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  1. Article ; Online: STRESS INDUCED CHRONIC INSOMNIA (ANIDRA) AND IT’S MANAGEMENT WITH DASHAMULA KWATHA SHIRODHARA

    Anil Kumar Singh / H M Chandola / B Ravishankar

    Journal of Drug Delivery and Therapeutics, Vol 3, Iss

    2013  Volume 3

    Abstract: Sleep is one of the most important physiological processes responsible for the maintenance of health. It is one of the states of brain activity generally resultant effect of exhaustion and fatigue. ‘Sleep’ is defined as unconsciousness from which the ... ...

    Abstract Sleep is one of the most important physiological processes responsible for the maintenance of health. It is one of the states of brain activity generally resultant effect of exhaustion and fatigue. ‘Sleep’ is defined as unconsciousness from which the person can be aroused by external stimulus or other. It is different from coma. In coma state person can not be aroused. The incidence of sleep disturbance is very common in all age groups irrespective of caste, community, race, socio-economic status and sex etc. which might be related to the life style, environmental influence, mental tension, changed food habits and day to day stress. These ultimately disturb the psychoneuro-biological rhythm of sleep broadly discussed under sleep disorders. Nidra is one among the primary tripod of life 1 . Ten patients of stress induced chronic Insomnia (Anidra) have been studied to evaluate the role of psychic traits (Manasabhava) in etiopathogenesis and management of disease. Dashamula kwatha Shirodhara half an hour daily in morning for 21 days showed highly significant relief on Sleeplessness (61.29%), Distress (63.64%) , Sleep Time, Sleep Quality and Freshness after Awakening (100% each).Relief in mental health has been observed based on Hamilton’s Anxiety Rating Scale, Hamilton’s Depression Raring Scale, Brief Psychiatric Rating Scale and Manasabhav pariksha on Ayurvedic parameters . Key words: Anidra, Psychic traits, Manasabhava, Sleep, Stress, Chronic Insomnia, Dashamula kwatha Shirodhara.
    Keywords Therapeutics. Psychotherapy ; RC475-489 ; Psychiatry ; RC435-571 ; Neurology. Diseases of the nervous system ; RC346-429 ; Neurosciences. Biological psychiatry. Neuropsychiatry ; RC321-571 ; Internal medicine ; RC31-1245 ; Medicine ; R ; DOAJ:Therapeutics ; DOAJ:Medicine (General) ; DOAJ:Health Sciences
    Subject code 150
    Language English
    Publishing date 2013-05-01T00:00:00Z
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article ; Online: LITERARY REVIEW OF SOMANATHI TAMRA BHASMA

    Sudheendra Honwad / T. Shridhara Bairy / B. Ravishankar

    International Journal of Research in Ayurveda and Pharmacy, Vol 3, Iss 1, Pp 1-

    2012  Volume 4

    Abstract: Somanathi Tamra Bhasma is unique method of Tamra Bhasma preparation, which is prepared by using Tamra, Parada, Gandhaka, Manashila & Haritala as ingredients, more than 10 references are available in different Rasagranthas for the preparation of Somanathi ...

    Abstract Somanathi Tamra Bhasma is unique method of Tamra Bhasma preparation, which is prepared by using Tamra, Parada, Gandhaka, Manashila & Haritala as ingredients, more than 10 references are available in different Rasagranthas for the preparation of Somanathi Tamra Bhasma, few differences of opinions are noted considering the quantity of Gandhaka used & the method adopted for the preparation of the same, this article highlight literary review & method of preparation of Somanathi Tamra Bhasma.
    Keywords Tamra ; Gandhaka ; Somanathi Tamra Bhasma. ; Pharmacy and materia medica ; RS1-441 ; Medicine ; R ; DOAJ:Pharmacy and materia medica ; DOAJ:Medicine (General) ; DOAJ:Health Sciences
    Language English
    Publishing date 2012-02-01T00:00:00Z
    Publisher International Journal of Research in Ayurveda and Pharmacy
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article ; Online: Histological Evaluation of the Effect of Tamra Bhasma (Copper Based Metallic) and Jasada Bhasma (Zinc Based Mineral) Formulations on Testis of Wistar Albino Rats

    Ravi Bhaskar / Megha A Doshi / S Anjana / Shakunthala R Pai / B Ravishankar / Naveen Kumar / Ravi Mundugaru / Savitha Hemalatha

    Journal of Clinical and Diagnostic Research, Vol 12, Iss 12, Pp AC16-AC

    2018  Volume 18

    Abstract: Introduction: The metallic or herbo-mineral preparations used in the Indian system of medicine may cause a toxic effect on mammalian tissues. The broad therapeutic usage of these formulations in the form of Bhasmas is required to be ascertained for any ... ...

    Abstract Introduction: The metallic or herbo-mineral preparations used in the Indian system of medicine may cause a toxic effect on mammalian tissues. The broad therapeutic usage of these formulations in the form of Bhasmas is required to be ascertained for any adverse effects on the reproductive system. Aim: Present study was undertaken to evaluate the toxic effects of Tamra Bhasma and Jasada Bhasma on male gonads using Wistar albino rats. Materials and Methods: The experimental animals were divided into five different groups comprising of five male rats in each group. Group-I rats were used as the control. Group-II rats received Tamra Bhasma at a Therapeutic Dose (TED). Group-III rats received Tamra Bhasma at five times of therapeutic dose (TED×5). Group-IV rats received Jasada Bhasma at a therapeutic dose (TED), and Group-V rats received Jasada Bhasma five times of therapeutic dose (TED×5) for 28 days. The testes were harvested from these rats, the gross weight of each testes was noted and further processed for histological studies. Results: Testes of the experimental rats treated with both Bhasmas at therapeutic dose level did not show toxicity changes histologically. However, upon the exposure to a higher therapeutic (TED×5) level, it did show the histological features with the indication of decreased spermatogenesis. Conclusion: Test drugs were relatively safer and did not produce any marked toxic effect. However, at higher doses both drugs may produce toxicity on the testis. The higher dose used in the present study was much higher than routinely practiced clinical doses. Therefore, dose-dependent usage of these Bhasmas is recommended.
    Keywords male gonad ; spermatogenesis ; testes ; toxicity ; Medicine ; R
    Subject code 630 ; 610
    Language English
    Publishing date 2018-12-01T00:00:00Z
    Publisher JCDR Research and Publications Private Limited
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article: Development of quality standards of medicinal mistletoe – Helicanthes elastica (Desr.) Danser employing Pharmacopoeial procedures

    Sunil Kumar, K.N / B. Ravishankar / B. Yashovarma / J. Thomas / R. Rajakrishnan

    Saudi Journal of Biological Sciences. 2016 Nov., v. 23

    2016  

    Abstract: Helicanthes elastica (Desr.) Danser (Loranthaceae), commonly known as Indian mango mistletoe, is a parasitic shrub found widely growing on mango trees in southern India. Development of monographic quality standards is need of the hour for Pharmacopoeial/ ... ...

    Abstract Helicanthes elastica (Desr.) Danser (Loranthaceae), commonly known as Indian mango mistletoe, is a parasitic shrub found widely growing on mango trees in southern India. Development of monographic quality standards is need of the hour for Pharmacopoeial/extra-Pharmacopoeial and folk medicinal plants. Systematic pharmacognostical evaluation of leaves of H. elastica has been carried out employing Pharmacopoeial procedures of testing herbal drugs. Macro–microscopic features of H. elastica leaf were recorded. Ethanolic extract was tested positive for alkaloids, steroids, carbohydrates, tannins, saponins and phenols. HPTLC fingerprint profile was developed for the identification of extracts using reference standard β-sitosterol glucoside. Results of the present investigation would serve as a source of pharmacognostical information and a document to control the quality of H. elastica (Desr.) Danser.
    Keywords alkaloids ; beta-sitosterol ; glucosides ; herbal medicines ; leaves ; Loranthaceae ; mangoes ; medicinal plants ; phenols ; reference standards ; saponins ; shrubs ; tannins ; trees ; India
    Language English
    Dates of publication 2016-11
    Size p. 674-686.
    Publishing place Elsevier B.V.
    Document type Article
    ZDB-ID 2515206-3
    ISSN 1319-562X
    ISSN 1319-562X
    DOI 10.1016/j.sjbs.2016.02.023
    Database NAL-Catalogue (AGRICOLA)

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  5. Article ; Online: IgG4 related renal disease

    A Rohan / B Ravishankar / S Vishwanath / M Vankalakunti / B Kishore / H S Ballal

    Indian Journal of Nephrology, Vol 24, Iss 6, Pp 382-

    A wolf in sheep′s clothing

    2014  Volume 386

    Abstract: IgG4 related disease is a fibro-inflammatory condition with involvement of renal and extra renal organs, characterized by lymphoplasmacytic infiltration with organ dysfunction. We describe three cases of IgG4 related renal disease from a tertiary care ... ...

    Abstract IgG4 related disease is a fibro-inflammatory condition with involvement of renal and extra renal organs, characterized by lymphoplasmacytic infiltration with organ dysfunction. We describe three cases of IgG4 related renal disease from a tertiary care hospital in south India.
    Keywords IgG4 related renal disease ; interstitial nephritis ; storiform fibrosis ; Diseases of the genitourinary system. Urology ; RC870-923 ; Specialties of internal medicine ; RC581-951 ; Internal medicine ; RC31-1245 ; Medicine ; R
    Language English
    Publishing date 2014-01-01T00:00:00Z
    Publisher Wolters Kluwer Medknow Publications
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article ; Online: A PHARMACEUTICAL COMPARISON OF GUDUCHI GHRITA PREPARED FROM MALE AND FEMALE PLANTS OF TINOSPORA CORDIFOLIA (WILLD.) MIERS.

    BK Ashok / Bhat Savitha D / PK Prajapati / B Ravishankar

    International Journal of Research in Ayurveda and Pharmacy, Vol 2, Iss 4, Pp 1016-

    2011  Volume 1019

    Abstract: Pharmaceutical study appreciates the importance of formulation preparation which ultimately determines the nature and magnitude of pharmacological activity expressed. Guduchi is one among the most important medicinal plants of India and various ... ...

    Abstract Pharmaceutical study appreciates the importance of formulation preparation which ultimately determines the nature and magnitude of pharmacological activity expressed. Guduchi is one among the most important medicinal plants of India and various formulations of Guduchi ghrita are mentioned in different Ayurvedic classical texts. In the present study, a simple formulation of Guduchi ghrita which is used for treatment of chronic fever wherein no other ingredient except Guduchi was selected and a comparative pharmaceutical study of Guduchi ghrita prepared from male and female plants was carried out. The preparation of Guduchi ghrita formulations were carried out by adopting standard operative procedure. The result of this study shows that ghrita prepared from male plant yielded more quantity of finished product than that of female plant.
    Keywords Guduchi ghrita ; Tinospora cordifolia ; Swarasa ; Rasayana ; dioecious. ; Pharmacy and materia medica ; RS1-441 ; Medicine ; R ; DOAJ:Pharmacy and materia medica ; DOAJ:Medicine (General) ; DOAJ:Health Sciences
    Subject code 580
    Language English
    Publishing date 2011-04-01T00:00:00Z
    Publisher International Journal of Research in Ayurveda and Pharmacy
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article ; Online: Toxicological study of Balacaturbhadrika churna

    Mukeshkumar B Nariya / Parag Parmar / Vinay J Shukla / B Ravishankar

    Journal of Ayurveda and Integrative Medicine, Vol 2, Iss 2, Pp 79-

    2011  Volume 84

    Abstract: Balacaturbhadrika churna has an important place in pediatric practice in Ayurveda. Millennia of use of this formulation bears testimony to its safety when used for prolonged duration in children. This prompted us to initiate a long-term, acute oral ... ...

    Abstract Balacaturbhadrika churna has an important place in pediatric practice in Ayurveda. Millennia of use of this formulation bears testimony to its safety when used for prolonged duration in children. This prompted us to initiate a long-term, acute oral toxicity evaluation of Balacaturbhadrika churna in rats. The study was carried out by administering Balacaturbhadrika churna orally once only in a dose up to 2000 mg/kg. For long-term toxicity, Balacaturbhadrika churna was administered in doses of 450 and 900 mg/kg orally for 45 consecutive days. The effects of the drug on ponderal changes, hematological, biochemical and histological parameters were noted. The acute toxicity experiment showed that the drug did not produce any signs and symptoms of toxicity (or mortality) up to the dose of 2000 mg/kg. Long-term toxicity results showed that, even at higher dose of 900 mg/kg, Balacaturbhadrika churna did not affect the parameters studied, to a significant extent. The doses employed for these toxicity studies were several times higher than normal clinical doses of Balacaturbhadrika churna, hence the observed changes will probably not become apparent at therapeutic dose level.
    Keywords Aconitum heterophyllum ; acute toxicity ; Balacaturbhadrika churna ; long-term toxicity ; Medicine (General) ; R5-920 ; Medicine ; R
    Subject code 590
    Language English
    Publishing date 2011-01-01T00:00:00Z
    Publisher Medknow Publications
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Article ; Online: SCREENING OF ANTINOCICEPTIVE ACTIVITY OF EUPHORBIA FUSIFORMIS BUCH-HAM

    BK Ashok / Bhat Savitha D / Sorake Ravi Rao / B Ravishankar

    International Journal of Research in Ayurveda and Pharmacy, Vol 2, Iss 1, Pp 27-

    2011  Volume 29

    Abstract: Antinociceptive activity of Euphorbia fusiformis root powder was investigated using acetic acid writhing, tail flick and formalin induced paw licking tests. The test was performed at two dose levels in Swiss albino mice and Wistar strain albino rats. ... ...

    Abstract Antinociceptive activity of Euphorbia fusiformis root powder was investigated using acetic acid writhing, tail flick and formalin induced paw licking tests. The test was performed at two dose levels in Swiss albino mice and Wistar strain albino rats. Oral administration of Euphorbia fusiformis root powder did not produce any significant effect on acetic acid induced writhings, however in tail flick test it significantly raised pain threshold at both dose levels and is prolonged. Moreover, at high dose level it significantly inhibited the formalin induced paw licking responses at both the phases. The result of pharmacological tests performed in the present study suggests that Euphorbia fusiformis root possesses potent analgesic property which is mediated via central inhibitory mechanism. This could provide a rationale for the use of this plant in treatment of rheumatism in folk medicine.
    Keywords Euphorbia fusiformis ; Tail flick ; Writhing ; Analgesic ; Formalin ; Pharmacy and materia medica ; RS1-441 ; Medicine ; R ; DOAJ:Pharmacy and materia medica ; DOAJ:Medicine (General) ; DOAJ:Health Sciences
    Language English
    Publishing date 2011-02-01T00:00:00Z
    Publisher International Journal of Research in Ayurveda and Pharmacy
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Article ; Online: Acute and subchronic toxicity study of Tamra bhasma (incinerated copper) prepared from Ashodhita (unpurified) and Shodhita (purified) tamra in rats

    C Y Jagtap / B K Ashok / B J Patgiri / P K Prajapati / B Ravishankar

    Indian Journal of Pharmaceutical Sciences, Vol 75, Iss 3, Pp 346-

    2013  Volume 352

    Abstract: The use of metals in traditional medicines is very often seen as matter of concern these days, especially the Bhasma preparations which are always under stringent observations for containing highly reactive inorganic elements such as lead, mercury, ... ...

    Abstract The use of metals in traditional medicines is very often seen as matter of concern these days, especially the Bhasma preparations which are always under stringent observations for containing highly reactive inorganic elements such as lead, mercury, arsenic and others. One of the Bhasma extensively used in routine Ayurvedic practice is Tamra (copper) bhasma. If it is not prepared properly or Shodhana procedure is not done properly, it acts as a poison. To indicate its toxic potential, Ashtamahadoshas (eight major ill effects) have been quoted in classics and due emphasis have been given to its Shodhana procedure. In the present study, Tamra bhasma prepared from Shodhita and Ashodhita Tamra was subjected to oral toxicity study to ascertain the role of Shodhana process on safety profile of Tamra bhasma on subchronic administration to albino rats. Both the samples were administered to rats for 45 consecutive days at the doses of 5.5, 27.5, and 55 mg/kg. Animals were sacrificed on 46 th day and parameters like hematological, serum biochemical, and histopathology of various organs were studied. Results showed that Tamra bhasma prepared from Ashodhita Tamra has pathological implications on different hematological, serum biochemical and cytoarchitecture of different organs even at therapeutic dose level (5.5 mg/kg). Whereas, Tamra bhasma prepared from Shodhita Tamra is safe even at five-fold to therapeutic equivalent doses (27.5 mg/kg). These observations emphasize the role of Shodhana and importance of dose in expression of toxicity of the medicinal preparations.
    Keywords Amrutikarana ; copper ; herbomineral formulation ; LD 50 ; Marana ; Shodhana ; Pharmacy and materia medica ; RS1-441 ; Medicine ; R
    Subject code 630
    Language English
    Publishing date 2013-01-01T00:00:00Z
    Publisher Medknow Publications
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Article ; Online: Evaluation of hypoglycaemic and anti-hyperglycaemic activities of Guduchi Ghana in Swiss albino mice

    Rohit Sharma / Vijay Kumar / B K Ashok / R Galib / P K Prajapati / B Ravishankar

    International Journal of Green Pharmacy, Vol 7, Iss 2, Pp 145-

    2013  Volume 148

    Abstract: Background: Diabetes mellitus is a common endocrine disorder, characterized by hyperglycaemia resulting from defects in insulin secretion, insulin action or both. Ayurvedic herbs are relatively low cost, more suitable and have negligible side-effects ... ...

    Abstract Background: Diabetes mellitus is a common endocrine disorder, characterized by hyperglycaemia resulting from defects in insulin secretion, insulin action or both. Ayurvedic herbs are relatively low cost, more suitable and have negligible side-effects than synthetic oral anti-hyperglycaemic agents. Guduchi is reported as highly potent anti-diabetic herb in Ayurveda and Guduchi Ghanavati is popularly known by the Ayurvedic fraternity for its therapeutic properties on Madhumeha represented as diabetes mellitus. Aim: The aim of this study is to evaluate hypoglycaemic and anti-hyperglycaemic activities of Guduchi Ghana (GG) in Swiss albino mice. Materials and Methods: Hypoglycaemic and anti-hyperglycaemic potential of GG was evaluated in normal mice using both 18 h fasted mice model and oral glucose tolerance test. GG was suspended in distilled water and administered to animals at the dose of 130 mg/kg. Statistical Analysis: The results were statistically interpreted using Student′s ′t′- test for paired and unpaired data to assess the statistical significance and the significant level was set at P < 0.05. Results: GG showed mild reduction in blood sugar level (BSL) at all the time intervals in normoglycaemic mice. In anti-hyperglycaemic activity, glibenclamide at a dose of 0.65 mg/kg studied as the reference standard to compare the potency of test drug. Administration of GG prior to glucose over load resulted significant attenuation in BSL at 60 min, 90 min and 120 min in comparison to glucose control group. Conclusions: GG has mild hypoglycaemic and significant anti-hyperglycaemic activity and can be used in the treatment of diabetes mellitus as well as a supportive drug without fear of producing hypoglycaemia.
    Keywords Anti-hyperglycaemic ; Ghana ; glibenclamide ; Guduchi ; hypoglycaemic ; tinospora cordifolia ; Therapeutics. Pharmacology ; RM1-950 ; Medicine ; R
    Language English
    Publishing date 2013-01-01T00:00:00Z
    Publisher Medknow Publications
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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