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  1. Article ; Online: Expression and functional activity of cytochrome P450 enzymes in human hepatocytes with sustainable reproducibility for in vitro phenotyping studies.

    Bachour-El Azzi, Pamela / Chesné, Christophe / Uehara, Shotaro

    Advances in pharmacology (San Diego, Calif.)

    2022  Volume 95, Page(s) 285–305

    Abstract: Primary human hepatocytes are an essential in vitro tool for evaluating drug metabolism, drug-drug interactions, and hepatotoxicity. This model is considered as the gold standard in matter of DMPK studies in both industrial and academic research. The ... ...

    Abstract Primary human hepatocytes are an essential in vitro tool for evaluating drug metabolism, drug-drug interactions, and hepatotoxicity. This model is considered as the gold standard in matter of DMPK studies in both industrial and academic research. The primary human hepatocytes are used either in suspension or in monolayer, as fresh or frozen cells. However, the use of this model is limited due to the lack of availability, rapid loss of functionality, high cost as well as the variable hepatocyte plating efficiencies in culture and the limited stock of hepatocytes derived from the same origin. Chimeric TK-NOG mice with humanized livers (humanized liver mice) are an attractive platform for drug metabolism and toxicity, which were produced by transplanting human hepatocytes into immunodeficient mice with injured livers. Here, we show that, using humanized mouse liver, in vivo human hepatocyte repopulation was over ~100-fold enabling the continuous and abundant use of human hepatocytes of the same origin and improving their plateability. In our latest cell preparations, hepatocytes isolated from humanized liver mice (Hu-Liver cells) exhibited high purity (ratio of HLA-positive cells: 92±3%), good viability (75±12%), and yield (1.0×10
    MeSH term(s) Animals ; Cells, Cultured ; Cytochrome P-450 Enzyme System/genetics ; Cytochrome P-450 Enzyme System/metabolism ; Hepatocytes ; Humans ; Liver/metabolism ; Mice ; Reproducibility of Results
    Chemical Substances Cytochrome P-450 Enzyme System (9035-51-2)
    Language English
    Publishing date 2022-06-30
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 1557-8925
    ISSN (online) 1557-8925
    DOI 10.1016/bs.apha.2022.05.009
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  2. Article: Primary Adenosquamous Carcinoma of the Prostate with Rectal Invasion.

    Azzi, Pierre / Bossé, Dominique / Cagiannos, Ilias / Borowy-Borowski, Paul / Tiberi, David

    Case reports in urology

    2022  Volume 2022, Page(s) 7613482

    Abstract: Prostate adenosquamous carcinoma (pASC) is a rare form of prostate cancer accounting for <1% of all cases. It is generally considered an aggressive variant often presenting with significant symptom burden and/or metastatic disease. Given its rarity, ... ...

    Abstract Prostate adenosquamous carcinoma (pASC) is a rare form of prostate cancer accounting for <1% of all cases. It is generally considered an aggressive variant often presenting with significant symptom burden and/or metastatic disease. Given its rarity, optimal management of this cancer is unknown. We present a case of a patient with pASC treated with radiotherapy and chemotherapy with excellent symptomatic improvement and local control.
    Language English
    Publishing date 2022-06-24
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2627659-8
    ISSN 2090-6978 ; 2090-696X
    ISSN (online) 2090-6978
    ISSN 2090-696X
    DOI 10.1155/2022/7613482
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  3. Article ; Online: Etiology of stillbirth in a tertiary care center: a retrospective cohort study assessing ultrasound, laboratory, and pathology investigations.

    Osborne, Brenden / Mitra, Sohini / Karol, Dalia / Azzi, Pierre / Ou, Kelsie / Alibhai, Kameela M / Murphy, Malia S Q / El-Chaâr, Darine

    The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians

    2023  Volume 36, Issue 2, Page(s) 2277131

    Abstract: Background: Canadian stillbirth data are limited, and a significant proportion of pregnancies resulting in stillbirth have no attributable cause. The objective of this study was to characterize stillbirth case investigations and management at a tertiary ...

    Abstract Background: Canadian stillbirth data are limited, and a significant proportion of pregnancies resulting in stillbirth have no attributable cause. The objective of this study was to characterize stillbirth case investigations and management at a tertiary care hospital in Ontario, Canada.
    Methods: This was a retrospective chart review study of all cases of singleton stillbirth at The Ottawa Hospital between 1 January 2012 and 31 December 2017. Terminations and multiples stillbirths were excluded. Chart reviews were conducted to extract maternal sociodemographic, obstetrical, and fetal characteristics, including results from antenatal ultrasounds, autopsy, placenta pathology, and laboratory investigations.
    Results: A total of 155 eligible cases of stillbirth were identified, resulting in a 6-year stillbirth rate of 4.2 per 1000 total births. The median maternal age was 31.0 years (IQR: 29.0, 35.0) and the median gestational age at delivery was 28 weeks (IQR: 24, 35). A total of 9 (5.8%) pregnant individuals had a history of previous stillbirth. Of the 155 stillbirths, 35% underwent the full suite of post-loss laboratory, placental, and fetal autopsy investigations. 63.2% of cases had post-loss laboratory investigations completed. 76% and 71% of cases had fetal autopsy and placenta pathology evaluations completed, respectively. Antenatal characteristics associated with stillbirth included fetal anomalies/genetic markers (27.1%), umbilical cord and placental anomalies (24.5%), fetal growth abnormalities (27.7%), cervical/uterine abnormalities (11.6%), and amniotic fluid abnormalities (25.1%). The most common autopsy findings included evidence of infection (22.7%), fetal anomalies (12.6%), and fetal hypoxia (10%). The most common placental pathology findings included features of placental insufficiency (21.8%), retroplacental abnormalities (16.3%), and umbilical cord accident/infarct (15.4%).
    Conclusions: Our findings demonstrate that as many as two-thirds of singleton stillbirth cases at our center did not receive the post-perinatal loss investigations recommended by clinical practice guidelines. More thorough collection of post-stillbirth data at all levels (institutional, provincial, national) is warranted to improve our understanding of stillbirth epidemiology, etiology, and management in Canada.
    MeSH term(s) Female ; Pregnancy ; Humans ; Stillbirth/epidemiology ; Placenta/pathology ; Tertiary Care Centers ; Retrospective Studies ; Canada
    Language English
    Publishing date 2023-11-05
    Publishing country England
    Document type Journal Article
    ZDB-ID 2077261-0
    ISSN 1476-4954 ; 1057-0802 ; 1476-7058
    ISSN (online) 1476-4954
    ISSN 1057-0802 ; 1476-7058
    DOI 10.1080/14767058.2023.2277131
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    Zs.A 3510: Show issues Location:
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  4. Article: How to Foster 'New Approach Methodology' Toxicologists.

    Doktorova, Tatyana Y / Azzi, Pamela / Hofer, Joelle / Messner, Catherine J / Gaiser, Carine / Werner, Sophie / Singh, Pranika / Hardy, Barry / Suter-Dick, Laura / Chesne, Christophe

    Alternatives to laboratory animals : ATLA

    2022  Volume 50, Issue 1, Page(s) 71–75

    Abstract: The need to reduce, refine and replace animal experimentation has led to a boom in the establishment of new approach methodologies (NAMs). This promising trend brings the hope that the replacement of animals by using NAMs will become increasingly ... ...

    Abstract The need to reduce, refine and replace animal experimentation has led to a boom in the establishment of new approach methodologies (NAMs). This promising trend brings the hope that the replacement of animals by using NAMs will become increasingly accepted by regulators, included in legislation, and consequently more-often implemented by industry. The majority of NAMs, however, are still not very well understood, either due to the complexity of the applied approach or the data analysis workflow. A potential solution to this problem is the provision of better educational resources to scientists new to the area - showcasing the added value of NAMs and outlining various ways of overcoming issues associated with knowledge gaps. In this paper, the educational exchange between four institutions - namely, two universities and two SMEs - via a series of video training sessions, is described. The goal of this exchange was to showcase an exemplary event to help introduce scientists to non-animal approaches, and to actively support the development of resources enabling the use of alternatives to laboratory animals.
    MeSH term(s) Animal Experimentation ; Animal Testing Alternatives/methods ; Animals ; Universities
    Language English
    Publishing date 2022-02-18
    Publishing country England
    Document type Journal Article
    ZDB-ID 605800-0
    ISSN 0261-1929
    ISSN 0261-1929
    DOI 10.1177/02611929221078945
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  5. Article ; Conference proceedings: Corantes Artificiais Orgânicos em Doces em Massas: Adequação da Indústria Alimentícia Frente ao Monitoramento

    Yudice, Eliana Della Coletta / de Mattos, Elaine Cristina / Gioccondo, Maria Antônia Stefanin / Azzi, Patrícia / Daros, Vilma Dos Santos Menezes Gaiotto / Col, Rute Dal

    International Journal of Nutrology

    2018  Volume 11, Issue S 01

    Event/congress XXI I Congresso Brasileiro de Nutrologia, Porto Alegre, 2018-09-27
    Language Portuguese
    Publishing date 2018-09-01
    Publisher Thieme Revinter Publicações Ltda
    Publishing place Stuttgart ; New York
    Document type Article ; Conference proceedings
    ISSN 2595-2854 ; 1984-3011
    ISSN (online) 2595-2854
    ISSN 1984-3011
    DOI 10.1055/s-0038-1674570
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  6. Article ; Online: Cellular Accumulation and Toxic Effects of Bile Acids in Cyclosporine A-Treated HepaRG Hepatocytes.

    Sharanek, Ahmad / Burban, Audrey / Humbert, Lydie / Bachour-El Azzi, Pamela / Felix-Gomes, Neuza / Rainteau, Dominique / Guillouzo, Andre

    Toxicological sciences : an official journal of the Society of Toxicology

    2015  Volume 147, Issue 2, Page(s) 573–587

    Abstract: Alteration of bile acid (BA) profiles and secretion by cholestatic drugs represents a major clinical issue. Species differences exist in BA composition, synthesis, and regulation; however presently, there is no in vitro reproducible cell model to perform ...

    Abstract Alteration of bile acid (BA) profiles and secretion by cholestatic drugs represents a major clinical issue. Species differences exist in BA composition, synthesis, and regulation; however presently, there is no in vitro reproducible cell model to perform studies on BAs in humans. We have evaluated the capacity of the human HepaRG cell line to synthesize, conjugate, and secrete BAs, and analyzed changes in BA content and profile after cyclosporine A (CsA) treatment. Our data show that HepaRG cells produced normal BAs at daily levels comparable, though in different proportions, to those measured in primary human hepatocytes. A 4-h treatment with CsA led to BA accumulation and profile changes associated with occurrence of cholestatic features, while after 24 h BAs were decreased in cell layers and increased in media. The latter effects resulted from reduced function of BA uptake transporter (Na(+)-taurocholate cotransporting polypeptide), reduced expression of BA metabolizing enzymes, including cytochrome P4507A1, cytochrome P4508B1, and cytochrome P45027A1, and induction of alternative basolateral transporters. Noteworthy, HepaRG cells incubated in a 2% serum-supplemented medium showed dose-dependent accumulation of the cytotoxic BA lithocholic acid in a nonsulfoconjugated form associated with early inhibition of the canalicular transporter MRP2 and sulfotransferase 2A1. In summary, our data bring the first demonstration that an in vitro human liver cell line is able to produce and secrete conjugated BAs, and to accumulate endogenous BAs transiently, concomitantly to occurrence of various other cholestatic features following CsA treatment. Retention of the hydrophobic lithocholic acid supports its toxic role in drug-induced cholestasis. Overall, our results argue on the suitability of HepaRG cells for investigating mechanisms involved in the development of the disease.
    MeSH term(s) Bile Acids and Salts/analysis ; Bile Acids and Salts/metabolism ; Bile Acids and Salts/toxicity ; Blotting, Western ; Cell Line ; Cholestanetriol 26-Monooxygenase/metabolism ; Cholesterol 7-alpha-Hydroxylase/metabolism ; Cyclosporine/pharmacology ; Dose-Response Relationship, Drug ; Gene Expression/drug effects ; Hepatocytes/chemistry ; Hepatocytes/drug effects ; Humans ; Steroid 12-alpha-Hydroxylase/metabolism
    Chemical Substances Bile Acids and Salts ; Cyclosporine (83HN0GTJ6D) ; CYP7A1 protein, human (EC 1.14.14.23) ; Cholesterol 7-alpha-Hydroxylase (EC 1.14.14.23) ; CYP27A1 protein, human (EC 1.14.15.15) ; Cholestanetriol 26-Monooxygenase (EC 1.14.15.15) ; Steroid 12-alpha-Hydroxylase (EC 1.14.18.8)
    Language English
    Publishing date 2015-10
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1420885-4
    ISSN 1096-0929 ; 1096-6080
    ISSN (online) 1096-0929
    ISSN 1096-6080
    DOI 10.1093/toxsci/kfv155
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    Zs.A 1709: Show issues Location:
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  7. Article ; Online: Comparative Localization and Functional Activity of the Main Hepatobiliary Transporters in HepaRG Cells and Primary Human Hepatocytes.

    Bachour-El Azzi, Pamela / Sharanek, Ahmad / Burban, Audrey / Li, Ruoya / Guével, Rémy Le / Abdel-Razzak, Ziad / Stieger, Bruno / Guguen-Guillouzo, Christiane / Guillouzo, André

    Toxicological sciences : an official journal of the Society of Toxicology

    2015  Volume 145, Issue 1, Page(s) 157–168

    Abstract: The role of hepatobiliary transporters in drug-induced liver injury remains poorly understood. Various in vivo and in vitro biological approaches are currently used for studying hepatic transporters; however, appropriate localization and functional ... ...

    Abstract The role of hepatobiliary transporters in drug-induced liver injury remains poorly understood. Various in vivo and in vitro biological approaches are currently used for studying hepatic transporters; however, appropriate localization and functional activity of these transporters are essential for normal biliary flow and drug transport. Human hepatocytes (HHs) are considered as the most suitable in vitro cell model but erratic availability and inter-donor functional variations limit their use. In this work, we aimed to compare localization of influx and efflux transporters and their functional activity in differentiated human HepaRG hepatocytes with fresh HHs in conventional (CCHH) and sandwich (SCHH) cultures. All tested influx and efflux transporters were correctly localized to canalicular [bile salt export pump (BSEP), multidrug resistance-associated protein 2 (MRP2), multidrug resistance protein 1 (MDR1), and MDR3] or basolateral [Na(+)-taurocholate co-transporting polypeptide (NTCP) and MRP3] membrane domains and were functional in all models. Contrary to other transporters, NTCP and BSEP were less abundant and active in HepaRG cells, cellular uptake of taurocholate was 2.2- and 1.4-fold and bile excretion index 2.8- and 2.6-fold lower, than in SCHHs and CCHHs, respectively. However, when taurocholate canalicular efflux was evaluated in standard and divalent cation-free conditions in buffers or cell lysates, the difference between the three models did not exceed 9.3%. Interestingly, cell imaging showed higher bile canaliculi contraction/relaxation activity in HepaRG hepatocytes and larger bile canaliculi networks in SCHHs. Altogether, our results bring new insights in mechanisms involved in bile acids accumulation and excretion in HHs and suggest that HepaRG cells represent a suitable model for studying hepatobiliary transporters and drug-induced cholestasis.
    MeSH term(s) Cell Line ; Hepatocytes/metabolism ; Humans ; Membrane Transport Proteins/metabolism
    Chemical Substances Membrane Transport Proteins
    Language English
    Publishing date 2015-05
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1420885-4
    ISSN 1096-0929 ; 1096-6080
    ISSN (online) 1096-0929
    ISSN 1096-6080
    DOI 10.1093/toxsci/kfv041
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  8. Article ; Online: Impact of inflammation on chlorpromazine-induced cytotoxicity and cholestatic features in HepaRG cells.

    Bachour-El Azzi, Pamela / Sharanek, Ahmad / Abdel-Razzak, Ziad / Antherieu, Sebastien / Al-Attrache, Houssein / Savary, Camille C / Lepage, Sylvie / Morel, Isabelle / Labbe, Gilles / Guguen-Guillouzo, Christiane / Guillouzo, André

    Drug metabolism and disposition: the biological fate of chemicals

    2014  Volume 42, Issue 9, Page(s) 1556–1566

    Abstract: Several factors are thought to be implicated in the occurrence of idiosyncratic adverse drug reactions. The present work aimed to question as to whether inflammation is a determinant factor in hepatic lesions induced by chlorpromazine (CPZ) using the ... ...

    Abstract Several factors are thought to be implicated in the occurrence of idiosyncratic adverse drug reactions. The present work aimed to question as to whether inflammation is a determinant factor in hepatic lesions induced by chlorpromazine (CPZ) using the human HepaRG cell line. An inflammation state was induced by a 24-hour exposure to proinflammatory cytokines interleukin-6 (IL-6) and IL-1β; then the cells were simultaneously treated with CPZ and/or cytokine for 24 hours or daily for 5 days. The inflammatory response was assessed by induction of C-reactive protein and IL-8 transcripts and proteins as well as inhibition of CPZ metabolism and down-regulation of cytochrome 3A4 (CYP3A4) and CYP1A2 transcripts, two major cytochrome P450 (P450) enzymes involved in its metabolism. Most effects of cotreatments with cytokines and CPZ were amplified or only observed after five daily treatments; they mainly included increased cytotoxicity and overexpression of oxidative stress-related genes, decreased Na(+)-taurocholate cotransporting polypeptide mRNA levels and activity, a key transporter involved in bile acids uptake, and deregulation of several other transporters. However, CPZ-induced inhibition of taurocholic acid efflux and pericanalicular F-actin distribution were not affected. In addition, a time-dependent induction of phospholipidosis was noticed in CPZ-treated cells, without obvious influence of the inflammatory stress. In summary, our results show that an inflammatory state induced by proinflammatory cytokines increased cytotoxicity and enhanced some cholestatic features induced by the idiosyncratic drug CPZ in HepaRG cells. These changes, together with inhibition of P450 activities, could have important consequences if extrapolated to the in vivo situation.
    MeSH term(s) Actins/genetics ; Actins/metabolism ; Bile Acids and Salts/genetics ; Bile Acids and Salts/metabolism ; C-Reactive Protein/genetics ; C-Reactive Protein/metabolism ; Cell Line ; Chlorpromazine/adverse effects ; Cholestasis/chemically induced ; Cholestasis/genetics ; Cholestasis/metabolism ; Cytochrome P-450 CYP1A2/genetics ; Cytochrome P-450 CYP1A2/metabolism ; Cytochrome P-450 CYP3A/genetics ; Cytochrome P-450 CYP3A/metabolism ; Down-Regulation/genetics ; Humans ; Inflammation/genetics ; Inflammation/metabolism ; Interleukins/genetics ; Interleukins/metabolism ; Organic Anion Transporters, Sodium-Dependent/genetics ; Organic Anion Transporters, Sodium-Dependent/metabolism ; Oxidative Stress/genetics ; RNA, Messenger/genetics ; Symporters/genetics ; Symporters/metabolism ; Taurocholic Acid/genetics ; Taurocholic Acid/metabolism
    Chemical Substances Actins ; Bile Acids and Salts ; Interleukins ; Organic Anion Transporters, Sodium-Dependent ; RNA, Messenger ; Symporters ; sodium-bile acid cotransporter (145420-23-1) ; Taurocholic Acid (5E090O0G3Z) ; C-Reactive Protein (9007-41-4) ; CYP1A2 protein, human (EC 1.14.14.1) ; Cytochrome P-450 CYP1A2 (EC 1.14.14.1) ; Cytochrome P-450 CYP3A (EC 1.14.14.1) ; CYP3A4 protein, human (EC 1.14.14.55) ; Chlorpromazine (U42B7VYA4P)
    Language English
    Publishing date 2014-07-07
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 186795-7
    ISSN 1521-009X ; 0090-9556
    ISSN (online) 1521-009X
    ISSN 0090-9556
    DOI 10.1124/dmd.114.058123
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    Zs.A 1014: Show issues Location:
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  9. Article ; Online: Oxidative stress plays a major role in chlorpromazine-induced cholestasis in human HepaRG cells.

    Anthérieu, Sébastien / Bachour-El Azzi, Pamela / Dumont, Julie / Abdel-Razzak, Ziad / Guguen-Guillouzo, Christiane / Fromenty, Bernard / Robin, Marie-Anne / Guillouzo, André

    Hepatology (Baltimore, Md.)

    2013  Volume 57, Issue 4, Page(s) 1518–1529

    Abstract: Unlabelled: Drugs induce cholestasis by diverse and still poorly understood mechanisms in humans. Early hepatic effects of chlorpromazine (CPZ), a neuroleptic drug known for years to induce intrahepatic cholestasis, were investigated using the ... ...

    Abstract Unlabelled: Drugs induce cholestasis by diverse and still poorly understood mechanisms in humans. Early hepatic effects of chlorpromazine (CPZ), a neuroleptic drug known for years to induce intrahepatic cholestasis, were investigated using the differentiated human hepatoma HepaRG cells. Generation of reactive oxygen species (ROS) was detected as early as 15 minutes after CPZ treatment and was associated with an altered mitochondrial membrane potential and disruption of the pericanalicular distribution of F-actin. Inhibition of [3H]-taurocholic acid efflux was observed after 30 minutes and was mostly prevented by N-acetyl cysteine (NAC) cotreatment, indicating a major role of oxidative stress in CPZ-induced bile acid (BA) accumulation. Moreover, 24-hour treatment with CPZ decreased messenger RNA (mRNA) expression of the two main canalicular bile transporters, bile salt export pump (BSEP) and multidrug resistance protein 3 (MDR3). Additional CPZ effects included inhibition of Na+ -dependent taurocholic cotransporting polypeptide (NTCP) expression and activity, multidrug resistance-associated protein 4 (MRP4) overexpression and CYP8B1 inhibition that are involved in BA uptake, basolateral transport, and BA synthesis, respectively. These latter events likely represent hepatoprotective responses which aim to reduce intrahepatic accumulation of toxic BA. Compared to CPZ effects, overloading of HepaRG cells with high concentrations of cholic and chenodeoxycholic acids induced a delayed oxidative stress and, similarly, after 24 hours it down-regulated BSEP and MDR3 in parallel to a decrease of NTCP and CYP8B1 and an increase of MRP4. By contrast, low BA concentrations up-regulated BSEP and MDR3 in the absence of oxidative stress.
    Conclusion: These data provide evidence that, among other mechanisms, oxidative stress plays a major role as both a primary causal and an aggravating factor in the early CPZ-induced intrahepatic cholestasis in human hepatocytes.
    MeSH term(s) ATP Binding Cassette Subfamily B Member 11 ; ATP Binding Cassette Transporter, Sub-Family B/metabolism ; ATP-Binding Cassette Transporters/metabolism ; Actins/metabolism ; Carcinoma, Hepatocellular/metabolism ; Carcinoma, Hepatocellular/pathology ; Cell Line, Tumor ; Chlorpromazine/adverse effects ; Chlorpromazine/pharmacology ; Cholestasis/chemically induced ; Cholestasis/metabolism ; Cholestasis/physiopathology ; Humans ; In Vitro Techniques ; Liver Neoplasms/metabolism ; Liver Neoplasms/pathology ; Membrane Potential, Mitochondrial/drug effects ; Oxidative Stress/drug effects ; Oxidative Stress/physiology ; Reactive Oxygen Species/metabolism ; Taurocholic Acid/metabolism
    Chemical Substances ABCB11 protein, human ; ATP Binding Cassette Subfamily B Member 11 ; ATP Binding Cassette Transporter, Sub-Family B ; Actins ; Reactive Oxygen Species ; multidrug resistance protein 3 ; Taurocholic Acid (5E090O0G3Z) ; Chlorpromazine (U42B7VYA4P)
    Language English
    Publishing date 2013-04
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 604603-4
    ISSN 1527-3350 ; 0270-9139
    ISSN (online) 1527-3350
    ISSN 0270-9139
    DOI 10.1002/hep.26160
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  10. Article ; Online: Search for Scalar Leptoquarks Produced via τ-Lepton-Quark Scattering in pp Collisions at sqrt[s]=13  TeV.

    Hayrapetyan, A / Tumasyan, A / Adam, W / Andrejkovic, J W / Bergauer, T / Chatterjee, S / Damanakis, K / Dragicevic, M / Escalante Del Valle, A / Hussain, P S / Jeitler, M / Krammer, N / Liko, D / Mikulec, I / Schieck, J / Schöfbeck, R / Schwarz, D / Sonawane, M / Templ, S /
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    Physical review letters

    2024  Volume 132, Issue 6, Page(s) 61801

    Abstract: The first search for scalar leptoquarks produced in τ-lepton-quark collisions is presented. It is based on a set of proton-proton collision data recorded with the CMS detector at the LHC at a center-of-mass energy of 13 TeV corresponding to an integrated ...

    Abstract The first search for scalar leptoquarks produced in τ-lepton-quark collisions is presented. It is based on a set of proton-proton collision data recorded with the CMS detector at the LHC at a center-of-mass energy of 13 TeV corresponding to an integrated luminosity of 138  fb^{-1}. The reconstructed final state consists of a jet, significant missing transverse momentum, and a τ lepton reconstructed through its hadronic or leptonic decays. Limits are set on the product of the leptoquark production cross section and branching fraction and interpreted as exclusions in the plane of the leptoquark mass and the leptoquark-τ-quark coupling strength.
    Language English
    Publishing date 2024-02-23
    Publishing country United States
    Document type Journal Article
    ZDB-ID 208853-8
    ISSN 1079-7114 ; 0031-9007
    ISSN (online) 1079-7114
    ISSN 0031-9007
    DOI 10.1103/PhysRevLett.132.061801
    Database MEDical Literature Analysis and Retrieval System OnLINE

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