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  1. AU="Bacci, M R"
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  1. Article: Value of Diaphragm Ultrasonography for Extubation: A Single-Blinded Randomized Clinical Trial.

    Toledo, T G / Bacci, M R

    Critical care research and practice

    2023  Volume 2023, Page(s) 8403971

    Abstract: Introduction: Daily evaluation of mechanically ventilated (MV) patients is essential for successful extubation. Proper withdrawal prevents complications and reduces the cost of hospitalization in the intensive care unit (ICU). Diaphragm ultrasonography ( ...

    Abstract Introduction: Daily evaluation of mechanically ventilated (MV) patients is essential for successful extubation. Proper withdrawal prevents complications and reduces the cost of hospitalization in the intensive care unit (ICU). Diaphragm ultrasonography (DUS) has emerged as a potential instrument for determining whether a patient is ready to be extubated. This study compared the efficacy rate of extubation using a standard withdrawal protocol and DUS in patients with MV.
    Methods: A randomized, parallel, single-blind, controlled study was conducted on ICU patients undergoing MV. Patients were randomly assigned to either the control (conventional weaning protocol) group or intervention (DUS-guided weaning) group in a 1 : 1 ratio. The primary outcome measure was the rate of reintubation and hospital mortality.
    Results: Forty patients were randomized to the trial. The mean age of the sample was 70 years, representing an older population. The extubation success rate was 90% in both groups. There was no reintubation in the first 48 hours and only two reintubations in both groups between the second and seventh days. The hospital mortality risk in patients with acute kidney injury was positively correlated with age and the need for hemodialysis.
    Language English
    Publishing date 2023-09-19
    Publishing country Egypt
    Document type Journal Article
    ZDB-ID 2573849-5
    ISSN 2090-1313 ; 2090-1305
    ISSN (online) 2090-1313
    ISSN 2090-1305
    DOI 10.1155/2023/8403971
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: A systematic review of artificial intelligence algorithms for predicting acute kidney injury.

    Bacci, M R / Minczuk, C V B / Fonseca, F L A

    European review for medical and pharmacological sciences

    2023  Volume 27, Issue 20, Page(s) 9872–9879

    Abstract: Objective: Acute kidney injury (AKI) increases mortality and costs in hospitalized patients. New methods for early AKI identification have been developed with targeted biomarkers and electronic health records data analysis. Machine learning (ML) use in ... ...

    Abstract Objective: Acute kidney injury (AKI) increases mortality and costs in hospitalized patients. New methods for early AKI identification have been developed with targeted biomarkers and electronic health records data analysis. Machine learning (ML) use in diagnostics and health data analysis has recently increased. We performed a systematic review to analyze the use of ML for AKI prediction in hospitalized adults.
    Materials and methods: Tubmed, EMBASE, Cochrane, and Web of Science databases were searched until 31st March of 2023. English-language studies using ML in adults for AKI prediction were included using predetermined eligibility search terms such as acute kidney injury, machine learning, and artificial intelligence. Two reviewers evaluated the publications' titles, abstracts, and full texts separately and obtained appropriate data. The main outcome was an area under the curve (AUC) result of at least 0.70.
    Results: Ten studies in 102 articles were included involving 242,251 patients. Deep learning (AUC 0.907 in critical care AKI; AUC 0.797 in hospitalized patients AKI) was similar to Logistic regression (AUC 0.877 in critical care AKI; AUC 0.789 in hospitalized patients). Decision tree constructions had similar AUC.
    Conclusions: In this review, most ML models analyzed fulfilled the main outcome. AKI is multifactorial; however, ML performed well with different etiologies, such as cardiac-related AKI, drug-related AKI, and critical care patients. Overfitting data and constructing black box models are limitations that might jeopardize the generalization and comprehension of the results. Most studies were single-center, and three manuscripts used the same database with a predominantly Caucasian population, resulting in a lack of diversity and reducing external generalization. In conclusion, ML could effectively predict AKI in hospitalized adults. Future directions rely on including a more diverse population and completing prospective and controlled trials.
    MeSH term(s) Adult ; Humans ; Artificial Intelligence ; Prospective Studies ; Biomarkers ; Machine Learning ; Acute Kidney Injury/diagnosis ; Acute Kidney Injury/etiology
    Chemical Substances Biomarkers
    Language English
    Publishing date 2023-10
    Publishing country Italy
    Document type Systematic Review ; Journal Article
    ZDB-ID 605550-3
    ISSN 2284-0729 ; 1128-3602 ; 0392-291X
    ISSN (online) 2284-0729
    ISSN 1128-3602 ; 0392-291X
    DOI 10.26355/eurrev_202310_34164
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1887: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  3. Article ; Online: Association between irisin and major chronic diseases: a review.

    Gouveia, M C / Vella, J P / Cafeo, F R / Affonso Fonseca, F L / Bacci, M R

    European review for medical and pharmacological sciences

    2016  Volume 20, Issue 19, Page(s) 4072–4077

    Abstract: Objective: Irisin is a muscle-secreted protein released into the circulation by cleavage of fibronectin type III domain containing protein 5(FNDC5). Since its discovery in 2012, it has been the subject of many researches due to its physiological role. ... ...

    Abstract Objective: Irisin is a muscle-secreted protein released into the circulation by cleavage of fibronectin type III domain containing protein 5(FNDC5). Since its discovery in 2012, it has been the subject of many researches due to its physiological role. It is believed that understanding irisin's function may be the key to comprehend many diseases and their development. The aim of this study is to perform a systematic review in order to establish whether there is an association of irisin's levels with obesity, diabetes mellitus, non-alcoholic steatohepatitis, chronic kidney disease and cancer in terms of prognosis.
    Materials and methods: The articles that support these findings were selected from Medline using the keyword "irisin" and filtered with "humans only". The selected articles were in English and with abstract.
    Results: Higher baseline irisin concentrations are associated with greater reductions in glycemia and insulinemia after weight loss in obese subjects. Besides, it was observed that macrovascular disease, a complication of diabetes, was developed when there were lower levels of irisin. In addition, although not statistically significant, high levels of irisin were associated with portal inflammation and severity of histological lesions. Its concentrations decreased with increasing chronic kidney disease stage, and they were not only independently and positively predicted by renal function and insulin resistance but also associated with sarcopenia and carotid atherosclerosis in patients undergoing peritoneal dialysis. Regarding cancer, irisin reduced the proliferation, viability and migration of malignant breast cells. Finally, it is also related to bone health once its concentration is associated with previous osteoporotic fractures.
    Conclusions: In every condition studied, irisin's concentrations were related to the development of the disease.
    MeSH term(s) Chronic Disease ; Fibronectins/metabolism ; Humans ; Insulin Resistance ; Obesity ; Prognosis ; Sarcopenia
    Chemical Substances FNDC5 protein, human ; Fibronectins
    Language English
    Publishing date 2016-10
    Publishing country Italy
    Document type Journal Article ; Review
    ZDB-ID 605550-3
    ISSN 2284-0729 ; 1128-3602 ; 0392-291X
    ISSN (online) 2284-0729
    ISSN 1128-3602 ; 0392-291X
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1887: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  4. Article ; Online: Quality of life on hemodialysis and inflammation: a descriptive analysis.

    Bacci, M R / Adami, F / Figueiredo, F W S / Alves, B C A / da Veiga, G L / Fonseca, F L A

    Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas

    2018  Volume 51, Issue 6, Page(s) e7355

    Abstract: Chronic kidney disease (CKD) is highly prevalent worldwide. Patients with CKD on hemodialysis are more likely to present behavioral changes and worse quality of life as a result of their routine and complications. They also have higher levels of ... ...

    Abstract Chronic kidney disease (CKD) is highly prevalent worldwide. Patients with CKD on hemodialysis are more likely to present behavioral changes and worse quality of life as a result of their routine and complications. They also have higher levels of cytokines. The aim of this study is to assess the relationship between the inflammatory profile and quality of life measured by KDOQL-SF36 in hemodialysis outpatients. Patients older than 21 years of age and on routine hemodialysis for at least 6 months with treatment on a regular weekly basis were included and their anthropometric parameters and serum inflammatory markers were evaluated. Thirty patients consented to participate. Homocysteine (Hcy) levels were correlated with worse glomerular filtration rate (GFR; P=0.003) and creatinine (P=0.002). IL-6 was not correlated with worse nutritional status taking into account body mass index (BMI; kg/m2; P=0.83). On the other hand, TNF-alpha was positively correlated with albumin (P=0.008), nutritional status by BMI (P=0.04), and nutritional status by arm circumference area (P=0.04). IL-6 was correlated with activity limitation (P=0.02) and Hcy with work status (P=0.04). Hcy was correlated with nutritional status and inflammatory markers. In this population, the majority of the sections in KDOQL-SF36 were not correlated with cytokines levels.
    MeSH term(s) Adult ; Biomarkers/blood ; Body Mass Index ; Creatinine/blood ; Cytokines/blood ; Female ; Glomerular Filtration Rate ; Homocysteine/blood ; Humans ; Inflammation/blood ; Inflammation/etiology ; Male ; Nutritional Status ; Quality of Life/psychology ; Renal Dialysis/adverse effects ; Renal Dialysis/psychology ; Renal Insufficiency, Chronic/blood ; Renal Insufficiency, Chronic/therapy ; Serum Albumin/analysis ; Surveys and Questionnaires ; Tumor Necrosis Factor-alpha/blood
    Chemical Substances Biomarkers ; Cytokines ; Serum Albumin ; Tumor Necrosis Factor-alpha ; Homocysteine (0LVT1QZ0BA) ; Creatinine (AYI8EX34EU)
    Language English
    Publishing date 2018
    Publishing country Brazil
    Document type Journal Article ; Observational Study
    ZDB-ID 786234-9
    ISSN 1414-431X ; 0100-879X
    ISSN (online) 1414-431X
    ISSN 0100-879X
    DOI 10.1590/1414-431x20187355
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Diagnosis of the infection by the Helicobacter pylori through stool examination: method standardization in adults.

    Chehter, E Z / Bacci, M R / Fonseca, F L A / Gonçalves, J A C / Buchalla, G / Shiraichi, S A R / Mariano, R C

    Clinical biochemistry

    2013  Volume 46, Issue 15, Page(s) 1622–1624

    Abstract: Objectives: Infection caused by Helicobacter pylori (H. pylori) is one of the most common causes of chronic infection in the world. The presence of the infection is strongly associated with the neoplasia of the gastrointestinal tract, and its diagnosis ... ...

    Abstract Objectives: Infection caused by Helicobacter pylori (H. pylori) is one of the most common causes of chronic infection in the world. The presence of the infection is strongly associated with the neoplasia of the gastrointestinal tract, and its diagnosis is easily made by means of invasive or non-invasive methods. Among such methods, the H. pylori antigen detection in stool through ELISA technique is easily performed and it is an alternative to endoscopy in children, since this exam is not usually indicated in this age group. The aim of the current study is to establish the standardization of the ELISA method for the detection of H. pylori in stool specimens in Brazil.
    Design and methods: Patients between 18 and 70 years of age were randomly selected in the gastroenterology ambulatory center at Faculdade de Medicina do ABC between 2007 and 2009. They all answered a questionnaire to investigate possible dyspeptic symptoms and then underwent endoscopy and detection of H. pylori through no more than 4 methods. Besides the gastric biopsy, established as the gold standard test, the urease test, the stool ELISA test and serology were also methods applied.
    Results: The sensitivity and specificity of the exams in this sample were respectively 87.2% and 44% for the stool ELISA test, 41.9% and 64% for serology, 65.6% and 58.8% for the urease test and 100% and 80.8% for the clinical analysis.
    Conclusions: The ROC curve showed a good correlation between the compared methods. In Brazil the standardization of the ELISA test for the detection of H. pylori in stool specimens constitutes a non-invasive diagnostic alternative.
    MeSH term(s) Adolescent ; Adult ; Antigens, Bacterial/blood ; Bacterial Proteins/analysis ; Biopsy ; Brazil ; Enzyme-Linked Immunosorbent Assay/methods ; Enzyme-Linked Immunosorbent Assay/standards ; Feces/microbiology ; Female ; Helicobacter Infections/diagnosis ; Helicobacter Infections/microbiology ; Helicobacter pylori/immunology ; Helicobacter pylori/isolation & purification ; Humans ; Male ; Middle Aged ; Sensitivity and Specificity ; Urease/analysis
    Chemical Substances Antigens, Bacterial ; Bacterial Proteins ; Urease (EC 3.5.1.5)
    Language English
    Publishing date 2013-10
    Publishing country United States
    Document type Journal Article
    ZDB-ID 390372-2
    ISSN 1873-2933 ; 0009-9120
    ISSN (online) 1873-2933
    ISSN 0009-9120
    DOI 10.1016/j.clinbiochem.2013.05.071
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 624: Show issues Location:
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  6. Article ; Online: IL-6 and TNF-α serum levels are associated with early death in community-acquired pneumonia patients.

    Bacci, M R / Leme, R C P / Zing, N P C / Murad, N / Adami, F / Hinnig, P F / Feder, D / Chagas, A C P / Fonseca, F L A

    Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas

    2015  Volume 48, Issue 5, Page(s) 427–432

    Abstract: Community-acquired pneumonia (CAP) is amongst the leading causes of death worldwide. As inflammatory markers, cytokines can predict outcomes, if interpreted together with clinical data and scoring systems such as CURB-65, CRB, and Acute Physiology and ... ...

    Abstract Community-acquired pneumonia (CAP) is amongst the leading causes of death worldwide. As inflammatory markers, cytokines can predict outcomes, if interpreted together with clinical data and scoring systems such as CURB-65, CRB, and Acute Physiology and Chronic Health Evaluation II (APACHE II). The aim of this study was to determine the impact of inflammatory biomarkers on the early mortality of hospitalized CAP patients. Twenty-seven CAP patients needing hospitalization were enrolled for the study and samples of interleukin-1 (IL-1) and interleukin-6 (IL-6), tumor necrosis factor alpha (TNF-α), C-reactive protein (CRP), and homocystein were collected at the time of admission (day 1) as well as on the seventh day of the treatment. There was a significant reduction in the levels of IL-6 between the first and the second collections. Median IL-6 values decreased from 24 pg/mL (day 1) to 8 pg/mL (day 7) (P=0.016). The median levels of TNF-α were higher in patients: i) with acute kidney injury (AKI) (P=0.045), ii) requiring mechanical ventilation (P=0.040), iii) with short hospital stays (P=0.009), iv) admitted to the intensive care unit (ICU) (P=0.040), v) who died early (P=0.003), and vi) with worse CRB scores (P=0.013). In summary, IL-6 and TNF-α levels were associated with early mortality of CAP patients. Longer admission levels demonstrated greater likelihood of early death and overall mortality, necessity of mechanical ventilation, and AKI.
    MeSH term(s) Adolescent ; Adult ; Age Factors ; Aged ; Aged, 80 and over ; Biomarkers/blood ; C-Reactive Protein/analysis ; Child ; Child, Preschool ; Community-Acquired Infections/complications ; Community-Acquired Infections/mortality ; Creatinine/blood ; Female ; Homocysteine/blood ; Humans ; Infant ; Infant, Newborn ; Interleukin-1/blood ; Interleukin-6/blood ; Length of Stay ; Male ; Middle Aged ; Pneumonia/complications ; Pneumonia/mortality ; Prospective Studies ; Respiration, Artificial ; Sex Factors ; Statistics, Nonparametric ; Tumor Necrosis Factor-alpha/blood ; Young Adult
    Chemical Substances Biomarkers ; Interleukin-1 ; Interleukin-6 ; Tumor Necrosis Factor-alpha ; Homocysteine (0LVT1QZ0BA) ; C-Reactive Protein (9007-41-4) ; Creatinine (AYI8EX34EU)
    Language English
    Publishing date 2015-05
    Publishing country Brazil
    Document type Journal Article
    ZDB-ID 786234-9
    ISSN 1414-431X ; 0100-879X
    ISSN (online) 1414-431X
    ISSN 0100-879X
    DOI 10.1590/1414-431X20144402
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.B 1359: Show issues Location:
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  7. Article ; Online: The use of vancomycin with its therapeutic and adverse effects: a review.

    Bruniera, F R / Ferreira, F M / Saviolli, L R M / Bacci, M R / Feder, D / da Luz Gonçalves Pedreira, M / Sorgini Peterlini, M A / Azzalis, L A / Campos Junqueira, V B / Fonseca, F L A

    European review for medical and pharmacological sciences

    2015  Volume 19, Issue 4, Page(s) 694–700

    Abstract: Objective: Vancomycin (VCM) is a tricyclic glycopeptide antibiotic produced by Streptococcus orientalis. Widely used in hospitals, it is indicated to fight severe infections caused by Gram-positive bacteria, especially with the advent of MRSA ( ... ...

    Abstract Objective: Vancomycin (VCM) is a tricyclic glycopeptide antibiotic produced by Streptococcus orientalis. Widely used in hospitals, it is indicated to fight severe infections caused by Gram-positive bacteria, especially with the advent of MRSA (methicillin-resistant Staphylococcus aureus), penicillin-resistant pneumococci among others. Furthermore, it is indicated for the treatment of patients allergic to penicillins and cephalosporins. Dose recommendations, dilution rates and types of infusion are controversial and also result in toxic effects. Aim of this paper was to perform a literature review showing the therapeutic and adverse effects of vancomycin.
    Materials and methods: This is a literature review of recent articles published on MEDLINE and SciELO databases in English, Portuguese and Spanish.
    Results: The main adverse effects of vancomycin are: hypotension, phlebitis, nephrotoxicity, ototoxicity, hypersensitivity reactions, red man syndrome, neutropenia, chills, fever, interstitial nephritis.
    Conclusions: The use of vancomycin is still very common; however, inadequate doses and prolonged therapy pose a risk of increasing minimum inhibitory concentrations (MICs), resulting in subtherapeutic levels, treatment failures and toxicity. Therefore, further studies should be conducted to optimize the administration of vancomycin, monitoring treatments from the beginning in order to ensure a safe and effective use of the drug.
    MeSH term(s) Anti-Bacterial Agents/adverse effects ; Anti-Bacterial Agents/therapeutic use ; Cephalosporins/therapeutic use ; Gram-Positive Bacteria/drug effects ; Gram-Positive Bacterial Infections/drug therapy ; Humans ; Methicillin-Resistant Staphylococcus aureus/drug effects ; Microbial Sensitivity Tests ; Neutropenia/chemically induced ; Vancomycin/adverse effects ; Vancomycin/therapeutic use
    Chemical Substances Anti-Bacterial Agents ; Cephalosporins ; Vancomycin (6Q205EH1VU)
    Language English
    Publishing date 2015-02
    Publishing country Italy
    Document type Journal Article ; Review
    ZDB-ID 605550-3
    ISSN 2284-0729 ; 1128-3602 ; 0392-291X
    ISSN (online) 2284-0729
    ISSN 1128-3602 ; 0392-291X
    Database MEDical Literature Analysis and Retrieval System OnLINE

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