LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 10 of total 197

Search options

  1. Article ; Online: The Yin and Yang of SARS-CoV-2 Mutation and Evolution.

    Badley, Andrew D

    Mayo Clinic proceedings

    2021  Volume 96, Issue 4, Page(s) 863–865

    MeSH term(s) COVID-19/epidemiology ; COVID-19/therapy ; COVID-19/virology ; Humans ; Mutation/genetics ; SARS-CoV-2/genetics ; SARS-CoV-2/pathogenicity ; Virus Replication/physiology
    Language English
    Publishing date 2021-02-03
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 124027-4
    ISSN 1942-5546 ; 0025-6196
    ISSN (online) 1942-5546
    ISSN 0025-6196
    DOI 10.1016/j.mayocp.2021.01.023
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Ua VI Zs.183: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  2. Book: Cell death during HIV infection

    Badley, Andrew D.

    2007  

    Author's details ed. by Andrew D. Badley
    Keywords HIV Infections ; Apoptosis ; T-Lymphocytes / pathology ; HIV infections ; Immunodeficiency ; T cells
    Subject code 616.979207
    Language English
    Size 544 S. : Ill., graph. Darst., 26cm
    Publisher CRC Press
    Publishing place Boca Raton u.a.
    Publishing country United States
    Document type Book
    Note Includes bibliographical references and index
    HBZ-ID HT014492629
    ISBN 978-1-4200-5375-3 ; 1-4200-5375-2
    Database Catalogue ZB MED Medicine, Health

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2009 A 2740 order for loan Magazin

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  3. Article ; Online: Dynamic modulation of the non-canonical NF-κB signaling pathway for HIV shock and kill.

    Chandrasekar, Aswath P / Maynes, Mark / Badley, Andrew D

    Frontiers in cellular and infection microbiology

    2024  Volume 14, Page(s) 1354502

    Abstract: HIV cure still remains an elusive target. The "Shock and Kill" strategy which aims to reactivate HIV from latently infected cells and subsequently kill them through virally induced apoptosis or immune mediated clearance, is the subject of widespread ... ...

    Abstract HIV cure still remains an elusive target. The "Shock and Kill" strategy which aims to reactivate HIV from latently infected cells and subsequently kill them through virally induced apoptosis or immune mediated clearance, is the subject of widespread investigation. NF-κB is a ubiquitous transcription factor which serves as a point of confluence for a number of intracellular signaling pathways and is also a crucial regulator of HIV transcription. Due to its relatively lower side effect profile and proven role in HIV transcription, the non-canonical NF-κB pathway has emerged as an attractive target for HIV reactivation, as a first step towards eradication. A comprehensive review examining this pathway in the setting of HIV and its potential utility to cure efforts is currently lacking. This review aims to summarize non-canonical NF-κB signaling and the importance of this pathway in HIV shock-and-kill efforts.
    MeSH term(s) Humans ; NF-kappa B/metabolism ; Virus Activation ; Virus Latency/physiology ; CD4-Positive T-Lymphocytes ; Signal Transduction ; HIV Infections/drug therapy
    Chemical Substances NF-kappa B
    Language English
    Publishing date 2024-03-05
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2619676-1
    ISSN 2235-2988 ; 2235-2988
    ISSN (online) 2235-2988
    ISSN 2235-2988
    DOI 10.3389/fcimb.2024.1354502
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  4. Article ; Online: Prime, shock and kill: BCL-2 inhibition for HIV cure.

    Chandrasekar, Aswath P / Badley, Andrew D

    Frontiers in immunology

    2022  Volume 13, Page(s) 1033609

    Abstract: While modern HIV therapy can effectively suppress viral replication, the persistence of the latent reservoir posits the greatest hurdle to complete cure. The "shock and kill" strategy is under investigation for HIV therapy, aiming to reactivate latent ... ...

    Abstract While modern HIV therapy can effectively suppress viral replication, the persistence of the latent reservoir posits the greatest hurdle to complete cure. The "shock and kill" strategy is under investigation for HIV therapy, aiming to reactivate latent HIV, and subsequently eliminate it through anti-retroviral therapy and host immune function. However, thus far, studies have yielded suboptimal results, stemming from a combination of ineffective latency reversal and poor immune clearance. Concomitantly, studies have now revealed the importance of the BCL-2 anti-apoptotic protein as a critical mediator of infected cell survival, reservoir maintenance and immune evasion in HIV. Furthermore, BCL-2 inhibitors are now recognized for their anti-HIV effects in pre-clinical studies. This minireview aims to examine the intersection of BCL-2 inhibition and current shock and kill efforts, hoping to inform future studies which may ultimately yield a cure for HIV.
    MeSH term(s) Humans ; Virus Latency ; HIV-1 ; HIV Infections ; Virus Activation ; Proto-Oncogene Proteins c-bcl-2
    Chemical Substances Proto-Oncogene Proteins c-bcl-2
    Language English
    Publishing date 2022-10-20
    Publishing country Switzerland
    Document type Journal Article ; Review ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2022.1033609
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  5. Article ; Online: Could proteasome inhibition improve therapeutic vaccine response in HIV?

    Cummins, Nathan W / Badley, Andrew D

    Vaccine

    2022  Volume 40, Issue 26, Page(s) 3514–3515

    MeSH term(s) HIV Infections/drug therapy ; HIV Infections/prevention & control ; HIV-1/physiology ; Humans ; Proteasome Endopeptidase Complex ; Vaccines/therapeutic use
    Chemical Substances Vaccines ; Proteasome Endopeptidase Complex (EC 3.4.25.1)
    Language English
    Publishing date 2022-05-12
    Publishing country Netherlands
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 605674-x
    ISSN 1873-2518 ; 0264-410X
    ISSN (online) 1873-2518
    ISSN 0264-410X
    DOI 10.1016/j.vaccine.2022.05.008
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 1930: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 458: Show issues

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  6. Article ; Online: CRISPR Taking the Front Seat in Immunotherapy.

    Kenderian, Saad S / Badley, Andrew D

    Journal of cellular immunology

    2020  Volume 2, Issue 4, Page(s) 143–148

    Language English
    Publishing date 2020-05-22
    Publishing country United States
    Document type Journal Article ; Comment
    ISSN 2689-2812
    ISSN (online) 2689-2812
    DOI 10.33696/immunology.2.032
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  7. Article ; Online: The long road to TRAIL therapy: a TRAILshort detour.

    Chandrasekar, Aswath P / Maynes, Mark / Badley, Andrew D

    Oncotarget

    2021  Volume 12, Issue 7, Page(s) 589–591

    Language English
    Publishing date 2021-03-30
    Publishing country United States
    Document type Editorial
    ZDB-ID 2560162-3
    ISSN 1949-2553 ; 1949-2553
    ISSN (online) 1949-2553
    ISSN 1949-2553
    DOI 10.18632/oncotarget.27902
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  8. Article ; Online: In Reply - Clinical Benefit of Lenzilumab in Cases of Coronavirus Disease 2019.

    Temesgen, Zelalem / Kenderian, Saad S / Badley, Andrew D

    Mayo Clinic proceedings

    2021  Volume 96, Issue 3, Page(s) 817–818

    MeSH term(s) Antibodies, Monoclonal, Humanized ; COVID-19 ; Cohort Studies ; Granulocyte-Macrophage Colony-Stimulating Factor ; Humans ; SARS-CoV-2
    Chemical Substances Antibodies, Monoclonal, Humanized ; Granulocyte-Macrophage Colony-Stimulating Factor (83869-56-1) ; lenzilumab (IE4X6497XK)
    Language English
    Publishing date 2021-01-11
    Publishing country England
    Document type Letter ; Comment
    ZDB-ID 124027-4
    ISSN 1942-5546 ; 0025-6196
    ISSN (online) 1942-5546
    ISSN 0025-6196
    DOI 10.1016/j.mayocp.2020.12.029
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Ua VI Zs.183: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  9. Article ; Online: In reply-Outcomes of COVID-19 With the Mayo Clinic Model of Care and Research.

    O'Horo, John C / Badley, Andrew D

    Mayo Clinic proceedings

    2021  Volume 96, Issue 4, Page(s) 1092–1093

    MeSH term(s) Ambulatory Care Facilities ; COVID-19 ; Humans ; SARS-CoV-2
    Language English
    Publishing date 2021-02-08
    Publishing country England
    Document type Letter ; Comment
    ZDB-ID 124027-4
    ISSN 1942-5546 ; 0025-6196
    ISSN (online) 1942-5546
    ISSN 0025-6196
    DOI 10.1016/j.mayocp.2021.02.005
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Ua VI Zs.183: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  10. Article: "Much ado to achieve nothing: prospects for curing HIV infection".

    Badley, Andrew D

    Molecular and cellular therapies

    2014  Volume 2, Page(s) 9

    Abstract: Currently there is significant scientific effort being directed at developing ways to create either a sterilizing cure, or functional cure for HIV infection. Multiple approaches are being evaluated under the broad headings of gene therapy, immune based ... ...

    Abstract Currently there is significant scientific effort being directed at developing ways to create either a sterilizing cure, or functional cure for HIV infection. Multiple approaches are being evaluated under the broad headings of gene therapy, immune based interventions, and treatments which depend upon HIV reactivation from latency to cause the death of cells which harbor the virus. Molecular and Cellular Therapies (MCT) welcomes all manuscripts devoted to increasing our understanding of determinants of affecting a cure for HIV and mechanistic studies determine the cellular and viral interventions necessary for achieving HIV cure.
    Language English
    Publishing date 2014-03-26
    Publishing country Denmark
    Document type Journal Article
    ZDB-ID 2740988-0
    ISSN 2052-8426
    ISSN 2052-8426
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

To top