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  1. AU="Béganton, Benoît"
  2. AU=Smith Zachary D.
  3. AU="Dotta, Federico"
  4. AU="Palmer, Andre"
  5. AU="Cai, Biao"
  6. AU="Leroux, Michel R"
  7. AU="Thomson, Jaidyn"
  8. AU="Novillo-Del Álamo, Blanca"
  9. AU="Deps, Patrícia D"

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  1. Artikel ; Online: Approches nouvelles pour l’étude des interactions protéine-protéine.

    Béganton, Benoît / Coyaud, Etienne / Mangé, Alain / Solassol, Jérôme

    Medecine sciences : M/S

    2019  Band 35, Heft 3, Seite(n) 223–231

    Abstract: The proteome is a dynamic system in which protein-protein interactions play a crucial role to model together the cellular phenotype. However, given the inherent limitation of the available technologies to depict the dynamic nature of these interactions, ... ...

    Titelübersetzung New approaches for protein-protein interaction study.
    Abstract The proteome is a dynamic system in which protein-protein interactions play a crucial role to model together the cellular phenotype. However, given the inherent limitation of the available technologies to depict the dynamic nature of these interactions, identify protein-protein interaction has for a long time represented an important challenge in proteomic. The recent development of BioID and APEX, two proximity-dependent labeling technologies, opens today new perspectives and yet start changing our vision of protein-protein interaction, and more globally our vision of the proteome. In this review, we describe the recent and conventional tools available to study protein-protein interactions, compare the advantages and limitations of these technics, and discuss the recent progress brought by the proximity-dependent labelling to complete our vision of the proteome, and thus better understand cellular mechanisms.
    Mesh-Begriff(e) Animals ; Biotinylation/methods ; Humans ; Protein Binding ; Protein Interaction Domains and Motifs ; Protein Interaction Maps ; Proteome/analysis ; Proteomics/methods ; Staining and Labeling/methods
    Chemische Substanzen Proteome
    Sprache Französisch
    Erscheinungsdatum 2019-04-01
    Erscheinungsland France
    Dokumenttyp Journal Article ; Review
    ZDB-ID 632733-3
    ISSN 1958-5381 ; 0767-0974
    ISSN (online) 1958-5381
    ISSN 0767-0974
    DOI 10.1051/medsci/2019035
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel ; Online: Protein interactions study through proximity-labeling.

    Béganton, Benoît / Solassol, Isabelle / Mangé, Alain / Solassol, Jérôme

    Expert review of proteomics

    2019  Band 16, Heft 8, Seite(n) 717–726

    Abstract: ... ...

    Abstract Introduction
    Mesh-Begriff(e) Animals ; Humans ; Mass Spectrometry ; Protein Binding ; Proteomics/methods ; Staining and Labeling/methods
    Sprache Englisch
    Erscheinungsdatum 2019-07-18
    Erscheinungsland England
    Dokumenttyp Journal Article
    ZDB-ID 2299100-1
    ISSN 1744-8387 ; 1478-9450
    ISSN (online) 1744-8387
    ISSN 1478-9450
    DOI 10.1080/14789450.2019.1638769
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

    Volltext online

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  3. Artikel: TERT

    Blateau, Pauline / Coyaud, Etienne / Laurent, Estelle / Béganton, Benoit / Ducros, Vincent / Chauchard, Géraldine / Vendrell, Julie A / Solassol, Jérôme

    Cancers

    2020  Band 12, Heft 8

    Abstract: Although the development of mitogen-activated protein kinase (MAPK) inhibitors has greatly improved the prognosis ... ...

    Abstract Although the development of mitogen-activated protein kinase (MAPK) inhibitors has greatly improved the prognosis of
    Sprache Englisch
    Erscheinungsdatum 2020-08-09
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers12082224
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  4. Artikel: Proximal Protein Interaction Landscape of RAS Paralogs.

    Béganton, Benoît / Coyaud, Etienne / Laurent, Estelle M N / Mangé, Alain / Jacquemetton, Julien / Le Romancer, Muriel / Raught, Brian / Solassol, Jérôme

    Cancers

    2020  Band 12, Heft 11

    Abstract: RAS proteins (KRAS, NRAS and HRAS) are frequently activated in different cancer types (e.g., non-small cell lung cancer, colorectal cancer, melanoma and bladder cancer). For many years, their activities were considered redundant due to their high degree ... ...

    Abstract RAS proteins (KRAS, NRAS and HRAS) are frequently activated in different cancer types (e.g., non-small cell lung cancer, colorectal cancer, melanoma and bladder cancer). For many years, their activities were considered redundant due to their high degree of sequence homology (80% identity) and their shared upstream and downstream protein partners. However, the high conservation of the Hyper-Variable-Region across mammalian species, the preferential activation of different RAS proteins in specific tumor types and the specific post-translational modifications and plasma membrane-localization of each paralog suggest they could ensure discrete functions. To gain insights into RAS proteins specificities, we explored their proximal protein-protein interaction landscapes using the proximity-dependent biotin identification technology (BioID) in Flp-In T-REx 293 cell lines stably transfected and inducibly expressing wild type KRAS4B, NRAS or HRAS. We identified more than 800 high-confidence proximal interactors, allowing us to propose an unprecedented comparative analysis of wild type RAS paralogs protein networks. These data bring novel information on poorly characterized RAS functions, e.g., its putative involvement in metabolic pathways, and on shared as well as paralog-specific protein networks that could partially explain the complexity of RAS functions. These networks of protein interactions open numerous avenues to better understand RAS paralogs biological activities.
    Sprache Englisch
    Erscheinungsdatum 2020-11-11
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers12113326
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  5. Artikel ; Online: FKBP4 connects mTORC2 and PI3K to activate the PDK1/Akt-dependent cell proliferation signaling in breast cancer.

    Mangé, Alain / Coyaud, Etienne / Desmetz, Caroline / Laurent, Estelle / Béganton, Benoit / Coopman, Peter / Raught, Brian / Solassol, Jérôme

    Theranostics

    2019  Band 9, Heft 23, Seite(n) 7003–7015

    Abstract: Purpose: ...

    Abstract Purpose:
    Mesh-Begriff(e) 3-Phosphoinositide-Dependent Protein Kinases/genetics ; 3-Phosphoinositide-Dependent Protein Kinases/metabolism ; Animals ; Breast Neoplasms/genetics ; Breast Neoplasms/metabolism ; Cell Line, Tumor ; Cell Proliferation ; Female ; Humans ; Mechanistic Target of Rapamycin Complex 2/genetics ; Mechanistic Target of Rapamycin Complex 2/metabolism ; Mice, Nude ; Phosphatidylinositol 3-Kinases/genetics ; Phosphatidylinositol 3-Kinases/metabolism ; Protein Binding ; Proto-Oncogene Proteins c-akt/genetics ; Proto-Oncogene Proteins c-akt/metabolism ; Signal Transduction ; Tacrolimus Binding Proteins/genetics ; Tacrolimus Binding Proteins/metabolism
    Chemische Substanzen 3-Phosphoinositide-Dependent Protein Kinases (EC 2.7.11.1) ; Mechanistic Target of Rapamycin Complex 2 (EC 2.7.11.1) ; PDPK1 protein, human (EC 2.7.11.1) ; Proto-Oncogene Proteins c-akt (EC 2.7.11.1) ; Tacrolimus Binding Proteins (EC 5.2.1.-) ; tacrolimus binding protein 4 (EC 5.2.1.-)
    Sprache Englisch
    Erscheinungsdatum 2019-09-21
    Erscheinungsland Australia
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2592097-2
    ISSN 1838-7640 ; 1838-7640
    ISSN (online) 1838-7640
    ISSN 1838-7640
    DOI 10.7150/thno.35561
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  6. Artikel ; Online: Circulating Cell Free Tumor DNA Detection as a Routine Tool forLung Cancer Patient Management.

    Vendrell, Julie A / Mau-Them, Frédéric Tran / Béganton, Benoît / Godreuil, Sylvain / Coopman, Peter / Solassol, Jérôme

    International journal of molecular sciences

    2017  Band 18, Heft 2

    Abstract: Circulating tumoral DNA (ctDNA), commonly named "liquid biopsy", has emerged as a new promising noninvasive tool to detect biomarker in several cancers including lung cancer. Applications involving molecular analysis of ctDNA in lung cancer have ... ...

    Abstract Circulating tumoral DNA (ctDNA), commonly named "liquid biopsy", has emerged as a new promising noninvasive tool to detect biomarker in several cancers including lung cancer. Applications involving molecular analysis of ctDNA in lung cancer have increased and encompass diagnosis, response to treatment, acquired resistance and prognosis prediction, while bypassing the problem of tumor heterogeneity. ctDNA may then help perform dynamic genetic surveillance in the era of precision medicine through indirect tumoral genomic information determination. The aims of this review were to examine the recent technical developments that allowed the detection of genetic alterations of ctDNA in lung cancer. Furthermore, we explored clinical applications in patients with lung cancer including treatment efficiency monitoring, acquired therapy resistance mechanisms and prognosis value.
    Mesh-Begriff(e) Biomarkers, Tumor ; Biopsy/methods ; Biopsy/standards ; DNA, Neoplasm/blood ; DNA, Neoplasm/genetics ; Diagnostic Tests, Routine/methods ; Diagnostic Tests, Routine/standards ; Disease Management ; Genomics/methods ; High-Throughput Nucleotide Sequencing ; Humans ; Lung Neoplasms/diagnosis ; Lung Neoplasms/genetics ; Lung Neoplasms/therapy ; Neoplastic Cells, Circulating/metabolism ; Neoplastic Cells, Circulating/pathology ; Polymerase Chain Reaction/methods ; Polymerase Chain Reaction/standards ; Precision Medicine/methods ; Precision Medicine/standards ; Prognosis ; Tumor Burden
    Chemische Substanzen Biomarkers, Tumor ; DNA, Neoplasm
    Sprache Englisch
    Erscheinungsdatum 2017-01-29
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article ; Review
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms18020264
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  7. Artikel ; Online: Pseudomonas aeruginosa ExlA and Serratia marcescens ShlA trigger cadherin cleavage by promoting calcium influx and ADAM10 activation.

    Reboud, Emeline / Bouillot, Stéphanie / Patot, Sabine / Béganton, Benoît / Attrée, Ina / Huber, Philippe

    PLoS pathogens

    2017  Band 13, Heft 8, Seite(n) e1006579

    Abstract: Pore-forming toxins are potent virulence factors secreted by a large array of bacteria. Here, we deciphered the action of ExlA from Pseudomonas aeruginosa and ShlA from Serratia marcescens on host cell-cell junctions. ExlA and ShlA are two members of a ... ...

    Abstract Pore-forming toxins are potent virulence factors secreted by a large array of bacteria. Here, we deciphered the action of ExlA from Pseudomonas aeruginosa and ShlA from Serratia marcescens on host cell-cell junctions. ExlA and ShlA are two members of a unique family of pore-forming toxins secreted by a two-component secretion system. Bacteria secreting either toxin induced an ExlA- or ShlA-dependent rapid cleavage of E-cadherin and VE-cadherin in epithelial and endothelial cells, respectively. Cadherin proteolysis was executed by ADAM10, a host cell transmembrane metalloprotease. ADAM10 activation is controlled in the host cell by cytosolic Ca2+ concentration. We show that Ca2+ influx, induced by ExlA or ShlA pore formation in the plasma membrane, triggered ADAM10 activation, thereby leading to cadherin cleavage. Our data suggest that ADAM10 is not a cellular receptor for ExlA and ShlA, further confirming that ADAM10 activation occurred via Ca2+ signalling. In conclusion, ExlA- and ShlA-secreting bacteria subvert a regulation mechanism of ADAM10 to activate cadherin shedding, inducing intercellular junction rupture, cell rounding and loss of tissue barrier integrity.
    Mesh-Begriff(e) ADAM10 Protein/metabolism ; Animals ; Bacterial Proteins/metabolism ; Bacterial Toxins/metabolism ; Blotting, Western ; Cadherins/metabolism ; Calcium/metabolism ; Enzyme Activation ; Female ; Gram-Negative Bacterial Infections/metabolism ; Hemolysin Proteins/metabolism ; Humans ; Mice ; Mice, Inbred BALB C ; Microscopy, Confocal ; Pseudomonas aeruginosa/pathogenicity ; Serratia marcescens/pathogenicity ; Virulence/physiology ; Virulence Factors/metabolism
    Chemische Substanzen Bacterial Proteins ; Bacterial Toxins ; Cadherins ; Hemolysin Proteins ; ShlA protein, Serratia marcescens ; Virulence Factors ; ADAM10 Protein (EC 3.4.24.81) ; Calcium (SY7Q814VUP)
    Sprache Englisch
    Erscheinungsdatum 2017-08
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 2205412-1
    ISSN 1553-7374 ; 1553-7366
    ISSN (online) 1553-7374
    ISSN 1553-7366
    DOI 10.1371/journal.ppat.1006579
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  8. Artikel ; Online: Detection of known and novel ALK fusion transcripts in lung cancer patients using next-generation sequencing approaches.

    Vendrell, Julie A / Taviaux, Sylvie / Béganton, Benoît / Godreuil, Sylvain / Audran, Patricia / Grand, David / Clermont, Estelle / Serre, Isabelle / Szablewski, Vanessa / Coopman, Peter / Mazières, Julien / Costes, Valérie / Pujol, Jean-Louis / Brousset, Pierre / Rouquette, Isabelle / Solassol, Jérôme

    Scientific reports

    2017  Band 7, Heft 1, Seite(n) 12510

    Abstract: Rearrangements of the anaplastic lymphoma kinase (ALK) gene in non-small cell lung cancer (NSCLC) represent a novel molecular target in a small subset of tumors. Although ALK rearrangements are usually assessed by immunohistochemistry (IHC) and ... ...

    Abstract Rearrangements of the anaplastic lymphoma kinase (ALK) gene in non-small cell lung cancer (NSCLC) represent a novel molecular target in a small subset of tumors. Although ALK rearrangements are usually assessed by immunohistochemistry (IHC) and fluorescence in situ hybridization (FISH), molecular approaches have recently emerged as relevant alternatives in routine laboratories. Here, we evaluated the use of two different amplicon-based next-generation sequencing (NGS) methods (AmpliSeq and Archer
    Mesh-Begriff(e) Adenocarcinoma of Lung/drug therapy ; Adenocarcinoma of Lung/genetics ; Adenocarcinoma of Lung/metabolism ; Adenocarcinoma of Lung/surgery ; Aged ; Anaplastic Lymphoma Kinase/genetics ; Anaplastic Lymphoma Kinase/metabolism ; Antineoplastic Agents/therapeutic use ; Carcinoma, Non-Small-Cell Lung/drug therapy ; Carcinoma, Non-Small-Cell Lung/genetics ; Carcinoma, Non-Small-Cell Lung/metabolism ; Carcinoma, Non-Small-Cell Lung/surgery ; Case-Control Studies ; Crizotinib/therapeutic use ; Dynactin Complex/genetics ; Dynactin Complex/metabolism ; Female ; Gene Expression ; Golgi Matrix Proteins/genetics ; Golgi Matrix Proteins/metabolism ; High-Throughput Nucleotide Sequencing/instrumentation ; High-Throughput Nucleotide Sequencing/methods ; Humans ; In Situ Hybridization, Fluorescence ; Lung Neoplasms/drug therapy ; Lung Neoplasms/genetics ; Lung Neoplasms/metabolism ; Lung Neoplasms/surgery ; Male ; Microtubule-Associated Proteins/genetics ; Microtubule-Associated Proteins/metabolism ; Middle Aged ; Neoplasm Staging ; Oncogene Proteins, Fusion/genetics ; Oncogene Proteins, Fusion/metabolism ; RNA, Messenger/genetics ; RNA, Messenger/metabolism
    Chemische Substanzen Antineoplastic Agents ; DCTN1 protein, human ; Dynactin Complex ; EML4-ALK fusion protein, human ; GCC2 protein, human ; Golgi Matrix Proteins ; Microtubule-Associated Proteins ; Oncogene Proteins, Fusion ; RNA, Messenger ; Crizotinib (53AH36668S) ; ALK protein, human (EC 2.7.10.1) ; Anaplastic Lymphoma Kinase (EC 2.7.10.1)
    Sprache Englisch
    Erscheinungsdatum 2017-10-02
    Erscheinungsland England
    Dokumenttyp Journal Article
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-017-12679-8
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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