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  1. Book ; Thesis: Funktionelle Charakterisierung des Na + , H + -Austauschers an kultivierten ruminalen Epithelzellen

    Böttcher, Almut

    Einfluß verschiedener extrazellulärer Faktoren und mögliche Regulationsmechanismen

    2000  

    Author's details von Almut Böttcher
    Language German
    Size IV, 110 S. : graph. Darst.
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Berlin, Freie Univ., Diss., 2000
    Note Zsfassung in engl. Sprache
    HBZ-ID HT013056097
    Database Catalogue ZB MED Nutrition, Environment, Agriculture

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    In stock of ZB MED Bonn / Germany

    Shelf markLoan statusLocation
    008/3188 available for loan (reading room) Freihandmagazin (U1)

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  2. Book ; Thesis: Funktionelle Charakterisierung des Na+/H+-Austauschers an kultivierten ruminalen Epithelzellen

    Böttcher, Almut

    Einfluß verschiedener extrazellulärer Faktoren und möglichen Regulationsmechanismen

    2000  

    Author's details vorgelegt von Almut Böttcher
    Language German
    Size IV, 110 S, graph. Darst
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Freie Univ., Diss.--Berlin, 2000
    Database Former special subject collection: coastal and deep sea fishing

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    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  3. Book ; Thesis: Funktionelle Charakterisierung des Na+/H+-Austauschers an kultivierten ruminalen Epithelzellen

    Böttcher, Almut

    Einfluß verschiedener extrazellulärer Faktoren und möglichen Regulationsmechanismen

    2000  

    Author's details vorgelegt von Almut Böttcher
    Language German
    Size IV, 110 S, graph. Darst
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Freie Univ., Diss.--Berlin, 2000
    Database Special collection on veterinary medicine and general parasitology

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    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  4. Article: Luminal hyperosmolarity decreases Na transport and impairs barrier function of sheep rumen epithelium.

    Schweigel, Monika / Freyer, Markus / Leclercq, Sabine / Etschmann, Benjamin / Lodemann, Ulrike / Böttcher, Almut / Martens, Holger

    Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology

    2005  Volume 175, Issue 8, Page(s) 575–591

    Abstract: The effects of luminal hyperosmolarity on Na and Cl transport were studied in rumen epithelium of sheep. An increase of luminal osmotic pressure with mannitol (350 and 450 mosm/l) caused a significant increase of tissue conductance, G (T), which is ... ...

    Abstract The effects of luminal hyperosmolarity on Na and Cl transport were studied in rumen epithelium of sheep. An increase of luminal osmotic pressure with mannitol (350 and 450 mosm/l) caused a significant increase of tissue conductance, G (T), which is linearly correlated with flux rates of (51)Cr-EDTA and indicates an increase of passive permeability. Studies with microelectrodes revealed, that an increase of the osmotic pressure caused a significant increase of the conductance of the shunt pathway from 1.23 +/- 0.10 (control) to 1.92 +/- 0.14 mS cm(-2) (450 mosm/l) without a change of fractional resistance. Hyperosmolarity significantly increased J (sm) and reduced J (net) Na. The effect of hyperosmolarity on J (ms) Na is explained by two independent and opposed effects: increase of passive permeability and inhibition of the Na(+)/H(+) exchanger. Hypertonic buffer solution induced a decrease of the intracellular pH (pH(i)) of isolated ruminal cells, which is consistent with an inhibition of Na(+)/H(+) exchange, probably isoform NHE-3, because NHE-3-mRNA was detectable in rumen epithelium. These data are in contrast to previous reports and reveal a disturbed Na transport and an impaired barrier function of the rumen epithelium, which predisposes translocation of rumen endotoxins and penetration of bacteria.
    MeSH term(s) Animals ; Cells, Cultured ; Chlorides/metabolism ; Chromium/metabolism ; Cyclic AMP/metabolism ; Edetic Acid/metabolism ; Electrophysiology ; Female ; Hydrogen-Ion Concentration ; Intestinal Mucosa/drug effects ; Intestinal Mucosa/physiology ; Male ; Mannitol/pharmacology ; Microelectrodes ; Osmolar Concentration ; Osmotic Pressure ; Permeability/drug effects ; Rumen/drug effects ; Rumen/physiology ; Sheep/physiology ; Sodium/metabolism ; Sodium-Hydrogen Exchangers/physiology ; Theophylline/pharmacology
    Chemical Substances Chlorides ; Sodium-Hydrogen Exchangers ; Chromium (0R0008Q3JB) ; Mannitol (3OWL53L36A) ; Edetic Acid (9G34HU7RV0) ; Sodium (9NEZ333N27) ; Theophylline (C137DTR5RG) ; Cyclic AMP (E0399OZS9N)
    Language English
    Publishing date 2005-11
    Publishing country Germany
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 231245-1
    ISSN 1432-136X ; 0174-1578
    ISSN (online) 1432-136X
    ISSN 0174-1578
    DOI 10.1007/s00360-005-0021-3
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Uc I Zs.171: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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