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  1. Article ; Online: Antifibrotic properties of hyaluronic acid crosslinked polyisocyanide hydrogels.

    Kumari, Jyoti / Hammink, Roel / Baaij, Jochem / Wagener, Frank A D T G / Kouwer, Paul H J

    Biomaterials advances

    2023  Volume 156, Page(s) 213705

    Abstract: Fibrosis is characterized by the formation of fibrous connective tissue in response to primary injury. As a result, an affected organ may lose part of its functionality due to chronic, organ-specific tissue damage. Since fibrosis is a leading cause of ... ...

    Abstract Fibrosis is characterized by the formation of fibrous connective tissue in response to primary injury. As a result, an affected organ may lose part of its functionality due to chronic, organ-specific tissue damage. Since fibrosis is a leading cause of death worldwide, targeting fibrotic diseases with antifibrotic hydrogels can be a lifesaving therapeutic strategy. This study developed a novel hybrid antifibrotic hydrogel by combining the synthetic polyisocyanide (PIC) with hyaluronic acid (HA). Gels of PIC are highly tailorable, thermosensitive, and strongly biomimetic in architecture and mechanical properties, whereas HA is known to promote non-fibrotic fetal wound healing and inhibits inflammatory signaling. The developed HA-PIC hybrids were biocompatible with physical properties comparable to those of the PIC gels. The antifibrotic nature of the gels was assessed by 3D cultures of human foreskin fibroblasts in the presence (or absence as control) of TGFβ1 that promotes differentiation into myofibroblasts, a critical step in fibrosis. Proliferation and macroscopic contraction assays and studies on the formation of stress fibers and characteristic fibrosis markers all indicate a strong antifibrotic nature of HA-PIC hydrogel. We showed that these effects originate from both the lightly crosslinked architecture and the presence of HA itself. The hybrid displaying both these effects shows the strongest antifibrotic nature and is a promising candidate for use as in vivo treatment for skin fibrosis.
    MeSH term(s) Humans ; Hydrogels/pharmacology ; Hyaluronic Acid/pharmacology ; Fibroblasts ; Myofibroblasts ; Fibrosis
    Chemical Substances Hydrogels ; Hyaluronic Acid (9004-61-9)
    Language English
    Publishing date 2023-11-22
    Publishing country Netherlands
    Document type Journal Article
    ISSN 2772-9508
    ISSN (online) 2772-9508
    DOI 10.1016/j.bioadv.2023.213705
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Structural and functional comparison of magnesium transporters throughout evolution.

    Franken, G A C / Huynen, M A / Martínez-Cruz, L A / Bindels, R J M / de Baaij, J H F

    Cellular and molecular life sciences : CMLS

    2022  Volume 79, Issue 8, Page(s) 418

    Abstract: Magnesium ( ... ...

    Abstract Magnesium (Mg
    MeSH term(s) Biological Transport ; Cations, Divalent/metabolism ; Magnesium/metabolism ; Membrane Transport Proteins/metabolism ; Phosphotransferases/metabolism
    Chemical Substances Cations, Divalent ; Membrane Transport Proteins ; Phosphotransferases (EC 2.7.-) ; Magnesium (I38ZP9992A)
    Language English
    Publishing date 2022-07-12
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 1358415-7
    ISSN 1420-9071 ; 1420-682X
    ISSN (online) 1420-9071
    ISSN 1420-682X
    DOI 10.1007/s00018-022-04442-8
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 195: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  3. Article ; Online: Structural and functional comparison of magnesium transporters throughout evolution

    Franken, G. A. C. / Huynen, M. A. / Martínez-Cruz, L. A. / Bindels, R. J. M. / de Baaij, J. H. F.

    Cell. Mol. Life Sci.. 2022 Aug., v. 79, no. 8 p.418-418

    2022  

    Abstract: Magnesium (Mg²⁺) is the most prevalent divalent intracellular cation. As co-factor in many enzymatic reactions, Mg²⁺ is essential for protein synthesis, energy production, and DNA stability. Disturbances in intracellular Mg²⁺ concentrations, therefore, ... ...

    Abstract Magnesium (Mg²⁺) is the most prevalent divalent intracellular cation. As co-factor in many enzymatic reactions, Mg²⁺ is essential for protein synthesis, energy production, and DNA stability. Disturbances in intracellular Mg²⁺ concentrations, therefore, unequivocally result in delayed cell growth and metabolic defects. To maintain physiological Mg²⁺ levels, all organisms rely on balanced Mg²⁺ influx and efflux via Mg²⁺ channels and transporters. This review compares the structure and the function of prokaryotic Mg²⁺ transporters and their eukaryotic counterparts. In prokaryotes, cellular Mg²⁺ homeostasis is orchestrated via the CorA, MgtA/B, MgtE, and CorB/C Mg²⁺ transporters. For CorA, MgtE, and CorB/C, the motifs that form the selectivity pore are conserved during evolution. These findings suggest that CNNM proteins, the vertebrate orthologues of CorB/C, also have Mg²⁺ transport capacity. Whereas CorA and CorB/C proteins share the gross quaternary structure and functional properties with their respective orthologues, the MgtE channel only shares the selectivity pore with SLC41 Na⁺/Mg²⁺ transporters. In eukaryotes, TRPM6 and TRPM7 Mg²⁺ channels provide an additional Mg²⁺ transport mechanism, consisting of a fusion of channel with a kinase. The unique features these TRP channels allow the integration of hormonal, cellular, and transcriptional regulatory pathways that determine their Mg²⁺ transport capacity. Our review demonstrates that understanding the structure and function of prokaryotic magnesiotropic proteins aids in our basic understanding of Mg²⁺ transport.
    Keywords DNA ; cations ; cell growth ; energy ; eukaryotic cells ; evolution ; homeostasis ; magnesium ; prokaryotic cells ; protein synthesis ; transcription (genetics) ; vertebrates
    Language English
    Dates of publication 2022-08
    Size p. 418.
    Publishing place Springer International Publishing
    Document type Article ; Online
    Note Review
    ZDB-ID 1358415-7
    ISSN 1420-9071 ; 1420-682X
    ISSN (online) 1420-9071
    ISSN 1420-682X
    DOI 10.1007/s00018-022-04442-8
    Database NAL-Catalogue (AGRICOLA)

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    In stock of ZB MED Bonn / Germany

    Z 4' 47/14: Show issues

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  4. Article ; Online: Reassessment of Prostate Biopsy Specimens for Patients Referred for Robot-assisted Radical Prostatectomy Rarely Influences Surgical Planning.

    Hoekstra, Robert J / Goossens, Ward J H / Beulens, Alexander / van Herk, Hilde / Hoevenaars, Brigiet M / de Baaij, Joost / Somford, Diederik M / Sedelaar, J P Michiel / van Basten, Jean-Paul A / Vrijhof, H J Eric J

    European urology open science

    2021  Volume 28, Page(s) 36–42

    Abstract: Background: The minimum volume standard is 100 robot-assisted radical prostatectomy (RARP) procedures per hospital in the Netherlands, so patients have to be referred to high-volume surgical centers for RARP. During preoperative work-up, prostate ... ...

    Abstract Background: The minimum volume standard is 100 robot-assisted radical prostatectomy (RARP) procedures per hospital in the Netherlands, so patients have to be referred to high-volume surgical centers for RARP. During preoperative work-up, prostate biopsies taken elsewhere are reassessed, with upgrading or downgrading of the initial Gleason grade group a possible consequence.
    Objective: To determine if prostate biopsy reassessment leads to adjustment of the surgical plan regarding a nerve-sparing approach and extended pelvic lymph node dissection (ePLND) during RARP.
    Design setting and participants: For 125 men who were referred to the Prosper prostate center at Canisius Wilhelmina Hospital (CWH) in the Netherlands between 2013 and 2016, results for the initial assessment of prostate biopsy by a local uropathologist were compared to results for biopsy reassessment by dedicated uropathologists at CWH.
    Results and limitations: The pathologists reached agreement in 80% of the cases. In cases for which there was disagreement (
    Conclusions: This study shows that there is large interobserver agreement between uropathologists in the assessment of Gleason grade group in prostate biopsy specimens. Reassessment rarely leads to a change in surgical plan regarding the indication for a nerve-sparing approach and ePLND. Therefore, reassessment of prostate biopsy before radical prostatectomy can be omitted when the initial pathological assessment was performed by a dedicated uropathologist.
    Patient summary: Reassessment of the initial prostate biopsy specimen for patients referred to a specialist center for robot-assisted removal of the prostate rarely influences surgical planning and can be omitted.
    Language English
    Publishing date 2021-04-27
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 3040546-4
    ISSN 2666-1683 ; 2058-4881
    ISSN (online) 2666-1683
    ISSN 2058-4881
    DOI 10.1016/j.euros.2021.04.003
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Preoperative PSMA-PET/CT as a predictor of biochemical persistence and early recurrence following radical prostatectomy with lymph node dissection.

    Baas, D J H / Schilham, M / Hermsen, R / de Baaij, J M S / Vrijhof, H J E J / Hoekstra, R J / Sedelaar, J P M / Küsters-Vandevelde, H V N / Gotthardt, M / Wijers, C H W / van Basten, J P / Somford, D M

    Prostate cancer and prostatic diseases

    2021  Volume 25, Issue 1, Page(s) 65–70

    Abstract: Background: This study aims to evaluate the predictive value of lymph nodes (LN) suspicious for metastases on preoperative prostate-specific membrane antigen (PSMA) PET/CT for biochemical persistence (BCP) and early biochemical recurrence (BCR) ... ...

    Abstract Background: This study aims to evaluate the predictive value of lymph nodes (LN) suspicious for metastases on preoperative prostate-specific membrane antigen (PSMA) PET/CT for biochemical persistence (BCP) and early biochemical recurrence (BCR) following robotic-assisted radical prostatectomy (RARP) with extended pelvic LN dissection (ePLND).
    Methods: We evaluated 213 patients with intermediate and high-risk prostate cancer (PCa) who underwent clinical staging with preoperative
    Results: Forty patients (19%) were PSMA+. The overall incidence of pN1 was 23%. Sensitivity, specificity, PPV and NPV on a per patient level for the detection of pN1 was 29%, 84%, 35%, and 80% respectively. BCP was observed in 26 of 211 patients (12%) and early BCR in 23 of 110 patients (21%). The presence of PSMA+ was a significant predictor for BCP (OR 7.1, 2.9-17.1 95% CI) and BCR (OR 8.1, 2.9-22.6 95% CI).
    Conclusion: Preoperative PSMA-PET/CT may be a valuable tool for patient counseling for RARP and ePLND as it is a significant predictor for the risk of postoperative BCP and early BCR. We conclude that an ePLND should not be avoided in men with intermediate or high-risk PCa and preoperative negative PSMA-PET/CT, as 20% have microscopic LN metastasis.
    MeSH term(s) Gallium Radioisotopes ; Humans ; Lymph Node Excision ; Male ; Positron Emission Tomography Computed Tomography ; Prostate/pathology ; Prostate-Specific Antigen ; Prostatectomy ; Prostatic Neoplasms/diagnostic imaging ; Prostatic Neoplasms/surgery
    Chemical Substances Gallium Radioisotopes ; Prostate-Specific Antigen (EC 3.4.21.77)
    Language English
    Publishing date 2021-09-01
    Publishing country England
    Document type Journal Article
    ZDB-ID 1419277-9
    ISSN 1476-5608 ; 1365-7852
    ISSN (online) 1476-5608
    ISSN 1365-7852
    DOI 10.1038/s41391-021-00452-y
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5277: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  6. Article ; Online: Inulin significantly improves serum magnesium levels in proton pump inhibitor-induced hypomagnesaemia.

    Hess, M W / de Baaij, J H F / Broekman, M / Bisseling, T M / Haarhuis, B / Tan, A / Te Morsche, R / Hoenderop, J G J / Bindels, R J M / Drenth, J P H

    Alimentary pharmacology & therapeutics

    2016  Volume 43, Issue 11, Page(s) 1178–1185

    Abstract: Background: Proton pump inhibitors (PPI) are among the most widely prescribed drugs to treat gastric acid-related disorders. PPI-induced hypomagnesaemia, a defect in intestinal absorption of Mg(2+) , can be a severe side effect of chronic PPI use.: ... ...

    Abstract Background: Proton pump inhibitors (PPI) are among the most widely prescribed drugs to treat gastric acid-related disorders. PPI-induced hypomagnesaemia, a defect in intestinal absorption of Mg(2+) , can be a severe side effect of chronic PPI use.
    Aim: To restore serum Mg(2+) concentrations in PPI-induced hypomagnesaemia patients by dietary supplementation with inulin fibres.
    Methods: Eleven patients with PPI-induced hypomagnesaemia and 10 controls were treated with inulin (20 g/day). Each trial consisted of two cycles of 14-day inulin treatment followed by a washout period of 14 days. Patients continued to use their PPI. Serum Mg(2+) levels served as the primary endpoint.
    Results: Inulin significantly enhanced serum Mg(2+) levels from 0.60 to 0.68 mmol/L in PPI-induced hypomagnesaemia patients, and from 0.84 to 0.93 mmol/L in controls. As a consequence 24 h urinary Mg(2+) excretion was significantly increased in patients with PPI-induced hypomagnesaemia (0.3-2.2 mmol/day). Symptoms related to hypomagnesaemia, including muscle cramps and paraesthesia, were reduced during intervention with inulin.
    Conclusion: Inulin increases serum Mg(2+) concentrations under PPI maintenance in patients with PPI-induced hypomagnesaemia.
    MeSH term(s) Adult ; Aged ; Case-Control Studies ; Female ; Humans ; Intestinal Absorption ; Inulin/administration & dosage ; Magnesium/blood ; Magnesium Deficiency/blood ; Male ; Middle Aged ; Muscle Cramp/drug therapy ; Proton Pump Inhibitors/adverse effects ; Proton Pump Inhibitors/therapeutic use ; Young Adult
    Chemical Substances Proton Pump Inhibitors ; Inulin (9005-80-5) ; Magnesium (I38ZP9992A)
    Language English
    Publishing date 2016-06
    Publishing country England
    Document type Journal Article
    ZDB-ID 639012-2
    ISSN 1365-2036 ; 0269-2813 ; 0953-0673
    ISSN (online) 1365-2036
    ISSN 0269-2813 ; 0953-0673
    DOI 10.1111/apt.13619
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2206: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  7. Book ; Thesis: Fotochemische cycloadditie van O-chinonen en andere 1,2-diketonen aan keteeniminen

    Baaij, Johan

    Photochemical cycloaddition of O-quinones and other 1,2-diketones to ketenimines

    1978  

    Title variant Photochemical cycloaddition of O-quinones and other 1,2-diketones to ketenimines
    Author's details Johan Baaij
    Language English ; Dutch
    Size 83 S, graph. Darst., Tab
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Univ., Diss.--Utrecht, 1978
    Note Engl. Zsfassung . - Auf d. Umschl.: Johan Baaij
    Database Former special subject collection: coastal and deep sea fishing

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  8. Book ; Thesis: Fotochemische cycloadditie van O-chinonen en andere 1,2-diketonen aan keteeniminen

    Baaij, Johan

    Photochemical cycloaddition of O-quinones and other 1,2-diketones to ketenimines

    1978  

    Title variant Photochemical cycloaddition of O-quinones and other 1,2-diketones to ketenimines
    Author's details Johan Baaij
    Language English ; Dutch
    Size 83 S, graph. Darst., Tab
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Univ., Diss.--Utrecht, 1978
    Note Engl. Zsfassung . - Auf d. Umschl.: Johan Baaij
    Database Library catalogue of the German National Library of Science and Technology (TIB), Hannover

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  9. Article: [Report on some qualitative aspects of the shortage of nurses in the Netherlands].

    BAAIJ, J H

    Het Ziekenhuiswezen

    1961  Volume 34, Page(s) 349–360

    MeSH term(s) Breast Feeding ; Humans ; Netherlands ; Nurses ; Nursing/statistics & numerical data
    Language Dutch
    Publishing date 1961-11
    Publishing country Netherlands
    Document type Journal Article
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Book: Sociale geneeskunde

    Baaij, J. H

    1971  

    MeSH term(s) Social Medicine
    Language Dutch
    Size 153 p., illus.
    Edition 4. herziene druk.
    Publisher Wolters-Noordhoff
    Publishing place Groningen
    Document type Book
    ISBN 9789001047498 ; 9001047491
    Database Catalogue of the US National Library of Medicine (NLM)

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