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  1. AU="Badawi, Manal F"
  2. AU="Maleki, Mobina"
  3. AU="Bocciolone, Luca"
  4. AU="Alpert, Eric"
  5. AU="Tanaka, Kenichiro"
  6. AU="Clarke, Marcus C C"
  7. AU="Giorgino, Andrea"
  8. AU="Iwazaki, Dai"
  9. AU="Hingray, Benoit"
  10. AU="Karaca, E."
  11. AU=Harmer Matthew James
  12. AU="Jamaludin, Faridi S"
  13. AU="Sahebalzamani, Afsaneh"
  14. AU="Valverde-Molina, José"
  15. AU="Xiangpeng Yuan"
  16. AU="Rajpoot, Akanksha"
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  18. AU="Nalesso, Giovanna"
  19. AU="Remzi, F"
  20. AU="Lely Solari"
  21. AU="Aldridge, Daniel L"
  22. AU=Gross Lissy Z F AU=Gross Lissy Z F
  23. AU="DeVita, Robert"
  24. AU=Berkenstock Meghan K
  25. AU=Saleh Mohammed
  26. AU="Ganesan, Anuradha"
  27. AU="Ye, Yi-Fan"
  28. AU="Astasov-Frauenhoffer, Monika"
  29. AU="Ferrer-Diaz, Alejandra I"
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  1. Article ; Online: The Effect of Glycyrrhizin on the Viability and Proliferation of Dental Pulp Stem Cells Compared to Intracanal Medicaments.

    Alrashidi, Mohammad A / Badawi, Manal F / Elbeltagy, Mohamed G / Badr, Amany E

    The journal of contemporary dental practice

    2024  Volume 25, Issue 3, Page(s) 267–275

    Abstract: Aim: To study the effect of glycyrrhizin (GA) on the viability and proliferation of dental pulp stem cells (DPSCs) compared with intracanal medicaments.: Materials and methods: Third molars of an adult donor were used to obtain the DPSCs. Flow ... ...

    Abstract Aim: To study the effect of glycyrrhizin (GA) on the viability and proliferation of dental pulp stem cells (DPSCs) compared with intracanal medicaments.
    Materials and methods: Third molars of an adult donor were used to obtain the DPSCs. Flow cytometry was utilized to conduct phenotypic analysis for DPSCs. The methyl-thiazol tetrazolium (MTT) test was used to detect the cell viability. Cell proliferation assay was conducted at distinct time intervals: 3, 5, and 7 days.
    Results: The flow cytometry analysis verified the positive expression of mesenchymal cell surface antigen molecules (CD73, CD90, and CD105) and the absence of hematological markers (CD14, CD34, and CD45) in the DPSCs. The cells that treated with concentrations more than 0.5 mg/mL of Ca(OH
    Conclusion: Based upon the potential of GA on DPSCs proliferation compared with Ca(OH)
    Clinical significance: This study emphasizes the significance of assessing alternative root canal medicaments and their impact on the proliferation and viability of DPSCs. The results regarding GA, specifically its impact on the viability and growth of DPSCs, provide essential understanding for its potential application as an intracanal medicine. This study adds to the continuous endeavors in identifying safer and more efficient intracanal therapies, which are essential for improving patient outcomes in endodontic operations. How to cite this article: Alrashidi MA, Badawi MF, Elbeltagy MG,
    MeSH term(s) Humans ; Dental Pulp/cytology ; Dental Pulp/drug effects ; Glycyrrhizic Acid/pharmacology ; Cell Proliferation/drug effects ; Cell Survival/drug effects ; Root Canal Irrigants/pharmacology ; Stem Cells/drug effects ; Flow Cytometry ; Calcium Hydroxide/pharmacology ; Cells, Cultured ; Adult
    Chemical Substances Glycyrrhizic Acid (6FO62043WK) ; Root Canal Irrigants ; Calcium Hydroxide (PF5DZW74VN)
    Language English
    Publishing date 2024-03-19
    Publishing country India
    Document type Journal Article ; Comparative Study
    ISSN 1526-3711
    ISSN (online) 1526-3711
    DOI 10.5005/jp-journals-10024-3652
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Examining the Effects of Asiaticoside on Dental Pulp Stem Cell Viability and Proliferation: A Promising Approach to Root Canal Treatment.

    Alazemi, Mohammad J / Badawi, Manal F / Elbeltagy, Mohamed G / Badr, Amany E

    The journal of contemporary dental practice

    2024  Volume 25, Issue 2, Page(s) 118–127

    Abstract: Aim: This study aims to evaluate the impact of asiaticoside (AC) on the viability and proliferation of dental pulp stem cells (DPSCs), considering the known negative effects of routinely used intracanal medicaments. This evaluation will be compared with ...

    Abstract Aim: This study aims to evaluate the impact of asiaticoside (AC) on the viability and proliferation of dental pulp stem cells (DPSCs), considering the known negative effects of routinely used intracanal medicaments. This evaluation will be compared with the outcomes from using traditional intracanal medicaments, specifically triple antibiotic paste (TAP) and calcium hydroxide [Ca(OH)
    Materials and methods: The DPSCs were obtained from the third molars of an adult donor. The application of flow cytometry was employed to do a phenotypic analysis on DPSCs using CD90, CD73, CD105, CD34, CD14, and CD45 antibodies. The methylthiazol tetrazolium (MTT) assay was employed to assess cellular viability. The cells were treated with different concentrations of TAP and Ca(OH)
    Results: The characterization of DPSCs was conducted by flow cytometry analysis, which verified the presence of mesenchymal cell surface antigen molecules (CD105, CD73, and CD90) and demonstrated the absence of hematopoietic markers (CD34, CD45, and CD14). Cells treated with concentrations over 0.5 mg/mL of TAP and Ca(OH)
    Conclusion: The cellular viability of the AC-treated cells was superior to that of the TAP and Ca(OH)
    Clinical significance: This study underscores the importance of evaluating alternative root canal medicaments and their effects on DPSCs' growth and vitality. The findings on AC, particularly its influence on the survival and proliferation of DPSCs, offer valuable insights for its probable use as an intracanal medication. This research contributes to the ongoing efforts to identify safer and more effective intracanal treatments, which are crucial for enhancing patient outcomes in endodontic procedures. How to cite this article: Alazemi MJ, Badawi MF, Elbeltagy MG,
    MeSH term(s) Humans ; Dental Pulp ; Dental Pulp Cavity ; Cell Survival ; Anti-Bacterial Agents/pharmacology ; Calcium Hydroxide/pharmacology ; Cell Proliferation ; Triterpenes
    Chemical Substances asiaticoside (PKO39VY215) ; Anti-Bacterial Agents ; Calcium Hydroxide (PF5DZW74VN) ; Triterpenes
    Language English
    Publishing date 2024-02-01
    Publishing country India
    Document type Journal Article
    ISSN 1526-3711
    ISSN (online) 1526-3711
    DOI 10.5005/jp-journals-10024-3636
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: A novel intra-tumoral drug delivery carrier for treatment of oral squamous cell carcinoma.

    Elsaady, Shimaa A / Aboushelib, Moustafa N / Al-Wakeel, Essam / Badawi, Manal F

    Scientific reports

    2023  Volume 13, Issue 1, Page(s) 11984

    Abstract: The treatment of oral squamous cell carcinoma (OSCC) includes systemic chemotherapy and is associated with aggressive side effects on patients. This study evaluated a new intra-tumor-targeted drug delivery method for the treatment of OSCC induced on the ... ...

    Abstract The treatment of oral squamous cell carcinoma (OSCC) includes systemic chemotherapy and is associated with aggressive side effects on patients. This study evaluated a new intra-tumor-targeted drug delivery method for the treatment of OSCC induced on the dorsum of the tongue in white mice. The induced tumors were examined by needle biopsy. A targeted anticancer drug (Cetuximab) and [Cisplatin and 5 Fluorouracil (5-FU)] chemotherapeutic agents were loaded on polyethylene glycol-polylactide-polyethylene glycol (PEG-PLA-PEG) nanoparticles (NPs) designed for intralesional injection while systemic administration was used as control. Fourier transform infrared spectroscopy (FTIR) was performed to study NP chemical structure, a drug release profile was conducted to study release kinetics, and histopathological evaluation was performed before and after treatment to evaluate tissue reactions (n-28, ά = 0.05). The drug release profile was characteristic of the chemotherapeutic agent showing early quick ascend followed by sustained slow release. FTIR peaks identified the polymeric structure of the drug nano-carrier. Histopathologic examination of chemically induced OSCC revealed different grades ranging from non-invasive to invasive stages of OSCC. Intra-tumoral test group revealed significant remission of observed cancer grade compared to the systemically administered group (X
    MeSH term(s) Mice ; Animals ; Drug Carriers/chemistry ; Carcinoma, Squamous Cell/drug therapy ; Mouth Neoplasms/drug therapy ; Squamous Cell Carcinoma of Head and Neck ; Drug Delivery Systems ; Polyethylene Glycols/chemistry ; Fluorouracil ; Head and Neck Neoplasms ; Nanoparticles/chemistry ; Cell Line, Tumor
    Chemical Substances Drug Carriers ; polyethylene glycol-polylactide-polyethylene glycol ; Polyethylene Glycols (3WJQ0SDW1A) ; Fluorouracil (U3P01618RT)
    Language English
    Publishing date 2023-07-25
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-023-38230-6
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Study of the effect of different surface treatments and surface roughness of veneered crowns on shear bond strength of ceramic brackets.

    Hammad, Shaza M / Badawi, Manal F / Ghazy, Mohamed H

    International journal of orthodontics (Milwaukee, Wis.)

    2011  Volume 22, Issue 2, Page(s) 31–37

    Abstract: The orthodontist is often faced with the problem of bonding brackets to ceramic restorations. The purpose of this study was to find the most reliable method for bonding ceramic brackets onto ceramic crowns. ...

    Abstract The orthodontist is often faced with the problem of bonding brackets to ceramic restorations. The purpose of this study was to find the most reliable method for bonding ceramic brackets onto ceramic crowns.
    MeSH term(s) Acid Etching, Dental ; Air Abrasion, Dental ; Analysis of Variance ; Ceramics ; Crowns ; Dental Bonding ; Dental Stress Analysis ; Dental Veneers ; Friction ; Humans ; Metal Ceramic Alloys ; Microscopy, Electron, Scanning ; Orthodontic Brackets ; Resin Cements ; Shear Strength ; Silicates ; Silicon Dioxide ; Statistics, Nonparametric ; Surface Properties ; Tooth Preparation/methods
    Chemical Substances Metal Ceramic Alloys ; Resin Cements ; Silicates ; Silicon Dioxide (7631-86-9)
    Language English
    Publishing date 2011
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2077898-3
    ISSN 1539-1450 ; 1048-1990
    ISSN 1539-1450 ; 1048-1990
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4662: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  5. Article ; Online: Microtensile bond strength of etch and rinse versus self-etch adhesive systems.

    Hamouda, Ibrahim M / Samra, Nagia R / Badawi, Manal F

    Journal of the mechanical behavior of biomedical materials

    2011  Volume 4, Issue 3, Page(s) 461–466

    Abstract: The aim of this study was to compare the microtensile bond strength of the etch and rinse adhesive versus one-component or two-component self-etch adhesives. Twelve intact human molar teeth were cleaned and the occlusal enamel of the teeth was removed. ... ...

    Abstract The aim of this study was to compare the microtensile bond strength of the etch and rinse adhesive versus one-component or two-component self-etch adhesives. Twelve intact human molar teeth were cleaned and the occlusal enamel of the teeth was removed. The exposed dentin surfaces were polished and rinsed, and the adhesives were applied. A microhybride composite resin was applied to form specimens of 4 mm height and 6 mm diameter. The specimens were sectioned perpendicular to the adhesive interface to produce dentin-resin composite sticks, with an adhesive area of approximately 1.4 mm(2). The sticks were subjected to tensile loading until failure occurred. The debonded areas were examined with a scanning electron microscope to determine the site of failure. The results showed that the microtensile bond strength of the etch and rinse adhesive was higher than that of one-component or two-component self-etch adhesives. The scanning electron microscope examination of the dentin surfaces revealed adhesive and mixed modes of failure. The adhesive mode of failure occurred at the adhesive/dentin interface, while the mixed mode of failure occurred partially in the composite and partially at the adhesive/dentin interface. It was concluded that the etch and rinse adhesive had higher microtensile bond strength when compared to that of the self-etch adhesives.
    MeSH term(s) Acrylic Resins ; Adhesives ; Analysis of Variance ; Composite Resins ; Dental Etching ; Humans ; Materials Testing ; Microscopy, Electron, Scanning ; Polyurethanes ; Tensile Strength
    Chemical Substances Acrylic Resins ; Adhesives ; Composite Dental Resin ; Composite Resins ; Polyurethanes
    Language English
    Publishing date 2011-04
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2378381-3
    ISSN 1878-0180 ; 1751-6161
    ISSN (online) 1878-0180
    ISSN 1751-6161
    DOI 10.1016/j.jmbbm.2010.12.007
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  6. Article ; Online: Effect of surface conditioning and taper angle on the retention of IPS e.max Press crowns.

    Madina, Manal M A / Ozcan, Mutlu / Badawi, Manal F

    Journal of prosthodontics : official journal of the American College of Prosthodontists

    2010  Volume 19, Issue 3, Page(s) 200–204

    Abstract: Purpose: The objective of this study was to evaluate the retentive strength of single-unit crowns with 10 degrees and 26 degrees taper angles cemented using two surface conditioning methods.: Materials and methods: Thirty-two freshly extracted sound ... ...

    Abstract Purpose: The objective of this study was to evaluate the retentive strength of single-unit crowns with 10 degrees and 26 degrees taper angles cemented using two surface conditioning methods.
    Materials and methods: Thirty-two freshly extracted sound human molars were divided into two groups (n = 16) and prepared in a standardized manner with 10 degrees and 26 degrees taper angles. All-ceramic (IPS e.max Press) single crowns were fabricated for the prepared teeth. The crowns were then subdivided into two groups (n = 8), according to type of surface conditioning for the intaglio surfaces. Half the groups were HF acid etched and silanized, and the other half were conditioned with tribochemical silica coating and silanization. The crowns were cemented using adhesive cement (Panavia F 2.0). Retentive strength was measured in a universal testing machine.
    Results: No significant difference was found between the mean retention forces for both 10 degrees and 26 degrees taper angles when the crowns were conditioned either with silica coating (613 +/- 190 N and 525 +/- 90 N, respectively), or with hydrofluoric (HF) acid etching and silanization (550 +/- 110 N and 490 +/- 130 N for 10 degrees and 26 degrees, respectively) (p= 0.32).
    Conclusion: Neither the surface conditioning type, nor the taper angle affected the retentive strength of IPS e.max Press single-unit crowns when cemented adhesively. Since silica coating and silanization did not show significant differences from HF acid gel and silanization, the former can be preferred for conditioning intaglio surfaces of glass ceramic crowns to avoid the use of the hazardous compound HF acid gel chairside.
    MeSH term(s) Acid Etching, Dental/methods ; Aluminum Oxide/chemistry ; Cementation/methods ; Coated Materials, Biocompatible/chemistry ; Crowns ; Dental Bonding ; Dental Etching/methods ; Dental Porcelain/chemistry ; Dental Prosthesis Retention ; Dental Stress Analysis/instrumentation ; Humans ; Hydrofluoric Acid/chemistry ; Materials Testing ; Resin Cements/chemistry ; Silanes/chemistry ; Silicon Dioxide/chemistry ; Stress, Mechanical ; Surface Properties ; Tooth Preparation, Prosthodontic/methods
    Chemical Substances Coated Materials, Biocompatible ; IPS e.max Press ; Panavia-Fluoro ; Resin Cements ; Silanes ; Dental Porcelain (12001-21-7) ; Silicon Dioxide (7631-86-9) ; Aluminum Oxide (LMI26O6933) ; Hydrofluoric Acid (RGL5YE86CZ)
    Language English
    Publishing date 2010-04
    Publishing country United States
    Document type Comparative Study ; Journal Article ; Randomized Controlled Trial
    ZDB-ID 1197213-0
    ISSN 1532-849X ; 1059-941X
    ISSN (online) 1532-849X
    ISSN 1059-941X
    DOI 10.1111/j.1532-849X.2009.00547.x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4029: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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