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  1. Article ; Online: A whole blood-based functional assay to characterize immunoglobulin A effector functions.

    Bacon, Alice / Cartagena García, Celia / van Schie, Karin A / Toes, René E M / Busnel, Jean-Marc

    Autoimmunity

    2024  Volume 57, Issue 1, Page(s) 2341629

    Abstract: Most investigations on the immune cell-activating potency of IgA used purified total IgA and/or specific isolated cell populations. As IgA2 has been reported to be more pro-inflammatory than IgA1, we aimed to employ a fast and convenient whole blood- ... ...

    Abstract Most investigations on the immune cell-activating potency of IgA used purified total IgA and/or specific isolated cell populations. As IgA2 has been reported to be more pro-inflammatory than IgA1, we aimed to employ a fast and convenient whole blood-based assay to individually probe the capacity of the two IgA subclasses to activate immune cells in close physiological conditions. To this end, whole blood from healthy donors (
    MeSH term(s) Immunoglobulin A ; Monocytes ; Neutrophils ; Leukocytes ; Flow Cytometry
    Chemical Substances Immunoglobulin A
    Language English
    Publishing date 2024-04-14
    Publishing country England
    Document type Journal Article
    ZDB-ID 1025450-x
    ISSN 1607-842X ; 0891-6934
    ISSN (online) 1607-842X
    ISSN 0891-6934
    DOI 10.1080/08916934.2024.2341629
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  2. Article: Letter from Melbourne: Ash Wednesday bush fires.

    Bacon, A

    British medical journal (Clinical research ed.)

    2010  Volume 286, Issue 6369, Page(s) 968–969

    Language English
    Publishing date 2010-08-25
    Publishing country England
    Document type Journal Article
    ZDB-ID 80088-0
    ISSN 0267-0623 ; 0959-8138 ; 0959-8146 ; 0007-1447
    ISSN 0267-0623 ; 0959-8138 ; 0959-8146 ; 0007-1447
    DOI 10.1136/bmj.286.6369.968
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  3. Article: Difference-in-differences with variation in treatment timing

    Goodman-Bacon, Andrew

    Journal of econometrics. 2021 Dec., v. 225, no. 2

    2021  

    Abstract: The canonical difference-in-differences (DD) estimator contains two time periods, ”pre” and ”post”, and two groups, ”treatment” and ”control”. Most DD applications, however, exploit variation across groups of units that receive treatment at different ... ...

    Abstract The canonical difference-in-differences (DD) estimator contains two time periods, ”pre” and ”post”, and two groups, ”treatment” and ”control”. Most DD applications, however, exploit variation across groups of units that receive treatment at different times. This paper shows that the two-way fixed effects estimator equals a weighted average of all possible two-group/two-period DD estimators in the data. A causal interpretation of two-way fixed effects DD estimates requires both a parallel trends assumption and treatment effects that are constant over time. I show how to decompose the difference between two specifications, and provide a new analysis of models that include time-varying controls.
    Keywords econometrics ; journals ; models ; temporal variation
    Language English
    Dates of publication 2021-12
    Size p. 254-277.
    Publishing place Elsevier B.V.
    Document type Article
    ZDB-ID 1460617-3
    ISSN 0304-4076
    ISSN 0304-4076
    DOI 10.1016/j.jeconom.2021.03.014
    Database NAL-Catalogue (AGRICOLA)

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  4. Article: Bougies.

    Bacon, A

    Anaesthesia and intensive care

    2009  Volume 37, Issue 3, Page(s) 497

    MeSH term(s) Equipment Design ; Humans ; Intubation, Intratracheal/instrumentation ; Terminology as Topic
    Language English
    Publishing date 2009-05-12
    Publishing country United States
    Document type Letter
    ZDB-ID 187524-3
    ISSN 1448-0271 ; 0310-057X
    ISSN (online) 1448-0271
    ISSN 0310-057X
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  5. Article ; Online: Treatment of Dysplasia Epiphysealis Hemimelica with Autologous Chondrocyte Implantation: A Case Report.

    Bacon, Adam / Delman, Connor M / Reynolds, James Phillip / Haus, Brian

    JBJS case connector

    2022  Volume 12, Issue 2, Page(s) 1–6

    Abstract: Case: We present a case of dysplasia epiphysealis hemimelica (DEH) involving the posteromedial distal femur in a 4-year-old girl. The patient underwent lesion resection with internal fixation of the articular cartilage followed by autologous chondrocyte ...

    Abstract Case: We present a case of dysplasia epiphysealis hemimelica (DEH) involving the posteromedial distal femur in a 4-year-old girl. The patient underwent lesion resection with internal fixation of the articular cartilage followed by autologous chondrocyte implantation (ACI) to restore the articular surface and epiphysis. At the 7-year follow-up, the patient had no pain or difficulty with participation in sports. Advanced imaging showed a stable articular surface with evidence of durable cartilage integration.
    Conclusion: DEH is a rare disease often treated by resection. In cases where the articular surface of the knee is involved, we have demonstrated that augmentation with ACI can be an effective treatment option.
    MeSH term(s) Bone Diseases, Developmental/diagnostic imaging ; Bone Diseases, Developmental/pathology ; Bone Diseases, Developmental/surgery ; Cartilage, Articular/surgery ; Child, Preschool ; Chondrocytes ; Female ; Femur/abnormalities ; Femur/pathology ; Femur/surgery ; Humans ; Tibia/abnormalities
    Language English
    Publishing date 2022-10-06
    Publishing country United States
    Document type Case Reports ; Journal Article
    ISSN 2160-3251
    ISSN (online) 2160-3251
    DOI e21.00668
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  6. Article ; Online: National Health Service interventions in England to improve care to Armed Forces veterans.

    Bacon, Andrew / Martin, E / Swarbrick, R / Treadgold, A

    BMJ military health

    2021  Volume 168, Issue 1, Page(s) 95–98

    Abstract: Armed Forces veterans (AFVs) are first and foremost citizens of the UK and are therefore-like all UK residents-entitled to universal healthcare, free at the point of need. This means that AFVs have nearly all their healthcare needs met by the NHS, which ... ...

    Abstract Armed Forces veterans (AFVs) are first and foremost citizens of the UK and are therefore-like all UK residents-entitled to universal healthcare, free at the point of need. This means that AFVs have nearly all their healthcare needs met by the NHS, which provides access to a full range of generic services. However, since 2013 there has been an Armed Forces team that can also support veterans. This review is an assessment of the work of this group over the last eight years. The health needs of AFVs have been investigated and are not significantly different from those of their demographically matched peers. However, due to their demographics, selection at recruitment and their roles, AFVs compared with the general population are more likely to be male, white and old and have fewer pre-existing or hereditary conditions. However, they do suffer from higher rates of musculoskeletal injury, different patterns of mental health illness and have historically been higher users-and abusers-of alcohol and tobacco. In addition to supporting mainstream services used by AFVs, the NHS in England commissions a bespoke range-specific
    MeSH term(s) COVID-19 ; England ; Female ; Humans ; Male ; Pandemics ; SARS-CoV-2 ; State Medicine ; Veterans
    Language English
    Publishing date 2021-03-19
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 3011686-7
    ISSN 2633-3775 ; 2633-3767
    ISSN (online) 2633-3775
    ISSN 2633-3767
    DOI 10.1136/bmjmilitary-2020-001739
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  7. Article ; Online: Generation of a thermostable, oral Zika vaccine that protects against virus challenge in non-human primates.

    Bacon, Andrew / Teixeira, Mauro / Costa, Vivian / Bone, Peter / Simmons, Jennifer / Drew, Jeffrey

    Vaccine

    2023  Volume 41, Issue 15, Page(s) 2524–2533

    Abstract: Here we report the development of a thermally stable, orally administered, candidate Zika vaccine using human serotype 5 adenovirus (AdHu5). We engineered AdHu5 to express the genes for the envelope and NS1 proteins of Zika virus. AdHu5 was formulated ... ...

    Abstract Here we report the development of a thermally stable, orally administered, candidate Zika vaccine using human serotype 5 adenovirus (AdHu5). We engineered AdHu5 to express the genes for the envelope and NS1 proteins of Zika virus. AdHu5 was formulated using a proprietary platform, OraPro, comprising a mix of sugars and modified amino acids that can overcome elevated temperatures (37 C), and an enteric coated capsule that protects the integrity of the AdHu5 from the acid in the stomach. This enables the delivery AdHu5 to the immune system of the small intestine. We show that oral delivery of AdHu5 elicited antigen-specific serum IgG immune responses in a mouse model and in a non-human primate model. Importantly, these immune responses were able reduce viral counts in mice and to prevent detectable viraemia in the non-human primates on challenge with live Zika virus. This candidate vaccine has significant advantages over many current vaccines that are maintained in a cold or ultra-cold chain and require parenteral administration.
    MeSH term(s) Humans ; Animals ; Mice ; Zika Virus ; Vaccines ; Zika Virus Infection ; Primates ; Antigens ; Antibodies, Viral ; Viral Vaccines ; Antibodies, Neutralizing
    Chemical Substances Vaccines ; Antigens ; Antibodies, Viral ; Viral Vaccines ; Antibodies, Neutralizing
    Language English
    Publishing date 2023-03-07
    Publishing country Netherlands
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 605674-x
    ISSN 1873-2518 ; 0264-410X
    ISSN (online) 1873-2518
    ISSN 0264-410X
    DOI 10.1016/j.vaccine.2023.02.055
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  8. Article: Using difference-in-differences to identify causal effects of COVID-19 policies

    Goodman-Bacon, Andrew / Marcus, Jan

    Surv. Res. Methods

    Abstract: Policymakers have implemented a wide range of non-pharmaceutical interventions to fight the spread of COVID-19. Variation in policies across jurisdictions and over time strongly suggests a difference-in-differences (DD) research design to estimate causal ...

    Abstract Policymakers have implemented a wide range of non-pharmaceutical interventions to fight the spread of COVID-19. Variation in policies across jurisdictions and over time strongly suggests a difference-in-differences (DD) research design to estimate causal effects of counter-COVID measures. We discuss threats to the validity of these DD designs and make recommendations about how researchers can avoid bias, interpret results accurately, and provide sound guidance to policymakers seeking to protect public health and facilitate an eventual economic recovery.
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #613628
    Database COVID19

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  9. Article ; Online: Using Difference-in-Differences to Identify Causal Effects of COVID-19 Policies

    Goodman-Bacon, Andrew / Marcus, Jan

    2020  

    Abstract: Policymakers have implemented a wide range of non-pharmaceutical interventions to fight the spread of COVID-19. Variation in policies across jurisdictions and over time strongly suggests a difference-in-differences (DD) research design to estimate causal ...

    Abstract Policymakers have implemented a wide range of non-pharmaceutical interventions to fight the spread of COVID-19. Variation in policies across jurisdictions and over time strongly suggests a difference-in-differences (DD) research design to estimate causal effects of counter-COVID measures. We discuss threats to the validity of these DD designs and make recommendations about how researchers can avoid bias, interpret results accurately, and provide sound guidance to policymakers seeking to protect public health and facilitate an eventual economic recovery.
    Keywords ddc:330 ; Difference-in-differences ; Non-pharmaceutical interventions ; COVID-19 ; Causal inference ; covid19
    Language English
    Publisher Southampton: European Survey Research Association
    Publishing country de
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Article ; Online: Coronavirus (COVID-19) in the United Kingdom

    Bacon, A.M. / Corr, P. J.

    A personality-based perspective on concerns and intention to self-isolate

    2020  

    Abstract: Objectives Public behaviour change is necessary to contain the spread of coronavirus (COVID‐19). Based on the reinforcement sensitivity theory (RST) framework, this study presents an examination of individual differences in some relevant psychological ... ...

    Abstract Objectives Public behaviour change is necessary to contain the spread of coronavirus (COVID‐19). Based on the reinforcement sensitivity theory (RST) framework, this study presents an examination of individual differences in some relevant psychological factors. Design Cross‐sectional psychometric. Methods UK respondents (N = 202) completed a personality questionnaire (RST‐PQ), measures of illness attitudes, concerns about the impact of coronavirus on health services and socio‐economic infrastructures, personal safety, and likelihood of voluntary self‐isolation. Results Respondents most concerned were older, had negative illness attitudes, and scored higher on reward reactivity (RR), indicating the motivation to take positive approach action despite prevailing worry/anxiety. Personal safety concerns were highest in those with negative illness attitudes and higher fight–flight–freeze system (FFFS, reflecting fear/avoidance) scores. Results suggest people are experiencing psychological conflict: between the urge to stay safe (FFFF‐related) and the desire to maintain a normal, pleasurable (RR‐related) life. Ways of ameliorating conflict may include maladaptive behaviours (panic buying), reflecting reward‐related displacement activity. Intended self‐isolation related to FFFS, but also low behavioural inhibition system (related to anxiety) scores. Older people reported themselves less likely to self‐isolate. Conclusions Interventions need to consider individual differences in psychological factors in behaviour change, and we discuss relevant literature to inform policy makers and communicators.
    Keywords BF Psychology ; HN Social history and conditions. Social problems. Social reform ; HV Social pathology. Social and public welfare ; QR355 Virology ; RA0421 Public health. Hygiene. Preventive Medicine ; covid19
    Subject code 150
    Language English
    Publishing date 2020-04-29
    Publisher British Psychological Society
    Publishing country uk
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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