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  1. Article ; Online: Mouvements anormaux.

    Bereau, Matthieu / Tranchant, Christine

    La Revue du praticien

    2022  Volume 72, Issue 1, Page(s) 93–100

    Title translation Abnormal movements.
    MeSH term(s) Dyskinesias ; Humans ; Movement Disorders/diagnosis ; Movement Disorders/etiology ; Movement Disorders/therapy ; Parkinson Disease
    Language French
    Publishing date 2022-03-08
    Publishing country France
    Document type Journal Article
    ZDB-ID 205365-2
    ISSN 2101-017X ; 0035-2640
    ISSN (online) 2101-017X
    ISSN 0035-2640
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: La maladie de Parkinson, une prise en soins intrinsèquement palliative.

    Auffret, Manon / Vérin, Marc / Giffard, Mathilde / Marguet, Delphine / Béreau, Matthieu / Patat, Marie

    Soins; la revue de reference infirmiere

    2024  Volume 69, Issue 883, Page(s) 53–57

    Abstract: Multidimensional, chronic, progressive and incurable, Parkinson's disease is, by definition, a palliative disease, and this from the moment of diagnosis. This vision, relatively new to neurology, calls for a paradigm shift, as well as a dual medical- ... ...

    Title translation Parkinson's disease: intrinsically palliative care.
    Abstract Multidimensional, chronic, progressive and incurable, Parkinson's disease is, by definition, a palliative disease, and this from the moment of diagnosis. This vision, relatively new to neurology, calls for a paradigm shift, as well as a dual medical-paramedical and home-hospital alliance. This approach allows us to better understand the specificities of Parkinson's disease and its treatments in terms of palliative issues.
    MeSH term(s) Humans ; Palliative Care ; Parkinson Disease/therapy ; Terminal Care
    Language French
    Publishing date 2024-02-16
    Publishing country France
    Document type English Abstract ; Journal Article
    ZDB-ID 604655-1
    ISSN 0038-0814
    ISSN 0038-0814
    DOI 10.1016/j.soin.2023.12.028
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Vieillissement et troubles du goût et de l’olfaction.

    Jacquot, Laurence / Bereau, Matthieu

    Soins. Gerontologie

    2020  Volume 25, Issue 145, Page(s) 18–21

    Abstract: Compared with other sensory modalities, age-related alterations in taste and smell are less known and less investigated in clinical practice. In fact, the elderly with a loss of smell or taste may not always report it or be aware of it. In addition, the ... ...

    Title translation Aging and disorders of taste and smell.
    Abstract Compared with other sensory modalities, age-related alterations in taste and smell are less known and less investigated in clinical practice. In fact, the elderly with a loss of smell or taste may not always report it or be aware of it. In addition, the clinical evaluation of taste and smell by specific tests is rarely performed.
    MeSH term(s) Aged ; Aging/physiology ; Humans ; Olfaction Disorders/diagnosis ; Smell/physiology ; Taste/physiology ; Taste Disorders/diagnosis
    Language French
    Publishing date 2020-07-17
    Publishing country France
    Document type Journal Article
    ZDB-ID 2246755-5
    ISSN 1268-6034
    ISSN 1268-6034
    DOI 10.1016/j.sger.2020.07.005
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Apathy in Parkinson's Disease: Clinical Patterns and Neurobiological Basis.

    Béreau, Matthieu / Van Waes, Vincent / Servant, Mathieu / Magnin, Eloi / Tatu, Laurent / Anheim, Mathieu

    Cells

    2023  Volume 12, Issue 12

    Abstract: Apathy is commonly defined as a loss of motivation leading to a reduction in goal-directed behaviors. This multidimensional syndrome, which includes cognitive, emotional and behavioral components, is one of the most prevalent neuropsychiatric features of ...

    Abstract Apathy is commonly defined as a loss of motivation leading to a reduction in goal-directed behaviors. This multidimensional syndrome, which includes cognitive, emotional and behavioral components, is one of the most prevalent neuropsychiatric features of Parkinson's disease (PD). It has been established that the prevalence of apathy increases as PD progresses. However, the pathophysiology and anatomic substrate of this syndrome remain unclear. Apathy seems to be underpinned by impaired anatomical structures that link the prefrontal cortex with the limbic system. It can be encountered in the prodromal stage of the disease and in fluctuating PD patients receiving bilateral chronic subthalamic nucleus stimulation. In these stages, apathy may be considered as a disorder of motivation that embodies amotivational behavioral syndrome, is underpinned by combined dopaminergic and serotonergic denervation and is dopa-responsive. In contrast, in advanced PD patients, apathy may be considered as cognitive apathy that announces cognitive decline and PD dementia, is underpinned by diffuse neurotransmitter system dysfunction and Lewy pathology spreading and is no longer dopa-responsive. In this review, we discuss the clinical patterns of apathy and their treatment, the neurobiological basis of apathy, the potential role of the anatomical structures involved and the pathways in motivational and cognitive apathy.
    MeSH term(s) Humans ; Apathy/physiology ; Parkinson Disease/metabolism ; Depression ; Limbic System ; Syndrome ; Dihydroxyphenylalanine
    Chemical Substances Dihydroxyphenylalanine (63-84-3)
    Language English
    Publishing date 2023-06-10
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2661518-6
    ISSN 2073-4409 ; 2073-4409
    ISSN (online) 2073-4409
    ISSN 2073-4409
    DOI 10.3390/cells12121599
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Efficacy of dalfampridine in neuromyelitis optica spectrum disorder: A pilot study.

    de Seze, Jérôme / Clerc, Christine / Béreau, Matthieu / Bourre, Bertrand / Zephir, Hélène / Collongues, Nicolas / Kremer, Laurent / Vermersch, Patrick / Bigaut, Kevin

    Multiple sclerosis journal - experimental, translational and clinical

    2024  Volume 10, Issue 1, Page(s) 20552173241233952

    Abstract: Objective: To assess the efficacy of dalfampridine in patients with neuromyelitis optica spectrum disorder.: Methods: We included 15 consecutive patients, who were started on a treatment of dalfampridine 10 mg twice daily for 2 weeks. Efficacy ... ...

    Abstract Objective: To assess the efficacy of dalfampridine in patients with neuromyelitis optica spectrum disorder.
    Methods: We included 15 consecutive patients, who were started on a treatment of dalfampridine 10 mg twice daily for 2 weeks. Efficacy assessment was based on walking ability improvement using Timed-25-Foot Walk and 12-item Multiple Sclerosis Walking Scale tests.
    Results: The mean Timed-25-Foot Walk score was reduced from 14.8 (±2.4) to 11.3 (±1.9) seconds (
    Conclusion: Dalfampridine seems to be useful for symptomatic treatment of walking impairment in neuromyelitis optica spectrum disorder.
    Language English
    Publishing date 2024-02-29
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2841884-0
    ISSN 2055-2173 ; 2055-2173
    ISSN (online) 2055-2173
    ISSN 2055-2173
    DOI 10.1177/20552173241233952
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Terminal Care in Parkinson's Disease: Real-Life Use of Continuous Subcutaneous Apomorphine Infusion to Improve Patient Comfort.

    Béreau, Matthieu / Giffard, Mathilde / Clairet, Anne-Laure / Degenne, Guillaume / Tatu, Laurent / Richfield, Edward / Magnin, Eloi / Vérin, Marc / Auffret, Manon

    Journal of Parkinson's disease

    2024  Volume 14, Issue 1, Page(s) 209–219

    Abstract: Background: There are currently no recommendations on the therapeutic management of Parkinson's disease (PD) patients at the end of life.: Objective: To describe a cohort of patients with PD who benefited from continuous subcutaneous apomorphine ... ...

    Abstract Background: There are currently no recommendations on the therapeutic management of Parkinson's disease (PD) patients at the end of life.
    Objective: To describe a cohort of patients with PD who benefited from continuous subcutaneous apomorphine infusion (CSAI) initiation at the end of their life as comfort care.
    Methods: This real-life cohort includes 14 PD patients, who benefited from 24-h, low-dose CSAI (0.5-3 mg/h) in the context of terminal care. Patient's comfort (pain, rigidity, and/or ability to communicate) and occurrence of CSAI-related side-effects (nausea/vomiting, cutaneous and behavioral manifestations) were evaluated based on medical records.
    Results: All patients (age 62-94 years, disease duration 2-32 years) presented with late-stage PD and a compromised oral route. Treatment lasted from a few hours to 39 days. CSAI led to substantial functional improvement, with a good safety profile. Overall clinical comfort was deemed improved by the medical team, the patient, and/or caregivers.
    Conclusions: CSAI might be a promising approach in PD terminal care, as it reduces motor symptoms and overall discomfort, with an apparent good safety profile. Use of the apomorphine pen, sublingual film or a classic syringe pump might be considered when apomorphine pumps are not available. Larger observational cohorts and randomized controlled trials are needed to establish the efficacy and tolerability of apomorphine in the context of terminal care and more broadly, in an advance care planning perspective.
    MeSH term(s) Humans ; Middle Aged ; Aged ; Aged, 80 and over ; Apomorphine ; Parkinson Disease/drug therapy ; Antiparkinson Agents/therapeutic use ; Patient Comfort ; Terminal Care
    Chemical Substances Apomorphine (N21FAR7B4S) ; Antiparkinson Agents
    Language English
    Publishing date 2024-01-11
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2620609-2
    ISSN 1877-718X ; 1877-7171
    ISSN (online) 1877-718X
    ISSN 1877-7171
    DOI 10.3233/JPD-230201
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: L5 Radiculopathy with Neurological Deficit Due To Sacral Insufficiency Fracture.

    Toussirot, Eric / Bereau, Matthieu / Aubry, Sebastien

    The Journal of rheumatology

    2020  Volume 47, Issue 6, Page(s) 939–940

    MeSH term(s) Fractures, Stress/complications ; Fractures, Stress/diagnostic imaging ; Humans ; Radiculopathy/complications ; Radiculopathy/diagnostic imaging ; Sacrum/diagnostic imaging ; Sacrum/injuries ; Spinal Fractures/complications ; Spinal Fractures/diagnostic imaging
    Language English
    Publishing date 2020-06-01
    Publishing country Canada
    Document type Journal Article
    ZDB-ID 194928-7
    ISSN 1499-2752 ; 0315-162X
    ISSN (online) 1499-2752
    ISSN 0315-162X
    DOI 10.3899/jrheum.190517
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Freezing of Gait and Its Levodopa Paradox.

    Nonnekes, Jorik / Bereau, Matthieu / Bloem, Bastiaan R

    JAMA neurology

    2019  Volume 77, Issue 3, Page(s) 287–288

    MeSH term(s) Antiparkinson Agents/adverse effects ; Gait Disorders, Neurologic/chemically induced ; Humans ; Levodopa/adverse effects ; Parkinson Disease/drug therapy
    Chemical Substances Antiparkinson Agents ; Levodopa (46627O600J)
    Language English
    Publishing date 2019-12-14
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2702023-X
    ISSN 2168-6157 ; 2168-6149
    ISSN (online) 2168-6157
    ISSN 2168-6149
    DOI 10.1001/jamaneurol.2019.4006
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: An unusual association of CANOMAD and rheumatoid arthritis with a long-term follow-up.

    Toussirot, Eric / Bereau, Matthieu / Sevrin, Philippe / Tatu, Laurent

    Joint bone spine

    2019  Volume 87, Issue 3, Page(s) 263–264

    MeSH term(s) Arthritis, Rheumatoid/diagnosis ; Arthritis, Rheumatoid/drug therapy ; Follow-Up Studies ; Humans ; Monoclonal Gammopathy of Undetermined Significance ; Paraproteinemias
    Language English
    Publishing date 2019-09-23
    Publishing country France
    Document type Letter
    ZDB-ID 2020487-5
    ISSN 1778-7254 ; 1297-319X
    ISSN (online) 1778-7254
    ISSN 1297-319X
    DOI 10.1016/j.jbspin.2019.09.009
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  10. Article ; Online: Vaccination and Induction of Autoimmune Diseases.

    Toussirot, Éric / Bereau, Matthieu

    Inflammation & allergy drug targets

    2016  Volume 14, Issue 2, Page(s) 94–98

    Abstract: Vaccines have been suspected of playing a role in inducing autoimmune disease (AID) for a long time. However, apart from certain specific vaccine strains and complications (such as the swine flu vaccine and Guillain-Barré syndrome in 1976, ... ...

    Abstract Vaccines have been suspected of playing a role in inducing autoimmune disease (AID) for a long time. However, apart from certain specific vaccine strains and complications (such as the swine flu vaccine and Guillain-Barré syndrome in 1976, thrombocytopenia and the Measles-Mumps-Rubella vaccine), this role has not been established. In spite of this, many isolated cases or series of cases of arthritis, vasculitis, and central or peripheral nervous system symptoms following vaccination have been reported. These cases tend to be very infrequent and usually only the shortterm outcomes are described. This paper will examine the arguments for and against the relationship between vaccines and AID, bearing in mind that no association between the two has been clearly identified up to now. The role of adjuvants in vaccines has been described by other teams and in a more general syndrome (Autoimmune/Autoinflammatory Syndrome Induced by Adjuvants). Thus, cases of AID triggered by vaccines are highly rare and raise questions about the interaction between vaccines and/or their adjuvants and the genetic context of autoimmune disease. These observations should therefore not undermine the benefits of vaccination.
    MeSH term(s) Adjuvants, Immunologic/adverse effects ; Animals ; Autoimmune Diseases/chemically induced ; Autoimmune Diseases/epidemiology ; Autoimmune Diseases/immunology ; Autoimmune Diseases/physiopathology ; Autoimmunity/drug effects ; Humans ; Risk Assessment ; Risk Factors ; Vaccination/adverse effects ; Vaccines/adverse effects
    Chemical Substances Adjuvants, Immunologic ; Vaccines
    Language English
    Publishing date 2016-01-05
    Publishing country United Arab Emirates
    Document type Journal Article ; Review
    ZDB-ID 2215862-5
    ISSN 2212-4055 ; 1871-5281
    ISSN (online) 2212-4055
    ISSN 1871-5281
    DOI 10.2174/1871528114666160105113046
    Database MEDical Literature Analysis and Retrieval System OnLINE

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