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  1. Article: Fatal hepatitis A virus infection in an adolescent.

    BaAlawi, Fatma / Hassan, Kowthar / Al Maamari, Khuloud / Balkhair, Abdullah

    IDCases

    2020  Volume 20, Page(s) e00721

    Abstract: Acute hepatitis A infection is largely self-limiting illness, rarely resulting in fulminant course with consequent hepatic failure and death. We present a 13-year old previously healthy Omani with fatal hepatitis A virus infection. This case highlights ... ...

    Abstract Acute hepatitis A infection is largely self-limiting illness, rarely resulting in fulminant course with consequent hepatic failure and death. We present a 13-year old previously healthy Omani with fatal hepatitis A virus infection. This case highlights the critical role of hepatitis A vaccination and argues for consideration of its inclusion in national vaccination programs in order to avert similar devastating consequences of yet another vaccine preventable disease.
    Language English
    Publishing date 2020-02-12
    Publishing country Netherlands
    Document type Case Reports
    ZDB-ID 2745454-X
    ISSN 2214-2509
    ISSN 2214-2509
    DOI 10.1016/j.idcr.2020.e00721
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: T Cell Depleted Haploidentical Hematopoietic Stem Cell Transplantation for Patients with Familial Hemophagocytic Lymphohistiocytosis Who Do Not Have Matched Family Donors: Experience in Oman.

    Nazir, Hanan F / Ba Alawi, Fatma S / Al Hosni, Saif / Al Rawas, Abdulhakim / Dennison, David

    Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation

    2020  Volume 26, Issue 6, Page(s) 1119–1123

    Abstract: Familial hemophagocytic lymphohistiocytosis (FHLH) is a potentially fatal disorder of immune regulation. Management includes chemotherapy followed by hematopoietic stem cell transplantation (HSCT). T cell depleted (TCD)-haploidentical HSCT could be an ... ...

    Abstract Familial hemophagocytic lymphohistiocytosis (FHLH) is a potentially fatal disorder of immune regulation. Management includes chemotherapy followed by hematopoietic stem cell transplantation (HSCT). T cell depleted (TCD)-haploidentical HSCT could be an option for those patients who do not have HLA matching family donor. The objective of this study was to report on the outcome of TCD-haploidentical HSCT in patients with FHLH who underwent transplantation at Sultan Qaboos University Hospital (SQUH). This is a retrospective report on 12 patients with FHLH who received TCD- haploidentical HSCT at SQUH between August 2010 and December 2018. Epidemiologic characteristics and details on the transplantation procedures and complications were collected from patients' electronic records. Twelve patients with FHLH received TCD-haploidentical HSCT after a myeloablative conditioning regimen composed of treosulfan/thiotepa/fludarabine/anti-thymocyte globulin and rituximab. The mean age at transplantation was 11.67 ± 8 months. All patients had Perforin gene mutations, except 1 patient who had an UNC-13D mutation. Most patients received TCRαβ
    MeSH term(s) Graft vs Host Disease ; Hematopoietic Stem Cell Transplantation ; Humans ; Lymphohistiocytosis, Hemophagocytic/therapy ; Oman ; Retrospective Studies ; T-Lymphocytes ; Transplantation Conditioning ; Treatment Outcome
    Language English
    Publishing date 2020-02-20
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1474865-4
    ISSN 1523-6536 ; 1083-8791
    ISSN (online) 1523-6536
    ISSN 1083-8791
    DOI 10.1016/j.bbmt.2020.02.014
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5082: Show issues Location:
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    Zs.MO 462: Show issues

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  3. Article ; Online: Identification of Asymptomatic Severe Acute Respiratory Syndrome Coronavirus 2 Infections Among Healthcare Workers at Sultan Qaboos University Hospital, Oman.

    Al Shibli, Amal / Al Jufaili, Mahmood / Al Alawi, Awatif / Balkhair, Abdullah / Al Zakwani, Ibrahim / Al Azri, Faisal / Al Maamari, Khuloud / Ba Alawi, Fatma / Al Qayoudhi, Azza / Al Ghafri, Hajar

    Sultan Qaboos University medical journal

    2023  Volume 23, Issue 3, Page(s) 336–343

    Abstract: Objectives: This study aimed to describe the incidence and features of asymptomatic COVID-19 infections among healthcare workers (HCWs) at a tertiary hospital in Oman.: Methods: This cross-sectional study was conducted between August 2020 and ... ...

    Abstract Objectives: This study aimed to describe the incidence and features of asymptomatic COVID-19 infections among healthcare workers (HCWs) at a tertiary hospital in Oman.
    Methods: This cross-sectional study was conducted between August 2020 and February 2021 among HCWs with no history of COVID-19 infection. An online questionnaire collected sociodemographic and clinical data. COVID-19 infection was diagnosed using nasopharyngeal/throat swabs, which were tested for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Analyses were performed using the Chi-squared test, Fisher's exact test or univariate ordinary least squares regression, as appropriate.
    Results: A total of 583 HCWs participated in the study, most of whom were female (56.6%), and the mean age was 35
    Conclusion: There was a greater frequency of SARS-CoV-2 positivity among HCWs working in low-risk areas, whereas HCWs who worked in high-risk areas were significantly more likely to report increased compliance with infection control strategies.
    MeSH term(s) Humans ; Female ; Adult ; Male ; COVID-19/epidemiology ; Oman/epidemiology ; Cross-Sectional Studies ; SARS-CoV-2 ; Hospitals, University ; Health Personnel
    Language English
    Publishing date 2023-08-28
    Publishing country Oman
    Document type Journal Article
    ZDB-ID 2650196-X
    ISSN 2075-0528 ; 2075-0528
    ISSN (online) 2075-0528
    ISSN 2075-0528
    DOI 10.18295/squmj.1.2023.008
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  4. Article ; Online: Short and long-term immune changes in different severity groups of COVID-19 disease.

    Maamari, Khuloud Al / Busaidi, Ibrahim Al / Kindi, Mahmood Al / Zadjali, Fahad / BaAlawi, Fatma / Anesta, Wijesinghe / Amri, Kawthar Al / Albalushi, Wafa / Balushi, Hamed Al / Amri, Ayman Al / Aljufaili, Mahmood / Al-Busaidi, Mujahid / Muharrmi, Zakariya Al / Balkhair, Abdullah / Riyami, Nafila Al / Ghanim, Zahraa / Alshekaili, Jalila

    International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases

    2022  Volume 122, Page(s) 776–784

    Abstract: Background: There are limited data on short- versus long-term changes in adaptive immune response across different COVID-19 disease severity groups.: Methods: A multicenter prospective study of 140 adult patients with COVID-19 (a total of 325 samples) ...

    Abstract Background: There are limited data on short- versus long-term changes in adaptive immune response across different COVID-19 disease severity groups.
    Methods: A multicenter prospective study of 140 adult patients with COVID-19 (a total of 325 samples) were analyzed for inflammatory markers and lymphocyte subsets at presentation, week 2, and week 24.
    Results: Inflammatory markers at presentation were higher in the critical/severe than in moderate and mild groups. A predominance of memory B cell response in the mild and moderate group was noted by week 2. In contrast, the immune system in the severe/critical group was dysfunctional, with expansion of exhausted CD8+ T cells and atypical memory B cells. By 24 weeks, there was a possible trend of normalization.
    Conclusion: There was substantial difference in the degree of inflammation and distribution of different B and T cell subsets in the different disease severity groups. Despite the initial dysfunctional immune response in the severe/critical group, a comparable memory B and CD8+ T cell responses to the mild group was achieved at 24 weeks.
    MeSH term(s) Adult ; CD8-Positive T-Lymphocytes ; COVID-19 ; Humans ; Prospective Studies ; SARS-CoV-2 ; T-Lymphocyte Subsets
    Language English
    Publishing date 2022-07-15
    Publishing country Canada
    Document type Journal Article ; Multicenter Study
    ZDB-ID 1331197-9
    ISSN 1878-3511 ; 1201-9712
    ISSN (online) 1878-3511
    ISSN 1201-9712
    DOI 10.1016/j.ijid.2022.07.026
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4516: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  5. Article ; Online: Hendra virus: a one health tale of flying foxes, horses and humans.

    Hazelton, Briony / Ba Alawi, Fatma / Kok, Jen / Dwyer, Dominic E

    Future microbiology

    2013  Volume 8, Issue 4, Page(s) 461–474

    Abstract: Hendra virus, a member of the family Paramyxoviridae, was first recognized following a devastating outbreak in Queensland, Australia, in 1994. The naturally acquired symptomatic infection, characterized by a rapidly progressive illness involving the ... ...

    Abstract Hendra virus, a member of the family Paramyxoviridae, was first recognized following a devastating outbreak in Queensland, Australia, in 1994. The naturally acquired symptomatic infection, characterized by a rapidly progressive illness involving the respiratory system and/or CNS, has so far only been recognized in horses and humans. However, there is potential for other species to be infected, with significant consequences for animal and human health. Prevention of infection involves efforts to interrupt the bat-to-horse and horse-to-human transmission interfaces. Education and infection-control efforts remain the key to reducing risk of transmission, particularly as no effective antiviral treatment is currently available. The recent release of an equine Hendra G glycoprotein subunit vaccine is an exciting advance that offers the opportunity to curb the recent increase in equine transmission events occurring in endemic coastal regions of Australia and thereby reduce the risk of infection in humans.
    MeSH term(s) Animals ; Chiroptera/virology ; Hendra Virus/physiology ; Henipavirus Infections/transmission ; Henipavirus Infections/veterinary ; Henipavirus Infections/virology ; Horse Diseases/transmission ; Horse Diseases/virology ; Horses ; Humans ; Zoonoses/transmission ; Zoonoses/virology
    Language English
    Publishing date 2013-04
    Publishing country England
    Document type Journal Article ; Review
    ISSN 1746-0921
    ISSN (online) 1746-0921
    DOI 10.2217/fmb.13.19
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  6. Article ; Online: Comparison of five CMV IgM immunoassays with CMV IgG avidity for diagnosis of primary CMV infection.

    BaAlawi, Fatma / Robertson, Peter W / Lahra, Monica / Rawlinson, William D

    Pathology

    2012  Volume 44, Issue 4, Page(s) 381–383

    MeSH term(s) Antibodies, Viral/blood ; Cytomegalovirus/immunology ; Cytomegalovirus/isolation & purification ; Cytomegalovirus Infections/blood ; Cytomegalovirus Infections/diagnosis ; Enzyme-Linked Immunosorbent Assay ; Humans ; Immunoglobulin G/blood ; Immunoglobulin M/blood ; Predictive Value of Tests
    Chemical Substances Antibodies, Viral ; Immunoglobulin G ; Immunoglobulin M
    Language English
    Publishing date 2012-06
    Publishing country England
    Document type Comparative Study ; Letter
    ZDB-ID 7085-3
    ISSN 1465-3931 ; 0031-3025
    ISSN (online) 1465-3931
    ISSN 0031-3025
    DOI 10.1097/PAT.0b013e328353bec0
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 723: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  7. Article ; Online: The reliability of HBV core antibody in serological screening for hepatitis B virus.

    Ba Alawi, Fatma / Robertson, Peter W / LePage, Amelia K / Jayamaha, Jude / Baleriola, Cristina / Rawlinson, William D

    Pathology

    2013  Volume 45, Issue 5, Page(s) 501–505

    Abstract: Introduction: Accurate diagnosis of hepatitis B virus (HBV) infection is essential for infection control, treatment and screening of potential blood, organ and tissue donors. We assessed the sensitivity of the HBsAg and HBcAb as screening assays alone ... ...

    Abstract Introduction: Accurate diagnosis of hepatitis B virus (HBV) infection is essential for infection control, treatment and screening of potential blood, organ and tissue donors. We assessed the sensitivity of the HBsAg and HBcAb as screening assays alone and in combination for detecting HBV infection in a series of Australian patients. The performance of the Architect (Abbott Diagnostics, Germany) and the Elecsys (Roche Diagnostics, Germany) platforms were assessed for detection of HBcAb.
    Methods: There were 2778 blood samples assessed using the COBAS Ampliprep/TaqMan test for HBV DNA, of which 331 sera had concurrent HBV serology testing. This allowed determination of the correlation between HBV DNA and different serological markers. Of the 331 sera, 260 had sufficient residual volume to be retested for HBcAb using both Elecsys and the Architect assays.
    Results: Of the 331 patients, one (0.3%) was negative by the Architect Anti-HBc II assay, in the presence of HBV DNA and positive HBsAg, consistent with recent infection. Positive HBcAb in the absence of HBV DNA was found in 67 of 331 (20.2%) patients. Of these, 18 of 67 had isolated HBcAb with negative results on all other tests, with 12 of 18 (3.6%) demonstrating low HBcAb signals on chemiluminscent microparticle assay. No cases of detectable HBV DNA in the presence of negative serology were found. When the HBcAb was used as a marker for past exposure or chronic HBV infection, the Architect Anti-HBc II assay demonstrated sensitivity and specificity of 98% and 79.9%, respectively, compared to 90% and 78.9%, respectively, for the Elecsys Anti-HBc assay. The combination of the Architect Anti-HBc II and HBsAg assays, as per conventional solid organ donor and recipient screening protocols, had 90% specificity and 100% sensitivity for determining HBV infection.
    Conclusion: This study shows that the use of combined HBsAg and HBcAb is sensitive and reliable for screening and predicting HBV nucleic acid test (NAT) positivity, whereas HBcAb alone missed an acute infection in this study population. There were no significant differences detectable between the Architect and the Elecsys HBcAb assays (p=0.001), suggesting laboratories should assess individual assays in the local population before use as screening tests.
    MeSH term(s) Adolescent ; Adult ; Aged ; Aged, 80 and over ; Australia/epidemiology ; Child ; DNA, Viral/blood ; Female ; Hepatitis B/blood ; Hepatitis B/diagnosis ; Hepatitis B/epidemiology ; Hepatitis B Antibodies/blood ; Hepatitis B Core Antigens/blood ; Hepatitis B Surface Antigens/blood ; Hepatitis B virus/immunology ; Humans ; Male ; Mass Screening/methods ; Middle Aged ; Reproducibility of Results ; Retrospective Studies ; Sensitivity and Specificity ; Serologic Tests/methods ; Viral Core Proteins/immunology ; Young Adult
    Chemical Substances DNA, Viral ; Hepatitis B Antibodies ; Hepatitis B Core Antigens ; Hepatitis B Surface Antigens ; Viral Core Proteins
    Language English
    Publishing date 2013-08
    Publishing country England
    Document type Evaluation Studies ; Journal Article
    ZDB-ID 7085-3
    ISSN 1465-3931 ; 0031-3025
    ISSN (online) 1465-3931
    ISSN 0031-3025
    DOI 10.1097/PAT.0b013e3283631cf9
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 723: Show issues Location:
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