients exceeded the ICU capacity despite an increase from 18 to 32 beds. Because of this, 59 (37%) of the 159 patients requiring ICU care were referred to other hospitals. From 27th March to 23rd April, consecutive patients who had respiratory failure or were unable to maintain an SpO2 > 90%, despite receiving 10-15 l/min of oxygen with a non-rebreather mask, were treated by continuous positive airway pressure (CPAP) unless the ICU physician judged that immediate intubation was indicated. We describe the characteristics, clinical course, and outcomes of these patients. The main outcome under study was CPAP discontinuation. RESULTS: CPAP was initiated in 49 patients and performed out of ICU in 41 (84%). Median age was 65 years (IQR = 54-71) and 36 (73%) were men. Median respiratory rate before CPAP was 36 (30-40) and median SpO2 was 92% (90-95) under 10 to 15 L/min oxygen flow. Median duration of CPAP was 3 days (IQR = 1-5). Reasons for discontinuation of CPAP were: intubation in 25 (51%), improvement in 16 (33%), poor tolerance in 6 (12%) and death in 2 (4%) patients. A decision not to intubate had been taken for 8 patients, including the 2 who died while on CPAP. Two patients underwent less than one hour CPAP for poor tolerance. In the end, 15 (38%) out of 39 evaluable patients recovered with only CPAP whereas 24 (62%) were intubated. CONCLUSIONS: CPAP is feasible in a non-ICU environment in the context of massive influx of patients. In our cohort up to 1/3 of the patients presenting with acute respiratory failure recovered without intubation.
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #868682
    Database COVID19

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