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  1. Article ; Online: New trials in the scene of cardiovascular disease: innovation, controversy, and reassurance.

    Badimon, Lina

    Cardiovascular research

    2021  Volume 117, Issue 4, Page(s) e52–e54

    MeSH term(s) Biomarkers/blood ; Cardiovascular Diseases/blood ; Cardiovascular Diseases/epidemiology ; Cardiovascular Diseases/prevention & control ; Clinical Trials as Topic ; Diffusion of Innovation ; Down-Regulation ; Drug Design ; Drug Development ; Dyslipidemias/blood ; Dyslipidemias/drug therapy ; Dyslipidemias/epidemiology ; Evidence-Based Medicine ; Heart Disease Risk Factors ; Humans ; Hypolipidemic Agents/adverse effects ; Hypolipidemic Agents/therapeutic use ; Lipids/blood ; Research Design ; Risk Assessment ; Treatment Outcome ; Videoconferencing
    Chemical Substances Biomarkers ; Hypolipidemic Agents ; Lipids
    Language English
    Publishing date 2021-01-21
    Publishing country England
    Document type Congress
    ZDB-ID 80340-6
    ISSN 1755-3245 ; 0008-6363
    ISSN (online) 1755-3245
    ISSN 0008-6363
    DOI 10.1093/cvr/cvab048
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 565: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  2. Article ; Online: ESC Advocacy (2018-2020): contributing to the ESC mission of reducing the burden of cardiovascular disease.

    Badimon, Lina

    Cardiovascular research

    2020  Volume 116, Issue 12, Page(s) e169–e170

    MeSH term(s) Cardiovascular Diseases/diagnosis ; Cardiovascular Diseases/epidemiology ; Cardiovascular Diseases/prevention & control ; Cooperative Behavior ; Diffusion of Innovation ; Europe/epidemiology ; Humans ; Interdisciplinary Communication ; International Cooperation ; Patient Advocacy ; Policy Making ; Preventive Health Services ; Public Health ; Societies, Medical ; Stakeholder Participation ; Technology Assessment, Biomedical
    Language English
    Publishing date 2020-05-16
    Publishing country England
    Document type Journal Article
    ZDB-ID 80340-6
    ISSN 1755-3245 ; 0008-6363
    ISSN (online) 1755-3245
    ISSN 0008-6363
    DOI 10.1093/cvr/cvaa237
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 565: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    ab Jg. 2022: Lesesaal (EG)

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  3. Article ; Online: Atherosclerotic Plaque VASA Vasorum in Diabetic Macroangiopathy: WHEN IS Important, but also HOW IS Needed.

    Badimon, Lina / Arderiu, Gemma

    Thrombosis and haemostasis

    2023  Volume 123, Issue 10, Page(s) 999–1002

    MeSH term(s) Humans ; Plaque, Atherosclerotic ; Vasa Vasorum ; Atherosclerosis ; Diabetes Mellitus ; Neovascularization, Pathologic
    Language English
    Publishing date 2023-06-23
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 518294-3
    ISSN 2567-689X ; 0340-6245
    ISSN (online) 2567-689X
    ISSN 0340-6245
    DOI 10.1055/a-2116-7261
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Uh III Zs.192: Show issues Location:
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    Zs.MO 433: Show issues

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  4. Article ; Online: Working together to advocate for cardiovascular research funding.

    Badimon, Lina

    European heart journal

    2019  Volume 40, Issue 28, Page(s) 2289

    MeSH term(s) Biomedical Research/economics ; Cardiology ; Cardiovascular Diseases ; Humans
    Language English
    Publishing date 2019-07-17
    Publishing country England
    Document type Journal Article
    ZDB-ID 603098-1
    ISSN 1522-9645 ; 0195-668X
    ISSN (online) 1522-9645
    ISSN 0195-668X
    DOI 10.1093/eurheartj/ehz509
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.MO 640: Show issues

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  5. Article ; Online: Novel cardioprotective approaches in ischaemic heart disease.

    Vilahur, Gemma / Radike, Monika / Badimon, Lina

    European heart journal

    2024  

    Language English
    Publishing date 2024-03-06
    Publishing country England
    Document type Journal Article
    ZDB-ID 603098-1
    ISSN 1522-9645 ; 0195-668X
    ISSN (online) 1522-9645
    ISSN 0195-668X
    DOI 10.1093/eurheartj/ehae058
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.MO 640: Show issues

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  6. Article ; Online: Monocyte-Platelet Complexes in Myocardial Infarction: Sub-Sets and Platelet-Derived Microvesicles Matter.

    Badimon, Lina

    Thrombosis and haemostasis

    2018  Volume 118, Issue 11, Page(s) 1854–1855

    MeSH term(s) Blood Platelets ; Cell-Derived Microparticles ; Humans ; Monocytes ; Myocardial Infarction
    Language English
    Publishing date 2018-10-17
    Publishing country Germany
    Document type Journal Article ; Comment
    ZDB-ID 518294-3
    ISSN 2567-689X ; 0340-6245
    ISSN (online) 2567-689X
    ISSN 0340-6245
    DOI 10.1055/s-0038-1675242
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Uh III Zs.192: Show issues Location:
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    Zs.MO 433: Show issues

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  7. Article ; Online: DJ-1 interacts with the ectopic ATP-synthase in endothelial cells during acute ischemia and reperfusion.

    Gallinat, Alex / Badimon, Lina

    Scientific reports

    2022  Volume 12, Issue 1, Page(s) 12753

    Abstract: Endothelial cells (ECs) play a central role in ischemia. ATP-Synthase is now recognized to be ectopically expressed in the cell surface of many cell types, with putative roles described in angiogenesis, proliferation, and intracellular pH regulation. DJ- ... ...

    Abstract Endothelial cells (ECs) play a central role in ischemia. ATP-Synthase is now recognized to be ectopically expressed in the cell surface of many cell types, with putative roles described in angiogenesis, proliferation, and intracellular pH regulation. DJ-1 is a multifunctional protein, involved in cell protection against ischemia, ischemia-reperfusion (I/R), and oxidative stress, that regulates mitochondrial ATP-synthase. Here we focused on the characterization of the endothelial dynamics of DJ-1, and its implication in the regulation of the ectopic ATP-synthase (ecATP-S) activity, during acute ischemia and I/R in ECs. We found that DJ-1 is secreted from ECs, by a mechanism enhanced in ischemia and I/R. A cleaved form of DJ-1 (DJ-1∆C) was found only in the secretome of ischemic cells. The ecATP-S activity increased following acute ischemia in ECs, coinciding with DJ-1 and DJ-1∆C secretion. The inhibition of DJ-1 expression inhibited the ecATP-S response to ischemia by ∼ 50%, and its exogenous administration maximized the effect, together with an enhanced Akt phosphorylation and angiotube-formation potential at reperfusion. Immunoprecipitation studies showed direct interaction between DJ-1 and the ecATP-S. Altogether suggesting that DJ-1 is actively cleaved and released from ischemic ECs and plays an important role in the regulation of the ecATP-S activity during acute ischemia and reperfusion.
    MeSH term(s) Adenosine Triphosphate/metabolism ; Endothelial Cells/metabolism ; Humans ; Ischemia ; Myocardial Reperfusion Injury/metabolism ; Protein Deglycase DJ-1/genetics ; Protein Deglycase DJ-1/metabolism ; Reperfusion
    Chemical Substances Adenosine Triphosphate (8L70Q75FXE) ; Protein Deglycase DJ-1 (EC 3.1.2.-)
    Language English
    Publishing date 2022-07-26
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-022-16998-3
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Novel cutting edge nano-strategies to address old long-standing complications in cardiovascular diseases. A comprehensive review.

    Tesoro, Laura / Hernandez, Ignacio / Saura, Marta / Badimón, Lina / Zaragoza, Carlos

    European journal of clinical investigation

    2024  , Page(s) e14208

    Abstract: Background: Cardiovascular diseases (CVD) impact a substantial portion of the global population and represent a significant threat to experiencing life-threatening outcomes, such as atherosclerosis, myocardial infarction, stroke and heart failure. ... ...

    Abstract Background: Cardiovascular diseases (CVD) impact a substantial portion of the global population and represent a significant threat to experiencing life-threatening outcomes, such as atherosclerosis, myocardial infarction, stroke and heart failure. Despite remarkable progress in pharmacology and medical interventions, CVD persists as a major public health concern, and now ranks as the primary global cause of death and the highest consumer of global budgets. Ongoing research endeavours persist in seeking novel therapeutic avenues and interventions to deepen our understanding of CVD, enhance prevention measures, and refine treatment strategies.
    Methods: Nanotechnology applied to the development of new molecular probes with diagnostic and theranostic properties represents one of the greatest technological challenges in preclinical and clinical research.
    Results: The application of nanotechnology in cardiovascular medicine holds great promise for advancing our understanding of CVDs and revolutionizing their diagnosis and treatment strategies, ultimately improving patient care and outcomes. In addition, the capacity of drug encapsulation in nanoparticles has significantly bolstered their biological safety, bioavailability and solubility. In combination with imaging technologies, molecular imaging has emerged as a pivotal therapeutic tool, offering insight into the molecular events underlying disease and facilitating targeted treatment approaches.
    Conclusion: Here, we present a comprehensive overview of the recent advancements in targeted nanoparticle approaches for diagnosing CVDs, encompassing molecular imaging techniques, underscoring the significant progress in theranostic, as a novel and promising therapeutic strategy.
    Language English
    Publishing date 2024-04-15
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 186196-7
    ISSN 1365-2362 ; 0014-2972 ; 0960-135X
    ISSN (online) 1365-2362
    ISSN 0014-2972 ; 0960-135X
    DOI 10.1111/eci.14208
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 677: Show issues Location:
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    ab Jg. 2022: Lesesaal (EG)

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  9. Article ; Online: Effects of Antioxidants in Fermented Beverages in Tissue Transcriptomics: Effect of Beer Intake on Myocardial Tissue after Oxidative Injury

    Gallinat, Alex / Vilahur, Gemma / Padro, Teresa / Badimon, Lina

    Antioxidants. 2023 May 13, v. 12, no. 5

    2023  

    Abstract: Fermented beverages, such as wine and beer, are rich in polyphenols that have been shown to have protective effects against oxidative stress. Oxidative stress plays a central role in the pathogenesis and progression of cardiovascular disease. However, ... ...

    Abstract Fermented beverages, such as wine and beer, are rich in polyphenols that have been shown to have protective effects against oxidative stress. Oxidative stress plays a central role in the pathogenesis and progression of cardiovascular disease. However, the potential benefits of fermented beverages on cardiovascular health need to be fully investigated at a molecular level. In this study, we aimed at analyzing the effects of beer consumption in modulating the transcriptomic response of the heart to an oxidative stress challenge induced by myocardial ischemia (MI) in the presence of hypercholesterolemia in a pre-clinical swine model. Previous studies have shown that the same intervention induces organ protective benefits. We report a dose-dependent up-regulation of electron transport chain members and the down-regulation of spliceosome-associated genes linked to beer consumption. Additionally, low-dose beer consumption resulted in a down-regulation of genes associated with the immune response, that was not shown for moderate-dose beer consumption. These findings, observed in animals having demonstrated beneficial effects at the organ-level, indicate that the antioxidants in beer differentially affect the myocardial transcriptome in a dose-dependent manner.
    Keywords animal models ; beers ; dose response ; electron transport chain ; fermentation ; heart ; hypercholesterolemia ; immune response ; myocardial ischemia ; oxidative stress ; oxidative toxicity ; pathogenesis ; polyphenols ; transcriptome ; transcriptomics ; wines
    Language English
    Dates of publication 2023-0513
    Publishing place Multidisciplinary Digital Publishing Institute
    Document type Article ; Online
    ZDB-ID 2704216-9
    ISSN 2076-3921
    ISSN 2076-3921
    DOI 10.3390/antiox12051096
    Database NAL-Catalogue (AGRICOLA)

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  10. Article: Atherosclerotic Plaque VASA Vasorum in Diabetic Macroangiopathy: WHEN IS Important, but also HOW IS Needed

    Badimon, Lina / Arderiu, Gemma

    Thrombosis and Haemostasis

    2023  Volume 123, Issue 10, Page(s) 999–1002

    Language English
    Publishing date 2023-06-23
    Publisher Georg Thieme Verlag KG
    Publishing place Stuttgart ; New York
    Document type Article
    ZDB-ID 518294-3
    ISSN 2567-689X ; 0340-6245
    ISSN (online) 2567-689X
    ISSN 0340-6245
    DOI 10.1055/a-2116-7261
    Database Thieme publisher's database

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    In stock of ZB MED Cologne/Königswinter

    Uh III Zs.192: Show issues Location:
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    Zs.MO 433: Show issues

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