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  1. Article ; Online: Using Initial Biopsies and Vertical Sections to Improve Trainees' Confidence in Performing Mohs Surgery.

    Lee, Jennifer / Bae, Edward / Yang, Eric J / Iwamoto, Satori

    Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.

    2024  Volume 50, Issue 5, Page(s) 418–422

    Abstract: Background: Tissue preservation and tumor clearance are hallmarks of Mohs micrographic surgery, but no standardized method currently exists to guide trainees on how to balance the two.: Objective: The authors provided residents and fellows with ... ...

    Abstract Background: Tissue preservation and tumor clearance are hallmarks of Mohs micrographic surgery, but no standardized method currently exists to guide trainees on how to balance the two.
    Objective: The authors provided residents and fellows with additional histologic information to enhance their surgical decision-making without changing the standard methodology of Mohs surgery.
    Methods and materials: Trainees were provided initial biopsy slides (IS) and frozen vertical sections (VS) of the first Mohs layer. All Mohs layers were excised in standard fashion, and vertically oriented sections were taken from the layer without disturbing the surgical margins to obtain VS. Surveys were used to assess trainees' confidence in performing Mohs surgery with and without these tools.
    Results: Trainees reported increased confidence in performing Mohs surgery when they reviewed IS before surgery and viewed VS of the first layer.
    Conclusion: Reviewing IS and VS improved trainees' confidence in performing Mohs surgery. This additional histological information was obtained while maintaining the usual steps of Mohs surgery. Objective information obtained from IS and VS may explain why trainees' confidence increased using this technique. Both IS and VS can be valuable teaching tools that may enhance trainees' ability to perform Mohs surgery.
    MeSH term(s) Mohs Surgery/education ; Humans ; Biopsy ; Clinical Competence ; Skin Neoplasms/surgery ; Skin Neoplasms/pathology ; Internship and Residency ; Frozen Sections
    Language English
    Publishing date 2024-03-08
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1227586-4
    ISSN 1524-4725 ; 1076-0512
    ISSN (online) 1524-4725
    ISSN 1076-0512
    DOI 10.1097/DSS.0000000000004116
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1212: Show issues Location:
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  2. Article: Cardiac Arrest Associated With Psilocybin Use and Hereditary Hemochromatosis.

    Bae, Suhwoo / Vaysblat, Michael / Bae, Edward / Dejanovic, Ilja / Pierce, Matthew

    Cureus

    2023  Volume 15, Issue 5, Page(s) e38669

    Abstract: Recreational drug use is a significant public health concern in various countries. It is well understood that usage of psychedelics/hallucinogens, such as lysergic acid diethylamide (LSD), ecstasy, phencyclidine (PCP), and psilocybin-containing mushrooms, ...

    Abstract Recreational drug use is a significant public health concern in various countries. It is well understood that usage of psychedelics/hallucinogens, such as lysergic acid diethylamide (LSD), ecstasy, phencyclidine (PCP), and psilocybin-containing mushrooms, has increased significantly over the last few decades, particularly in adolescents and young adults, yet the effects of these recreational drugs are poorly understood. Psilocybin has recently been studied as an alternative to traditional antidepressant therapies with potentially benign side effects. Here, we present the case of a 48-year-old male with a past medical history of attention-deficit/hyperactivity disorder on lisdexamfetamine who presented after a syncopal episode witnessed by his wife at home. He was found to be in ventricular fibrillation and subsequently had an extensive workup with cardiac magnetic resonance imaging (MRI), ischemic evaluation, and electrophysiology, which were unrevealing. He then received an automatic implantable cardiac defibrillator and was incidentally found to have hereditary hemochromatosis on outpatient follow-up. His polypharmacy may have potentially led to catecholamine release, leading to ventricular arrhythmia.
    Language English
    Publishing date 2023-05-07
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.38669
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: MOC-31 Antibody Immunolabeling During Mohs Surgery.

    Bae, Edward / Saap, Liliana / Breen, Catherine / Iwamoto, Satori

    Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.

    2022  Volume 48, Issue 6, Page(s) 595–600

    Abstract: Background: Ber-EP4 is an antibody that labels basal cell carcinoma (BCC) by targeting epithelial cell adhesion molecule (Ep-CAM). MOC-31, a monoclonal mouse antibody, also targets Ep-CAM and is currently used to differentiate several extracutaneous ... ...

    Abstract Background: Ber-EP4 is an antibody that labels basal cell carcinoma (BCC) by targeting epithelial cell adhesion molecule (Ep-CAM). MOC-31, a monoclonal mouse antibody, also targets Ep-CAM and is currently used to differentiate several extracutaneous epithelial tumors. However, the utility of MOC-31 has not been fully described in cutaneous tumors and in Mohs micrographic surgery (MMS).
    Objective: To evaluate MOC-31 labeling in BCC and other cutaneous tumors and to compare immunolabeling intensity of MOC-31 and Ber-EP4 in BCCs.
    Materials and methods: Nineteen permanently fixed and 29 frozen BCC specimens and 23 other cutaneous tumors were labeled with MOC-31; labeling intensity of tumors, epidermis, and adnexal structures were recorded. In a separate study, a blinded dermatopathologist compared labeling intensities of 8 BCC specimens, each labeled with MOC-31 and Ber-EP4.4.
    Results: MOC-31 labeled all BCCs. Eccrine coils and follicular bulbs did label variably, although this did not detract utility of MOC-31. Five of thirteen cutaneous squamous cell carcinomas and one of two Merkel cell carcinomas demonstrated MOC-31 positivity. MOC-31 and Ber-EP4 labeled BCCs similarly.
    Conclusion: MOC-31, an antibody directed against Ep-CAM, is sensitive for BCCs in frozen specimens encountered in MMS and permanently fixed specimen. In addition, MOC-31 demonstrated comparable immunolabeling characteristics with Ber-EP4 for BCCs.
    MeSH term(s) Animals ; Antibodies, Monoclonal ; Biomarkers, Tumor/metabolism ; Carcinoma, Basal Cell/diagnosis ; Carcinoma, Basal Cell/surgery ; Diagnosis, Differential ; Epithelial Cell Adhesion Molecule ; Humans ; Mice ; Mohs Surgery ; Skin Neoplasms/diagnosis
    Chemical Substances Antibodies, Monoclonal ; Biomarkers, Tumor ; Epithelial Cell Adhesion Molecule
    Language English
    Publishing date 2022-04-05
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1227586-4
    ISSN 1524-4725 ; 1076-0512
    ISSN (online) 1524-4725
    ISSN 1076-0512
    DOI 10.1097/DSS.0000000000003446
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    ab Jg. 2022: Lesesaal (EG)

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  4. Article: Development of High-Grade Sarcoma After Second Dose of Moderna Vaccine.

    Bae, Edward / Bae, Suhwoo / Vaysblat, Michael / Abdelwahed, Mohammed / Sarkar, Kumar / Bae, Stewart

    Cureus

    2023  Volume 15, Issue 4, Page(s) e37612

    Abstract: Coronavirus disease 2019 (COVID-19) is a disease characterized by predominantly respiratory symptoms, which can progress to respiratory failure. Due to the novelty of the vaccines, it is difficult to assess if there are any associated long-term side ... ...

    Abstract Coronavirus disease 2019 (COVID-19) is a disease characterized by predominantly respiratory symptoms, which can progress to respiratory failure. Due to the novelty of the vaccines, it is difficult to assess if there are any associated long-term side effects. Here, we present a case of an elderly female who received the Moderna COVID-19 vaccine and developed a high-grade sarcoma at the site of the injection. A 73-year-old female with a past medical history of hypertension, hyperlipidemia, and renal angiomyolipoma status post resection in 2019 presented with worsening right upper arm swelling for the past two weeks. She noticed the swelling two to four days after receiving her second dose of the Moderna vaccine within 1 cm from the prior injection site. Physical examination was remarkable for a 6 cm, circular, mobile, soft mass present in the right upper arm. MRI with and without contrast revealed a 5.2 cm soft tissue mass overlying the triceps region with irregular features concerning for malignancy. Fine needle aspiration revealed pathologic characteristics indicative of high-grade sarcoma. The patient ultimately had resection of the mass four months after the initial visit and was diagnosed as having grade 3, stage IIIA undifferentiated, pleomorphic high-grade sarcoma. Herein, we present a case demonstrating the development of high-grade sarcoma at the injection site in an elderly female patient within days of receiving the second dose of the Moderna COVID-19 vaccine. Currently, it is unclear whether there is a true association between the vaccines and malignancy or inflammatory response exacerbating underlying malignancy. This case highlights the necessity to investigate and be aware of such rare, adverse complications that may be associated with the novel COVID-19 vaccinations to guide physicians in their differential diagnosis.
    Language English
    Publishing date 2023-04-15
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.37612
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Revisiting the "jelly-roll" technique: New utility in diagnosing linear IgA bullous dermatosis mimicking toxic epidermal necrolysis.

    Khan, Samavia / Bae, Edward / Mathieu, Regine J / Elco, Christopher / Massoud, Cathy M / Firoz, Elnaz F

    JAAD case reports

    2023  Volume 41, Page(s) 75–76

    Language English
    Publishing date 2023-09-14
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2834220-3
    ISSN 2352-5126
    ISSN 2352-5126
    DOI 10.1016/j.jdcr.2023.08.041
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: IgA Vasculitis With Concurrent ANCA-Positivity in the Setting of Bacterial Endocarditis.

    Xiong, Michelle / Singer, Hannah / Bae, Edward / Mathieu, Regine / Seo, Su-Jean / Massoud, Cathy M

    Rhode Island medical journal (2013)

    2022  Volume 105, Issue 10, Page(s) 52–55

    Abstract: Cutaneous small vessel vasculitis (CSVV) or leukocytoclastic vasculitis (LCV) is a group of immune complex mediated vasculitides that affect dermal capillaries or post-capillary venules and classically presents as lower extremity palpable purpura. CSVV ... ...

    Abstract Cutaneous small vessel vasculitis (CSVV) or leukocytoclastic vasculitis (LCV) is a group of immune complex mediated vasculitides that affect dermal capillaries or post-capillary venules and classically presents as lower extremity palpable purpura. CSVV can be subdivided by antibody type and clinical features. In patients presenting with signs of LCV and ANCA positivity, clinicopathologic correlation is important in characterizing the type of vasculitis. We report an uncommon case of IgA vasculitis with concurrent ANCA-positivity attributed to bacterial endocarditis.
    MeSH term(s) Humans ; IgA Vasculitis ; Antibodies, Antineutrophil Cytoplasmic ; Vasculitis ; Endocarditis, Bacterial/complications ; Endocarditis, Bacterial/diagnosis ; Polyarteritis Nodosa
    Chemical Substances Antibodies, Antineutrophil Cytoplasmic
    Language English
    Publishing date 2022-12-01
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 419430-5
    ISSN 2327-2228 ; 0363-7913
    ISSN (online) 2327-2228
    ISSN 0363-7913
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 222: Show issues Location:
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  7. Article ; Online: Significance of Basal Cell Carcinomas Exhibiting Intravascular Invasion.

    Bae, Edward / Breen, Catherine / Vidal, Eduardo / Anderson-Dockter, Heidi / Snow, Stephen N / Liu, Rosemarie H / Longley, Bruce Jack / Iwamoto, Satori

    The American Journal of dermatopathology

    2023  Volume 45, Issue 7, Page(s) 448–453

    Abstract: Abstract: Intravascular invasion of tumor cells can be associated with metastasis in many cancers. Basal cell carcinomas (BCCs), however, rarely metastasize; therefore, the clinical impact of intravascularly invasive BCC (IVBCC) is currently unclear. ... ...

    Abstract Abstract: Intravascular invasion of tumor cells can be associated with metastasis in many cancers. Basal cell carcinomas (BCCs), however, rarely metastasize; therefore, the clinical impact of intravascularly invasive BCC (IVBCC) is currently unclear. Because of these facts and the rarity of IVBCC, questions have arisen on whether IVBCC truly exists. We present 4 cases of IVBCC: one case with obvious tumor islands within immunolabeled blood vessels in the context of advanced disease and 3 cases found incidentally during Mohs micrographic surgery. We discuss the difficulty in studying IVBCC, the idea that it could be due to artifact, and the lack of direct clinical-pathological correlation. Given these challenges, we propose diagnostic criteria for IVBCC to decrease ambiguity for pathological diagnosis. Such criteria may facilitate further studies on the clinical significance of IVBCC.
    MeSH term(s) Humans ; Skin Neoplasms/pathology ; Carcinoma, Basal Cell/pathology ; Mohs Surgery
    Language English
    Publishing date 2023-05-29
    Publishing country United States
    Document type Journal Article
    ZDB-ID 448469-1
    ISSN 1533-0311 ; 0193-1091
    ISSN (online) 1533-0311
    ISSN 0193-1091
    DOI 10.1097/DAD.0000000000002452
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1518: Show issues Location:
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  8. Article ; Online: Demographics, Risk Factors, and Incidence of Melanoma in Patients in the New England VA Healthcare system.

    Bae, Edward / Leone, Dominick / Konnikov, Nellie / Mahalingam, Meera

    Military medicine

    2018  Volume 184, Issue 5-6, Page(s) e408–e416

    Abstract: Introduction: A recent study found that the incidence of melanoma and melanoma-related mortality was decreasing in residents of the New England region. However, it is unknown whether this trend is conserved in Veterans of New England who constitute more ...

    Abstract Introduction: A recent study found that the incidence of melanoma and melanoma-related mortality was decreasing in residents of the New England region. However, it is unknown whether this trend is conserved in Veterans of New England who constitute more than 14% of the national Veteran population. Given this, our goal was to analyze the incidence of melanoma in patients of Veteran Integrated Service Network-1 (VISN-1) (geographically consisting of VA health care facilities in Connecticut, Maine, Massachusetts, New Hampshire, Rhode Island, and Vermont) and to calculate an incidence rate ratio (IRR) of melanoma in VISN-1 compared to the general population. Additional goals were to ascertain the risk/susceptibility of this patient population with a view to improve quality of care and outcomes.
    Materials and methods: Data for 523 cases of melanoma [2000-2011] were obtained from the regional branch of the Veterans Affairs Central Cancer Registry (VACCR) within the geographic area comprising VISN-1. A detailed retrospective chart review was conducted on these cases to gather demographic, risk factor, and clinical practice data. Demographic and incidence data from VISN-1 were compared to the general population via data from Surveillance, Epidemiology and End Results Program (SEER) from the same time period. Person-years (PY) were calculated for both populations to measure IRRs which was further standardized for age and gender.
    Results: VISN-1 patients were predominantly older (94.26% >50 years), Caucasian (99.43%) males (96.75%). Compared to the general population, VISN-1 patients experienced more invasive lesions defined as stage T1 or greater (4.33% vs. 57.12%, p < 0.001), but reduced melanoma-associated mortality (40.96% vs. 19.05%, p < 0.001) although all-cause mortality was approximately doubled (52.20% vs. 26.14%, p < 0.001). Metastatic disease-rates were similar in both [approximately 4% in both]. IRR of melanoma in VISN-1 patients was 0.36 (95% CI: 0.20-0.67; p = 0.0063) which persisted in all age groups/genders. 60.92% of VISN-1 patients had recreational sun-exposure history and 72.41% of tobacco use. 95.02% of melanomas were located in continuously/intermittently sun-exposed areas, 93.28% were surgically-treated with a median treatment delay of 31 days [range 18-48]. Median lost to follow-up was 0 day [range 0-681 days].
    Conclusions: Compared to the general population, melanoma incidence was lower in the VISN-1 cohort, possibly due to decreased UV index in the New England region, protective effects of past tobacco use, improved access to care through the VA and regional public health educational efforts. Yet melanomas were more often invasive in the VISN-1 cohort due to advanced age and male sex both of which are associated with more advanced disease at diagnosis. A strength of this study is the calculation of IRR using PY as this method enhances accuracy of incidence calculations. The data were limited by the fact that the population was from one geographic region and consisted mainly of elderly Caucasian males. Descriptive variable data such as sun-protective habits and risk factors from military service are limited by potential recall bias given the retrospective study design. Further study is necessary to replicate these results and to compare our data to Veteran populations from different geographic regions within the USA.
    MeSH term(s) Adult ; Aged ; Female ; Humans ; Incidence ; Male ; Melanoma/diagnosis ; Melanoma/epidemiology ; Middle Aged ; New England/epidemiology ; Registries/statistics & numerical data ; Retrospective Studies ; Risk Factors ; United States/epidemiology ; United States Department of Veterans Affairs/organization & administration ; United States Department of Veterans Affairs/statistics & numerical data ; Veterans/statistics & numerical data
    Language English
    Publishing date 2018-10-15
    Publishing country England
    Document type Journal Article
    ZDB-ID 391061-1
    ISSN 1930-613X ; 0026-4075
    ISSN (online) 1930-613X
    ISSN 0026-4075
    DOI 10.1093/milmed/usy267
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Erratum: The Gut Microbiome: Human Health and Inflammatory Skin Diseases.

    Mann, Emily A / Bae, Edward / Kostyuchek, Darya / Chung, Hye Jin / McGee, Jean S

    Annals of dermatology

    2020  Volume 32, Issue 5, Page(s) 440

    Abstract: This corrects the article on p. 265 in vol. 32.]. ...

    Abstract [This corrects the article on p. 265 in vol. 32.].
    Language English
    Publishing date 2020-09-29
    Publishing country Korea (South)
    Document type Published Erratum
    ZDB-ID 1012662-4
    ISSN 2005-3894 ; 1013-9087
    ISSN (online) 2005-3894
    ISSN 1013-9087
    DOI 10.5021/ad.2020.32.5.440
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: The Gut Microbiome: Human Health and Inflammatory Skin Diseases.

    Mann, Emily A / Bae, Edward / Kostyuchek, Darya / Chung, Hye Jin / McGee, Jean S

    Annals of dermatology

    2020  Volume 32, Issue 4, Page(s) 265–272

    Abstract: The human microbiome is a rich environment consisting of bacteria, fungi and other commensal microorganisms of the gut, mucosa and skin. The functional role of the gut microbiome includes facilitation in metabolism of macronutrients, maturation of the ... ...

    Abstract The human microbiome is a rich environment consisting of bacteria, fungi and other commensal microorganisms of the gut, mucosa and skin. The functional role of the gut microbiome includes facilitation in metabolism of macronutrients, maturation of the immune system, and production of pro- or anti-inflammatory signaling molecules and peptides. The identification of these resident organisms has brought about a new understanding of disease processes. Nevertheless, more questions remain regarding the interactions within the microbiome, its interactions with the host, and its contributions to the pathophysiology of disease. The purpose of this review is to examine the existing medical literature to highlight the role of the gut microbiome in human health, also paying attention to its role in several inflammatory skin diseases, namely atopic dermatitis, psoriasis, and rosacea.
    Language English
    Publishing date 2020-06-30
    Publishing country Korea (South)
    Document type Journal Article ; Review
    ZDB-ID 1012662-4
    ISSN 2005-3894 ; 1013-9087
    ISSN (online) 2005-3894
    ISSN 1013-9087
    DOI 10.5021/ad.2020.32.4.265
    Database MEDical Literature Analysis and Retrieval System OnLINE

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