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  1. Article: Variable Phenotypes in Alternating Hemiplegia of Childhood: A Genetically Proven Case Series.

    Mohanlal, Smilu / Babu, Sachin Suresh / Pachat, Divya

    Annals of Indian Academy of Neurology

    2021  Volume 24, Issue 3, Page(s) 449–450

    Language English
    Publishing date 2021-01-25
    Publishing country India
    Document type Journal Article
    ZDB-ID 2240174-X
    ISSN 1998-3549 ; 0972-2327
    ISSN (online) 1998-3549
    ISSN 0972-2327
    DOI 10.4103/aian.AIAN_495_20
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Genome-Based Therapeutics: Era of Precision Medicine in Genetic Epilepsies and Epileptic Encephalopathies.

    Balaji, Aarthi / Mohanlal, Smilu / Pachat, Divya / Babu, Sachin Suresh / Kumar, Ek Suresh / Mamukoya, Najiya / Das, Syama

    Annals of Indian Academy of Neurology

    2023  Volume 26, Issue 5, Page(s) 723–727

    Abstract: Introduction: The recent evolution of genomics has led to the development of targeted therapeutics, revolutionizing medical approaches. This study aimed to assess the impact of genetic testing on the current epilepsy management paradigm with a specific ... ...

    Abstract Introduction: The recent evolution of genomics has led to the development of targeted therapeutics, revolutionizing medical approaches. This study aimed to assess the impact of genetic testing on the current epilepsy management paradigm with a specific focus on the variability of outcomes subsequent to genetic diagnoses.
    Methodology: Data were collected retrospectively from a cohort of children aged 1-18 years, diagnosed with refractory epilepsy of confirmed genetic origin. The participants received care at a quaternary care center's pediatric neurology clinic from August 2019 to June 2021. The collected information included demographic characteristics, seizure types, EEG findings, imaging abnormalities, genetic diagnoses, attempted treatments, and seizure outcomes.
    Results: Among the 210 children with confirmed genetic diagnoses, 74 were included in the study. The gender distribution comprised 45 males and 29 females. Within the cohort, 68/74 exhibited single gene variations, with 23 cases associated with sodium/potassium/calcium channelopathies. Precision medicine could be applied to 25/74 cases. 17/74 children (22.97%) experienced a reduction of up to 50% in seizure frequency due to precision medicine implementation.
    Conclusion: While our study indicates the significance of genetic insights in adapting treatment approaches for pediatric epilepsy, it is important to temper our conclusions. The retrospective nature of our study confines our ability to definitively gauge the extent of precision medicine's utility. Our findings suggest the potential of genetic information to enhance epilepsy management, but the true impact of precision medicine can only be established through prospective investigations.
    Language English
    Publishing date 2023-10-26
    Publishing country India
    Document type Journal Article
    ZDB-ID 2240174-X
    ISSN 1998-3549 ; 0972-2327
    ISSN (online) 1998-3549
    ISSN 0972-2327
    DOI 10.4103/aian.aian_314_23
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Lance-Adams syndrome: A special case of a mother.

    Nigam, Gaurav Bhaskar / Babu, Sachin Suresh / Peter, C Sudhir / Peter, C Shobhna

    Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine

    2016  Volume 20, Issue 9, Page(s) 548–550

    Abstract: Predicting the neurological outcome in survivors of cardiorespiratory arrest is difficult. A distinction has been made between acute and chronic posthypoxic myoclonus, called myoclonic status epilepticus and Lance-Adams syndrome (LAS), respectively, with ...

    Abstract Predicting the neurological outcome in survivors of cardiorespiratory arrest is difficult. A distinction has been made between acute and chronic posthypoxic myoclonus, called myoclonic status epilepticus and Lance-Adams syndrome (LAS), respectively, with the acute condition carrying a bad prognosis. Here, we report a case of a 37-year-old female who developed seizures after a successful cardiopulmonary resuscitation. The available literature on such cases is very rare and has generally mentioned a poor outcome. However, our patient was successfully managed and showed clinical features of LAS. Thus, making an early diagnosis and proper management of hypoxic brain insults is positively related to improving the patient's functional outcome.
    Language English
    Publishing date 2016-02-18
    Publishing country India
    Document type Case Reports
    ZDB-ID 2121263-6
    ISSN 1998-359X ; 0972-5229
    ISSN (online) 1998-359X
    ISSN 0972-5229
    DOI 10.4103/0972-5229.190372
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Andersen-Tawil syndrome: A review of literature.

    Babu, Sachin Suresh / Nigam, Gaurav Bhaskar / Peter, C Sudhir / Peter, C Shobhna

    Neurology India

    2015  Volume 63, Issue 5, Page(s) 772–774

    Language English
    Publishing date 2015-09
    Publishing country India
    Document type Letter
    ZDB-ID 415522-1
    ISSN 1998-4022 ; 0028-3886
    ISSN (online) 1998-4022
    ISSN 0028-3886
    DOI 10.4103/0028-3886.166530
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 698: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  5. Article: Thalamus and vertical gaze: Arguing for an independent association.

    Babu, Sachin Suresh / Khanna, Laxmi / Peter, Sudhir / Chindrippu, Sobhana / Patras, Elisheba

    Annals of Indian Academy of Neurology

    2016  Volume 19, Issue 3, Page(s) 426–428

    Language English
    Publishing date 2016-08-11
    Publishing country India
    Document type Journal Article
    ZDB-ID 2240174-X
    ISSN 1998-3549 ; 0972-2327
    ISSN (online) 1998-3549
    ISSN 0972-2327
    DOI 10.4103/0972-2327.179981
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Three siblings with multiform seizures: An unusual presentation of Doose syndrome.

    Babu, Sachin Suresh / Peter, Chindripu Sudhir / Mogadati, Sobhana / Joseph, Phebe Miriam / Reddy, Nishant / Gupta, Priya

    The National medical journal of India

    2014  Volume 27, Issue 6, Page(s) 314–315

    Abstract: Doose syndrome, or epilepsy with myoclonic-atonic seizures, is a rare electroclinical syndrome. It is important to distinguish it from related epilepsy syndromes such as Lennox Gestaut syndrome and Dravet syndrome. We report the occurrence of this ... ...

    Abstract Doose syndrome, or epilepsy with myoclonic-atonic seizures, is a rare electroclinical syndrome. It is important to distinguish it from related epilepsy syndromes such as Lennox Gestaut syndrome and Dravet syndrome. We report the occurrence of this disorder in three siblings born of a non-consanguineous marriage.
    MeSH term(s) Child, Preschool ; Electroencephalography ; Epilepsies, Myoclonic/genetics ; Humans ; Seizures/genetics ; Siblings
    Language English
    Publishing date 2014-11
    Publishing country India
    Document type Journal Article
    ZDB-ID 645116-0
    ISSN 0970-258X
    ISSN 0970-258X
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2493: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  7. Article: Necrotizing autoimmune myopathy.

    Babu, Sachin Suresh / Khanna, Laxmi / Saran, Ravindra Kumar / Mittal, Gaurav / Peter, Sudhir / Sebastian, Ivy

    Annals of Indian Academy of Neurology

    2012  Volume 19, Issue 2, Page(s) 288–290

    Language English
    Publishing date 2012-04-07
    Publishing country India
    Document type Journal Article
    ZDB-ID 2240174-X
    ISSN 1998-3549 ; 0972-2327
    ISSN (online) 1998-3549
    ISSN 0972-2327
    DOI 10.4103/0972-2327.176864
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

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