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  1. Book ; Online ; E-Book: Epigenetics

    Doerfler, Walter / Böhm, Petra

    a different way of looking at genetics

    (Epigenetics and human health)

    2016  

    Author's details Walter Doerfler, Petra Böhm editors
    Series title Epigenetics and human health
    Language English
    Size 1 Online-Ressource (XVI, 254 Seiten), Illustrationen
    Publisher Springer
    Publishing place Cham
    Publishing country Switzerland
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    HBZ-ID HT019052683
    ISBN 978-3-319-27186-6 ; 9783319271842 ; 3-319-27186-5 ; 3319271849
    DOI 10.1007/978-3-319-27186-6
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

    Full text online

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  2. Book ; Thesis: Untersuchung zur Heparinapplikation im Bereich der hausärztlichen Patientenversorgung

    Germann, Petra

    2000  

    Author's details vorgelegt von Petra Germann
    Language German
    Size 89 Bl. : graph. Darst.
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Mannheim, Univ., Diss., 2000
    HBZ-ID HT012972141
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2001 E 1123 order for loan Magazin

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  3. Article ; Online: From molecular signatures to radiomics: tailoring neurooncological strategies through forecasting of glioma growth.

    Rauch, Philip / Aichholzer, Martin / Serra, Carlo / Zanier, Olivier / Staartjes, Victor E / Böhm, Petra / Seyer, Gregor / Wagner, Helga / Manakov, Ilja / Sonnberger, Michael / Stroh, Nico / Aspalter, Stefan / Aufschnaiter-Hiessböck, Kathrin / Rossmann, Tobias / Leibetseder, Annette / Katletz, Stefan / Gruber, Andreas / Gmeiner, Matthias / Stefanits, Harald

    Neurosurgical focus

    2024  Volume 56, Issue 2, Page(s) E5

    Abstract: Objective: Contemporary oncological paradigms for adjuvant treatment of low- and intermediate-grade gliomas are often guided by a limited array of parameters, overlooking the dynamic nature of the disease. The authors' aim was to develop a comprehensive ...

    Abstract Objective: Contemporary oncological paradigms for adjuvant treatment of low- and intermediate-grade gliomas are often guided by a limited array of parameters, overlooking the dynamic nature of the disease. The authors' aim was to develop a comprehensive multivariate glioma growth model based on multicentric data, to facilitate more individualized therapeutic strategies.
    Methods: Random slope models with subject-specific random intercepts were fitted to a retrospective cohort of grade II and III gliomas from the database at Kepler University Hospital (n = 191) to predict future mean tumor diameters. Deep learning-based radiomics was used together with a comprehensive clinical dataset and evaluated on an external prospectively collected validation cohort from University Hospital Zurich (n = 9). Prediction quality was assessed via mean squared prediction error.
    Results: A mean squared prediction error of 0.58 cm for the external validation cohort was achieved, indicating very good prognostic value. The mean ± SD time to adjuvant therapy was 28.7 ± 43.3 months and 16.1 ± 14.6 months for the training and validation cohort, respectively, with a mean of 6.2 ± 5 and 3.6 ± 0.7, respectively, for number of observations. The observed mean tumor diameter per year was 0.38 cm (95% CI 0.25-0.51) for the training cohort, and 1.02 cm (95% CI 0.78-2.82) for the validation cohort. Glioma of the superior frontal gyrus showed a higher rate of tumor growth than insular glioma. Oligodendroglioma showed less pronounced growth, anaplastic astrocytoma-unlike anaplastic oligodendroglioma-was associated with faster tumor growth. Unlike the impact of extent of resection, isocitrate dehydrogenase (IDH) had negligible influence on tumor growth. Inclusion of radiomics variables significantly enhanced the prediction performance of the random slope model used.
    Conclusions: The authors developed an advanced statistical model to predict tumor volumes both pre- and postoperatively, using comprehensive data prior to the initiation of adjuvant therapy. Using radiomics enhanced the precision of the prediction models. Whereas tumor extent of resection and topology emerged as influential factors in tumor growth, the IDH status did not. This study emphasizes the imperative of advanced computational methods in refining personalized low-grade glioma treatment, advocating a move beyond traditional paradigms.
    MeSH term(s) Humans ; Brain Neoplasms/diagnostic imaging ; Brain Neoplasms/surgery ; Brain Neoplasms/pathology ; Magnetic Resonance Imaging/methods ; Retrospective Studies ; Radiomics ; Glioma/surgery ; Oligodendroglioma ; Isocitrate Dehydrogenase/genetics ; Mutation
    Chemical Substances Isocitrate Dehydrogenase (EC 1.1.1.41)
    Language English
    Publishing date 2024-02-02
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2026589-X
    ISSN 1092-0684 ; 1092-0684
    ISSN (online) 1092-0684
    ISSN 1092-0684
    DOI 10.3171/2023.11.FOCUS23685
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Tailored Intraoperative MRI Strategies in High-Grade Glioma Surgery: A Machine Learning-Based Radiomics Model Highlights Selective Benefits.

    Aichholzer, Martin / Rauch, Philip / Kastler, Lucia / Pichler, Josef / Aufschnaiter-Hiessböck, Kathrin / Ruiz-Navarro, Francisco / Aspalter, Stefan / Hartl, Saskia / Schimetta, Wolfgang / Böhm, Petra / Manakov, Ilja / Thomae, Wolfgang / Gmeiner, Matthias / Gruber, Andreas / Stefanits, Harald

    Operative neurosurgery (Hagerstown, Md.)

    2023  

    Abstract: Background and objectives: In high-grade glioma (HGG) surgery, intraoperative MRI (iMRI) has traditionally been the gold standard for maximizing tumor resection and improving patient outcomes. However, recent Level 1 evidence juxtaposes the efficacy of ... ...

    Abstract Background and objectives: In high-grade glioma (HGG) surgery, intraoperative MRI (iMRI) has traditionally been the gold standard for maximizing tumor resection and improving patient outcomes. However, recent Level 1 evidence juxtaposes the efficacy of iMRI and 5-aminolevulinic acid (5-ALA), questioning the continued justification of iMRI because of its associated costs and extended surgical duration. Nonetheless, drawing from our clinical observations, we postulated that a subset of intricate HGGs may continue to benefit from the adjunctive application of iMRI.
    Methods: In a prospective study of 73 patients with HGG, 5-ALA was the primary technique for tumor delineation, complemented by iMRI to detect residual contrast-enhanced regions. Suboptimal 5-ALA efficacy was defined when (1) iMRI detected contrast-enhanced remnants despite 5-ALA's indication of a gross total resection or (2) surgeons observed residual fluorescence, contrary to iMRI findings. Radiomic features from preoperative MRIs were extracted using a U2-Net deep learning algorithm. Binary logistic regression was then used to predict compromised 5-ALA performance.
    Results: Resections guided solely by 5-ALA achieved an average removal of 93.14% of contrast-enhancing tumors. This efficacy increased to 97% with iMRI integration, albeit not statistically significant. Notably, for tumors with suboptimal 5-ALA performance, iMRI's inclusion significantly improved resection outcomes (P-value: .00013). The developed deep learning-based model accurately pinpointed these scenarios, and when enriched with radiomic parameters, showcased high predictive accuracy, as indicated by a Nagelkerke R2 of 0.565 and a receiver operating characteristic of 0.901.
    Conclusion: Our machine learning-driven radiomics approach predicts scenarios where 5-ALA alone may be suboptimal in HGG surgery compared with its combined use with iMRI. Although 5-ALA typically yields favorable results, our analyses reveal that HGGs characterized by significant volume, complex morphology, and left-sided location compromise the effectiveness of resections relying exclusively on 5-ALA. For these intricate cases, we advocate for the continued relevance of iMRI.
    Language English
    Publishing date 2023-12-22
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2767575-0
    ISSN 2332-4260 ; 2332-4252
    ISSN (online) 2332-4260
    ISSN 2332-4252
    DOI 10.1227/ons.0000000000001023
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1424 -ON-: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  5. Book: DNA methylation: basic mechanisms

    Böhm, Petra / Doerfler, Walter

    with 3 tables

    (Current topics in microbiology and immunology ; 301)

    2006  

    Author's details W. Doerfler and P. Böhm (eds.)
    Series title Current topics in microbiology and immunology ; 301
    Keywords Methylierung ; DNS
    Language English
    Size VI, 321 S, Ill., graph. Darst., 235 mm x 155 mm
    Publisher Springer
    Publishing place Berlin u.a.
    Document type Book
    Note Literaturangaben
    ISBN 3540291148 ; 9783540291145
    Database Special collection on veterinary medicine and general parasitology

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  6. Book: DNA methylation: development, genetic disease and cancer

    Böhm, Petra / Doerfler, Walter

    with 10 tables

    (Current topics in microbiology and immunology ; 310)

    2006  

    Author's details W. Doerfler and P. Böhm (eds.)
    Series title Current topics in microbiology and immunology ; 310
    Keywords Methylierung ; DNS
    Language English
    Size VIII, 282 S., Ill., graph. Darst., 24 cm
    Publisher Springer
    Publishing place Berlin u.a.
    Document type Book
    Note Literaturangaben
    ISBN 3540311807 ; 9783540311805
    Database Special collection on veterinary medicine and general parasitology

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    Inter-library loan at ZB MED

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  7. Book: DNA methylation: basic mechanisms

    Böhm, Petra / Doerfler, Walter

    with 3 tables

    (Current topics in microbiology and immunology ; 301)

    2006  

    Author's details W. Doerfler and P. Böhm (eds.)
    Series title Current topics in microbiology and immunology ; 301
    Keywords Methylierung ; DNS
    Language English
    Size VI, 321 S, Ill., graph. Darst., 235 mm x 155 mm
    Document type Book
    Note Literaturangaben
    ISBN 3540291148 ; 9783540291145
    Database Friedrich Loeffler-Institute, Federal Research Institute for Animal Health

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    Inter-library loan at ZB MED

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  8. Book: DNA methylation: development, genetic disease and cancer

    Böhm, Petra / Doerfler, Walter

    with 10 tables

    (Current topics in microbiology and immunology ; 310)

    2006  

    Author's details W. Doerfler and P. Böhm (eds.)
    Series title Current topics in microbiology and immunology ; 310
    Keywords Methylierung ; DNS
    Language English
    Size VIII, 282 S., Ill., graph. Darst., 24 cm
    Document type Book
    Note Literaturangaben
    ISBN 3540311807 ; 9783540311805
    Database Friedrich Loeffler-Institute, Federal Research Institute for Animal Health

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  9. Book: Adenoviruses: model and vectors in virus-host interactions

    Böhm, Petra / Doerfler, Walter

    immune system, oncogenesis, gene therapy ; with 14 tables

    (Current topics in microbiology and immunology ; 273)

    2004  

    Author's details W. Doerfler; P. Böhm (ed.)
    Series title Current topics in microbiology and immunology ; 273
    MeSH term(s) Adenoviridae/genetics ; Adenoviridae/immunology ; Gene Therapy ; Genetic Vectors ; Immune System/virology ; Oncogenic Viruses
    Keywords Adenoviruses ; Adénovirus ; Gene therapy ; Immune system ; Système immunitaire ; Thérapie génique ; Gentherapie ; Vektor ; Adenoviren ; Carcinogenese ; Immunsystem
    Language English
    Size VIII, 365 S, Ill., graph. Darst
    Publisher Springer
    Publishing place Berlin u.a.
    Document type Book
    Note Literaturangaben
    ISBN 3540068511 ; 35400068511 ; 9783540068518
    Database Former special subject collection: coastal and deep sea fishing

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  10. Book: Adenoviruses: model and vectors in virus-host interactions

    Böhm, Petra / Doerfler, Walter

    immune system, oncogenesis, gene therapy ; with 14 tables

    (Current topics in microbiology and immunology ; 273)

    2004  

    Author's details W. Doerfler; P. Böhm (ed.)
    Series title Current topics in microbiology and immunology ; 273
    MeSH term(s) Adenoviridae/genetics ; Adenoviridae/immunology ; Gene Therapy ; Genetic Vectors ; Immune System/virology ; Oncogenic Viruses
    Keywords Adenoviruses ; Adénovirus ; Gene therapy ; Immune system ; Système immunitaire ; Thérapie génique ; Gentherapie ; Vektor ; Adenoviren ; Carcinogenese ; Immunsystem
    Language English
    Size VIII, 365 S, Ill., graph. Darst
    Publisher Springer
    Publishing place Berlin u.a.
    Document type Book
    Note Literaturangaben
    ISBN 3540068511 ; 35400068511 ; 9783540068518
    Database Special collection on veterinary medicine and general parasitology

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