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Article ; Online: Dyslipidemia prevalence in nonobese, nondiabetic patients with obstructive sleep apnea: does sex matter?

Basoglu, Ozen K / Tasbakan, Mehmet Sezai / Kayikcioglu, Meral

Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine

2023 Volume 19, Issue 5, Page(s) 889–898

Abstract: Study objectives: Dyslipidemia in obstructive sleep apnea (OSA) has been attributed to confounding obesity and/or diabetes. This study aimed to examine lipid profiles in nondiabetic, nonobese patients with OSA and identify the possible effects of age ... ...

Abstract	Study objectives: Dyslipidemia in obstructive sleep apnea (OSA) has been attributed to confounding obesity and/or diabetes. This study aimed to examine lipid profiles in nondiabetic, nonobese patients with OSA and identify the possible effects of age and sex. Methods: We retrospectively evaluated the lipid parameters of 3,050 adults who underwent polysomnography. A total of 2,168 patients were excluded due to obesity (body mass index ≥ 30 kg/m Results: Of 882 patients (75% males, aged 46.8 ± 12.2 years) included in the study, 88.4% had OSA. Levels of total cholesterol ( Conclusions: After excluding confounding obesity and diabetes, patients with OSA have an impaired lipid profile including total cholesterol, LDL cholesterol, non-HDL cholesterol, and triglycerides. A significant association between dyslipidemia and OSA severity was observed in women but not in men. Citation: Basoglu OK, Tasbakan MS, Kayikcioglu M. Dyslipidemia prevalence in nonobese, nondiabetic patients with obstructive sleep apnea: does sex matter?
MeSH term(s)	Adult ; Male ; Humans ; Female ; Hypercholesterolemia ; Prevalence ; Retrospective Studies ; Sleep Apnea, Obstructive/therapy ; Dyslipidemias/epidemiology ; Triglycerides ; Cholesterol, LDL ; Cholesterol ; Obesity ; Lipoproteins
Chemical Substances	Triglycerides ; Cholesterol, LDL ; Cholesterol (97C5T2UQ7J) ; Lipoproteins
Language	English
Publishing date	2023-01-26
Publishing country	United States
Document type	Journal Article
ZDB-ID	2397213-0
ISSN	1550-9397 ; 1550-9389
ISSN (online)	1550-9397
ISSN	1550-9389
DOI	10.5664/jcsm.10490
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Article ; Online: Polygraphic evaluation of the effects of different rapid maxillary expansion appliances on sleep quality: A randomized clinical trial.

Gokce, Gokcenur / Basoglu, Ozen K / Veli, Ilknur

Sleep & breathing = Schlaf & Atmung

2022 Volume 27, Issue 2, Page(s) 651–659

Abstract: Background: The purpose of this clinical study was to assess the effects of different rapid maxillary expansion appliances on the severity of obstructive sleep apnea (OSA).: Material and methods: Patients having a narrow maxilla and identified with ... ...

Abstract	Background: The purpose of this clinical study was to assess the effects of different rapid maxillary expansion appliances on the severity of obstructive sleep apnea (OSA). Material and methods: Patients having a narrow maxilla and identified with OSA were divided randomly into three groups: tooth tissue-borne, tooth-borne, and bone-borne expanders. Changes in sleep parameters at baseline and 3-month follow-up detected by polygraphy were the primary outcome. Treatment of the crossbite was the secondary outcome. Dunn-Bonferroni tests, Kruskal-Wallis, and Wilcoxon analysis were applied for intra- and inter-group differences at p < 0.05 significance level. Results: Among 46 patients randomized, apnea-hypopnea index (AHI) changed from baseline to follow-up in all groups (- 1.6, p = 0.280; 0.6, p = 0.691; - 0.45, p = 0.796, respectively), with no between-group difference (p = 0.631). Oxygen desaturation index (ODI) altered from baseline to follow-up in all groups (0.80, p = 0.977; 0.20, p = 0.932; and - 1.00, p = 0.379, respectively), with no between-group difference (p = 0.858). There was no significant difference in minimum oxygen saturation from baseline to follow-up in all groups (0.00, p = 0.401; - 2.00, p = 0.887; 0.50, p = 0.407, respectively). No significant changes were observed in supine AHI from baseline to follow-up in all groups (0.00, p = 0.581; - 1.00, p = 0.393; 0.00, p = 0.972, respectively). The upper intermolar width increased from baseline to follow-up in all groups (5.04, p = 0.000; 3.15, p = 0.001; 5.41, p = 0.00, respectively) with no between-group difference (p = 0.560). Maxillary width increased from baseline to follow-up in all groups (4.25, p = 0.001; 4.74, p = 0.00; 4.49, p = 0.001, respectively) with no inter-group difference (p = 0.963). Conclusions: The amount of skeletal and dental expansion obtained in the maxilla was similar in all groups. Rapid maxillary expansion was not found to be effective in OSA treatment. Trial registration: ClinicalTrials.gov Identifier: NCT04604392.
MeSH term(s)	Humans ; Sleep Quality ; Sleep Apnea, Obstructive/therapy ; Sleep ; Malocclusion ; Orthodontic Appliances ; Palatal Expansion Technique
Language	English
Publishing date	2022-07-05
Publishing country	Germany
Document type	Randomized Controlled Trial ; Journal Article
ZDB-ID	1500381-4
ISSN	1522-1709 ; 1520-9512
ISSN (online)	1522-1709
ISSN	1520-9512
DOI	10.1007/s11325-022-02677-0
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Article ; Online: Could non-HDL-cholesterol be a better marker of atherogenic dyslipidemia in obstructive sleep apnea?

Basoglu, Ozen K / Tasbakan, Mehmet S / Kayikcioglu, Meral

Sleep medicine

2021 Volume 88, Page(s) 29–35

Abstract: Background/objective: Obstructive sleep apnea (OSA) is independently associated with dyslipidemia, a surrogate marker of atherosclerosis. Low-density lipoprotein (LDL)-cholesterol is accepted as a major independent risk factor for cardiovascular disease. ...

Abstract	Background/objective: Obstructive sleep apnea (OSA) is independently associated with dyslipidemia, a surrogate marker of atherosclerosis. Low-density lipoprotein (LDL)-cholesterol is accepted as a major independent risk factor for cardiovascular disease. However, non-high-density lipoprotein (HDL)-cholesterol is a better marker of atherogenic dyslipidemia and recommended as a target of lipid lowering therapy. We aimed to assess the prevalence of atherogenic dyslipidemia, and relationship between OSA severity and serum LDL-cholesterol and non-HDL cholesterol levels in OSA patients. Methods: We retrospectively evaluated treatment naïve 2361 subjects admitted to the sleep laboratory of a university hospital for polysomnography. All subjects' lipid profile including total cholesterol, LDL-cholesterol, HDL-cholesterol, triglycerides, and non-HDL-cholesterol were measured. Results: Out of 2361 patients (mean age 49.6 ± 11.9 years; 68.9% male, apnea-hypopnea index 36.6 ± 28.4/h), 185 (7.8%) had no OSA and 2176 (92.2%) had OSA. Atherogenic dyslipidemia prevalence was high (57-66%) in OSA patients, and especially increased in severe OSA compared to other groups (p < 0.05). Though total and LDL-cholesterol did not differ between those with and without OSA, non-HDL-cholesterol (p = 0.020), and triglycerides (p = 0.001) were higher and HDL-cholesterol levels (p = 0.018) were lower in OSA patients than non-OSA. Non-HDL-cholesterol was significantly correlated with OSA severity (p < 0.001) and hypoxia parameters (p < 0.01), whereas LDL-cholesterol showed no correlation. Conclusions: Atherogenic dyslipidemia is highly prevalent and non-HDL-cholesterol levels are significantly increased, predominantly in severe OSA patients. Non-HDL-cholesterol but not LDL-cholesterol, is significantly correlated with OSA severity and hypoxia parameters. Therefore, it could be better to use non-HDL-cholesterol, which is a guideline recommended target of lipid therapy, as a marker of atherosclerotic cardiovascular risk in OSA patients.
MeSH term(s)	Adult ; Atherosclerosis/epidemiology ; Atherosclerosis/etiology ; Biomarkers ; Cholesterol ; Dyslipidemias/epidemiology ; Female ; Humans ; Male ; Middle Aged ; Retrospective Studies ; Risk Factors ; Sleep Apnea, Obstructive ; Triglycerides
Chemical Substances	Biomarkers ; Triglycerides ; Cholesterol (97C5T2UQ7J)
Language	English
Publishing date	2021-10-14
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	2012041-2
ISSN	1878-5506 ; 1389-9457
ISSN (online)	1878-5506
ISSN	1389-9457
DOI	10.1016/j.sleep.2021.09.021
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Zs.A 5315: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
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Article: Effect of COVID-19 Pandemic on Sleep Quality and Mental State of Frontline Pulmonologists.

Haznedaroğlu, Damla İşman / Tunçel, Özlem Kuman / Hepdurgun, Cenan / Pırıldar, Şebnem / Başoğlu, Özen K

Noro psikiyatri arsivi

2022 Volume 59, Issue 4, Page(s) 315–320

Abstract: Introduction: This study aims to determine the sleep quality and its relationship with anxiety and depressive symptoms, working conditions and other factors among the frontline pulmonologists on active duty during the COVID-19 pandemic.: Method: An ... ...

Abstract	Introduction: This study aims to determine the sleep quality and its relationship with anxiety and depressive symptoms, working conditions and other factors among the frontline pulmonologists on active duty during the COVID-19 pandemic. Method: An online survey was conducted among pulmonologists in Turkey. The survey link was e-mailed to the members of the professional societies of pulmonologists. The volunteers were asked to fill in questions about their sociodemographics, medical and psychiatric history, working and housing conditions, perceived levels of support during the pandemic, as well as the sleep habits before the pandemic. Also, questions investigating the severity/level of their worries were inquired and they were asked to fill in two scale forms (the Hospital Anxiety Depression Scale and Pittsburgh Sleep Quality Index-PSQI). Results: The sample consisted of 179 pulmonologists who were divided into two groups according to PSQI as good sleepers (PSQI ≤5) and poor sleepers (PSQI >5). It was observed that 59.2% of the participants had poor sleep quality during the pandemic. Being anxious (p<0.0001, Odds ratio [OR]=0.139, 95% Confidence Interval [CI] [0.052-0.372]), working in intensive care unit (p=0.046, OR=2.363, 95% CI [1.015-5.497]), worry level about excessive increase of the number of patients above the capacity of the institution they worked in (p=0.018, OR=1.755, 95% CI [1.102-2.794]) and being dissatisfied with ones' sleep before the pandemic (p<0.016, OR=0.272, 95% CI [0.094-0.786]) were found to be the main factors that negatively affected the quality of sleep of pulmonologists during the pandemic. Conclusion: More than half of the pulmonologists in our sample group had low sleep quality during the pandemic. For establishing a good sleep regime for clinicians, its crucial to consider certain interventions on the affecting factors.
Language	English
Publishing date	2022-09-12
Publishing country	Turkey
Document type	Journal Article
ZDB-ID	2565770-7
ISSN	1300-0667
ISSN	1300-0667
DOI	10.29399/npa.28106
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Article ; Online: Gender differences in clinical and polysomnographic features of obstructive sleep apnea: a clinical study of 2827 patients.

Basoglu, Ozen K / Tasbakan, Mehmet Sezai

Sleep & breathing = Schlaf & Atmung

2017 Volume 22, Issue 1, Page(s) 241–249

Abstract: Purpose: Obstructive sleep apnea (OSA) is underdiagnosed in females due to different clinical presentation. We aimed to determine the effect of gender on clinical and polysomnographic features and identify predictors of OSA in women.: Methods: ... ...

Abstract	Purpose: Obstructive sleep apnea (OSA) is underdiagnosed in females due to different clinical presentation. We aimed to determine the effect of gender on clinical and polysomnographic features and identify predictors of OSA in women. Methods: Differences in demographic, clinical, and polysomnographic parameters between 2052 male and 775 female OSA patients were compared. Results: In female OSA patients, age (56.1 ± 9.7 vs. 50.4 ± 11.6 years, p < 0.0001) and body mass index (36.3 ± 8.6 vs. 31.8 ± 5.9 kg/m Conclusions: These data suggest that frequency and severity of sleep apnea is lower in female OSA patients, and they are presenting with female-specific symptoms and increased medical comorbidities. Therefore, female-specific questionnaires should be developed and used for preventing underdiagnosis of OSA.
MeSH term(s)	Body Mass Index ; Female ; Humans ; Male ; Middle Aged ; Polysomnography ; Retrospective Studies ; Sex Characteristics ; Sleep Apnea, Obstructive/physiopathology ; Sleep Stages
Language	English
Publishing date	2017-02-14
Publishing country	Germany
Document type	Comparative Study ; Journal Article ; Observational Study
ZDB-ID	1500381-4
ISSN	1522-1709 ; 1520-9512
ISSN (online)	1522-1709
ISSN	1520-9512
DOI	10.1007/s11325-017-1482-9
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Article ; Online: Metabolic dysfunction in OSA: Is there something new under the sun?

Almendros, Isaac / Basoglu, Özen K / Conde, Silvia V / Liguori, Claudio / Saaresranta, Tarja

Journal of sleep research

2021 Volume 31, Issue 1, Page(s) e13418

Abstract: The growing number of patients with obstructive sleep apnea is challenging healthcare systems worldwide. Obstructive sleep apnea is characterized by chronic intermittent hypoxaemia, episodes of apnea and hypopnea, and fragmented sleep. Cardiovascular and ...

Abstract	The growing number of patients with obstructive sleep apnea is challenging healthcare systems worldwide. Obstructive sleep apnea is characterized by chronic intermittent hypoxaemia, episodes of apnea and hypopnea, and fragmented sleep. Cardiovascular and metabolic diseases are common in obstructive sleep apnea, also in lean patients. Further, comorbidity burden is not unambiguously linked to the severity of obstructive sleep apnea. There is a growing body of evidence revealing diverse functions beyond the conventional tasks of different organs such as carotid body and gut microbiota. Chronic intermittent hypoxia and sleep loss due to sleep fragmentation are associated with insulin resistance. Indeed, carotid body is a multi-sensor organ not sensoring only hypoxia and hypercapnia but also acting as a metabolic sensor. The emerging evidence shows that obstructive sleep apnea and particularly chronic intermittent hypoxia is associated with non-alcoholic fatty liver disease. Gut dysbiosis seems to be an important factor in the pathophysiology of obstructive sleep apnea and its consequences. The impact of sleep fragmentation and intermittent hypoxia on the development of metabolic syndrome may be mediated via altered gut microbiota. Circadian misalignment seems to have an impact on the cardiometabolic risk in obstructive sleep apnea. Dysfunction of cerebral metabolism is also related to hypoxia and sleep fragmentation. Therefore, obstructive sleep apnea may alter cerebral metabolism and predispose to neurocognitive impairment. Moreover, recent data show that obstructive sleep apnea independently predicts impaired lipid levels. This mini-review will provide novel insights into the mechanisms of metabolic dysfunction in obstructive sleep apnea combining recent evidence from basic, translational and clinical research, and discuss the impact of positive airway pressure treatment on metabolic disorders.
MeSH term(s)	Gastrointestinal Microbiome ; Humans ; Hypoxia/complications ; Insulin Resistance ; Metabolic Diseases ; Metabolic Syndrome ; Sleep Apnea, Obstructive/complications ; Sleep Apnea, Obstructive/therapy
Language	English
Publishing date	2021-06-21
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	1122722-9
ISSN	1365-2869 ; 0962-1105
ISSN (online)	1365-2869
ISSN	0962-1105
DOI	10.1111/jsr.13418
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Zs.A 3464: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Rationale and Design of the Turkish Sleep Apnea Database - TURKAPNE: A National, Multicenter, Observational, Prospective Cohort Study.

Peker, Yüksel / Başoğlu, Özen K / Fırat, Hikmet

Turkish thoracic journal

2018 Volume 19, Issue 3, Page(s) 136–140

Abstract: Objectives: The primary aim of The Turkish Sleep Apnea Database (TURKAPNE) study is to generate a cross-sectional nationwide database for defining the clinical and polysomnographic characteristics of the patients with obstructive sleep apnea (OSA) in ... ...

Abstract	Objectives: The primary aim of The Turkish Sleep Apnea Database (TURKAPNE) study is to generate a cross-sectional nationwide database for defining the clinical and polysomnographic characteristics of the patients with obstructive sleep apnea (OSA) in Turkey. Materials and methods: In this ongoing project, all consecutive adults with suspected OSA are recruited from the sleep centers of the university and research hospitals in Turkey. Information on anthropometric data, educational status, driving license, smoking habits, alcohol use, comorbidities, drug use, questionnaires, polysomnographic, and/or cardiorespiratory polygraphic findings are recorded in a systematized Web-based report form. Blood glucose, lipids and other biochemical markers, lung function, and echocardiography measurements are optionally included. Follow-up data regarding treatment modality and compliance is assessed. Cross-sectional and longitudinal associations between OSA phenotypes and metabolic, pulmonary, and cardiovascular comorbidities as well as traffic accidents, and the impact of treatment will be further explored. We target a total sample of 10,000 participants. Results: The study was registered with ClinicalTrials.gov (NCT02784977) in May 2016 and the first patient was recruited in October 2017. A total of 1911 participants from 19 centers have been enrolled in the study by May 31, 2018. Conclusion: The TURKAPNE study will contribute to a better understanding of the health-related burden of OSA phenotypes and its association with the comorbidities and adverse outcomes, including traffic accidents in Turkey. The results may also contribute to a more personalized approach and better management of varying OSA phenotypes with concomitant disorders.
Language	English
Publishing date	2018-07-01
Publishing country	Turkey
Document type	Journal Article
ISSN	2149-2530
ISSN (online)	2149-2530
DOI	10.5152/TurkThoracJ.2018.18097
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Article ; Online: Comparison of clinical characteristics in patients with obesity hypoventilation syndrome and obese obstructive sleep apnea syndrome: a case-control study.

Basoglu, Ozen K / Tasbakan, Mehmet Sezai

The clinical respiratory journal

2014 Volume 8, Issue 2, Page(s) 167–174

Abstract: Introduction: Obesity hypoventilation syndrome (OHS) can be overlooked unless clinicians have a high index of suspicion. The present case-control study aimed to compare characteristics of patients with OHS and obese obstructive sleep apnea syndrome ( ... ...

Abstract	Introduction: Obesity hypoventilation syndrome (OHS) can be overlooked unless clinicians have a high index of suspicion. The present case-control study aimed to compare characteristics of patients with OHS and obese obstructive sleep apnea syndrome (OSAS), and to identify determinants of hypercapnia in OSAS patients. Methods: Demographic and anthropometric features, pulmonary function tests, blood gas analysis and sleep parameters of 59 OHS patients were compared to 295 body mass index-matched OSAS patients. Results: The rate of hypertension (67.8% vs 53.2%, respectively, P=0.027) was higher in OHS than OSAS group. In OHS patients, FVC (%) (P<0.0001), FEV1 (%) (P=0.001) and PaO2 (P<0.0001) were lower, whereas PaCO2 and HCO3 levels were increased (P<0.0001). Daytime sleepiness was more frequent (89.8% vs 68.5%, respectively, P=0.002), and Epworth sleepiness scores were higher (14.0 vs 11.9, respectively, P=0.021) in OHS than OSAS patients. In polysomnography, lowest and mean SpO2 were decreased, and sleep time with SpO2 <90% was increased in patients with OHS (P<0.0001). Multivariate analysis showed that hypercapnia was associated independently with HCO3 (P<0.0001) and daytime SaO2 (P=0.003). Besides, HCO3 level ≥ 27 mEq/L had a sensitivity of 88.1% and specificity of 73.1%, and SaO2 ≤ 95% had a sensitivity of 64.4% and specificity of 73.9% for identifying OHS. Conclusion: It was shown that OHS patients have increased rate of hypertension, daytime sleepiness and HCO3 , and decreased lung functions and PaO2 levels than OSAS patients. The present results support that elevated bicarbonate levels and decreased oxygen saturations in obese OSAS patients should prompt clinicians to predict OHS.
MeSH term(s)	Blood Gas Analysis ; Body Mass Index ; Carbon Dioxide/blood ; Female ; Humans ; Hypercapnia/etiology ; Hypercapnia/physiopathology ; Male ; Middle Aged ; Obesity Hypoventilation Syndrome/blood ; Obesity Hypoventilation Syndrome/complications ; Obesity Hypoventilation Syndrome/physiopathology ; Oxygen/blood ; Polysomnography ; Respiratory Function Tests ; Retrospective Studies ; Sleep Apnea Syndromes/blood ; Sleep Apnea Syndromes/complications ; Sleep Apnea Syndromes/physiopathology
Chemical Substances	Carbon Dioxide (142M471B3J) ; Oxygen (S88TT14065)
Language	English
Publishing date	2014-04
Publishing country	England
Document type	Comparative Study ; Journal Article ; Observational Study
ZDB-ID	2442214-9
ISSN	1752-699X ; 1752-6981
ISSN (online)	1752-699X
ISSN	1752-6981
DOI	10.1111/crj.12054
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Article ; Online: Elevated risk of sleepiness-related motor vehicle accidents in patients with obstructive sleep apnea syndrome: a case-control study.

Basoglu, Ozen K / Tasbakan, Mehmet Sezai

Traffic injury prevention

2014 Volume 15, Issue 5, Page(s) 470–476

Abstract: Objectives: The present case-control study aimed to determine whether obstructive sleep apnea syndrome (OSAS) patients are at an increased risk for sleepiness-related motor vehicle accidents (MVAs) than controls and to identify disease-related factors ... ...

Abstract	Objectives: The present case-control study aimed to determine whether obstructive sleep apnea syndrome (OSAS) patients are at an increased risk for sleepiness-related motor vehicle accidents (MVAs) than controls and to identify disease-related factors associated with accident risk. Methods: Demographic, anthropometric, clinical, and polysomnographic parameters of 312 OSAS patients were compared with 156 age- and sex-matched primary snoring subjects. Results: The rate of OSAS patients reporting accident was higher than snoring subjects (21.2% vs. 11.5%, P = .011), and OSAS was associated with an increase in accident risk (odds ratio = 2.06, 95% confidence interval [CI], 1.17 to 3.61, P = .012). Younger OSAS patients (P = .001) and those who were male (P = .001), had greater neck circumference (P = .002), had a higher Epworth sleepiness score (ESS; P < .0001), and had a higher apnea-hypopnea index (AHI; p = .039) had more MVAs than OSAS patients. Daytime sleepiness was associated with a 2.74-fold increase (95% CI, 1.54 to 4.87, P = .001) in accident risk. In multiple logistic regression analysis, accident risk was associated with neck circumference (P < .031) and ESS (P < .0001). In addition, accident risk could be excluded in OSAS patients with neck circumference < 43 cm and ESS < 11 (sensitivity 33.3%, specificity 85.8%). Conclusions: The present results show that OSAS patients have a twofold higher risk of traffic accidents than control subjects, and increased neck circumference and excessive daytime sleepiness are useful in predicting OSAS patients at higher risk of having accidents.
MeSH term(s)	Accidents, Traffic/statistics & numerical data ; Adult ; Case-Control Studies ; Disorders of Excessive Somnolence/epidemiology ; Female ; Humans ; Male ; Middle Aged ; Neck/anatomy & histology ; Retrospective Studies ; Risk Assessment ; Sleep Apnea, Obstructive/complications
Language	English
Publishing date	2014
Publishing country	England
Document type	Journal Article
ZDB-ID	2089818-6
ISSN	1538-957X ; 1538-9588
ISSN (online)	1538-957X
ISSN	1538-9588
DOI	10.1080/15389588.2013.830213
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Article ; Online: Evaluation of Periorbital Tissues in Obstructive Sleep Apnea Syndrome.

Karaca, Irmak / Yağcı, Ayşe / Palamar, Melis / Taşbakan, Mehmet Sezai / Başoğlu, Özen K

Turkish journal of ophthalmology

2020 Volume 50, Issue 6, Page(s) 356–361

Abstract: Objectives: To evaluate periorbital tissue alterations including eyelid laxity and eyelash ptosis in patients with obstructive sleep apnea syndrome (OSAS).: Materials and methods: Based on polysomnography, 96 eyes of 48 patients with moderate/severe ... ...

Abstract	Objectives: To evaluate periorbital tissue alterations including eyelid laxity and eyelash ptosis in patients with obstructive sleep apnea syndrome (OSAS). Materials and methods: Based on polysomnography, 96 eyes of 48 patients with moderate/severe OSAS (Group 1) and 44 eyes of 22 patients with simple snoring (Group 2) were enrolled. Comprehensive eye examination along with eyelid laxity measurements including vertical and anterior distraction, presence of dermatochalasis, interpalpebral distance, and levator function were assessed. The presence and severity of eyelash ptosis were also noted. Results: The mean ages of Group 1 and Group 2 were 49.9±11.4 (range: 26-67) and 50.6±8.9 (range: 27-69) years, respectively (p=0.557). The mean vertical and anterior distraction distances in Group 1 (13.3±4.1 [range, 6-27] mm and 7.4±2.1 [range, 3-13.5] mm, respectively) were significantly higher than in Group 2 (p<0.05). Dermatochalasis and eyelash ptosis were found to be significantly more frequent in Group 1 (52.1% and 81.3%, respectively). The severity of eyelash ptosis was also higher in OSAS (p<0.05). No significant difference in interpalpebral distance or levator muscle function was detected. Conclusion: In patients with severe OSAS, eyelid laxity was more prominent and eyelash ptosis was more frequent and severe.
MeSH term(s)	Blepharoptosis/diagnosis ; Blepharoptosis/etiology ; Cross-Sectional Studies ; Female ; Follow-Up Studies ; Humans ; Male ; Middle Aged ; Polysomnography ; Prospective Studies ; Severity of Illness Index ; Sleep Apnea, Obstructive/complications ; Sleep Apnea, Obstructive/diagnosis
Language	English
Publishing date	2020-12-31
Publishing country	Turkey
Document type	Journal Article
ZDB-ID	2586160-8
ISSN	2149-8709 ; 2147-2661 ; 1300-0659 ; 1300-0659 ; 2149-8695
ISSN (online)	2149-8709 ; 2147-2661 ; 1300-0659
ISSN	1300-0659 ; 2149-8695
DOI	10.4274/tjo.galenos.2020.35033
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