LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 10 of total 270

Search options

  1. Article ; Online: Is heat shock protein 90 inhibition a relevant treatment strategy for psoriasis?

    Bachelez, Hervé

    The British journal of dermatology

    2022  Volume 186, Issue 5, Page(s) 771–772

    MeSH term(s) HSP90 Heat-Shock Proteins ; Humans ; Psoriasis/drug therapy
    Chemical Substances HSP90 Heat-Shock Proteins
    Language English
    Publishing date 2022-05-03
    Publishing country England
    Document type Journal Article ; Comment
    ZDB-ID 80076-4
    ISSN 1365-2133 ; 0007-0963
    ISSN (online) 1365-2133
    ISSN 0007-0963
    DOI 10.1111/bjd.21298
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Ui VI Zs.23: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  2. Article ; Online: Pustular psoriasis and related pustular skin diseases.

    Bachelez, H

    The British journal of dermatology

    2018  Volume 178, Issue 3, Page(s) 614–618

    Abstract: Patients with pustular psoriasis or related pustular diseases may have genetic abnormalities impairing the function of key players of the innate skin immune system. Recently, identification of these abnormalities has changed the paradigm of several of ... ...

    Abstract Patients with pustular psoriasis or related pustular diseases may have genetic abnormalities impairing the function of key players of the innate skin immune system. Recently, identification of these abnormalities has changed the paradigm of several of these diseases. These include generalized pustular psoriasis, palmoplantar pustular psoriasis and acrodermatitis continua of Hallopeau, and also drug-induced acute exanthematous generalized pustular eruption. Identified mutations in IL36RN, CARD14 and AP1S3 in different groups of patients lead to enhanced inflammatory cascade in several cellular subtypes including keratinocytes, and to the recruitment and activation of neutrophils and macrophages. These insights have unveiled pathophysiological features that shift the existing paradigms and emphasize the autoinflammatory nature of skin pustular disorders. They also highlight the crucial role of the innate immune system across entities belonging to the psoriasis disease spectrum, allowing identification of new appealing therapeutic targets.
    MeSH term(s) Acrodermatitis/genetics ; Acrodermatitis/pathology ; CARD Signaling Adaptor Proteins/genetics ; Drug Eruptions/genetics ; Drug Eruptions/pathology ; Guanylate Cyclase/genetics ; Humans ; Immunity, Innate/physiology ; Interleukins/genetics ; Membrane Proteins/genetics ; Mutation/genetics ; Precision Medicine ; Psoriasis/genetics ; Psoriasis/pathology ; Psoriasis/therapy ; Vesicular Transport Proteins/genetics
    Chemical Substances AP1S3 protein, human ; CARD Signaling Adaptor Proteins ; IL36RN protein, human ; Interleukins ; Membrane Proteins ; Vesicular Transport Proteins ; CARD14 protein, human (EC 4.6.1.-) ; Guanylate Cyclase (EC 4.6.1.2)
    Language English
    Publishing date 2018-01-15
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 80076-4
    ISSN 1365-2133 ; 0007-0963
    ISSN (online) 1365-2133
    ISSN 0007-0963
    DOI 10.1111/bjd.16232
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Ui VI Zs.23: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  3. Article ; Online: Pustular Psoriasis: The Dawn of a New Era.

    Bachelez, Hervez

    Acta dermato-venereologica

    2020  Volume 100, Issue 3, Page(s) adv00034

    Abstract: Pustular psoriasis is a clinically heterogeneous entity of different, orphan disease subtypes, among which the most clearly defined are generalized pustular psoriasis, palmoplantar psoriasis, and acrodermatitis continua of Hallopeau. Although ... ...

    Abstract Pustular psoriasis is a clinically heterogeneous entity of different, orphan disease subtypes, among which the most clearly defined are generalized pustular psoriasis, palmoplantar psoriasis, and acrodermatitis continua of Hallopeau. Although phenotypically and genetically distinct from psoriasis vulgaris, these subtypes may be associated with plaque psoriasis lesions, establishing the rationale for their inclusion in the psoriasis spectrum. Unlike psoriasis, however, their genetic background is thought to be mainly monogenic, as shown by the recent identification of mutations in 3 different genes of the skin innate immune system; IL36RN, CARD14 and AP1S3. These major advances in the understanding of the disease pathogenesis have led to the design and ongoing development of tailored therapeutic approaches, which are highly necessary given the refractory nature of pustular psoriasis in response to most available antipsoriatic drugs.
    MeSH term(s) CARD Signaling Adaptor Proteins/genetics ; Diagnosis, Differential ; Guanylate Cyclase/genetics ; Humans ; Interleukins/genetics ; Membrane Proteins/genetics ; Phenotype ; Psoriasis/diagnosis ; Psoriasis/drug therapy ; Psoriasis/genetics ; Psoriasis/immunology ; Vesicular Transport Proteins/genetics
    Chemical Substances AP1S3 protein, human ; CARD Signaling Adaptor Proteins ; IL36RN protein, human ; Interleukins ; Membrane Proteins ; Vesicular Transport Proteins ; CARD14 protein, human (EC 4.6.1.-) ; Guanylate Cyclase (EC 4.6.1.2)
    Language English
    Publishing date 2020-01-30
    Publishing country Sweden
    Document type Journal Article ; Review
    ZDB-ID 80007-7
    ISSN 1651-2057 ; 0001-5555
    ISSN (online) 1651-2057
    ISSN 0001-5555
    DOI 10.2340/00015555-3388
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Ui VI Zs.101: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  4. Article: Quoi de neuf en thérapeutique dermatologique?

    Bachelez, H

    Annales de dermatologie et de venereologie

    2015  Volume 142 Suppl 3, Page(s) S49–54

    Abstract: During the ongoing year were published results from clinical trials opening new perspectives in the treatment of chronic inflammatory and dysimmune skin diseases. If this therapeutic development still predominantly on moderate-to- severe forms of plaque ... ...

    Title translation What's New in Dermatological Therapy?.
    Abstract During the ongoing year were published results from clinical trials opening new perspectives in the treatment of chronic inflammatory and dysimmune skin diseases. If this therapeutic development still predominantly on moderate-to- severe forms of plaque psoriasis, it tends to be more diversified towards moderate-to- severe forms of other diseases heavily impacting on patients'lives such as atopic dermatitis in adulthood, and hidradenitis suppurativa. Likewise, the development of IL-17 and IL-23 biological inhibitors, but also of small molecules such as tofacitinib in psoriasis, and the achievement of dupilumab phase 2 studies in atopic dermatitis provide evidence for the high efficacy of these therapies, while adalimumab is the first drug to be approved for the treatment of hidradenitis suppurativa. On the other hand, advances in vaccinology allowed the successful development of innovative vaccine respectively against Herpes zoster and 9 serotypes of human papillomavirus. For all these interventions, prolonged real-life pharmacovigilance will be necessary to provide a more accurate picture of their respective benefit-to- risk balances.
    MeSH term(s) Dermatitis, Atopic/drug therapy ; Hidradenitis Suppurativa/drug therapy ; Humans ; Psoriasis/drug therapy
    Language French
    Publishing date 2015-12
    Publishing country France
    Document type English Abstract ; Journal Article ; Review
    ZDB-ID 391805-1
    ISSN 2214-5451 ; 0151-9638
    ISSN (online) 2214-5451
    ISSN 0151-9638
    DOI 10.1016/S0151-9638(16)30006-0
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Ui VI Zs.30: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  5. Article ; Online: Time to accurately determine the burden of generalized pustular psoriasis at the population level.

    Choon, Siew Eng / Bachelez, Hervé

    The British journal of dermatology

    2022  Volume 186, Issue 6, Page(s) 919–920

    MeSH term(s) Acute Disease ; Chronic Disease ; Humans ; Psoriasis/epidemiology ; Skin Diseases, Vesiculobullous
    Language English
    Publishing date 2022-04-28
    Publishing country England
    Document type Journal Article
    ZDB-ID 80076-4
    ISSN 1365-2133 ; 0007-0963
    ISSN (online) 1365-2133
    ISSN 0007-0963
    DOI 10.1111/bjd.21588
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Ui VI Zs.23: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  6. Article: Infliximab.

    Goujon, C / Bachelez, H

    Annales de dermatologie et de venereologie

    2019  Volume 146, Issue 6-7, Page(s) 483–486

    Title translation Infliximab.
    MeSH term(s) Contraindications, Drug ; Dermatologic Agents/pharmacology ; Drug Monitoring ; Female ; Half-Life ; Humans ; Infliximab/pharmacology ; Maternal-Fetal Exchange ; Pregnancy ; Psoriasis/drug therapy
    Chemical Substances Dermatologic Agents ; Infliximab (B72HH48FLU)
    Language French
    Publishing date 2019-06-20
    Publishing country France
    Document type Journal Article
    ZDB-ID 391805-1
    ISSN 2214-5451 ; 0151-9638
    ISSN (online) 2214-5451
    ISSN 0151-9638
    DOI 10.1016/j.annder.2019.04.013
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Ui VI Zs.30: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  7. Article ; Online: Interleukin 23 inhibitors for psoriasis: not just another number.

    Bachelez, Hervé

    Lancet (London, England)

    2017  Volume 390, Issue 10091, Page(s) 208–210

    Language English
    Publishing date 2017-07-15
    Publishing country England
    Document type Journal Article
    ZDB-ID 3306-6
    ISSN 1474-547X ; 0023-7507 ; 0140-6736
    ISSN (online) 1474-547X
    ISSN 0023-7507 ; 0140-6736
    DOI 10.1016/S0140-6736(17)31474-5
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Ua VI Zs.5: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)
    Zs.MG 94: Show issues

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  8. Article ; Online: Understanding generalized pustular psoriasis for improved patient care.

    Choon, Siew Eng / Barker, Jonathan / Bachelez, Herve

    Experimental dermatology

    2023  Volume 32, Issue 8, Page(s) 1186–1187

    MeSH term(s) Humans ; Psoriasis/therapy ; Chronic Disease ; Acute Disease ; Exanthema
    Language English
    Publishing date 2023-08-07
    Publishing country Denmark
    Document type Editorial
    ZDB-ID 1130936-2
    ISSN 1600-0625 ; 0906-6705
    ISSN (online) 1600-0625
    ISSN 0906-6705
    DOI 10.1111/exd.14883
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 3508: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  9. Article: Psoriasis pustuleux.

    Bachelez, H

    Annales de dermatologie et de venereologie

    2012  Volume 139 Suppl 2, Page(s) S34–8

    Abstract: The pustular forms o f psoriasis make up a heterogeneous entity from a clinical point of view. However, the existence of clinically detectable aseptic pustular lesions is common to all these forms. How they are related to plaque psoriasis, also called ... ...

    Title translation Pustular psoriasis.
    Abstract The pustular forms o f psoriasis make up a heterogeneous entity from a clinical point of view. However, the existence of clinically detectable aseptic pustular lesions is common to all these forms. How they are related to plaque psoriasis, also called psoriasis vulgaris, the most frequent form of psoriasis, and the genetic and molecular mechanisms recently updated in some forms, have renewed interest in these pustular forms, resulting in reconsideration of their place within cutaneous and systemic inflammatory diseases.
    MeSH term(s) Humans ; Psoriasis/complications ; Psoriasis/diagnosis
    Language French
    Publishing date 2012-04
    Publishing country France
    Document type English Abstract ; Journal Article
    ZDB-ID 391805-1
    ISSN 2214-5451 ; 0151-9638
    ISSN (online) 2214-5451
    ISSN 0151-9638
    DOI 10.1016/S0151-9638(12)70108-4
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Ui VI Zs.30: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

To top