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Book ; Conference proceedings: Tumour site concordance and mechanisms of carcinogenesis

Baan, Robert A.

(IARC scientific publications ; no. 165)

2019

Event/congress	IARC Worskhop on Tumour Site Concordance and Mechanisms of Carcniogenesis (2012, Lyon)
Author's details	edited by Robert A. Baan, Bernard W. Stewart, and Kurt Straif
Series title	IARC scientific publications ; no. 165
Collection
Language	English
Size	xxii, 292 Seiten, Illustrationen, Diagramme
Publisher	International Agency for Research on Cancer
Publishing place	Lyon
Publishing country	France
Document type	Book ; Conference proceedings
Note	This statement was unanimously endorsed by the participants in the Workshop on Tumour Site Concordance and Mechanisms of Carcinogenesis, which was convened by IARC on 16-18 April and 28-30 November 2012 in Lyon
HBZ-ID	HT020113886
ISBN	978-92-832-2217-0 ; 92-832-2217-2
Database	Catalogue ZB MED Medicine, Health

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2019 A 802	available for loan (reading room)	Lesesaal EG

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Article ; Online: The Monographs Programme of the International Agency for Research on Cancer. A brief history of its Preamble.

Baan, Robert A / Straif, Kurt

ALTEX

2021 Volume 39, Issue 3, Page(s) 443–450

Abstract: Since the early 1970s, the Monographs published by the International Agency for Research on Cancer (IARC) apply rigorous procedures for the scientific review and evaluation of carcinogenic hazards. The Preamble to the IARC Monographs describes the ... ...

Abstract	Since the early 1970s, the Monographs published by the International Agency for Research on Cancer (IARC) apply rigorous procedures for the scientific review and evaluation of carcinogenic hazards. The Preamble to the IARC Monographs describes the objective and scope of the Monographs Programme, the scientific principles and procedures used in developing a Monograph, the types of evidence considered, and the scientific criteria that guide the evaluations. This article presents an overview of the historical development of the Preamble from the time it began to take shape in the late 1970s up to and including the most recent update in 2019. Over the years, the IARC Monographs Programme has taken account of scientific and procedural advances in identifying, reviewing, evaluating, and integrating evidence to define causes of human cancer. Since the previous edition of the Preamble in 2006, the new developments include a stronger emphasis on mechanistic evidence based on key characteristics of carcinogens; greater consideration of exposure assessment methods in epidemiological studies; and integration of the streams of evidence on cancer in humans, cancer in experimental animals, and mechanisms in reaching the overall evaluations. Thus, the Preamble now allows an evaluation process in the absence of data from animal studies, and the evidence on key characteristics of cancer may be contributed by new approach methodologies, thus potentially reducing or avoiding the use of experimental animals.
MeSH term(s)	Animals ; Animals, Laboratory ; Carcinogens/toxicity ; Humans ; International Agencies ; Neoplasms/chemically induced ; Publications
Chemical Substances	Carcinogens
Language	English
Publishing date	2021-06-16
Publishing country	Germany
Document type	Journal Article
ZDB-ID	165707-0
ISSN	1868-8551 ; 1018-4562 ; 0946-7785
ISSN (online)	1868-8551
ISSN	1018-4562 ; 0946-7785
DOI	10.14573/altex.2004081
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Article: Letter of concern.

Baan, Robert A

Mutation research

2010 Volume 695, Issue 1-2, Page(s) 1

MeSH term(s)	Comet Assay ; DNA Damage ; Dose-Response Relationship, Radiation ; Female ; Fibroblasts/radiation effects ; Granulosa Cells/radiation effects ; Humans ; Radio Waves/adverse effects
Language	English
Publishing date	2010-01
Publishing country	Netherlands
Document type	Comment ; Letter
ZDB-ID	206607-5
ISSN	1873-135X ; 0027-5107 ; 1383-5718 ; 0165-1110 ; 0165-1161 ; 0165-7992 ; 0921-8777 ; 0165-1218 ; 1383-5726 ; 0167-8817 ; 0921-8734 ; 1383-5742
ISSN (online)	1873-135X
ISSN	0027-5107 ; 1383-5718 ; 0165-1110 ; 0165-1161 ; 0165-7992 ; 0921-8777 ; 0165-1218 ; 1383-5726 ; 0167-8817 ; 0921-8734 ; 1383-5742
DOI	10.1016/j.mrgentox.2009.11.004
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Article: Editorial: controversy related to two published papers.

Baan, Robert A

Mutation research

2009 Volume 673, Issue 1, Page(s) 1

MeSH term(s)	Animals ; Humans ; Periodicals as Topic ; Publications/standards
Language	English
Publishing date	2009-02-19
Publishing country	Netherlands
Document type	Comment ; Editorial
ZDB-ID	206607-5
ISSN	1873-135X ; 0027-5107 ; 1383-5718 ; 0165-1110 ; 0165-1161 ; 0165-7992 ; 0921-8777 ; 0165-1218 ; 1383-5726 ; 0167-8817 ; 0921-8734 ; 1383-5742
ISSN (online)	1873-135X
ISSN	0027-5107 ; 1383-5718 ; 0165-1110 ; 0165-1161 ; 0165-7992 ; 0921-8777 ; 0165-1218 ; 1383-5726 ; 0167-8817 ; 0921-8734 ; 1383-5742
DOI	10.1016/j.mrgentox.2008.11.003
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Article ; Online: Carcinogenic hazards from inhaled carbon black, titanium dioxide, and talc not containing asbestos or asbestiform fibers: recent evaluations by an IARC Monographs Working Group.

Baan, Robert A

Inhalation toxicology

2007 Volume 19 Suppl 1, Page(s) 213–228

Abstract: In February 2006, an IARC Monographs Working Group reevaluated the carcinogenic hazards to humans of carbon black, titanium dioxide, and talc, which belong to the group of poorly soluble, low-toxicity particles. The review of the relevant literature and ... ...

Abstract	In February 2006, an IARC Monographs Working Group reevaluated the carcinogenic hazards to humans of carbon black, titanium dioxide, and talc, which belong to the group of poorly soluble, low-toxicity particles. The review of the relevant literature and the evaluations by the Working Group will be published in Volume 93 of the IARC Monographs series. This article summarizes the Working Group's conclusions. Epidemiological studies among workers in carbon black production and in the rubber industry provided inadequate evidence of carcinogenicity. The overall data from cancer studies in rodents exposed to carbon black provided sufficient evidence of carcinogenicity. The Working Group evaluated carbon black as possibly carcinogenic to humans, Group 2B. Reviewing the epidemiological studies in the titanium dioxide production industry, the Working Group concluded that there is inadequate evidence of carcinogenicity. Overall, the results from rodent cancer studies with titanium dioxide were considered to provide sufficient evidence. Titanium dioxide was evaluated as possibly carcinogenic to humans, Group 2B. Epidemiological studies on talc miners and millers provided inadequate evidence of carcinogenicity of inhaled talc not containing asbestos or asbestiform fibers. The evidence from rodent cancer studies was considered limited. The Working Group evaluated inhaled talc not containing asbestos or asbestiform fibers as not classifiable as to its carcinogenicity to humans, Group 3. The Working Group noted that prolonged exposure to inhaled particles at sufficiently high concentrations in experimental animals may lead to impairment of normal clearance mechanisms in the alveolar region of the lung, resulting in a continued buildup of particles that eventually leads to excessive lung burdens accompanied by chronic alveolar inflammation. The inflammatory response may give rise to increased generation of reactive oxygen species, cell injury, cell proliferation, fibrosis, induction of mutations, and, ultimately, cancer. Since many of these steps also occur in workers in dusty jobs, such as coal miners, data on cancer in animals obtained under conditions of impaired lung clearance were considered relevant to humans. In addition, impaired lung clearance in rodents exposed to ultrafine particles occurs at much lower mass concentrations than with fine particles, which adds to the human relevance.
MeSH term(s)	Animals ; Asbestos/administration & dosage ; Asbestos/toxicity ; Carcinogens, Environmental/administration & dosage ; Carcinogens, Environmental/toxicity ; Hazardous Substances/administration & dosage ; Hazardous Substances/toxicity ; Humans ; Inhalation Exposure/adverse effects ; Lung Neoplasms/chemically induced ; Lung Neoplasms/epidemiology ; Lung Neoplasms/etiology ; Societies, Scientific ; Soot/administration & dosage ; Soot/toxicity ; Talc/administration & dosage ; Talc/toxicity ; Titanium/administration & dosage ; Titanium/toxicity ; World Health Organization
Chemical Substances	Carcinogens, Environmental ; Hazardous Substances ; Soot ; Asbestos (1332-21-4) ; Talc (14807-96-6) ; titanium dioxide (15FIX9V2JP) ; Titanium (D1JT611TNE)
Language	English
Publishing date	2007-08-29
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S. ; Review
ZDB-ID	1038809-6
ISSN	1091-7691 ; 0895-8378
ISSN (online)	1091-7691
ISSN	0895-8378
DOI	10.1080/08958370701497903
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Article ; Online: Overview of biological mechanisms of human carcinogens.

Birkett, Nicholas / Al-Zoughool, Mustafa / Bird, Michael / Baan, Robert A / Zielinski, Jan / Krewski, Daniel

Journal of toxicology and environmental health. Part B, Critical reviews

2019 Volume 22, Issue 7-8, Page(s) 288–359

Abstract: This review summarizes the carcinogenic mechanisms for 109 Group 1 human carcinogens identified as causes of human cancer through Volume 106 of the IARC Monographs. The International Agency for Research on Cancer (IARC) evaluates human, experimental and ... ...

Abstract	This review summarizes the carcinogenic mechanisms for 109 Group 1 human carcinogens identified as causes of human cancer through Volume 106 of the IARC Monographs. The International Agency for Research on Cancer (IARC) evaluates human, experimental and mechanistic evidence on agents suspected of inducing cancer in humans, using a well-established weight of evidence approach. The monographs provide detailed mechanistic information about all carcinogens. Carcinogens with closely similar mechanisms of action (e.g. agents emitting alpha particles) were combined into groups for the review. A narrative synopsis of the mechanistic profiles for the 86 carcinogens or carcinogen groups is presented, based primarily on information in the IARC monographs, supplemented with a non-systematic review. Most carcinogens included a genotoxic mechanism.
MeSH term(s)	Animals ; Carcinogenesis/chemically induced ; Carcinogens/toxicity ; Humans ; Mutagens/toxicity ; Neoplasms/chemically induced ; Neoplasms/pathology
Chemical Substances	Carcinogens ; Mutagens
Language	English
Publishing date	2019-10-20
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	1415246-0
ISSN	1521-6950 ; 1093-7404
ISSN (online)	1521-6950
ISSN	1093-7404
DOI	10.1080/10937404.2019.1643539
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Article ; Online: Development of a database on key characteristics of human carcinogens.

Al-Zoughool, Mustafa / Bird, Michael / Rice, Jerry / Baan, Robert A / Billard, Mélissa / Birkett, Nicholas / Krewski, Daniel / Zielinski, Jan M

Journal of toxicology and environmental health. Part B, Critical reviews

2019 Volume 22, Issue 7-8, Page(s) 264–287

Abstract: A database on mechanistic characteristics of human carcinogenic agents was developed by collecting mechanistic information on agents identified as human carcinogens (Group 1) by the International Agency for Research on Cancer (IARC) in ... ...

Abstract	A database on mechanistic characteristics of human carcinogenic agents was developed by collecting mechanistic information on agents identified as human carcinogens (Group 1) by the International Agency for Research on Cancer (IARC) in the
MeSH term(s)	Animals ; Carcinogenesis/chemically induced ; Carcinogenicity Tests ; Carcinogens/toxicity ; Databases, Factual ; Humans ; Neoplasms/chemically induced
Chemical Substances	Carcinogens
Language	English
Publishing date	2019-08-04
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	1415246-0
ISSN	1521-6950 ; 1093-7404
ISSN (online)	1521-6950
ISSN	1093-7404
DOI	10.1080/10937404.2019.1642593
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Article ; Online: Development of a database on tumors and tumor sites in humans and in experimental animals for 'Group 1 agents identified through volume 109 of the

Grosse, Yann / Lajoie, Pascale / Billard, Mélissa / Krewski, Daniel / Rice, Jerry / Baan, Robert A / Cogliano, Vincent / Bird, Michael / Zielinski, Jan M

Journal of toxicology and environmental health. Part B, Critical reviews

2019 Volume 22, Issue 7-8, Page(s) 237–243

Abstract: Volume 100 in the series ... ...

Abstract	Volume 100 in the series of
MeSH term(s)	Animals ; Animals, Laboratory ; Carcinogens/toxicity ; Databases, Factual ; Humans ; Neoplasms/chemically induced ; Neoplasms/pathology
Chemical Substances	Carcinogens
Language	English
Publishing date	2019-10-15
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	1415246-0
ISSN	1521-6950 ; 1093-7404
ISSN (online)	1521-6950
ISSN	1093-7404
DOI	10.1080/10937404.2019.1642601
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Article ; Online: Development of an Evidence-Based Risk Assessment Framework.

ALTEX

2022 Volume 39, Issue 4, Page(s) 667–693

Abstract: Assessment of potential human health risks associated with environmental and other agents requires careful evaluation of all available and relevant evidence for the agent of interest, including both data-rich and data-poor agents. With the advent of ... ...

Abstract	Assessment of potential human health risks associated with environmental and other agents requires careful evaluation of all available and relevant evidence for the agent of interest, including both data-rich and data-poor agents. With the advent of new approach methodologies in toxicological risk assessment, guidance on integrating evidence from mul-tiple evidence streams is needed to ensure that all available data is given due consideration in both qualitative and quantitative risk assessment. The present report summarizes the discussions among academic, government, and private sector participants from North America and Europe in an international workshop convened to explore the development of an evidence-based risk assessment framework, taking into account all available evidence in an appropriate manner in order to arrive at the best possible characterization of potential human health risks and associated uncertainty. Although consensus among workshop participants was not a specific goal, there was general agreement on the key consider-ations involved in evidence-based risk assessment incorporating 21st century science into human health risk assessment. These considerations have been embodied into an overarching prototype framework for evidence integration that will be explored in more depth in a follow-up meeting.
MeSH term(s)	Humans ; Risk Assessment ; Europe
Language	English
Publishing date	2022-09-01
Publishing country	Germany
Document type	Journal Article
ZDB-ID	165707-0
ISSN	1868-8551 ; 1018-4562 ; 0946-7785
ISSN (online)	1868-8551
ISSN	1018-4562 ; 0946-7785
DOI	10.14573/altex.2004041
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Article: Man-made mineral (vitreous) fibres: evaluations of cancer hazards by the IARC Monographs Programme.

Baan, Robert A / Grosse, Yann

Mutation research

2004 Volume 553, Issue 1-2, Page(s) 43–58

Abstract: Man-made vitreous (glass-like) fibres are non-crystalline, fibrous inorganic substances (silicates) made primarily from rock, slag, glass or other processed minerals. These materials, also called man-made mineral fibres, include glass fibres (used in ... ...

Abstract	Man-made vitreous (glass-like) fibres are non-crystalline, fibrous inorganic substances (silicates) made primarily from rock, slag, glass or other processed minerals. These materials, also called man-made mineral fibres, include glass fibres (used in glass wool and continuous glass filament), rock or stone wool, slag wool and refractory ceramic fibres. They are widely used for thermal and acoustical insulation and to a lesser extent for other purposes. These products are potentially hazardous to human health because they release airborne respirable fibres during their production, use and removal. Man-made mineral fibres and man-made vitreous fibres have been the subject of reviews by IARC Monographs Working Groups in 1987 and 2001, respectively, which resulted in evaluations of the carcinogenic hazard to humans from exposure to these materials. These reviews and evaluations have been published as Volumes 43 and 81 of the IARC Monographs series [IARC Monographs on the Evaluation of Carcinogenic Risks to Humans, vol. 43, Man-made Mineral Fibres and Radon (1988); IARC Monographs on the Evaluation of Carcinogenic Risks to Humans, vol. 81, Man-made Vitreous Fibres (2002)]. The re-evaluation in 2001 was undertaken because there have been substantial improvements in the quality of the epidemiological information available on the carcinogenicity to humans of glass fibres, continuous glass filament and rock/slag wool. The new evaluations have addressed the limitations of earlier cohort studies, particularly concerning the lack of adjustment with respect to concomitant risk factors such as smoking and other sources of occupational exposure. In addition, the evaluation of the evidence for carcinogenicity of glass fibres to experimental animals has been refined, by making a distinction between insulation glass wool and special-purpose glass fibres. The results of the evaluations in 1987 and 2001 are thus different in several aspects. In this paper, the reviews and evaluations of the carcinogenic hazards of exposure to man-made mineral fibres (MMMF, Monograph volume 43, [1]) and man-made vitreous fibres (MMVF, Monograph volume 81, [2]) are summarised, and the differences explained. In particular, the considerations of the respective IARC Monographs Working Groups (1987, 2001) in reaching their conclusions are discussed in some detail.
MeSH term(s)	Animals ; Carcinogens/toxicity ; Humans ; Lung Neoplasms/epidemiology ; Lung Neoplasms/etiology ; Mineral Fibers/toxicity ; Neoplasms/epidemiology ; Neoplasms/etiology ; Occupational Exposure ; Reproducibility of Results ; Silicon Dioxide/toxicity
Chemical Substances	Carcinogens ; Mineral Fibers ; Silicon Dioxide (7631-86-9)
Language	English
Publishing date	2004-09-03
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S. ; Research Support, U.S. Gov't, P.H.S. ; Review
ZDB-ID	206607-5
ISSN	1873-135X ; 0027-5107 ; 1383-5718 ; 0165-1110 ; 0165-1161 ; 0165-7992 ; 0921-8777 ; 0165-1218 ; 1383-5726 ; 0167-8817 ; 0921-8734 ; 1383-5742
ISSN (online)	1873-135X
ISSN	0027-5107 ; 1383-5718 ; 0165-1110 ; 0165-1161 ; 0165-7992 ; 0921-8777 ; 0165-1218 ; 1383-5726 ; 0167-8817 ; 0921-8734 ; 1383-5742
DOI	10.1016/j.mrfmmm.2004.06.019
Database	MEDical Literature Analysis and Retrieval System OnLINE

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