Article ; Online: Cell-cycle involvement in autophagy and apoptosis in yeast.
Mechanisms of ageing and development
2017 Volume 161, Issue Pt B, Page(s) 211–224
Abstract: Regulation of the cell cycle and apoptosis are two eukaryotic processes required to ensure maintenance of genomic integrity, especially in response to DNA damage. The ease with which yeast, amongst other eukaryotes, can switch from cellular proliferation ...
| Abstract | Regulation of the cell cycle and apoptosis are two eukaryotic processes required to ensure maintenance of genomic integrity, especially in response to DNA damage. The ease with which yeast, amongst other eukaryotes, can switch from cellular proliferation to cell death may be the result of a common set of biochemical factors which play dual roles depending on the cell's physiological state. A wide variety of homologues are shared between different yeasts and metazoans and this conservation confirms their importance. This review gives an overview of key molecular players involved in yeast cell-cycle regulation, and those involved in mechanisms which are induced by cell-cycle dysregulation. One such mechanism is autophagy which, depending on the severity and type of DNA damage, may either contribute to the cell's survival or death. Cell-cycle dysregulation due to checkpoint deficiency leads to mitotic catastrophe which in turn leads to programmed cell death. Molecular players implicated in the yeast apoptotic pathway were shown to play important roles in the cell cycle. These include the metacaspase Yca1p, the caspase-like protein Esp1p, the cohesin subunit Mcd1p, as well as the inhibitor of apoptosis protein Bir1p. The roles of these molecular players are discussed. |
|---|---|
| MeSH term(s) | Apoptosis/physiology ; Autophagy/physiology ; Carrier Proteins/genetics ; Carrier Proteins/metabolism ; Caspases/genetics ; Caspases/metabolism ; Cell Cycle/physiology ; Cell Cycle Proteins/genetics ; Cell Cycle Proteins/metabolism ; Chromosomal Proteins, Non-Histone/genetics ; Chromosomal Proteins, Non-Histone/metabolism ; Saccharomyces cerevisiae/genetics ; Saccharomyces cerevisiae/metabolism ; Saccharomyces cerevisiae Proteins/genetics ; Saccharomyces cerevisiae Proteins/metabolism ; Separase/genetics ; Separase/metabolism |
| Chemical Substances | Bir1 protein, S cerevisiae ; Carrier Proteins ; Cell Cycle Proteins ; Chromosomal Proteins, Non-Histone ; MCD1 protein, S cerevisiae ; Saccharomyces cerevisiae Proteins ; Caspases (EC 3.4.22.-) ; MCA1 protein, S cerevisiae (EC 3.4.22.-) ; ESP1 protein, S cerevisiae (EC 3.4.22.49) ; Separase (EC 3.4.22.49) |
| Language | English |
| Publishing date | 2017-01 |
| Publishing country | Ireland |
| Document type | Journal Article ; Review |
| ZDB-ID | 183915-9 |
| ISSN | 1872-6216 ; 0047-6374 |
| ISSN (online) | 1872-6216 |
| ISSN | 0047-6374 |
| DOI | 10.1016/j.mad.2016.07.006 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
More links
Kategorien
In stock of ZB MED Cologne/Königswinter
| Zs.A 1012: Show issues | Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG) |
Order via subito
This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.