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  1. Article ; Online: Case Report: Multiple Ocular Manifestations Assisted in the Diagnosis of Systemic Sarcoidosis.

    Zhu, Miao-Miao / Ba, Xiao-Qun / Liu, Lan

    Optometry and vision science : official publication of the American Academy of Optometry

    2022  Volume 99, Issue 7, Page(s) 598–604

    Abstract: Significance: Sarcoidosis is a variable, multisystem granulomatous disease, which can affect many organs including the lungs, lymph nodes, and eyes. It is difficult to differentiate sarcoidosis and tuberculosis because of their similar clinical and ... ...

    Abstract Significance: Sarcoidosis is a variable, multisystem granulomatous disease, which can affect many organs including the lungs, lymph nodes, and eyes. It is difficult to differentiate sarcoidosis and tuberculosis because of their similar clinical and pathological features.
    Purpose: This study aimed to describe a sarcoidosis case with typical ocular and systemic manifestations combined with suspected tuberculosis infection.
    Case report: A 30-year-old Chinese man, initially diagnosed with tuberculosis, presented with typical ocular sarcoidosis during antituberculosis therapy. The ocular surface, anterior chamber, anterior chamber angle, ciliary body, vitreous, optic disc, and lacrimal gland of the patient all exhibited manifestations of sarcoidosis, although optic disc involvement has rarely been reported. Typical ocular sarcoidosis manifestations and positive responses to corticosteroid therapy of the patient helped us reach the diagnosis of systemic sarcoidosis. The patient was followed up for 48 months and showed significant improvement of miliary nodules and lymph nodes in both lungs. However, the appearance of uveitis in the right eye persisted because of nonadherence to steroid treatment.
    Conclusions: This case shows the importance of ophthalmic evaluation in the diagnosis and management of sarcoidosis and supports a possible role of Mycobacterium tuberculosis in the pathogenesis of sarcoidosis.
    MeSH term(s) Adult ; Biopsy/adverse effects ; Diagnosis, Differential ; Granuloma/diagnosis ; Humans ; Male ; Sarcoidosis/diagnosis ; Uveitis/diagnosis ; Uveitis/etiology
    Language English
    Publishing date 2022-06-09
    Publishing country United States
    Document type Case Reports ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1001706-9
    ISSN 1538-9235 ; 1040-5488
    ISSN (online) 1538-9235
    ISSN 1040-5488
    DOI 10.1097/OPX.0000000000001912
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  2. Article ; Online: A study of using carbon nanoparticles to improve lymph nodes staging for laparoscopic-assisted radical right hemicolectomy in colon cancer.

    Pan, Lelin / Ye, Feng / Liu, Jing-Jing / Ba, Xiao-Qun / Sheng, Qin-Song

    International journal of colorectal disease

    2018  Volume 33, Issue 8, Page(s) 1131–1134

    Abstract: Purpose: This study aimed to analyze and evaluate the feasibility of using carbon nanoparticles (CNs) to track lymph nodes (LNs) metastases in right colon tumors, especially for patients who underwent laparoscopic-assisted radical right hemicolectomy.!## ...

    Abstract Purpose: This study aimed to analyze and evaluate the feasibility of using carbon nanoparticles (CNs) to track lymph nodes (LNs) metastases in right colon tumors, especially for patients who underwent laparoscopic-assisted radical right hemicolectomy.
    Method: A total of 99 patients were enrolled in this retrospective study between November 2015 and September 2017 (control group n = 47). One day before surgery, 1 ml of CNs suspension was injected into the submucosal layer around the site of the primary lesions by colonoscopy. Then complete mesocolic excision (CME) of laparoscopic right hemicolectomy was performed. CNs-stained LNs were identified and counted from all dissected LNs after surgery.
    Results: The dates showed that the number of total harvested LNs and the number of positive patients in the experimental group increased significantly compared with the control group (respectively, P < 0.01 and P < 0.05). The increase of positive percentage shifted some patients toward higher stage, although the total number of positive LNs changed a little bit. In addition, the duration for pathologist to dissect LNs became shorter (26.4 vs. 31.1 min, P < 0.05).
    Conclusion: Therefore, the CNs are not only a good tattoo in laparoscopic-assisted operation, but could be regarded as a better pathological evaluating tool for tumor treatment.
    MeSH term(s) Carbon ; China ; Colectomy ; Colonic Neoplasms/diagnosis ; Colonic Neoplasms/pathology ; Humans ; Laparoscopy ; Lymph Node Excision ; Lymph Nodes ; Lymphatic Metastasis/diagnosis ; Nanoparticles ; Neoplasm Staging ; Retrospective Studies
    Chemical Substances Carbon (7440-44-0)
    Language English
    Publishing date 2018-04-16
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 84975-3
    ISSN 1432-1262 ; 0179-1958
    ISSN (online) 1432-1262
    ISSN 0179-1958
    DOI 10.1007/s00384-018-3050-6
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    Zs.A 2121: Show issues Location:
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  3. Article ; Online: 'Ectopic' suprasellar type IIa PRL-secreting pituitary adenoma.

    Zhou, Heng-Jun / Pan, De-Sheng / Ba, Xiao-Qun / Zhan, Ren-Ya / Zheng, Xiu-Jue / Ma, Yue-Hui

    Pituitary

    2017  Volume 20, Issue 4, Page(s) 477–484

    Abstract: Background: Ectopic pituitary adenomas (EPAs) are rare, and the suprasellar cistern seems to be the most common location. At this time, no detailed original classification, diagnosis, or treatment protocols for suprasellar pituitary adenomas (SPAs) have ...

    Abstract Background: Ectopic pituitary adenomas (EPAs) are rare, and the suprasellar cistern seems to be the most common location. At this time, no detailed original classification, diagnosis, or treatment protocols for suprasellar pituitary adenomas (SPAs) have been described.
    Case description: A 19-year-old man showed visual disturbances and lack of libido for 3 years, he suffered a sharp decline in vision with only light perception in the last week. Magnetic resonance imaging scans revealed a large suprasellar cystic lesion with a normal pituitary in the sella turcica. Endocrinological findings showed an extremely high prolactin level of 1250 ng/mL. Because of the sharp decline in vision, the patient underwent total removal of the suprasellar lesion using a transfrontal interhemispheric approach. The tumor pedicle originated in the lower pituitary stalk without any connection to the anterior pituitary gland in the sella turcica, while the diaphragma sellae was incomplete. Clinical and endocrinological cure criteria were fulfilled and postoperative pathology confirmed a prolactin-secreting pituitary adenoma.
    Conclusion: Ectopic suprasellar pituitary adenomas (ESPAs) are extremely rare intracranial extracerebral tumors. SPAs can be classified into three types according to their origin and their relationship with surrounding tissue. Only type III is theoretically a true ectopic, based on previous reports. Thus, ESPAs are uncommon compared to other EPAs. Our case is the first reported case of a type IIa 'E'SPA and the first description of this subtype classification until now. The pars tuberalis may be different from the pars distalis, and each subtype of adenohypophyseal cells may have different migration characteristics, which leads to different proportions of each hormone-secreting subtype in SPAs and EPAs. Transsphenoidal surgery is minimally invasive, but transcranial surgery may remain a universal option for the treatment of suprasellar lesions.
    Language English
    Publishing date 2017-08
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 1385151-2
    ISSN 1573-7403 ; 1386-341X
    ISSN (online) 1573-7403
    ISSN 1386-341X
    DOI 10.1007/s11102-017-0807-9
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    Zs.A 6139: Show issues Location:
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  4. Article: Induced phase separation of mutant NF2 imprisons the cGAS-STING machinery to abrogate antitumor immunity

    Meng, Fansen / Yu, Zhengyang / Zhang, Dan / Chen, Shasha / Guan, Hongxin / Zhou, Ruyuan / Wu, Qirou / Zhang, Qian / Liu, Shengduo / Venkat Ramani, Mukesh Kumar / Yang, Bing / Ba, Xiao-Qun / Zhang, Jing / Huang, Jun / Bai, Xueli / Qin, Jun / Feng, Xin-Hua / Ouyang, Songying / Zhang, Yan Jessie /
    Liang, Tingbo / Xu, Pinglong

    Elsevier Inc. Molecular cell. 2021 Oct. 21, v. 81, no. 20

    2021  

    Abstract: Missense mutations of the tumor suppressor Neurofibromin 2 (NF2/Merlin/schwannomin) result in sporadic to frequent occurrences of tumorigenesis in multiple organs. However, the underlying pathogenicity of NF2-related tumorigenesis remains mostly unknown. ...

    Abstract Missense mutations of the tumor suppressor Neurofibromin 2 (NF2/Merlin/schwannomin) result in sporadic to frequent occurrences of tumorigenesis in multiple organs. However, the underlying pathogenicity of NF2-related tumorigenesis remains mostly unknown. Here we found that NF2 facilitated innate immunity by regulating YAP/TAZ-mediated TBK1 inhibition. Unexpectedly, patient-derived individual mutations in the FERM domain of NF2 (NF2m) converted NF2 into a potent suppressor of cGAS-STING signaling. Mechanistically, NF2m gained extreme associations with IRF3 and TBK1 and, upon innate nucleic acid sensing, was directly induced by the activated IRF3 to form cellular condensates, which contained the PP2A complex, to eliminate TBK1 activation. Accordingly, NF2m robustly suppressed STING-initiated antitumor immunity in cancer cell-autonomous and -nonautonomous murine models, and NF2m-IRF3 condensates were evident in human vestibular schwannomas. Our study reports phase separation-mediated quiescence of cGAS-STING signaling by a mutant tumor suppressor and reveals gain-of-function pathogenesis for NF2-related tumors by regulating antitumor immunity.
    Keywords carcinogenesis ; gain-of-function mutation ; humans ; innate immunity ; mice ; mutants ; neoplasms ; nucleic acids ; pathogenicity ; separation
    Language English
    Dates of publication 2021-1021
    Size p. 4147-4164.e7.
    Publishing place Elsevier Inc.
    Document type Article
    ZDB-ID 1415236-8
    ISSN 1097-4164 ; 1097-2765
    ISSN (online) 1097-4164
    ISSN 1097-2765
    DOI 10.1016/j.molcel.2021.07.040
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  5. Article ; Online: Induced phase separation of mutant NF2 imprisons the cGAS-STING machinery to abrogate antitumor immunity.

    Meng, Fansen / Yu, Zhengyang / Zhang, Dan / Chen, Shasha / Guan, Hongxin / Zhou, Ruyuan / Wu, Qirou / Zhang, Qian / Liu, Shengduo / Venkat Ramani, Mukesh Kumar / Yang, Bing / Ba, Xiao-Qun / Zhang, Jing / Huang, Jun / Bai, Xueli / Qin, Jun / Feng, Xin-Hua / Ouyang, Songying / Zhang, Yan Jessie /
    Liang, Tingbo / Xu, Pinglong

    Molecular cell

    2021  Volume 81, Issue 20, Page(s) 4147–4164.e7

    Abstract: Missense mutations of the tumor suppressor Neurofibromin 2 (NF2/Merlin/schwannomin) result in sporadic to frequent occurrences of tumorigenesis in multiple organs. However, the underlying pathogenicity of NF2-related tumorigenesis remains mostly unknown. ...

    Abstract Missense mutations of the tumor suppressor Neurofibromin 2 (NF2/Merlin/schwannomin) result in sporadic to frequent occurrences of tumorigenesis in multiple organs. However, the underlying pathogenicity of NF2-related tumorigenesis remains mostly unknown. Here we found that NF2 facilitated innate immunity by regulating YAP/TAZ-mediated TBK1 inhibition. Unexpectedly, patient-derived individual mutations in the FERM domain of NF2 (NF2m) converted NF2 into a potent suppressor of cGAS-STING signaling. Mechanistically, NF2m gained extreme associations with IRF3 and TBK1 and, upon innate nucleic acid sensing, was directly induced by the activated IRF3 to form cellular condensates, which contained the PP2A complex, to eliminate TBK1 activation. Accordingly, NF2m robustly suppressed STING-initiated antitumor immunity in cancer cell-autonomous and -nonautonomous murine models, and NF2m-IRF3 condensates were evident in human vestibular schwannomas. Our study reports phase separation-mediated quiescence of cGAS-STING signaling by a mutant tumor suppressor and reveals gain-of-function pathogenesis for NF2-related tumors by regulating antitumor immunity.
    MeSH term(s) Animals ; Female ; Gene Expression Regulation, Neoplastic ; HCT116 Cells ; HEK293 Cells ; Humans ; Immunity, Innate ; Interferon Regulatory Factor-3/genetics ; Interferon Regulatory Factor-3/metabolism ; Macrophages, Peritoneal/immunology ; Macrophages, Peritoneal/metabolism ; Male ; Melanoma, Experimental/genetics ; Melanoma, Experimental/immunology ; Melanoma, Experimental/metabolism ; Melanoma, Experimental/pathology ; Membrane Proteins/genetics ; Membrane Proteins/metabolism ; Mice, Inbred C57BL ; Mice, Transgenic ; Mutation, Missense ; Neoplasms/genetics ; Neoplasms/immunology ; Neoplasms/metabolism ; Neoplasms/pathology ; Neurofibromin 2/genetics ; Neurofibromin 2/metabolism ; Nucleotidyltransferases/genetics ; Nucleotidyltransferases/metabolism ; Protein Serine-Threonine Kinases/genetics ; Protein Serine-Threonine Kinases/metabolism ; Signal Transduction ; Tumor Escape ; Mice
    Chemical Substances IRF3 protein, human ; Interferon Regulatory Factor-3 ; Irf3 protein, mouse ; Membrane Proteins ; NF2 protein, human ; Neurofibromin 2 ; STING1 protein, human ; Sting1 protein, mouse ; Tbk1 protein, mouse (EC 2.7.1.-) ; Protein Serine-Threonine Kinases (EC 2.7.11.1) ; TBK1 protein, human (EC 2.7.11.1) ; Nucleotidyltransferases (EC 2.7.7.-) ; cGAS protein, human (EC 2.7.7.-) ; cGAS protein, mouse (EC 2.7.7.-)
    Language English
    Publishing date 2021-08-27
    Publishing country United States
    Document type Journal Article ; Video-Audio Media
    ZDB-ID 1415236-8
    ISSN 1097-4164 ; 1097-2765
    ISSN (online) 1097-4164
    ISSN 1097-2765
    DOI 10.1016/j.molcel.2021.07.040
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