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  1. AU="Badeński, Andrzej"
  2. AU="Esponda, Omar"
  3. AU="Laliève, Laura"
  4. AU="Sarah L. Quigley"
  5. AU="Von Kodolitsch, Y."
  6. AU="Stone, Louise"
  7. AU="Herrera, Yadira"
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  18. AU="Lebrero, María Eugenia"
  19. AU="Beukenhorst, Anna L"
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  1. Article ; Online: A Rare De Novo Mutation in the

    Badeńska, Marta / Pac, Małgorzata / Badeński, Andrzej / Rutkowska, Karolina / Czubilińska-Łada, Justyna / Płoski, Rafał / Bohynikova, Nadezda / Szczepańska, Maria

    International journal of molecular sciences

    2024  Volume 25, Issue 8

    Abstract: Idiopathic nephrotic syndrome is the most common chronic glomerular disease in children. Treatment with steroids is usually successful; however, in a small percentage of patients, steroid resistance is observed. The most frequent histologic kidney ... ...

    Abstract Idiopathic nephrotic syndrome is the most common chronic glomerular disease in children. Treatment with steroids is usually successful; however, in a small percentage of patients, steroid resistance is observed. The most frequent histologic kidney feature of steroid-resistant nephrotic syndrome (SRNS) is focal segmental glomerulosclerosis (FSGS). Genetic testing has become a valuable diagnostic tool in defining the etiology of SRNS, leading to the identification of a genetic cause. The
    MeSH term(s) Humans ; Male ; Nephrotic Syndrome/genetics ; Nephrotic Syndrome/drug therapy ; Nephrotic Syndrome/congenital ; Adolescent ; Glomerulosclerosis, Focal Segmental/genetics ; Glomerulosclerosis, Focal Segmental/drug therapy ; Mutation ; Carrier Proteins/genetics ; Nerve Tissue Proteins
    Chemical Substances TRIM8 protein, human ; Carrier Proteins ; Nerve Tissue Proteins
    Language English
    Publishing date 2024-04-19
    Publishing country Switzerland
    Document type Case Reports
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms25084486
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Assessment of Brain-Derived Neurotrophic Factor (BDNF) Concentration in Children with Idiopathic Nephrotic Syndrome.

    Badeński, Andrzej / Badeńska, Marta / Świętochowska, Elżbieta / Didyk, Agnieszka / Morawiec-Knysak, Aurelia / Szczepańska, Maria

    International journal of molecular sciences

    2022  Volume 23, Issue 20

    Abstract: Idiopathic nephrotic syndrome (INS) is a chronic disease affecting children in early childhood. It is characterized by proteinuria, hypoalbuminemia, edema and hyperlipidemia. To date, the diagnosis is usually established at an advanced stage of ... ...

    Abstract Idiopathic nephrotic syndrome (INS) is a chronic disease affecting children in early childhood. It is characterized by proteinuria, hypoalbuminemia, edema and hyperlipidemia. To date, the diagnosis is usually established at an advanced stage of proteinuria. Therefore, new methods of early INS detection are desired. This study was designed to assess brain-derived neurotrophic factor (BDNF) as a potential marker in the early diagnosis of INS. The study group included patients with a diagnosis of idiopathic nephrotic syndrome (
    MeSH term(s) Child ; Humans ; Child, Preschool ; Nephrotic Syndrome/metabolism ; Brain-Derived Neurotrophic Factor ; Proteinuria/urine ; Biomarkers
    Chemical Substances Brain-Derived Neurotrophic Factor ; Biomarkers
    Language English
    Publishing date 2022-10-14
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms232012312
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: The Role of Brain-Derived Neurotrophic Factor (BDNF) in Diagnosis and Treatment of Epilepsy, Depression, Schizophrenia, Anorexia Nervosa and Alzheimer's Disease as Highly Drug-Resistant Diseases: A Narrative Review.

    Gliwińska, Aleksandra / Czubilińska-Łada, Justyna / Więckiewicz, Gniewko / Świętochowska, Elżbieta / Badeński, Andrzej / Dworak, Marta / Szczepańska, Maria

    Brain sciences

    2023  Volume 13, Issue 2

    Abstract: Brain-derived neurotrophic factor (BDNF) belongs to the family of neurotrophins, which are growth factors with trophic effects on neurons. BDNF is the most widely distributed neurotrophin in the central nervous system (CNS) and is highly expressed in the ...

    Abstract Brain-derived neurotrophic factor (BDNF) belongs to the family of neurotrophins, which are growth factors with trophic effects on neurons. BDNF is the most widely distributed neurotrophin in the central nervous system (CNS) and is highly expressed in the prefrontal cortex (PFC) and hippocampus. Its distribution outside the CNS has also been demonstrated, but most studies have focused on its effects in neuropsychiatric disorders. Despite the advances in medicine in recent decades, neurological and psychiatric diseases are still characterized by high drug resistance. This review focuses on the use of BDNF in the developmental assessment, treatment monitoring, and pharmacotherapy of selected diseases, with a particular emphasis on epilepsy, depression, anorexia, obesity, schizophrenia, and Alzheimer's disease. The limitations of using a molecule with such a wide distribution range and inconsistent method of determination are also highlighted.
    Language English
    Publishing date 2023-01-18
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2651993-8
    ISSN 2076-3425
    ISSN 2076-3425
    DOI 10.3390/brainsci13020163
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Assessment of Interleukin-15 (IL-15) Concentration in Children with Idiopathic Nephrotic Syndrome.

    Badeński, Andrzej / Badeńska, Marta / Świętochowska, Elżbieta / Janek, Artur / Gliwińska, Aleksandra / Morawiec-Knysak, Aurelia / Szczepańska, Maria

    International journal of molecular sciences

    2023  Volume 24, Issue 8

    Abstract: Idiopathic nephrotic syndrome (INS) is a chronic glomerular disease in children, characterized by severe proteinuria, hypoalbuminemia, and/or presence of edema and hyperlipidemia. The pathogenesis, however, has not been yet established. The clinical ... ...

    Abstract Idiopathic nephrotic syndrome (INS) is a chronic glomerular disease in children, characterized by severe proteinuria, hypoalbuminemia, and/or presence of edema and hyperlipidemia. The pathogenesis, however, has not been yet established. The clinical course of the disease is characterized by frequent relapses. Interleukin-15 (IL-15) is a pro-inflammatory cytokine, that apart from its involvement in the immune system, was found to be playing a vital role in various cells' functioning, including renal tissue. It is desirable to look for new predictors of INS. Our study aimed to evaluate IL-15 as a potential marker in the early diagnosis of the disease. The cohort participating in the study consisted of patients hospitalized in Clinical Hospital No. 1 in Zabrze, from December 2019 to December 2021, including study group with INS (
    MeSH term(s) Humans ; Child ; Nephrotic Syndrome/diagnosis ; Interleukin-15 ; Proteinuria/diagnosis ; Proteinuria/etiology ; Cytokines
    Chemical Substances Interleukin-15 ; Cytokines
    Language English
    Publishing date 2023-04-10
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms24086993
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Associations between renalase concentration and the occurrence of selected diseases.

    Czubilińska-Łada, Justyna / Gliwińska, Aleksandra / Badeński, Andrzej / Szczepańska, Maria

    Endokrynologia Polska

    2020  Volume 71, Issue 4, Page(s) 334–342

    Abstract: Renalase is a recently identified flavoprotein oxidase, secreted mainly by the kidneys, which takes part in the degradation of catecholamines. The catecholamine inactivating effect results in the modulation of the sympathetic system tension and, ... ...

    Abstract Renalase is a recently identified flavoprotein oxidase, secreted mainly by the kidneys, which takes part in the degradation of catecholamines. The catecholamine inactivating effect results in the modulation of the sympathetic system tension and, consequently, in a decrease of blood pressure, myocardial contractility, heart rate, and vascular tone. Besides its enzymatic capacity, renalase shows cytoprotective properties by activating mitogen-activated protein kinase (MAPK) pathway. Several single nucleotide polymorphisms (SNPs) of the renalase gene have been identified, of which the most widely studied in relation to the development of selected diseases are rs2296545, rs10887800, and rs2576178. Numerous publications prove the contribution of renalase to the occurrence of cardiovascular diseases, kidney diseases, ischaemic stroke, diabetes type 1 and 2, as well as female infertility and schizophrenia. Further extended research into the various mechanisms of renalase activity may result in the use of this oxidase or its analogues as a therapeutic and/or diagnostic tool.
    MeSH term(s) Cardiovascular Diseases/enzymology ; Diabetes Mellitus/enzymology ; Female ; Humans ; Infertility, Female/enzymology ; Kidney Diseases/enzymology ; Male ; Monoamine Oxidase/metabolism ; Schizophrenia/enzymology ; Sympathetic Nervous System/physiology
    Chemical Substances Monoamine Oxidase (EC 1.4.3.4) ; renalase (EC 1.4.3.4.)
    Language English
    Publishing date 2020-08-27
    Publishing country Poland
    Document type Journal Article ; Review
    ZDB-ID 419270-9
    ISSN 2299-8306 ; 0423-104X
    ISSN (online) 2299-8306
    ISSN 0423-104X
    DOI 10.5603/EP.a2020.0044
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 204: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  6. Article: The influence of cord blood renalase and advanced oxidation protein products (AOPPs) on perinatal and anthropometric parameters of newborns of mothers with gestational hypertension.

    Czubilińska-Łada, Justyna / Badeński, Andrzej / Świętochowska, Elżbieta / Nowak-Borzęcka, Lucyna / Sadownik, Beata / Behrendt, Jakub / Szczepańska, Maria

    Advances in clinical and experimental medicine : official organ Wroclaw Medical University

    2022  Volume 31, Issue 9, Page(s) 973–979

    Abstract: Background: Renalase is an enzyme secreted by the kidneys, which takes part in the regulation of arterial pressure, myocardial contractility and modulation of vascular resistance, but its effect on renalase levels in newborns has not been studied yet. ... ...

    Abstract Background: Renalase is an enzyme secreted by the kidneys, which takes part in the regulation of arterial pressure, myocardial contractility and modulation of vascular resistance, but its effect on renalase levels in newborns has not been studied yet. The levels of advanced oxidation protein products (AOPPs) were also evaluated as a marker of oxidative stress.
    Objectives: This study examined whether renalase and AOPP levels are different in the cord blood of newborns exposed to gestational hypertension (HT). The association of both factors with perinatal and anthropometric data among the studied patients was assessed.
    Material and methods: The study included 89 newborns: 30 newborns from the study group, whose mothers were diagnosed with gestational HT, and 59 newborns born from normal pregnancies, who formed the control group. Anthropometric measurements and perinatal data in newborns in both groups were recorded.
    Results: A significantly lower (p < 0.001) concentration of renalase was found in the study group (median (Q1-Q3): 23.96 μg/mL (20.63-26.91 μg/mL)) as compared to the control group (median (Q1-Q3): 37.54 μg/mL (33.78-40.02 μg/mL)). In case of AOPPs, a significantly higher (p < 0.001) concentration of AOPPs was observed in the study group (median (Q1-Q3): 131.65 μmol/L (113.80-146.10 μmol/L)) than in the controls (median (Q1-Q3): 93.70 μmol/L (87.10-111.20 μmol/L)).
    Conclusions: A significant difference between renalase and AOPP concentrations between the study and control groups has been demonstrated. Both factors may influence anthropometric and perinatal outcomes of newborns.
    MeSH term(s) Advanced Oxidation Protein Products ; Female ; Fetal Blood ; Humans ; Hypertension, Pregnancy-Induced/diagnosis ; Infant, Newborn ; Monoamine Oxidase ; Pregnancy
    Chemical Substances Advanced Oxidation Protein Products ; Monoamine Oxidase (EC 1.4.3.4) ; renalase (EC 1.4.3.4.)
    Language English
    Publishing date 2022-06-02
    Publishing country Poland
    Document type Journal Article
    ZDB-ID 2270257-X
    ISSN 1899-5276 ; 1230-025X
    ISSN 1899-5276 ; 1230-025X
    DOI 10.17219/acem/149399
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6489: Show issues Location:
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  7. Article ; Online: A "mysterious ghost kidney stone" in an 8-year-old boy with a solitary right kidney, obstructive megaureter, and ureterostomy: Answers.

    Badeński, Andrzej / Bjanid, Omar / Badeńska, Marta / Chmiela, Bartosz / Adamczyk, Piotr / Kudela, Grzegorz / Moskal, Grzegorz / Szczepańska, Maria

    Pediatric nephrology (Berlin, Germany)

    2020  Volume 36, Issue 4, Page(s) 865–868

    Language English
    Publishing date 2020-07-21
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 631932-4
    ISSN 1432-198X ; 0931-041X
    ISSN (online) 1432-198X
    ISSN 0931-041X
    DOI 10.1007/s00467-020-04709-x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2196: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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  8. Article ; Online: A "mysterious ghost kidney stone" in an 8-year-old boy with a solitary right kidney, obstructive megaureter and ureterostomy: Questions.

    Badeński, Andrzej / Bjanid, Omar / Badeńska, Marta / Chmiela, Bartosz / Adamczyk, Piotr / Kudela, Grzegorz / Moskal, Grzegorz / Szczepańska, Maria

    Pediatric nephrology (Berlin, Germany)

    2020  Volume 36, Issue 4, Page(s) 863–864

    Language English
    Publishing date 2020-07-21
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 631932-4
    ISSN 1432-198X ; 0931-041X
    ISSN (online) 1432-198X
    ISSN 0931-041X
    DOI 10.1007/s00467-020-04707-z
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2196: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  9. Article ; Online: Atypical Hemolytic Uremic Syndrome (aHUS) and Adenosine Deaminase (ADA)-Deficient Severe Combined Immunodeficiency (SCID)-Two Diseases That Exacerbate Each Other: Case Report.

    Bogdał, Anna / Badeński, Andrzej / Pac, Małgorzata / Wójcicka, Anna / Badeńska, Marta / Didyk, Agnieszka / Trembecka-Dubel, Elżbieta / Dąbrowska-Leonik, Nel / Walaszczyk, Małgorzata / Matysiak, Natalia / Morawiec-Knysak, Aurelia / Szczepański, Tomasz / Szczepańska, Maria

    International journal of molecular sciences

    2021  Volume 22, Issue 17

    Abstract: Hemolytic uremic syndrome (HUS) is defined by the triad of microangiopathic hemolytic anemia, thrombocytopenia, and acute kidney injury (AKI). Atypical HUS (aHUS), distinguished by its etiology, is caused by uncontrolled overactivation of the alternative ...

    Abstract Hemolytic uremic syndrome (HUS) is defined by the triad of microangiopathic hemolytic anemia, thrombocytopenia, and acute kidney injury (AKI). Atypical HUS (aHUS), distinguished by its etiology, is caused by uncontrolled overactivation of the alternative complement pathway. The correct diagnosis of aHUS is complex and involves various gene mutations. Severe combined immunodeficiency (SCID), characterized by severe T-cell lymphocytopenia and a lack of antigen-specific T-cell and B-cell immune responses, is of seldom occurrence. In 10-15% of pediatric patients, SCID is caused by adenosine deaminase (ADA) deficiency. The authors describe the case of a boy who suffered from both aHUS and ADA-deficient SCID. At the age of 9 months, the patient presented acute kidney injury with anuria and coagulopathy. The diagnosis of aHUS was established on the basis of alternative complement pathway deregulation and disease-associated gene mutations. Further examination revealed immune system failure and, at the age of 13 months, the ADA deficiency was confirmed by genetic tests and the boy was diagnosed with ADA-SCID. ADA SCID has recently been described as a possible triggering factor of aHUS development and progression. However, more research is required in this field. Nevertheless, it is crucial in clinical practice to be aware of these two co-existing life-threatening diseases.
    MeSH term(s) Acute Kidney Injury/complications ; Acute Kidney Injury/diagnosis ; Adenosine Deaminase/metabolism ; Agammaglobulinemia/complications ; Agammaglobulinemia/diagnosis ; Agammaglobulinemia/physiopathology ; Anemia, Hemolytic/diagnosis ; Atypical Hemolytic Uremic Syndrome/diagnosis ; Atypical Hemolytic Uremic Syndrome/physiopathology ; Comorbidity ; Humans ; Infant ; Male ; Mutation/genetics ; Severe Combined Immunodeficiency/complications ; Severe Combined Immunodeficiency/diagnosis ; Severe Combined Immunodeficiency/physiopathology ; Thrombocytopenia/diagnosis ; Thrombotic Microangiopathies/diagnosis
    Chemical Substances Adenosine Deaminase (EC 3.5.4.4)
    Language English
    Publishing date 2021-08-31
    Publishing country Switzerland
    Document type Case Reports
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms22179479
    Database MEDical Literature Analysis and Retrieval System OnLINE

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