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  1. Article ; Online: Engaging people who use drugs in clinical research: integrating facilitated telemedicine for HCV into substance use treatment.

    Talal, Andrew H / George, Saliyah J / Talal, Lillian A / Dharia, Arpan / Ventuneac, Ana / Baciewicz, Gloria / Perumalswami, Ponni V / Dickerson, Suzanne S

    Research involvement and engagement

    2023  Volume 9, Issue 1, Page(s) 63

    Abstract: Background: People who use drugs (PWUD) have difficulty participating in clinical research. We evaluated approaches to engage PWUD in clinical research, using facilitated telemedicine for hepatitis C virus (HCV) care as an example.: Methods: We ... ...

    Abstract Background: People who use drugs (PWUD) have difficulty participating in clinical research. We evaluated approaches to engage PWUD in clinical research, using facilitated telemedicine for hepatitis C virus (HCV) care as an example.
    Methods: We analyzed stakeholder interview transcripts and study-related data (i.e., progress reports, meeting minutes) from interrelated studies to understand engagement experiences at the patient, site, and organizational levels. Stakeholders include patient-participants, opioid treatment program (OTP) staff and administrators, and research team members involved in HCV management through facilitated telemedicine integrated into OTPs.
    Results: Three themes emerged. Initially, the research team sought understanding of the unique culture and community of each OTP (Theme 1). The team built trusting relationships through education, communication, and feedback (Theme 2). Finally, the research team enhanced collaborative care and incorporated the patients' voice to improve health outcomes (Theme 3). Patient-participants and OTP staff endorsed the integrated HCV care approach. Engagement practices are summarized as the CREATE framework (C = culture, R = respect, E = educate, A = advantage, T = trust, E = endorse).
    Conclusions: PWUD engagement in clinical research is maximized by building trusting relationships with open communication channels. Understanding the community, demonstrating respect, and augmenting knowledge are foundational for engaging PWUD in clinical research. These practices are transferable to engagement of PWUD in clinical research broadly.
    Language English
    Publishing date 2023-08-02
    Publishing country England
    Document type Journal Article
    ZDB-ID 2834246-X
    ISSN 2056-7529 ; 2056-7529
    ISSN (online) 2056-7529
    ISSN 2056-7529
    DOI 10.1186/s40900-023-00474-x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Evaluation of knowledge and confidence following opioid overdose prevention training: A comparison of types of training participants and naloxone administration methods.

    Ashrafioun, Lisham / Gamble, Stephanie / Herrmann, Michele / Baciewicz, Gloria

    Substance abuse

    2016  Volume 37, Issue 1, Page(s) 76–81

    Abstract: Background: The purpose of the current study was to assess the effect of opioid overdose prevention training on participants' knowledge about opioid overdose and confidence to recognize and respond to opioid overdose situations as a function of naloxone ...

    Abstract Background: The purpose of the current study was to assess the effect of opioid overdose prevention training on participants' knowledge about opioid overdose and confidence to recognize and respond to opioid overdose situations as a function of naloxone administration (i.e., injection vs. intranasal spray) and participant type (friend/family, provider, "other").
    Methods: Opioid overdose prevention trainings were offered throughout a mid-sized metropolitan area in the northeast. Participants (n = 428) were trained to administer naloxone via intramuscular injection (n = 154) or intranasal spray (n = 274). All training participants were given pre-post assessments of knowledge about opioid overdose and confidence to recognize and respond to opioid overdose situations.
    Results: Participants' overall knowledge and confidence increased significantly from pre- to post-training (ps < .001). There was no significant association between knowledge and route of administration or participant type. Knowledge significantly increased from pre- to post-training in all participant types (ps < .001). Confidence improved significantly from pre- to post-training across both routes of administration (ps < .001). However, confidence was higher among those who were trained using the intranasal naloxone compared to those who were trained using the intramuscular injection naloxone at pre- (p = .011) and post-training (p < .001). Confidence increased from pre- to post-training in each of the participant types (ps < .001). Post-hoc tests revealed that confidence was higher among providers and friends/family members compared to "other" participants, such as first responders, only at post-training (p < .05).
    Conclusions: Opioid overdose trainings are effective in increasing knowledge and confidence related to opioid overdose situations. Findings suggest that trainees are more confident administering naloxone via intranasal spray compared to injection. Future research should attempt to identify other factors that may increase the likelihood of trainees' effectively intervening in opioid overdose situations.
    MeSH term(s) Administration, Intranasal ; Analgesics, Opioid/adverse effects ; Drug Overdose/drug therapy ; Drug Overdose/prevention & control ; Health Knowledge, Attitudes, Practice ; Health Personnel/education ; Health Personnel/psychology ; Humans ; Injections, Intramuscular ; Naloxone/administration & dosage ; Naloxone/therapeutic use ; Narcotic Antagonists/therapeutic use ; Program Evaluation
    Chemical Substances Analgesics, Opioid ; Narcotic Antagonists ; Naloxone (36B82AMQ7N)
    Language English
    Publishing date 2016
    Publishing country United States
    Document type Comparative Study ; Evaluation Studies ; Journal Article ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 1458030-5
    ISSN 1547-0164 ; 0889-7077
    ISSN (online) 1547-0164
    ISSN 0889-7077
    DOI 10.1080/08897077.2015.1110550
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Monocarboxylate Transporter Inhibition with Osmotic Diuresis Increases γ-Hydroxybutyrate Renal Elimination in Humans: A Proof-of-Concept Study.

    Morris, Marilyn E / Morse, Bridget L / Baciewicz, Gloria J / Tessena, Matthew M / Acquisto, Nicole M / Hutchinson, David J / Dicenzo, Robert

    Journal of clinical toxicology

    2014  Volume 1, Issue 2, Page(s) 1000105

    Abstract: Background and objective: The purpose of the current study was to demonstrate proof-of-concept that monocarboxylate transporter (MCT) inhibition with L-lactate combined with osmotic diuresis increases renal clearance of γ-hydroxybutyrate (GHB) in human ... ...

    Abstract Background and objective: The purpose of the current study was to demonstrate proof-of-concept that monocarboxylate transporter (MCT) inhibition with L-lactate combined with osmotic diuresis increases renal clearance of γ-hydroxybutyrate (GHB) in human subjects. GHB is a substrate for human and rodent MCTs, which are responsible for GHB renal reabsorption, and this therapy increases GHB renal clearance in rats.
    Methods: Ten healthy volunteers were administered GHB orally as sodium oxybate 50 mg/kg (4.5 gm maximum dose) on two different study days. On study day 1, GHB was administered alone. On study day 2, treatment of L-lactate 0.125 mmol/kg and mannitol 200 mg/kg followed by L-lactate 0.75 mmol/kg/hr was administered intravenously 30 minutes after GHB ingestion. Blood and urine were collected for 6 hours, analyzed for GHB, and pharmacokinetic and statistical analyses performed.
    Results: L-lactate/mannitol administration significantly increased GHB renal clearance compared to GHB alone, 439 vs. 615 mL/hr (P=0.001), and increased the percentage of GHB dose excreted in the urine, 2.2 vs. 3.3% (P=0.021). Total clearance was unchanged.
    Conclusions: MCT inhibition with L-lactate combined with osmotic diuresis increases GHB renal elimination in humans. No effect on total clearance was observed in this study due to the negligible contribution of renal clearance to total clearance at this low GHB dose. Considering the nonlinear renal elimination of GHB, further research in overdose cases is warranted to assess the efficacy of this treatment strategy for increasing renal and total clearance at high GHB doses.
    Language English
    Publishing date 2014-03-25
    Publishing country United States
    Document type Journal Article
    ISSN 2161-0495
    ISSN 2161-0495
    DOI 10.4172/2161-0495.1000105
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Reliability of the Lifetime Inventory of Drug Use Consequences (INDUC) in methadone maintenance patients.

    Conner, Kenneth R / Ross, Mary Ellen / Baciewicz, Gloria / Sworts, Luke M / Meldrum, Sean C

    Journal of psychoactive drugs

    2009  Volume 41, Issue 1, Page(s) 93–98

    Abstract: One hundred twenty one opiate-dependent individuals in methadone maintenance treatment at an urban university medical center in the U.S. were administered the Inventory of Drug Use Consequences (InDUC), and 68 subjects provided follow-up assessments at ... ...

    Abstract One hundred twenty one opiate-dependent individuals in methadone maintenance treatment at an urban university medical center in the U.S. were administered the Inventory of Drug Use Consequences (InDUC), and 68 subjects provided follow-up assessments at two to six weeks. The sample included 61 (50.4%) women; 86 (71.1%) of the subjects reported that they were White, 29 (24.0%) Black, and six (5.0%) other race. The mean age was 41.9 (SD = 9.7) years. Ninety-nine (81.8%) of participants had used opiates intravenously. INDUC total scores and a short form showed high internal consistency (alpha) and test-retest reliability (ICC) across gender, race, ethnicity, and education, supporting their use as global measures of drug use consequences. The interpersonal scale was also reliable across strata whereas the physical and intrapersonal scales were not reliable. The impulse control and social responsibility scales were stable but not internally consistent.
    MeSH term(s) Adult ; Analgesics, Opioid/therapeutic use ; Behavior, Addictive ; Drug Users/psychology ; Female ; Humans ; Impulsive Behavior ; Interpersonal Relations ; Male ; Methadone/therapeutic use ; Middle Aged ; Opioid-Related Disorders/psychology ; Opioid-Related Disorders/rehabilitation ; Predictive Value of Tests ; Psychometrics ; Reproducibility of Results ; Social Responsibility ; Surveys and Questionnaires ; Time Factors ; Treatment Outcome
    Chemical Substances Analgesics, Opioid ; Methadone (UC6VBE7V1Z)
    Language English
    Publishing date 2009-05-20
    Publishing country United States
    Document type Journal Article
    ZDB-ID 392405-1
    ISSN 2159-9777 ; 0279-1072
    ISSN (online) 2159-9777
    ISSN 0279-1072
    DOI 10.1080/02791072.2009.10400678
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.B 1121: Show issues Location:
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  5. Article: Outcomes with the ARISE approach to engaging reluctant drug- and alcohol-dependent individuals in treatment.

    Landau, Judith / Stanton, M Duncan / Brinkman-Sull, David / Ikle, David / McCormick, David / Garrett, James / Baciewicz, Gloria / Shea, Robert R / Browning, Ashley / Wamboldt, Frederick

    The American journal of drug and alcohol abuse

    2004  Volume 30, Issue 4, Page(s) 711–748

    Abstract: Our goal was to explore, through a Stage I NIH clinical study, the effectiveness of a manual-driven, timely response method for helping the "concerned other" get resistant substance abusers into treatment/self-help with minimum professional time/effort. ... ...

    Abstract Our goal was to explore, through a Stage I NIH clinical study, the effectiveness of a manual-driven, timely response method for helping the "concerned other" get resistant substance abusers into treatment/self-help with minimum professional time/effort. A manual-driven protocol, "A Relational Sequence for Engagement (ARISE)," was applied with 110 consecutive, initial calls/contacts from concerned others; no cases excluded for research, refusal, or other reasons. The research was conducted at two upstate New York outpatient drug/alcohol clinics. Participants were concerned others who called regarding a cocaine, alcohol, or "other drug" abuser (N = 110); participating family/friends: 11 ARISE clinicians; and 110 substance abusers. ARISE is a graduated continuum starting with the least demanding option/stage, increasing effort as needed to engage substance abusers in treatment/self-help. Stage I: Coaching the concerned other to arrange a meeting of significant others, inviting the substance abuser; Stage II: 1 to 5 additional meetings (median = 2); Stage III: A modified Johnson "Intervention." Primary outcome variables were substance abuser engagement (or not) in treatment/self-help; days between first call and engagement; clinician time/effort. Predictors were concerned other, substance abuser, and clinician demographics; number of participants per case; and Collateral Addiction Severity Index. ARISE resulted in an 83% success rate (55% at Stage I). Median days to engagement was 7 (IQR = 2 to 14). Average total time (telephone, sessions) per case was 1.5 hours. Treatment/self-help chosen was 95% treatment and 5% self-help. Number of family/ friends involved correlated 0.69 with a success/efficiency index. Conclusions. A call from a family member or concerned other for help in getting a loved one into treatment is a rich opportunity for treatment professionals and agencies to engage substance abusers in treatment. These initial calls are similar to referral calls from EAPs or probation officers looking to get an individual started in treatment. ARISE provides an effective, swift, and cost-efficient option for engaging substance abusers in treatment or self-help. The more significant others involved, the greater the success of treatment engagement.
    MeSH term(s) Adolescent ; Adult ; Aged ; Aged, 80 and over ; Alcoholism/psychology ; Alcoholism/rehabilitation ; Caregivers/psychology ; Cocaine-Related Disorders/psychology ; Cocaine-Related Disorders/rehabilitation ; Combined Modality Therapy ; Counseling ; Family Therapy ; Female ; Friends/psychology ; Health Knowledge, Attitudes, Practice ; Humans ; Male ; Middle Aged ; Motivation ; New York ; Opioid-Related Disorders/psychology ; Opioid-Related Disorders/rehabilitation ; Outcome Assessment (Health Care) ; Patient Acceptance of Health Care ; Patient Care Team ; Self Care ; Self-Help Groups ; Social Support ; Substance-Related Disorders/psychology ; Substance-Related Disorders/rehabilitation ; Systems Theory
    Language English
    Publishing date 2004-11-10
    Publishing country England
    Document type Clinical Trial ; Journal Article ; Multicenter Study ; Research Support, U.S. Gov't, P.H.S.
    ZDB-ID 193086-2
    ISSN 0095-2990
    ISSN 0095-2990
    DOI 10.1081/ada-200037533
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1137: Show issues Location:
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