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  1. Article ; Online: Repetitive Head Trauma Induces Chronic Traumatic Encephalopathy by Multiple Mechanisms.

    Cherry, Jonathan D / Babcock, Katharine J / Goldstein, Lee E

    Seminars in neurology

    2020  Volume 40, Issue 4, Page(s) 430–438

    Abstract: Exposure to repetitive neurotrauma increases lifetime risk for developing progressive cognitive deficits, neurobehavioral abnormalities, and chronic traumatic encephalopathy (CTE). CTE is a tau protein neurodegenerative disease first identified in boxers ...

    Abstract Exposure to repetitive neurotrauma increases lifetime risk for developing progressive cognitive deficits, neurobehavioral abnormalities, and chronic traumatic encephalopathy (CTE). CTE is a tau protein neurodegenerative disease first identified in boxers and recently described in athletes participating in other contact sports (notably American football, ice hockey, rugby, and wrestling) and in military veterans with blast exposure. Currently, CTE can only be diagnosed by neuropathological examination of the brain after death. The defining diagnostic lesion of CTE consists of patchy perivascular accumulations of hyperphosphorylated tau protein that localize in the sulcal depths of the cerebral cortex. Neuronal abnormalities, axonopathy, neurovascular dysfunction, and neuroinflammation are triggered by repetitive head impacts (RHIs) and likely act as catalysts for CTE pathogenesis and progression. However, the specific mechanisms that link RHI to CTE are unknown. This review will explore two important areas of CTE pathobiology. First, we will review what is known about the biomechanical properties of RHI that initiate CTE-related pathologies. Second, we will provide an overview of key features of CTE neuropathology and how these contribute to abnormal tau hyperphosphorylation, accumulation, and spread.
    MeSH term(s) Chronic Traumatic Encephalopathy/etiology ; Chronic Traumatic Encephalopathy/metabolism ; Chronic Traumatic Encephalopathy/pathology ; Humans ; Tauopathies/etiology ; Tauopathies/metabolism ; Tauopathies/pathology ; tau Proteins/metabolism
    Chemical Substances MAPT protein, human ; tau Proteins
    Language English
    Publishing date 2020-07-16
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 603165-1
    ISSN 1098-9021 ; 0271-8235
    ISSN (online) 1098-9021
    ISSN 0271-8235
    DOI 10.1055/s-0040-1713620
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1737: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  2. Article: Repetitive Head Trauma Induces Chronic Traumatic Encephalopathy by Multiple Mechanisms

    Cherry, Jonathan D. / Babcock, Katharine J. / Goldstein, Lee E.

    Seminars in Neurology

    (Chronic Traumatic Encephalopathy)

    2020  Volume 40, Issue 04, Page(s) 430–438

    Abstract: Exposure to repetitive neurotrauma increases lifetime risk for developing progressive cognitive deficits, neurobehavioral abnormalities, and chronic traumatic encephalopathy (CTE). CTE is a tau protein neurodegenerative disease first identified in boxers ...

    Series title Chronic Traumatic Encephalopathy
    Abstract Exposure to repetitive neurotrauma increases lifetime risk for developing progressive cognitive deficits, neurobehavioral abnormalities, and chronic traumatic encephalopathy (CTE). CTE is a tau protein neurodegenerative disease first identified in boxers and recently described in athletes participating in other contact sports (notably American football, ice hockey, rugby, and wrestling) and in military veterans with blast exposure. Currently, CTE can only be diagnosed by neuropathological examination of the brain after death. The defining diagnostic lesion of CTE consists of patchy perivascular accumulations of hyperphosphorylated tau protein that localize in the sulcal depths of the cerebral cortex. Neuronal abnormalities, axonopathy, neurovascular dysfunction, and neuroinflammation are triggered by repetitive head impacts (RHIs) and likely act as catalysts for CTE pathogenesis and progression. However, the specific mechanisms that link RHI to CTE are unknown. This review will explore two important areas of CTE pathobiology. First, we will review what is known about the biomechanical properties of RHI that initiate CTE-related pathologies. Second, we will provide an overview of key features of CTE neuropathology and how these contribute to abnormal tau hyperphosphorylation, accumulation, and spread.
    Keywords chronic traumatic encephalopathy (CTE) ; concussion ; neurodegeneration ; tau protein traumatic brain injury (TBI)
    Language English
    Publishing date 2020-07-16
    Publisher Thieme Medical Publishers
    Publishing place Stuttgart ; New York
    Document type Article
    ZDB-ID 603165-1
    ISSN 1098-9021 ; 0271-8235
    ISSN (online) 1098-9021
    ISSN 0271-8235
    DOI 10.1055/s-0040-1713620
    Database Thieme publisher's database

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1737: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  3. Article ; Online: Interface astrogliosis in contact sport head impacts and military blast exposure.

    Babcock, Katharine J / Abdolmohammadi, Bobak / Kiernan, Patrick T / Mahar, Ian / Cherry, Jonathan D / Alvarez, Victor E / Goldstein, Lee E / Stein, Thor D / McKee, Ann C / Huber, Bertrand R

    Acta neuropathologica communications

    2022  Volume 10, Issue 1, Page(s) 52

    Abstract: Exposure to military blast and repetitive head impacts (RHI) in contact sports is associated with increased risk of long-term neurobehavioral sequelae and cognitive deficits, and the neurodegenerative disease chronic traumatic encephalopathy (CTE). At ... ...

    Abstract Exposure to military blast and repetitive head impacts (RHI) in contact sports is associated with increased risk of long-term neurobehavioral sequelae and cognitive deficits, and the neurodegenerative disease chronic traumatic encephalopathy (CTE). At present, the exact pathogenic mechanisms of RHI and CTE are unknown, and no targeted therapies are available. Astrocytes have recently emerged as key mediators of the multicellular response to head trauma. Here, we investigated interface astrogliosis in blast and impact neurotrauma, specifically in the context of RHI and early stage CTE. We compared postmortem brain tissue from former military veterans with a history of blast exposure with and without a neuropathological diagnosis of CTE, former American football players with a history of RHI with and without a neuropathological diagnosis of CTE, and control donors without a history of blast, RHI exposure or CTE diagnosis. Using quantitative immunofluorescence, we found that astrogliosis was higher at the grey-white matter interface in the dorsolateral frontal cortex, with mixed effects at the subpial surface and underlying cortex, in both blast and RHI donors with and without CTE, compared to controls. These results indicate that certain astrocytic alterations are associated with both impact and blast neurotrauma, and that different astroglial responses take place in distinct brain regions.
    MeSH term(s) Chronic Traumatic Encephalopathy/pathology ; Football/injuries ; Gliosis/complications ; Humans ; Neurodegenerative Diseases/complications ; Neuropathology
    Language English
    Publishing date 2022-04-13
    Publishing country England
    Document type Journal Article ; Research Support, U.S. Gov't, Non-P.H.S. ; Research Support, N.I.H., Extramural
    ZDB-ID 2715589-4
    ISSN 2051-5960 ; 2051-5960
    ISSN (online) 2051-5960
    ISSN 2051-5960
    DOI 10.1186/s40478-022-01358-z
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

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  4. Article ; Online: Gadolinium Deposition in the Rat Brain Measured with Quantitative MRI versus Elemental Mass Spectrometry.

    Hua, Ning / Minaeva, Olga / Lupoli, Nicola / Franz, Erich S / Liu, Xiuping / Moncaster, Juliet A / Babcock, Katharine J / Jara, Hernán / Tripodis, Yorghos / Guermazi, Ali / Soto, Jorge A / Anderson, Stephan W / Goldstein, Lee E

    Radiology

    2022  Volume 306, Issue 1, Page(s) 244–251

    Abstract: Background T1-weighted MRI and quantitative longitudinal relaxation rate (R1) mapping have been used to evaluate gadolinium retention in the brain after gadolinium-based contrast agent (GBCA) administration. Whether MRI measures accurately reflect ... ...

    Abstract Background T1-weighted MRI and quantitative longitudinal relaxation rate (R1) mapping have been used to evaluate gadolinium retention in the brain after gadolinium-based contrast agent (GBCA) administration. Whether MRI measures accurately reflect gadolinium regional distribution and concentration in the brain remains unclear. Purpose To compare gadolinium retention in rat forebrain measured with in vivo quantitative MRI R1 and ex vivo laser ablation inductively coupled plasma mass spectrometry (LA-ICP-MS) mapping after gadobenate, gadopentetate, gadodiamide, or gadobutrol administration. Materials and Methods Adult female Sprague-Dawley rats were randomly assigned to one of five groups (eight per group) and administered gadobenate, gadopentetate, gadodiamide, gadobutrol (2.4 mmol/kg per week for 5 weeks), or saline (4.8 mL/kg per week for 5 weeks). MRI R1 mapping was performed at baseline and 1 week after the final injection to determine R1 and ΔR1. Postmortem brains from the same rats were analyzed with LA-ICP-MS elemental mapping to determine regional gadolinium concentrations. Student
    MeSH term(s) Rats ; Female ; Animals ; Gadolinium ; Rats, Sprague-Dawley ; Gadolinium DTPA ; Organometallic Compounds ; Contrast Media ; Meglumine ; Magnetic Resonance Imaging/methods ; Brain ; Mass Spectrometry
    Chemical Substances gadodiamide (84F6U3J2R6) ; gadobutrol (1BJ477IO2L) ; Gadolinium (AU0V1LM3JT) ; Gadolinium DTPA (K2I13DR72L) ; Organometallic Compounds ; Contrast Media ; Meglumine (6HG8UB2MUY)
    Language English
    Publishing date 2022-09-20
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 80324-8
    ISSN 1527-1315 ; 0033-8419
    ISSN (online) 1527-1315
    ISSN 0033-8419
    DOI 10.1148/radiol.212171
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Ue I Zs.106: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  5. Article ; Online: Nonhomogeneous Gadolinium Retention in the Cerebral Cortex after Intravenous Administration of Gadolinium-based Contrast Agent in Rats and Humans.

    Minaeva, Olga / Hua, Ning / Franz, Erich S / Lupoli, Nicola / Mian, Asim Z / Farris, Chad W / Hildebrandt, Audrey M / Kiernan, Patrick T / Evers, Laney E / Griffin, Allison D / Liu, Xiuping / Chancellor, Sarah E / Babcock, Katharine J / Moncaster, Juliet A / Jara, Hernan / Alvarez, Victor E / Huber, Bertrand R / Guermazi, Ali / Latour, Lawrence L /
    McKee, Ann C / Soto, Jorge A / Anderson, Stephan W / Goldstein, Lee E

    Radiology

    2019  Volume 294, Issue 2, Page(s) 377–385

    Abstract: Background Gadolinium retention after repeated gadolinium-based contrast agent (GBCA) exposure has been reported in subcortical gray matter. However, gadolinium retention in the cerebral cortex has not been systematically investigated. Purpose To ... ...

    Abstract Background Gadolinium retention after repeated gadolinium-based contrast agent (GBCA) exposure has been reported in subcortical gray matter. However, gadolinium retention in the cerebral cortex has not been systematically investigated. Purpose To determine whether and where gadolinium is retained in rat and human cerebral cortex. Materials and Methods The cerebral cortex in Sprague-Dawley rats treated with gadopentetate dimeglumine (three doses over 4 weeks; cumulative gadolinium dose, 7.2 mmol per kilogram of body weight;
    MeSH term(s) Administration, Intravenous ; Adult ; Animals ; Cerebral Cortex/metabolism ; Contrast Media/administration & dosage ; Contrast Media/pharmacokinetics ; Female ; Gadolinium DTPA/administration & dosage ; Gadolinium DTPA/pharmacokinetics ; Humans ; Male ; Mass Spectrometry/methods ; Middle Aged ; Models, Animal ; Rats ; Rats, Sprague-Dawley
    Chemical Substances Contrast Media ; Gadolinium DTPA (K2I13DR72L)
    Language English
    Publishing date 2019-11-26
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 80324-8
    ISSN 1527-1315 ; 0033-8419
    ISSN (online) 1527-1315
    ISSN 0033-8419
    DOI 10.1148/radiol.2019190461
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Ue I Zs.106: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  6. Article: Assessing clinicopathological correlation in chronic traumatic encephalopathy: rationale and methods for the UNITE study.

    Mez, Jesse / Solomon, Todd M / Daneshvar, Daniel H / Murphy, Lauren / Kiernan, Patrick T / Montenigro, Philip H / Kriegel, Joshua / Abdolmohammadi, Bobak / Fry, Brian / Babcock, Katharine J / Adams, Jason W / Bourlas, Alexandra P / Papadopoulos, Zachary / McHale, Lisa / Ardaugh, Brent M / Martin, Brett R / Dixon, Diane / Nowinski, Christopher J / Chaisson, Christine /
    Alvarez, Victor E / Tripodis, Yorghos / Stein, Thor D / Goldstein, Lee E / Katz, Douglas I / Kowall, Neil W / Cantu, Robert C / Stern, Robert A / McKee, Ann C

    Alzheimer's research & therapy

    2015  Volume 7, Issue 1, Page(s) 62

    Abstract: Introduction: Chronic traumatic encephalopathy (CTE) is a progressive neurodegeneration associated with repetitive head impacts. Understanding Neurologic Injury and Traumatic Encephalopathy (UNITE) is a U01 project recently funded by the National ... ...

    Abstract Introduction: Chronic traumatic encephalopathy (CTE) is a progressive neurodegeneration associated with repetitive head impacts. Understanding Neurologic Injury and Traumatic Encephalopathy (UNITE) is a U01 project recently funded by the National Institute of Neurological Disorders and Stroke and the National Institute of Biomedical Imaging and Bioengineering. The goal of the UNITE project is to examine the neuropathology and clinical presentation of brain donors designated as "at risk" for the development of CTE based on prior athletic or military exposure. Here, we present the rationale and methodology for UNITE.
    Methods: Over the course of 4 years, we will analyze the brains and spinal cords of 300 deceased subjects who had a history of repetitive head impacts sustained during participation in contact sports at the professional or collegiate level or during military service. Clinical data are collected through medical record review and retrospective structured and unstructured family interviews conducted by a behavioral neurologist or neuropsychologist. Blinded to the clinical data, a neuropathologist conducts a comprehensive assessment for neurodegenerative disease, including CTE, using published criteria. At a clinicopathological conference, a panel of physicians and neuropsychologists, blinded to the neuropathological data, reaches a clinical consensus diagnosis using published criteria, including proposed clinical research criteria for CTE.
    Results: We will investigate the validity of these clinical criteria and sources of error by using recently validated neuropathological criteria as a gold standard for CTE diagnosis. We also will use statistical modeling to identify diagnostic features that best predict CTE pathology.
    Conclusions: The UNITE study is a novel and methodologically rigorous means of assessing clinicopathological correlation in CTE. Our findings will be critical for developing future iterations of CTE clinical diagnostic criteria.
    MeSH term(s) Athletes ; Athletic Injuries/complications ; Brain/pathology ; Brain Injury, Chronic/etiology ; Brain Injury, Chronic/pathology ; Brain Injury, Chronic/physiopathology ; Consensus ; Female ; Humans ; Immunohistochemistry ; Interviews as Topic ; Male ; Military Personnel ; Neurodegenerative Diseases/etiology ; Neurodegenerative Diseases/pathology ; Neurodegenerative Diseases/physiopathology ; Retrospective Studies ; Spinal Cord/pathology ; War-Related Injuries/complications
    Language English
    Publishing date 2015-10-12
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 2506521-X
    ISSN 1758-9193
    ISSN 1758-9193
    DOI 10.1186/s13195-015-0148-8
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

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