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Article ; Online: Conjugate treatment with high concentration normobaric oxygen and hyaluronic acid for vaginal atrophy: a prospective study.

Barbero, M / Villasco, A / Villa, M / Badellino, E / Marello, E / Botta, G

European review for medical and pharmacological sciences

2023 Volume 27, Issue 5, Page(s) 2011–2017

Abstract: Objective: Vulvovaginal atrophy is a condition closely related to low circulating estrogen levels, with post-menopause being the main cause. However, patients of childbearing age may also present with these symptoms due to treatments that reduce ... ...

Abstract	Objective: Vulvovaginal atrophy is a condition closely related to low circulating estrogen levels, with post-menopause being the main cause. However, patients of childbearing age may also present with these symptoms due to treatments that reduce estrogen production. Local estrogen therapy is the causal treatment of local symptoms, but it is not always accepted and is often abandoned by patients. In recent years, alternative therapies have been proposed: fractional CO2 laser or the conjugate treatment with normobaric oxygen and hyaluronic acid, the latter being the subject of this study. The study aimed to evaluate the effectiveness of conjugate topical treatment with normobaric oxygen and hyaluronic acid. Patients and methods: 50 patients were evaluated and treated with 5 applications of 15 minutes each, every 15 days, with Caressflow®. All patients presented at least one of the symptoms related to vulvovaginal atrophy: dryness, burning, and dyspareunia. In all cases, vulvoscopy, colposcopy, and cervicovaginal cytology were performed. The patients were interviewed with an analogic scale (VAS) concerning the severity of symptoms before and after the treatment. Colposcopy and PAP-smear were assessed by mean of Vaginal Health Index Score (VHI) at baseline and at the end of the treatment. Results: All patients completed the treatment scheme and presented with a significant improvement in subjective symptoms. The colposcopy and PAP-smear performed 10 days after the end of the last treatment showed a significant improvement in the appearance and elasticity of the vaginal epithelium and the cytological picture, which showed, in the sample taken after treatment, hyaluronic acid vesicles within the cell cytoplasm. Conclusions: This study corroborates the data presented in the latest published papers on the effectiveness of treatment with normobaric O2 and hyaluronic acid on vaginal atrophy. Efficacy has been confirmed both in terms of subjective symptoms reported by the patients and objective improvement at colposcopy and PAP-smear cytology.
MeSH term(s)	Female ; Humans ; Hyaluronic Acid/therapeutic use ; Prospective Studies ; Oxygen ; Treatment Outcome ; Vulva/pathology ; Atrophy/pathology ; Vaginal Diseases ; Vagina/pathology ; Estrogens ; Lasers, Gas
Chemical Substances	Hyaluronic Acid (9004-61-9) ; Oxygen (S88TT14065) ; Estrogens
Language	English
Publishing date	2023-03-17
Publishing country	Italy
Document type	Journal Article
ZDB-ID	605550-3
ISSN	2284-0729 ; 1128-3602 ; 0392-291X
ISSN (online)	2284-0729
ISSN	1128-3602 ; 0392-291X
DOI	10.26355/eurrev_202303_31567
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Article ; Online: Development and clinical application of a tool to identify frailty in elderly patients with gynecological cancers.

Ferrero, Annamaria / Massobrio, Roberta / Villa, Michela / Badellino, Enrico / Sanjinez, Jeremy Oscar Smith Pezua / Giorgi, Margherita / Testi, Alessandra / Govone, Francesca / Attianese, Daniela / Biglia, Nicoletta

International journal of gynecological cancer : official journal of the International Gynecological Cancer Society

2023

Abstract: Objective: Frailty is more reliable than chronological age in predicting the effectiveness and tolerability of treatments in cancer patients. An increasing number of screening tools have been proposed, however none have received unanimous consent or ... ...

Abstract	Objective: Frailty is more reliable than chronological age in predicting the effectiveness and tolerability of treatments in cancer patients. An increasing number of screening tools have been proposed, however none have received unanimous consent or been specifically designed for women with gynecological malignancies.This study's aim was to develop a clinical application of a screening tool to identify frail patients >70 years old diagnosed with either ovarian or endometrial cancers. Methods: A 20 item questionnaire was developed and administered to the cohort before surgery or neoadjuvant chemotherapy. A cut-off for frailty definition was determined by analyzing the correlation of questionnaire scores with the completion of treatments. The association between frailty and treatment related complications was assessed using a Chi-squared test for categorical variables and a t-test for continuous variables. Results: Our study included 100 patients, 50% diagnosed with endometrial cancer and 50% with ovarian cancer. A questionnaire score of 4 was the best cut-off for frailty definition (sensitivity 77%, specificity 100%). Surgical grade III and grade IV complications were observed only in frail patients (p=0.01) and hospitalization was significantly longer in frail women affected by ovarian cancer (p=0.01). Frail patients were more exposed to chemotherapy administration delay (p=0.0005), treatment discontinuation (p=0.001) and hematological toxicities, especially anemia ≥grade 2 (p=0.009) and thrombocytopenia any grade (p=0.0001). Conclusion: With a cut-off score of 4, our tool can identify frail patients with significantly higher incidence of grade III-IV postoperative complications, length of stay, medical treatment discontinuation rates and hematological toxicities.
Language	English
Publishing date	2023-07-24
Publishing country	England
Document type	Journal Article
ZDB-ID	1070385-8
ISSN	1525-1438 ; 1048-891X
ISSN (online)	1525-1438
ISSN	1048-891X
DOI	10.1136/ijgc-2023-004306
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Article ; Online: Ultrasonographic diagnosis of adnexal masses: interobserver agreement in the interpretation of videos, using IOTA terminology.

Massobrio, Roberta / Mariani, Luca Liban / Conti, Daniele / De Grandis, Tiziana / Buonomo, Francesca / Badellino, Enrico / Novara, Lorenzo / Bounous, Valentina Elisabetta / Perotto, Stefania / Mancarella, Matteo / Ferrero, Annamaria / Biglia, Nicoletta / Fuso, Luca

Archives of gynecology and obstetrics

2023 Volume 309, Issue 1, Page(s) 211–218

Abstract: Objectives: Aim of this study is to estimate interobserver agreement in classifying adnexal tumors using IOTA terms, simple rules and subjective assessment. In addition, we related observers' accuracy with their experience in gynecological ... ...

Abstract	Objectives: Aim of this study is to estimate interobserver agreement in classifying adnexal tumors using IOTA terms, simple rules and subjective assessment. In addition, we related observers' accuracy with their experience in gynecological ultrasonography and the year of IOTA certification. Methods: Eleven observers with three different levels of experience evaluated videoclips of 70 adnexal masses, defining tumor type according to IOTA terms and definitions, classifying the mass using IOTA Simple rules and Subjective assessment as well as providing Color Score evaluation. Sensitivity, specificity and area under the ROC curve were calculated and the year of IOTA certification was related with operators' accuracy through Pearson correlation coefficient. Interobserver agreement was estimated calculating percentage of agreement, Fleiss kappa and Cohen's kappa. Results: We found a positive correlation between the year of IOTA certification and operators' accuracy (Pearson coefficient 0.694), especially among the observers with the least experience, the residents (p = 0.003). For tumor type classification, identification of papillary projections and classification of tumors using subjective assessment, agreement among all observers was moderate (Fleiss kappa 0.455, 0.552, and 0.476, respectively) and increased with the years of experience. Agreement in the application of Simple Rules was moderate in all examiners with IOTA certification, with Fleiss kappa in the range of (0.403, 0.498). For Color Score assignment interobserver agreement among all observers was fair (Cohen's kappa 0.380). Conclusions: Even among expert examiners, the results of adnexal lesion assessment can be inconsistent. Experience impacts on accuracy and agreement in subjective assessment, while the application of Simple Rules can mitigate the role of experience in interobserver agreement. The knowledge of IOTA models among residents seams to improve their diagnostic accuracy, showing the benefits of IOTA terminology for in training sonographers.
MeSH term(s)	Female ; Humans ; Diagnosis, Differential ; Observer Variation ; Ultrasonography ; ROC Curve ; Adnexal Diseases/diagnosis ; Neoplasms ; Sensitivity and Specificity ; Ovarian Neoplasms/pathology
Language	English
Publishing date	2023-10-04
Publishing country	Germany
Document type	Journal Article
ZDB-ID	896455-5
ISSN	1432-0711 ; 0932-0067
ISSN (online)	1432-0711
ISSN	0932-0067
DOI	10.1007/s00404-023-07233-z
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Article ; Online: Immunonutrition in ovarian cancer: clinical and immunological impact?

Ferrero, Annamaria / Vassallo, Daniela / Geuna, Massimo / Fuso, Luca / Villa, Michela / Badellino, Enrico / Barboni, Martina / Coata, Paola / Santoro, Nathalie / Delgado Bolton, Roberto C / Biglia, Nicoletta

Journal of gynecologic oncology

2022 Volume 33, Issue 6, Page(s) e77

Abstract: Objective: Malnutrition is frequent in ovarian cancer (OC) patients and may compromise post-operative outcomes. The aim of this study is to evaluate the impact of pre-operative immunonutrition on the surgical outcome of OC patients, and on their ... ...

Abstract	Objective: Malnutrition is frequent in ovarian cancer (OC) patients and may compromise post-operative outcomes. The aim of this study is to evaluate the impact of pre-operative immunonutrition on the surgical outcome of OC patients, and on their nutritional, inflammatory and peripheral blood immune status. Methods: A prospective study was performed between September 2016 and April 2020. Immune-enhancing enteral nutrition was administered to 42 patients before surgery according to their nutritional status assessed by the Malnutritional Universal Screening Tool. Biochemical and hematological monitoring was performed before and after immunonutrition. Post-operative outcomes were assessed and compared with those of a similar group of patients treated without nutritional support. Results: Of the 42 immune-nourished patients, 23 (54.8%) had a low, 11 (26.2%) an intermediate and 8 (19%) a high risk of malnutrition. After the immunonutritional intake, significant variations of prealbumin, creatinine and white blood cells were detected. All T cell populations had an increasing trend, in particular CD3 Conclusion: Pre-operative immunonutrition improves the surgical outcome of OC patients. After immunonutrition, an increase of CD3
MeSH term(s)	Humans ; Female ; Prospective Studies ; Enteral Nutrition ; Ovarian Neoplasms/surgery ; Carcinoma, Ovarian Epithelial ; Malnutrition/therapy ; Postoperative Complications/epidemiology ; Postoperative Complications/prevention & control
Language	English
Publishing date	2022-08-12
Publishing country	Korea (South)
Document type	Journal Article
ZDB-ID	2478405-9
ISSN	2005-0399 ; 2005-0380
ISSN (online)	2005-0399
ISSN	2005-0380
DOI	10.3802/jgo.2022.33.e77
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Zs.A 6484: Show issues

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Article: Valutazione del rischio da movimentazione manuale dei carichi nel reparto ortofrutta in un esercizio commerciale di medie dimensioni.

Draicchio, F / Silvetti, A / Badellino, E / Vinci, F

Giornale italiano di medicina del lavoro ed ergonomia

2007 Volume 29, Issue 3 Suppl, Page(s) 573–575

Abstract: There is little in the literature about the risks of manual handling of material in supermarkets and what there is refers solely to storehouse work. This contrasts with the substantial number of studies of the risk of repeated arm movements among ... ...

Title translation	Biomechanical risk assessment of manual material handling in vegetables and fruit departments of supermarkets.
Abstract	There is little in the literature about the risks of manual handling of material in supermarkets and what there is refers solely to storehouse work. This contrasts with the substantial number of studies of the risk of repeated arm movements among supermarket cash-desk staff. The scarcity of information is partly due to the difficulties of applying widely employed, standardized evaluation methods in this sector. One of the conditions limiting the application of the NIOSH protocol in this retail sector is that lifting tasks are so often closely tied to transport. The biomechanical analysis method we used brought to light considerable risks in many of the steps investigated: unpacking the pallet, unloading the crates from the pallet to the ground, lifting them from the floor onto display stands, and filling the boxes on the stands with goods before the shop opens. Images acquired on site were analyzed in the laboratory. We selected the most indicative images, which were then studied as regards posture and biomechanics using Apalys 3.0 software (ILMCAD GmbH, Ilmenau, Germany). Biomechemical analysis was done on the following movements: unloading crates from the pallet, positioning them on fruit and vegetable department display stands, and filling the boxes on the stands. We obtained a prediction of 2720 to 5472 N for the load at the lumbosacral junction (L5-S1). Simulation of the NIOSH index gave a value of 2.69 in the only case where the Waters protocol could be applied.
MeSH term(s)	Biomechanical Phenomena ; Humans ; Occupational Exposure ; Posture ; Risk Assessment ; Software
Language	Italian
Publishing date	2007-07
Publishing country	Italy
Document type	English Abstract ; Journal Article
ZDB-ID	603103-1
ISSN	1592-7830 ; 0391-9889
ISSN	1592-7830 ; 0391-9889
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Article: Rischio biomeccanico nel settore del trasporto aereo: la movimentazione manuale dei passeggeri a ridotta mobilità (PRM).

Draicchio, F / Campoli, G / Silvetti, A / Badellino, E / Forzano, F / Ranavolo, A / Iavicoli, S / Campagna, G / Raffaele, G / Gismondi, M

Giornale italiano di medicina del lavoro ed ergonomia

2012 Volume 34, Issue 3 Suppl, Page(s) 112–115

Abstract: As the airport traffic increases there is a continuous increase of passengers with different motor disabilities. Disabled passenger's assistance causes a biomechanical overload in airport workers. Some disabled passengers are classified by IATA as WCHC ( ... ...

Title translation	Air transport biomechanical risk: reduced mobility passengers' handling.
Abstract	As the airport traffic increases there is a continuous increase of passengers with different motor disabilities. Disabled passenger's assistance causes a biomechanical overload in airport workers. Some disabled passengers are classified by IATA as WCHC (wheel chair in cabin or Charlie). Our study, was performed in one of the most important Italian airport on Charlie passengers (about 10% of all assistances). We identified four critical points: 1) wheelchair and baggage moving (unstable load), 2) inclined ramps with worker's backwards steps and braked wheelchair to prevent passenger tipping or falling, 3) transfer from standard wheelchair to bicycle wheelchair, specifically designed for the aisle; 4.) transfer from bicycle wheelchair to aircraft seat. The last two points required sometimes to lift passengers over the armrest and positioning them on a window side seat, causing a serious increase of biomechanical load. For each critical point we have proposed technical and organizational measures to reduce airport worker's biomechanical risk.
MeSH term(s)	Airports ; Biomechanical Phenomena ; Disabled Persons ; Humans ; Lifting/adverse effects ; Occupational Exposure/adverse effects ; Risk Factors ; Wheelchairs
Language	Italian
Publishing date	2012-07
Publishing country	Italy
Document type	English Abstract ; Journal Article
ZDB-ID	603103-1
ISSN	1592-7830 ; 0391-9889
ISSN	1592-7830 ; 0391-9889
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Article: Pre-natal (segment II) toxicity study of cinnamic aldehyde in the Sprague-Dawley rat.

Mantovani, A / Stazi, A V / Macri, C / Ricciardi, C / Piccioni, A / Badellino, E

Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association

1989 Volume 27, Issue 12, Page(s) 781–786

Abstract: Cinnamic aldehyde (CA) was administered by gavage to Sprague-Dawley rats on days 7-17 of pregnancy at doses of 5,25 or 250 mg/kg body weight/day. Significantly lower weight gain of the dams was observed at the two higher dose levels. No significant dose- ... ...

Abstract	Cinnamic aldehyde (CA) was administered by gavage to Sprague-Dawley rats on days 7-17 of pregnancy at doses of 5,25 or 250 mg/kg body weight/day. Significantly lower weight gain of the dams was observed at the two higher dose levels. No significant dose-related increase of abnormalities was observed: the incidence of poor cranial ossification was significantly increased in all treated groups, while reduced ossification of the tympanic bulla was increased at 25 or 250 mg/kg/day. Significant increases of the incidences of dilated pelvis/reduced papilla in the kidney, dilated ureters and greater than or equal to 2 abnormal sternebrae per foetus were detected in the 2-mg/kg group, which had the highest overall prevalence of minor abnormalities. Since significant increases in the incidences of reduced cranial ossification, dilated ureters and renal variants were observed at 5 mg/kg, a dose at which there was no detectable maternal toxicity, it is suggested that the foetus might be slightly more sensitive than the adult to the action of CA.
MeSH term(s)	Acrolein/analogs & derivatives ; Acrolein/toxicity ; Aldehydes/toxicity ; Animals ; Bone and Bones/abnormalities ; Female ; Flavoring Agents/toxicity ; Osteogenesis/drug effects ; Pregnancy ; Rats ; Rats, Inbred Strains ; Teratogens ; Urinary Tract/abnormalities
Chemical Substances	Aldehydes ; Flavoring Agents ; Teratogens ; Acrolein (7864XYD3JJ) ; cinnamaldehyde (SR60A3XG0F)
Language	English
Publishing date	1989-12
Publishing country	England
Document type	Journal Article
ZDB-ID	782617-5
ISSN	1873-6351 ; 0278-6915
ISSN (online)	1873-6351
ISSN	0278-6915
DOI	10.1016/0278-6915(89)90108-7
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Zs.A 529: Show issues

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Article: A basis for estimation of consumption: literature values for selected food volatiles. Part III.

De Vincenzi, M / Badellino, E / Di Folco, S / Dracos, A / Magliola, M / Stacchini, A / Stacchini, P / Silano, V

Food additives and contaminants

1989 Volume 6, Issue 2, Page(s) 235–267

Abstract: Quantitative data on volatile compounds have been reported in 16 food items. No publications reporting quantitative data were found for two of these 16 food products, i.e. avocado and jackfruit. About 550 volatile compounds have been assayed globally in ... ...

Abstract	Quantitative data on volatile compounds have been reported in 16 food items. No publications reporting quantitative data were found for two of these 16 food products, i.e. avocado and jackfruit. About 550 volatile compounds have been assayed globally in the other 14 food products. Mango and raspberry were the products with the greatest number of volatile compounds; the most representative substances were benzaldehyde, ethyl acetate, limonene, and 2-phenylethanol.
MeSH term(s)	Flavoring Agents/analysis ; Food Additives/analysis ; Food Analysis ; Oils, Volatile/analysis ; Oils, Volatile/classification ; Volatilization
Chemical Substances	Flavoring Agents ; Food Additives ; Oils, Volatile
Language	English
Publishing date	1989-04
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	49417-3
ISSN	0265-203X
ISSN	0265-203X
DOI	10.1080/02652038909373779
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Article: Teratogenicity study of ammonium glycyrrhizinate in the Sprague-Dawley rat.

Mantovani, A / Ricciardi, C / Stazi, A V / Macri, C / Piccioni, A / Badellino, E / De Vincenzi, M / Caiola, S / Patriarca, M

Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association

1988 Volume 26, Issue 5, Page(s) 435–440

Abstract: Ammonium glycyrrhizinate (AG), a commercially used salt of glycyrrhizic acid, was administered in the drinking-water to Sprague-Dawley rats on days 7-17 of pregnancy. The actual intakes were 0, 21.33 +/- 1.22, 238.75 +/- 17.50 and 679.94 +/- 69.87 mg AG/ ... ...

Abstract	Ammonium glycyrrhizinate (AG), a commercially used salt of glycyrrhizic acid, was administered in the drinking-water to Sprague-Dawley rats on days 7-17 of pregnancy. The actual intakes were 0, 21.33 +/- 1.22, 238.75 +/- 17.50 and 679.94 +/- 69.87 mg AG/kg body weight/day for groups 0, 1, 2 and 3, respectively. AG caused polydipsia in the dams. Foetuses from the treated litters did not present an increase in external malformations, a decrease in weight or a decrease in the degree of ossification. However, there was a slight but significant increase in embryolethality and in the prevalence of external haemorrhages. Skeletal examination revealed a dose-related increase in minor anomalies, especially in the sternebral variants. Renal ectopy also increased significantly at the highest dose. These results indicate that the possible embryotoxicity of aromatizing compounds should be considered.
MeSH term(s)	Aldosterone/blood ; Animals ; Bone and Bones/drug effects ; Bone and Bones/embryology ; Dose-Response Relationship, Drug ; Female ; Fetus/drug effects ; Glycyrrhetinic Acid/analogs & derivatives ; Glycyrrhetinic Acid/toxicity ; Glycyrrhizic Acid ; Potassium/blood ; Pregnancy ; Rats ; Rats, Inbred Strains ; Sodium/blood
Chemical Substances	Aldosterone (4964P6T9RB) ; Glycyrrhizic Acid (6FO62043WK) ; Sodium (9NEZ333N27) ; Glycyrrhetinic Acid (P540XA09DR) ; Potassium (RWP5GA015D)
Language	English
Publishing date	1988-05
Publishing country	England
Document type	Journal Article
ZDB-ID	782617-5
ISSN	1873-6351 ; 0278-6915
ISSN (online)	1873-6351
ISSN	0278-6915
DOI	10.1016/0278-6915(88)90054-3
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Article: Pre-natal (segment II) toxicity study of cinnamic aldehyde in the Sprague-Dawley rat

Mantovani, A / Stazi, A.V / Macri, C / Ricciardi, C / Piccioni, A / Badellino, E

Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. Dec 1989. v. 27 (12)

1989

Keywords	abnormal development ; cinnamic acid ; aldehydes ; toxicity ; dosage ; pregnancy ; weight gain ; ureter ; bone formation ; fetal development ; rats
Language	English
Dates of publication	1989-12
Size	p. 781-786.
Document type	Article
ZDB-ID	782617-5
ISSN	1873-6351 ; 0278-6915
ISSN (online)	1873-6351
ISSN	0278-6915
Database	NAL-Catalogue (AGRICOLA)

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