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Article ; Online: Inconsistency between supplement and article?

Babaoglu, Hakan

2018 Volume 78, Issue 8, Page(s) e84

MeSH term(s)	Disease Progression ; Humans ; Inflammation ; Magnetic Resonance Imaging ; Spondylarthritis
Language	English
Publishing date	2018-06-19
Publishing country	England
Document type	Letter ; Comment
ZDB-ID	7090-7
ISSN	1468-2060 ; 0003-4967
ISSN (online)	1468-2060
ISSN	0003-4967
DOI	10.1136/annrheumdis-2018-213844
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Article ; Online: Effects of intrauterine device use on attack frequency and severity ın woman of reproductive age with familial Mediterranean fever.

Özdemir Ulusoy, Bahar / Güven, Serdar Can / Babaoğlu, Hakan / Ulusoy, Can Ozan / Armağan, Berkan / Kayacan Erdoğan, Esra / Maraş, Yüksel / Doğan, İsmail / Orhan, Kevser / Koçak Ulucaköy, Rezan / Atalar, Ebru / Omma, Ahmet / Küçükşahin, Orhan / Erten, Şükran

Archives of gynecology and obstetrics

2024 Volume 309, Issue 5, Page(s) 2041–2046

Abstract: Aim: Familial Mediterranean fever (FMF) is the most common inherited autoinflammatory disease in the world. There are known triggers to initiate an FMF attack, yet potential effects of intrauterine devices (IUD) in women of reproductive age have not ... ...

Abstract	Aim: Familial Mediterranean fever (FMF) is the most common inherited autoinflammatory disease in the world. There are known triggers to initiate an FMF attack, yet potential effects of intrauterine devices (IUD) in women of reproductive age have not been evaluated before. Method: Consecutive female patients with FMF who ever used IUD over the age of 18 were enrolled. Female patients with FMF were sub grouped according to the type of IUD they use. FMF attack frequency, severity, duration, presence of dysmenorrhea, severity of dysmenorrhea, having attacks during menstruation before and after IUD use were questioned. Demographic and clinical data were collected from hospital database. Results: When all patients with IUD use were evaluated, it was found that the frequency of attacks increased after IUD insertion at 3rd and 12th months (median [min-max] attack frequency at 3rd month, 1 (0-3) vs 1 (0-6), p = 0.002, median [min-max] attack frequency at 12th month, 2 (0-12) vs 3.5 (0-18), p = 0.028). Attack severity measured by VAS pain was also significantly increased. Attack duration and menstrual pain was similar before and after IUD use. Attack frequency at 3rd and 12th months, attack severity and menstrual pain was all increased significantly in Cu-IUD users, whereas none of these parameters deteriorated in LNG-IUD group. Conclusion: IUD use, especially Cu-IUD, may increase the frequency and severity of attacks in female patients with FMF. Clinicians may benefit from considering LGN-IUD if IUDs are preferred as contraception in women of childbearing age with FMF.
MeSH term(s)	Female ; Humans ; Adult ; Middle Aged ; Dysmenorrhea/etiology ; Familial Mediterranean Fever/complications ; Intrauterine Devices/adverse effects ; Contraceptive Agents, Female ; Contraception ; Intrauterine Devices, Copper/adverse effects
Chemical Substances	Contraceptive Agents, Female
Language	English
Publishing date	2024-03-13
Publishing country	Germany
Document type	Journal Article
ZDB-ID	896455-5
ISSN	1432-0711 ; 0932-0067
ISSN (online)	1432-0711
ISSN	0932-0067
DOI	10.1007/s00404-024-07413-5
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Article ; Online: Comment on: Inpatient epidemiology and economic burden of granulomatosis with polyangiitis: a 10-year study of the national inpatient sample.

Satış, Hasan / Kayahan, Neslihan / Babaoğlu, Hakan / Akdoğan, Orhun / Yapar, Dilek

Rheumatology (Oxford, England)

2020 Volume 59, Issue 12, Page(s) e158

MeSH term(s)	Cost of Illness ; Granulomatosis with Polyangiitis/epidemiology ; Humans ; Inpatients
Language	English
Publishing date	2020-12-17
Publishing country	England
Document type	Journal Article ; Comment
ZDB-ID	1464822-2
ISSN	1462-0332 ; 1462-0324
ISSN (online)	1462-0332
ISSN	1462-0324
DOI	10.1093/rheumatology/keaa490
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Article: Duration of anti-TNF treatment in vascular Behçet's disease: better to prolong treatment?

Atas, Nuh / Babaoglu, Hakan / Varan, Ozkan / Tufan, Abdurrahman

Clinical and experimental rheumatology

2018 Volume 36, Issue 6 Suppl 115, Page(s) 147

MeSH term(s)	Adult ; Anti-Inflammatory Agents/administration & dosage ; Behcet Syndrome/diagnosis ; Behcet Syndrome/drug therapy ; Behcet Syndrome/immunology ; Drug Administration Schedule ; Echocardiography, Transesophageal ; Heart Diseases/diagnostic imaging ; Heart Diseases/drug therapy ; Heart Diseases/immunology ; Humans ; Infliximab/administration & dosage ; Male ; Recurrence ; Thrombosis/diagnostic imaging ; Thrombosis/drug therapy ; Thrombosis/immunology ; Time Factors ; Treatment Outcome ; Tumor Necrosis Factor-alpha/antagonists & inhibitors ; Tumor Necrosis Factor-alpha/immunology
Chemical Substances	Anti-Inflammatory Agents ; Tumor Necrosis Factor-alpha ; Infliximab (B72HH48FLU)
Language	English
Publishing date	2018-05-31
Publishing country	Italy
Document type	Case Reports ; Letter
ZDB-ID	605886-3
ISSN	1593-098X ; 0392-856X
ISSN (online)	1593-098X
ISSN	0392-856X
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Article ; Online: Associations between Depressive Disorders and Inflammatory Rheumatic Diseases.

Varan, Özkan / Babaoğlu, Hakan / Göker, Berna

Current topics in medicinal chemistry

2018 Volume 18, Issue 16, Page(s) 1395–1401

Abstract: Depressive disorders, are not only common but also among the leading causes of disability worldwide. They are associated with increased incidences of various other diseases. It has been shown that in patients with autoimmune diseases, when depression ... ...

Abstract	Depressive disorders, are not only common but also among the leading causes of disability worldwide. They are associated with increased incidences of various other diseases. It has been shown that in patients with autoimmune diseases, when depression coexists, the quality of life is worse and medical treatment and management is compromised. Depression-like symptoms, such as fatigue and disinterest are also common in inflammatory rheumatic diseases and often associated with poor quality of life. Medical therapy targeting inflammation results in alleviation of these symptoms in many patients. Interestingly, there is cumulating evidence suggesting potential roles of inflammatory cytokines in the pathogenesis of major depression. Effects of some of the biological agents used in rheumatic diseases have been studied on depressive disorders. Results have been controversial and further studies are needed in this area. These findings suggest associations between depression and inflammatory rheumatic diseases and raise the possibility that treatment of one of them might influence the outcome of the other. We have reviewed the current literature on associations between depression and inflammatory rheumatologic diseases, such as rheumatoid arthritis, systemic lupus erythematosus, Sjögren's syndrome and ankylosing spondylitis.
MeSH term(s)	Cytokines/metabolism ; Depressive Disorder/genetics ; Depressive Disorder/metabolism ; Depressive Disorder/pathology ; Humans ; Inflammation/genetics ; Inflammation/metabolism ; Inflammation/pathology ; Rheumatic Diseases/genetics ; Rheumatic Diseases/metabolism ; Rheumatic Diseases/pathology
Chemical Substances	Cytokines
Language	English
Publishing date	2018-08-01
Publishing country	United Arab Emirates
Document type	Journal Article ; Review
ZDB-ID	2064823-6
ISSN	1873-4294 ; 1568-0266
ISSN (online)	1873-4294
ISSN	1568-0266
DOI	10.2174/1568026618666180516100805
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Article ; Online: Relationship between serum adenosine deaminase levels and liver histology in autoimmune hepatitis.

Torgutalp, Murat / Efe, Cumali / Babaoglu, Hakan / Kav, Taylan

World journal of gastroenterology

2017 Volume 23, Issue 21, Page(s) 3876–3882

Abstract: Aim: To evaluate the relationship between serum adenosine deaminase (ADA) levels and histological features in patients with autoimmune hepatitis (AIH).: Methods: A total of 80 subjects (52 AIH cases and 28 healthy controls) were included in the study. ...

Abstract	Aim: To evaluate the relationship between serum adenosine deaminase (ADA) levels and histological features in patients with autoimmune hepatitis (AIH). Methods: A total of 80 subjects (52 AIH cases and 28 healthy controls) were included in the study. Patients were diagnosed according to the simplified criteria suggested by the International Autoimmune Hepatitis Group. All of the cases had been diagnosed with AIH between 2010-2015 at Hacettepe University, Department of Gastroenterology. Serum blood samples were collected and stored at -80 °C until the biochemical estimation of ADA activity. The diagnosis of patients was confirmed by liver biopsy. Serum ADA > 20 U/L was considered to be high level. Results: Mean serum ADA levels were significantly higher in AIH patients than those in healthy controls (25.4 ± 9.6 U/L Conclusion: Because of the positive correlation with inflammatory activity, serum ADA level may be a potential biomarker for predicting or monitoring histological activity in patients with AIH.
Language	English
Publishing date	2017-06-07
Publishing country	United States
Document type	Journal Article
ZDB-ID	2185929-2
ISSN	2219-2840 ; 1007-9327
ISSN (online)	2219-2840
ISSN	1007-9327
DOI	10.3748/wjg.v23.i21.3876
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Article ; Online: A single-center rheumatology experience of sarcoidosis: observations from 70 patients.

Konak, Hatice Ecem / Güven, Serdar Can / Atalar, Ebru / Akyüz Dağlı, Pınar / Koçak Ulucaköy, Rezan / Kayacn Erdoğan, Esra / Babaoğlu, Hakan / Orhan, Kevser / Doğan, İsmail / Maraş, Yüksel / Omma, Ahmet / Küçükşahin, Orhan / Erten, Şükran

Sarcoidosis, vasculitis, and diffuse lung diseases : official journal of WASOG

2023 Volume 40, Issue 3, Page(s) e2023033

Abstract: Background: The aim of this study is to determine the demographic, clinical and laboratory characteristics of the patients who followed up with the diagnosis of sarcoidosis, to investigate the distribution frequency of rheumatological findings and to ... ...

Abstract	Background: The aim of this study is to determine the demographic, clinical and laboratory characteristics of the patients who followed up with the diagnosis of sarcoidosis, to investigate the distribution frequency of rheumatological findings and to examine the disease management from the perspective of rheumatology. Methods: Patients who were followed up with the diagnosis of sarcoidosis in the rheumatology clinic of Ankara City Hospital between November 2019 and November 2022 were evaluated. Demographic, clinical, radiological, serological, laboratory, and histopathological findings, and rheumatological, systemic, and locomotor system examination findings of the patients were obtained from the medical data registered in the hospital. Results: A total of seventy sarcoidosis patients (48.98 ± 11.78 years, %75 female) were included in the study. Joint involvement was observed in 64.3% of cases, skin involvement in 48.6% of cases, and ocular involvement in 25.7% of cases. The ankle was the most frequently involved joint, followed by the knee and small joints in the foot. Corticosteroids were the most used therapeutic agent, and pulmonary and joint findings were the most common reasons for starting treatment. Conclusions: Sarcoidosis is a disease that mimics many diseases, misdiagnosis and treatment should be avoided with a good and fast differential diagnosis. Clinicians, especially rheumatologists, should remember sarcoidosis more frequently and keep it in mind in the differential diagnosis.
Language	English
Publishing date	2023-09-13
Publishing country	Italy
Document type	Journal Article
ZDB-ID	1339192-6
ISSN	2532-179X ; 1124-0490
ISSN (online)	2532-179X
ISSN	1124-0490
DOI	10.36141/svdld.v40i3.14063
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Article ; Online: Non-criteria autoantibodies in antiphospholipid syndrome may be associated with underlying disease activity.

Akyüz Dağlı, Pınar / Erden, Abdulsamet / Babaoğlu, Hakan / Karakaş, Özlem / Özdemir Ulusoy, Bahar / Konak, Hatice Ecem / Armağan, Berkan / Erten, Şükran / Omma, Ahmet

Irish journal of medical science

2023 Volume 193, Issue 2, Page(s) 1099–1107

Abstract: Background: Antiphospholipid syndrome (APS) is a systemic autoimmune disorder characterized by persistent antiphospholipid antibodies (aPLs) with arterial and venous thrombosis and/or pregnancy morbidity. In recent years, several studies have ... ...

Abstract	Background: Antiphospholipid syndrome (APS) is a systemic autoimmune disorder characterized by persistent antiphospholipid antibodies (aPLs) with arterial and venous thrombosis and/or pregnancy morbidity. In recent years, several studies have highlighted the potential role of non-criteria aPL in diagnosing APS patients. Aim: This study aimed to determine the association of the presence of non-criteria aPL antibodies to the clinical and laboratory features of patients with a diagnosis of APS. Methods: Eighty patients diagnosed with APS and under observation in the rheumatology clinic of Ankara City Hospital were assessed. Patient demographic and clinical features were meticulously recorded. Non-criteria antibodies tested in our center included antiphosphatidylserine IgA, antiphosphatidylserine IgM, beta 2 glycoprotein IgA, anti-cardiolipin IgA, antiphospholipid antibody IgG, and antiphospholipid antibody IgM. Antibodies from patients who were tested for at least one non-criteria antibody were documented. Results: Out of 80 patients, 55 (68.8%) were tested for at least one non-criteria antibody, and 29 of those patients (52.7%) tested positive for at least one non-criteria antibody. The antiphospholipid antibody IgM and the beta 2 glycoprotein IgA were the most commonly tested non-criteria antibodies. Patients with non-criteria antibody positivity had a higher frequency of Ds DNA positivity and low complement (62.0% vs. 35.0%, p = 0.042; 69.0% vs. 38.0%, p = 0.023), respectively. In addition, positivity for anti-cardiolipin IgG and b2 glycoprotein IgG was significantly higher in the group positive for non-criteria antibodies (79% vs. 31%, p ≤ 0.001; 72.0% vs. 19%, p ≤ 0.001). There was no significant difference between the clinical features of patients with at least one positivity for non-criteria antibodies and those without. Conclusion: Systemic lupus erythematosus (SLE) is the most commonly associated disease with APS, being present in approximately 35% of cases [1]. Since the majority of the patient group in our study had APS that was secondary to SLE, non-criteria antibody positivity may be linked to the immunological activity of SLE. Large multicenter studies are necessary to investigate the clinical significance of isolated/combined positivity for criterion/non-criteria aPLs.
MeSH term(s)	Female ; Pregnancy ; Humans ; Antiphospholipid Syndrome/complications ; Antiphospholipid Syndrome/diagnosis ; Autoantibodies ; Antibodies, Antiphospholipid ; Lupus Erythematosus, Systemic/complications ; Antibodies, Anticardiolipin ; beta 2-Glycoprotein I ; Immunoglobulin M ; Immunoglobulin G ; Immunoglobulin A
Chemical Substances	Autoantibodies ; Antibodies, Antiphospholipid ; Antibodies, Anticardiolipin ; beta 2-Glycoprotein I ; Immunoglobulin M ; Immunoglobulin G ; Immunoglobulin A
Language	English
Publishing date	2023-09-22
Publishing country	Ireland
Document type	Journal Article
ZDB-ID	390895-1
ISSN	1863-4362 ; 0021-1265
ISSN (online)	1863-4362
ISSN	0021-1265
DOI	10.1007/s11845-023-03519-y
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Article ; Online: Time to Lupus Low Disease Activity State in the Hopkins Lupus Cohort: Role of African American Ethnicity.

Babaoğlu, Hakan / Li, Jessica / Goldman, Daniel / Magder, Laurence S / Petri, Michelle

Arthritis care & research

2020 Volume 72, Issue 2, Page(s) 225–232

Abstract: Objective: Lupus low disease activity state (LLDAS) is a potential treat-to-target goal in systemic lupus erythematosus (SLE). This study determined predictors of time to reach LLDAS in a longitudinal cohort.: Methods: Patients were grouped according ...

Abstract	Objective: Lupus low disease activity state (LLDAS) is a potential treat-to-target goal in systemic lupus erythematosus (SLE). This study determined predictors of time to reach LLDAS in a longitudinal cohort. Methods: Patients were grouped according to LLDAS status at cohort entry. Those who did not satisfy LLDAS at cohort entry were analyzed prospectively. The Kaplan-Meier approach was used to estimate the time to LLDAS. Cox regression was used to identify patient characteristics that were associated with time to LLDAS. Results: The probability of LLDAS attainment within 1 year was 52% for Caucasians, 36% for African Americans, and 33% for SLE patients with renal involvement. The median time to LLDAS was 1.1 years. In multivariable models, African American ethnicity, baseline prednisone >10 mg daily, hypocomplementemia, baseline damage, and baseline renal activity remained significant predictors of longer time to attain LLDAS, while disease duration <1 year and cutaneous activity were associated with earlier attainment. Conclusion: LLDAS is potentially attainable in the majority of SLE patients. The time to LLDAS was found to be longer in African American patients with SLE. Characteristics of African American patients with SLE, such as renal activity and hypocomplementemia, were also independent predictors of slower attainment of LLDAS. These findings point to the need to include African American patients with SLE in both clinical and pharmaceutical research.
MeSH term(s)	Adult ; African Americans/ethnology ; Cohort Studies ; Disease Progression ; European Continental Ancestry Group/ethnology ; Female ; Follow-Up Studies ; Humans ; Longitudinal Studies ; Lupus Erythematosus, Systemic/diagnosis ; Lupus Erythematosus, Systemic/ethnology ; Male ; Middle Aged ; Prospective Studies ; Severity of Illness Index ; Time Factors
Language	English
Publishing date	2020-01-09
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	645059-3
ISSN	2151-4658 ; 0893-7524 ; 2151-464X
ISSN (online)	2151-4658
ISSN	0893-7524 ; 2151-464X
DOI	10.1002/acr.24063
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Article ; Online: Should our approach to diuretic using in patients with gout change?

Tecer, Duygu / Yardımcı, Gozde Kubra / Sari, Alper / Babaoglu, Hakan

Arthritis research & therapy

2018 Volume 20, Issue 1, Page(s) 241

MeSH term(s)	Diuretics ; Gout ; Humans ; Hypertension ; Uric Acid
Chemical Substances	Diuretics ; Uric Acid (268B43MJ25)
Language	English
Publishing date	2018-10-26
Publishing country	England
Document type	Letter ; Comment
ZDB-ID	2107602-9
ISSN	1478-6362 ; 1478-6354
ISSN (online)	1478-6362
ISSN	1478-6354
DOI	10.1186/s13075-018-1716-7
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