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  1. Article ; Online: Neuroanatomical and prognostic associations of depression in Parkinson's disease.

    Badenoch, James B / Paris, Alvar / Jacobs, Benjamin Meir / Noyce, Alastair J / Marshall, Charles R / Waters, Sheena

    Journal of neurology, neurosurgery, and psychiatry

    2024  

    Abstract: Background: Depression is reported as a risk factor, prodromal feature and late consequence of Parkinson's disease (PD). We aimed to evaluate the timing, neuroanatomy and prognostic implications of depression in PD.: Methods: We used data from 434 ... ...

    Abstract Background: Depression is reported as a risk factor, prodromal feature and late consequence of Parkinson's disease (PD). We aimed to evaluate the timing, neuroanatomy and prognostic implications of depression in PD.
    Methods: We used data from 434 023 participants from UK Biobank with 14.1 years of follow-up. Multivariable regression models established associations of depression with incident PD and regional brain volumes. Cox proportional hazards models assessed prognostic associations of depression in PD with incident dementia and all-cause mortality.
    Results: Of 2632 individuals with incident PD, 539 (20.5%) were diagnosed with depression at some point. Depression was associated with an increased risk of subsequent PD (risk ratio 1.53, 95% CI 1.37 to 1.72). Among incident PD cases, depression prevalence rose progressively from 10 years pre-PD diagnosis (OR 2.10, 95% CI 1.57 to 2.83) to 10 years postdiagnosis (OR 3.51, 95% CI 1.33 to 9.22). Depression severity in PD was associated with reduced grey matter volume in structures including the thalamus and amygdala. Depression prior to PD diagnosis increased risk of dementia (HR 1.47, 95% CI 1.05 to 2.07) and mortality (HR 1.30, 95% CI 1.07 to 1.58).
    Conclusions: This large-scale prospective study demonstrated that depression prevalence increases from 10 years before PD diagnosis and is a marker of cortical and subcortical volume loss. Depression before PD diagnosis signals a worse prognosis in terms of dementia and mortality. This has clinical implications in stratifying people with poorer cognitive and prognostic trajectory in PD.
    Language English
    Publishing date 2024-04-03
    Publishing country England
    Document type Journal Article
    ZDB-ID 3087-9
    ISSN 1468-330X ; 0022-3050
    ISSN (online) 1468-330X
    ISSN 0022-3050
    DOI 10.1136/jnnp-2023-333007
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Neurological and psychiatric presentations associated with human monkeypox virus infection: A systematic review and meta-analysis.

    Badenoch, James B / Conti, Isabella / Rengasamy, Emma R / Watson, Cameron J / Butler, Matthew / Hussain, Zain / Carter, Ben / Rooney, Alasdair G / Zandi, Michael S / Lewis, Glyn / David, Anthony S / Houlihan, Catherine F / Easton, Ava / Michael, Benedict D / Kuppalli, Krutika / Nicholson, Timothy R / Pollak, Thomas A / Rogers, Jonathan P

    EClinicalMedicine

    2022  Volume 52, Page(s) 101644

    Abstract: Background: Neuropsychiatric presentations of monkeypox (MPX) infection have not been well characterised, despite evidence of nervous system involvement associated with the related smallpox infection.: Methods: In this pre-registered (PROSPERO ID ... ...

    Abstract Background: Neuropsychiatric presentations of monkeypox (MPX) infection have not been well characterised, despite evidence of nervous system involvement associated with the related smallpox infection.
    Methods: In this pre-registered (PROSPERO ID 336649) systematic review and meta-analysis, we searched MEDLINE, EMBASE, PsycINFO, AMED and the preprint server MedRxiv up to 31/05/2022. Any study design of humans infected with MPX that reported a neurological or psychiatric presentation was included. For eligible symptoms, we calculated a pooled prevalence using an inverse variance approach and corresponding 95% confidence intervals. The degree of variability that could be explained by between-study heterogeneity was assessed using the
    Findings: From 1705 unique studies, we extracted data on 19 eligible studies (1512 participants, 1031 with confirmed infection using CDC criteria or PCR testing) most of which were cohort studies and case series with no control groups. Study quality was generally moderate. Three clinical features were eligible for meta-analysis: seizure 2.7% (95% CI 0.7-10.2%, I
    Interpretation: There is preliminary evidence for a range of neuropsychiatric presentations including severe neurological complications (encephalitis and seizure) and nonspecific neurological features (confusion, headache and myalgia). There is less evidence regarding the psychiatric presentations or sequelae of MPX. This may warrant surveillance within the current MPX outbreak, with prospective longitudinal studies evaluating the mid- to long-term sequelae of the virus. Robust methods to evaluate the potential causality of MPX with these clinical features are required. More evidence is necessary to explain heterogeneity in prevalence estimates.
    Funding: UKRI/MRC (MR/V03605X/1), MRC-CSF (MR/V007181/1), MRC/AMED (MR/T028750/1) and the Wellcome Trust (102186/B/13/Z) and (102186/B/13/Z) and UCLH BRC.
    Language English
    Publishing date 2022-09-08
    Publishing country England
    Document type Journal Article
    ISSN 2589-5370
    ISSN (online) 2589-5370
    DOI 10.1016/j.eclinm.2022.101644
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Cognitive domains affected post-COVID-19; a systematic review and meta-analysis.

    Fanshawe, Jack B / Sargent, Brendan F / Badenoch, James B / Saini, Aman / Watson, Cameron J / Pokrovskaya, Aleksandra / Aniwattanapong, Daruj / Conti, Isabella / Nye, Charles / Burchill, Ella / Hussain, Zain U / Said, Khanafi / Kuhoga, Elinda / Tharmaratnam, Kukatharmini / Pendered, Sophie / Mbwele, Bernard / Taquet, Maxime / Wood, Greta K / Rogers, Jonathan P /
    Hampshire, Adam / Carson, Alan / David, Anthony S / Michael, Benedict D / Nicholson, Timothy R / Paddick, Stella-Maria / Leek, Charles E

    European journal of neurology

    2024  , Page(s) e16181

    Abstract: Background and purpose: This review aims to characterize the pattern of post-COVID-19 cognitive impairment, allowing better prediction of impact on daily function to inform clinical management and rehabilitation.: Methods: A systematic review and ... ...

    Abstract Background and purpose: This review aims to characterize the pattern of post-COVID-19 cognitive impairment, allowing better prediction of impact on daily function to inform clinical management and rehabilitation.
    Methods: A systematic review and meta-analysis of neurocognitive sequelae following COVID-19 was conducted, following PRISMA-S guidelines. Studies were included if they reported domain-specific cognitive assessment in patients with COVID-19 at >4 weeks post-infection. Studies were deemed high-quality if they had >40 participants, utilized healthy controls, had low attrition rates and mitigated for confounders.
    Results: Five of the seven primary Diagnostic and Statistical Manual of Mental Disorders (DSM-5) cognitive domains were assessed by enough high-quality studies to facilitate meta-analysis. Medium effect sizes indicating impairment in patients post-COVID-19 versus controls were seen across executive function (standardised mean difference (SMD) -0.45), learning and memory (SMD -0.55), complex attention (SMD -0.54) and language (SMD -0.54), with perceptual motor function appearing to be impacted to a greater degree (SMD -0.70). A narrative synthesis of the 56 low-quality studies also suggested no obvious pattern of impairment.
    Conclusions: This review found moderate impairments across multiple domains of cognition in patients post-COVID-19, with no specific pattern. The reported literature was significantly heterogeneous, with a wide variety of cognitive tasks, small sample sizes and disparate initial disease severities limiting interpretability. The finding of consistent impairment across a range of cognitive tasks suggests broad, as opposed to domain-specific, brain dysfunction. Future studies should utilize a harmonized test battery to facilitate inter-study comparisons, whilst also accounting for the interactions between COVID-19, neurological sequelae and mental health, the interplay between which might explain cognitive impairment.
    Language English
    Publishing date 2024-02-20
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 1280785-0
    ISSN 1468-1331 ; 1351-5101 ; 1471-0552
    ISSN (online) 1468-1331
    ISSN 1351-5101 ; 1471-0552
    DOI 10.1111/ene.16181
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.MO 592: Show issues

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  4. Article ; Online: Persistent neuropsychiatric symptoms after COVID-19: a systematic review and meta-analysis.

    Badenoch, James B / Rengasamy, Emma R / Watson, Cameron / Jansen, Katrin / Chakraborty, Stuti / Sundaram, Ritika D / Hafeez, Danish / Burchill, Ella / Saini, Aman / Thomas, Lucretia / Cross, Benjamin / Hunt, Camille K / Conti, Isabella / Ralovska, Sylvia / Hussain, Zain / Butler, Matthew / Pollak, Thomas A / Koychev, Ivan / Michael, Benedict D /
    Holling, Heinz / Nicholson, Timothy R / Rogers, Jonathan P / Rooney, Alasdair G

    Brain communications

    2021  Volume 4, Issue 1, Page(s) fcab297

    Abstract: The nature and extent of persistent neuropsychiatric symptoms after COVID-19 are not established. To help inform mental health service planning in the pandemic recovery phase, we systematically determined the prevalence of neuropsychiatric symptoms in ... ...

    Abstract The nature and extent of persistent neuropsychiatric symptoms after COVID-19 are not established. To help inform mental health service planning in the pandemic recovery phase, we systematically determined the prevalence of neuropsychiatric symptoms in survivors of COVID-19. For this pre-registered systematic review and meta-analysis (PROSPERO ID CRD42021239750), we searched MEDLINE, EMBASE, CINAHL and PsycINFO to 20 February 2021, plus our own curated database. We included peer-reviewed studies reporting neuropsychiatric symptoms at post-acute or later time-points after COVID-19 infection and in control groups where available. For each study, a minimum of two authors extracted summary data. For each symptom, we calculated a pooled prevalence using generalized linear mixed models. Heterogeneity was measured with
    Language English
    Publishing date 2021-12-17
    Publishing country England
    Document type Journal Article ; Review
    ISSN 2632-1297
    ISSN (online) 2632-1297
    DOI 10.1093/braincomms/fcab297
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Persistent neuropsychiatric symptoms after COVID-19: a systematic review and meta-analysis.

    Badenoch, James B / Rengasamy, Emma R / Watson, Cameron J / Jansen, Katrin / Chakraborty, Stuti / Sundaram, Ritika D / Hafeez, Danish / Burchill, Ella / Saini, Aman / Thomas, Lucretia / Cross, Benjamin / Hunt, Camille K / Conti, Isabella / Ralovska, Sylvia / Hussain, Zain / Butler, Matthew / Pollak, Thomas A / Koychev, Ivan / Michael, Benedict D /
    Holling, Heinz / Nicholson, Timothy R / Rogers, Jonathan P / Rooney, Alasdair G / The SARS-CoV-Neuro Collaboration

    medRxiv

    Abstract: Background: The nature and extent of persistent neuropsychiatric symptoms after COVID-19 are not established. To help inform mental health service planning in the pandemic recovery phase, we systematically determined the prevalence of neuropsychiatric ... ...

    Abstract Background: The nature and extent of persistent neuropsychiatric symptoms after COVID-19 are not established. To help inform mental health service planning in the pandemic recovery phase, we systematically determined the prevalence of neuropsychiatric symptoms in survivors of COVID-19. Methods: For this pre-registered systematic review and meta-analysis (PROSPERO ID CRD42021239750) we searched PubMed, EMBASE, CINAHL and PsycINFO to 20th February 2021, plus our own curated database. We included peer-reviewed studies reporting neuropsychiatric symptoms at post-acute or later time-points after COVID-19 infection, and in control groups where available. For each study a minimum of two authors extracted summary data. For each symptom we calculated a primary pooled prevalence using generalised linear mixed models. Heterogeneity was measured with I2. Subgroup analyses were conducted for COVID-19 hospitalisation, severity, and duration of follow-up. Results: From 2,844 unique titles we included 51 studies (n=18,917 patients). The mean duration of follow-up after COVID-19 was 77 days (range 14-182 days). Study quality was generally moderate. The most frequent neuropsychiatric symptom was sleep disturbance (pooled prevalence=27.4% [95%CI 21.4-34.4%]), followed by fatigue (24.4% [17.5-32.9%]), objective cognitive impairment (20.2% [10.3-35.7%]), anxiety (19.1%[13.3-26.8%]), and post-traumatic stress (15.7% [9.9-24.1%]). Only two studies reported symptoms in control groups, both reporting higher frequencies in Covid-19 survivors versus controls. Between-study heterogeneity was high (I2=79.6%-98.6%). There was little or no evidence of differential symptom prevalence based on hospitalisation status, severity, or follow-up duration. Conclusion: Neuropsychiatric symptoms are common and persistent after recovery from COVID-19. The literature on longer-term consequences is still maturing, but indicates a particularly high frequency of insomnia, fatigue, cognitive impairment, and anxiety disorders in the first six months after infection.
    Keywords covid19
    Language English
    Publishing date 2021-05-04
    Publisher Cold Spring Harbor Laboratory Press
    Document type Article ; Online
    DOI 10.1101/2021.04.30.21256413
    Database COVID19

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