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  1. Artikel ; Online: Impact of being underweight before pregnancy on preterm birth by race/ethnicity and insurance status in California: an analysis of birth records.

    Diamond-Smith, Nadia / Baer, Rebecca J / Jelliffe-Pawlowski, Laura

    The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians

    2024  Band 37, Heft 1, Seite(n) 2321486

    Abstract: Background: The US still has a high burden of preterm birth (PTB), with important disparities by race/ethnicity and poverty status. There is a large body of literature looking at the impact of pre-pregnancy obesity on PTB, but fewer studies have ... ...

    Abstract Background: The US still has a high burden of preterm birth (PTB), with important disparities by race/ethnicity and poverty status. There is a large body of literature looking at the impact of pre-pregnancy obesity on PTB, but fewer studies have explored the association between underweight status on PTB, especially with a lens toward health disparities. Furthermore, little is known about how weight, specifically pre-pregnancy underweight status, and socio-economic-demographic factors such as race/ethnicity and insurance status, interact with each other to contribute to risks of PTB.
    Objectives: The objective of this study was to measure the association between pre-pregnancy underweight and PTB and small for gestational age (SGA) among a large sample of births in the US. Our secondary objective was to see if underweight status and two markers of health disparities - race/ethnicity and insurance status (public vs. other) - on PTB.
    Study design: We used data from all births in California from 2011 to 2017, which resulted in 3,070,241 singleton births with linked hospital discharge records. We ran regression models to estimate the relative risk of PTB by underweight status, by race/ethnicity, and by poverty (Medi-cal status). We then looked at the interaction between underweight status and race/ethnicity and underweight and poverty on PTB.
    Results: Black and Asian women were more likely to be underweight (aRR = 1.0, 95% CI: 1.01, 1.1 and aRR = 1.4, 95% CI: 1.4, 1.5, respectively), and Latina women were less likely to be underweight (aRR = 0.7, 95% CI: 0.7, 0.7). Being underweight was associated with increased odds of PTB (aRR = 1.3, 95% CI 1.3-1.3) and, after controlling for underweight, all nonwhite race/ethnic groups had increased odds of PTB compared to white women. In interaction models, the combined effect of being both underweight and Black, Indigenous and People of Color (BIPOC) statistically significantly reduced the relative risk of PTB (aRR = 0.9, 95% CI: 0.8, 0.9) and SGA (aRR = 1.0, 95% CI: 0.9, 1.0). The combined effect of being both underweight and on public insurance increased the relative risk of PTB (aRR = 1.1, 95% CI: 1.1, 1.2) but there was no additional effect of being both underweight and on public insurance on SGA (aRR = 1.0, 95% CI: 1.0, 1.0).
    Conclusions: We confirm and build upon previous findings that being underweight preconception is associated with increased risk of PTB and SGA - a fact often overlooked in the focus on overweight and adverse birth outcomes. Additionally, our findings suggest that the effect of being underweight on PTB and SGA differs by race/ethnicity and by insurance status, emphasizing that other factors related to inequities in access to health care and poverty are contributing to disparities in PTB.
    Mesh-Begriff(e) Infant, Newborn ; Female ; Humans ; Pregnancy ; Birth Certificates ; Ethnicity ; Premature Birth/epidemiology ; Thinness/complications ; Thinness/epidemiology ; Insurance Coverage ; Parturition ; California/epidemiology
    Sprache Englisch
    Erscheinungsdatum 2024-03-03
    Erscheinungsland England
    Dokumenttyp Journal Article
    ZDB-ID 2077261-0
    ISSN 1476-4954 ; 1057-0802 ; 1476-7058
    ISSN (online) 1476-4954
    ISSN 1057-0802 ; 1476-7058
    DOI 10.1080/14767058.2024.2321486
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  2. Artikel ; Online: Pregnancy characteristics and outcomes among birthing individuals with a diagnosis of fetal alcohol syndrome.

    Schellenberg, Hannah / Baer, Rebecca J / Bandoli, Gretchen

    Alcohol, clinical & experimental research

    2023  Band 48, Heft 2, Seite(n) 295–301

    Abstract: Background: Fetal alcohol syndrome (FAS) can have adverse effects on health outcomes throughout the life course. Adults with FAS have an increased risk of chronic and infectious diseases. Although these conditions can affect reproductive health, few ... ...

    Abstract Background: Fetal alcohol syndrome (FAS) can have adverse effects on health outcomes throughout the life course. Adults with FAS have an increased risk of chronic and infectious diseases. Although these conditions can affect reproductive health, few have described perinatal outcomes among individuals with an FAS diagnosis.
    Methods: We analyzed data from the Study of Mothers and Infants, an administrative birth cohort derived from California birth certificates linked with a hospital discharge database. The cohort consisted of 7.3 million singleton, live births between 2005 and 2021. FAS was identified by International Classification of Diseases (ICD) codes in maternal hospital discharge records. Pregnancy and birth outcomes were captured via ICD codes in maternal or infant records. We performed descriptive analyses for pregnancy and birth outcomes by maternal FAS diagnosis.
    Results: There were 35 babies born to 30 individuals with an FAS diagnosis between 2005 and 2021 (0.5/100,000 live births). The prevalence of births to individuals with an FAS diagnosis increased over the period. Individuals with an FAS diagnosis were more likely to identify as non-Hispanic White, or "other/multiple" race, and less likely to be Hispanic than those without FAS. They were also more likely to be publicly insured and less than 18 years old. Birthing individuals with FAS were also more likely to use nicotine during pregnancy and to have diagnoses of mental health disorders, epilepsy, substance use disorders, preexisting or gestational hypertension, and sexually transmitted infections or other infections complicating pregnancy. Infants of individuals with FAS were more likely to be born prematurely or small for gestational age and be admitted to the neonatal intensive care unit.
    Conclusions: These findings highlight the need for improved recognition of FAS among birthing people. The results suggest that individuals with FAS would benefit from early and sustained medical care prior to pregnancy to optimize perinatal outcomes.
    Sprache Englisch
    Erscheinungsdatum 2023-12-14
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ISSN 2993-7175
    ISSN (online) 2993-7175
    DOI 10.1111/acer.15236
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  3. Artikel ; Online: Prenatal cannabis use disorder and gastroschisis in California, 2007-19.

    Delker, Erin / Baer, Rebecca J / Kelly, Ann E / Chambers, Christina / Bandoli, Gretchen

    International journal of epidemiology

    2024  Band 53, Heft 2

    Abstract: Background: Gastroschisis is a congenital anomaly of the abdominal wall with an unknown aetiology. Recent trends in the prevalence of gastroschisis suggest that changing environmental or behavioural factors may contribute. We examined whether prenatal ... ...

    Abstract Background: Gastroschisis is a congenital anomaly of the abdominal wall with an unknown aetiology. Recent trends in the prevalence of gastroschisis suggest that changing environmental or behavioural factors may contribute. We examined whether prenatal cannabis use disorder was associated with gastroschisis.
    Methods: The Study of Outcomes of Mothers and Infants is a population-based cohort compiled of California birth records that have been linked to Department of Health Care Access and Information hospitalization, emergency department and ambulatory surgery records. We included 2007-19 singleton live births (n = 5 774 656). Cannabis use disorder was measured by diagnosis codes at any visit during pregnancy or at birth. Gastroschisis was measured by diagnosis or surgical repair procedure codes at birth or during the first year of life.
    Results: The prevalence of cannabis use disorder was about 1%. The prevalence of gastroschisis was 0.14% and 0.06% among those with and without cannabis use disorder, respectively. There were positive associations between cannabis use disorder and gastroschisis when using a multivariable model [adjusted risk ratio (aRR) = 1.3, 95% confidence interval (CI) 1.0, 1.7) and a matched sample approach (aRR = 1.5, 95% CI 1.1, 2.1). The association varied by maternal age and was largest among people aged >34 years (aRR = 2.5, 95% CI 1.0, 5.8).
    Conclusions: We confirm findings of a positive association between cannabis exposure and gastroschisis and add that it is strongest when maternal age is greater than 34 years. More investigation into whether the association is causal, and why the association varies by maternal age, is encouraged.
    Mesh-Begriff(e) Pregnancy ; Infant, Newborn ; Female ; Infant ; Humans ; Gastroschisis/epidemiology ; Gastroschisis/diagnosis ; Risk Factors ; Maternal Age ; California/epidemiology ; Substance-Related Disorders ; Marijuana Abuse/epidemiology ; Prevalence
    Sprache Englisch
    Erscheinungsdatum 2024-03-19
    Erscheinungsland England
    Dokumenttyp Journal Article
    ZDB-ID 187909-1
    ISSN 1464-3685 ; 0300-5771
    ISSN (online) 1464-3685
    ISSN 0300-5771
    DOI 10.1093/ije/dyae042
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  4. Artikel ; Online: Disparities in the impact of heat wave definitions on emergency department visits during the first year of life among preterm and full-term infants in California.

    Teyton, Anaïs / Ndovu, Allan / Baer, Rebecca J / Bandoli, Gretchen / Benmarhnia, Tarik

    Environmental research

    2024  Band 248, Seite(n) 118299

    Abstract: Introduction: Heat waves will be aggravated due to climate change, making this a critical public health threat. However, heat wave definitions to activate alert systems can be ambiguous, highlighting the need to assess a range of definitions to identify ...

    Abstract Introduction: Heat waves will be aggravated due to climate change, making this a critical public health threat. However, heat wave definitions to activate alert systems can be ambiguous, highlighting the need to assess a range of definitions to identify those that contribute to the most adverse health outcomes. Additionally, children are highly susceptible to the impacts of heat waves, especially infants, despite the lack of focus on this subpopulation. We aimed to assess the relationship between 30 heat wave definitions and the first all-cause emergency department (ED) visits for California infants. We also examined modification of this relationship by preterm birth status and demographic characteristics to identify possible health disparities.
    Methods: Live-born, singleton deliveries from the Study of Outcomes in Mothers and Infants born in 2014-2018 were included. Thirty heat wave definitions were assessed based on temperature metrics (minimum/maximum temperatures), thresholds (90th; 92.5th; 95th; 97.5th; 99th percentiles), and duration (1-; 2-; 3-days). A time-stratified case-crossover design assessed heat wave impacts on ED visits using infants with a warm season ED visit (May-October) within the first year of life (n = 228,250). Effect modification by preterm birth status, age, sex, race/ethnicity, education, and delivery payment type was also investigated.
    Results: Infants demonstrated increased risk of an ED visit with exposure to all heat definitions. The 3-day minimum temperature 99th percentile definition had the highest adjusted odds ratio (AOR: 1.14; 95% CI: 1.05-1.23) for the total population. Term infants were more affected by some heat waves than preterm infants. Effect modification was additionally identified, such as by maternal education.
    Discussion: This study provides insight on the heat wave definitions that lead to adverse health outcomes and the identification of the most susceptible infants to these impacts, which has implications on heat-related interventions.
    Mesh-Begriff(e) Female ; Humans ; Infant, Newborn ; California ; Emergency Room Visits ; Emergency Service, Hospital ; Hot Temperature ; Infant, Premature ; Premature Birth/epidemiology ; Male
    Sprache Englisch
    Erscheinungsdatum 2024-01-23
    Erscheinungsland Netherlands
    Dokumenttyp Journal Article
    ZDB-ID 205699-9
    ISSN 1096-0953 ; 0013-9351
    ISSN (online) 1096-0953
    ISSN 0013-9351
    DOI 10.1016/j.envres.2024.118299
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  5. Artikel ; Online: Pregnancies complicated by bulimia nervosa are at increased risk of chorioamnionitis, anemia, and preterm birth.

    Baer, Rebecca J / Bandoli, Gretchen / Jelliffe-Pawlowski, Laura L / Rhee, Kyung E / Chambers, Christina D

    American journal of obstetrics and gynecology

    2024  

    Sprache Englisch
    Erscheinungsdatum 2024-03-08
    Erscheinungsland United States
    Dokumenttyp Letter
    ZDB-ID 80016-8
    ISSN 1097-6868 ; 0002-9378
    ISSN (online) 1097-6868
    ISSN 0002-9378
    DOI 10.1016/j.ajog.2024.03.006
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  6. Artikel ; Online: Exposure to Air Pollution and Emergency Department Visits During the First Year of Life Among Preterm and Full-term Infants.

    Teyton, Anaïs / Baer, Rebecca J / Benmarhnia, Tarik / Bandoli, Gretchen

    JAMA network open

    2023  Band 6, Heft 2, Seite(n) e230262

    Abstract: Importance: Previous studies have focused on exposure to fine particulate matter 2.5 μm or less in diameter (PM2.5) and on birth outcome risks; however, few studies have evaluated the health consequences of PM2.5 exposure on infants during their first ... ...

    Abstract Importance: Previous studies have focused on exposure to fine particulate matter 2.5 μm or less in diameter (PM2.5) and on birth outcome risks; however, few studies have evaluated the health consequences of PM2.5 exposure on infants during their first year of life and whether prematurity could exacerbate such risks.
    Objective: To assess the association of PM2.5 exposure with emergency department (ED) visits during the first year of life and determine whether preterm birth status modifies the association.
    Design, setting, and participants: This individual-level cohort study used data from the Study of Outcomes in Mothers and Infants cohort, which includes all live-born, singleton deliveries in California. Data from infants' health records through their first birthday were included. Participants included 2 175 180 infants born between 2014 and 2018, and complete data were included for an analytic sample of 1 983 700 (91.2%). Analysis was conducted from October 2021 to September 2022.
    Exposures: Weekly PM2.5 exposure at the residential ZIP code at birth was estimated from an ensemble model combining multiple machine learning algorithms and several potentially associated variables.
    Main outcomes and measures: Main outcomes included the first all-cause ED visit and the first infection- and respiratory-related visits separately. Hypotheses were generated after data collection and prior to analysis. Pooled logistic regression models with a discrete time approach assessed PM2.5 exposure and time to ED visits during each week of the first year of life and across the entire year. Preterm birth status, sex, and payment type for delivery were assessed as effect modifiers.
    Results: Of the 1 983 700 infants, 979 038 (49.4%) were female, 966 349 (48.7%) were Hispanic, and 142 081 (7.2%) were preterm. Across the first year of life, the odds of an ED visit for any cause were greater among both preterm (AOR, 1.056; 95% CI, 1.048-1.064) and full-term (AOR, 1.051; 95% CI, 1.049-1.053) infants for each 5-μg/m3 increase in exposure to PM2.5. Elevated odds were also observed for infection-related ED visit (preterm: AOR, 1.035; 95% CI, 1.001-1.069; full-term: AOR, 1.053; 95% CI, 1.044-1.062) and first respiratory-related ED visit (preterm: AOR, 1.080; 95% CI, 1.067-1.093; full-term: AOR,1.065; 95% CI, 1.061-1.069). For both preterm and full-term infants, ages 18 to 23 weeks were associated with the greatest odds of all-cause ED visits (AORs ranged from 1.034; 95% CI, 0.976-1.094 to 1.077; 95% CI, 1.022-1.135).
    Conclusions and relevance: Increasing PM2.5 exposure was associated with an increased ED visit risk for both preterm and full-term infants during the first year of life, which may have implications for interventions aimed at minimizing air pollution.
    Mesh-Begriff(e) Humans ; Infant, Newborn ; Infant ; Female ; Male ; Air Pollutants/analysis ; Premature Birth ; Cohort Studies ; Air Pollution ; Particulate Matter/analysis ; Emergency Service, Hospital
    Chemische Substanzen Air Pollutants ; Particulate Matter
    Sprache Englisch
    Erscheinungsdatum 2023-02-01
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ISSN 2574-3805
    ISSN (online) 2574-3805
    DOI 10.1001/jamanetworkopen.2023.0262
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  7. Artikel ; Online: Maternal penicillin allergy and infant outcomes: Results from a large administrative cohort.

    Wang, Laura A / Baer, Rebecca J / Namazy, Jennifer A / Chambers, Christina D

    The journal of allergy and clinical immunology. In practice

    2023  Band 12, Heft 4, Seite(n) 1080–1082.e1

    Mesh-Begriff(e) Infant ; Humans ; Penicillins/adverse effects ; Anti-Bacterial Agents/adverse effects ; Drug Hypersensitivity/diagnosis ; Drug Hypersensitivity/epidemiology ; Drug Hypersensitivity/drug therapy ; Family ; Hypersensitivity/drug therapy ; Retrospective Studies
    Chemische Substanzen Penicillins ; Anti-Bacterial Agents
    Sprache Englisch
    Erscheinungsdatum 2023-12-11
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 2843237-X
    ISSN 2213-2201 ; 2213-2198
    ISSN (online) 2213-2201
    ISSN 2213-2198
    DOI 10.1016/j.jaip.2023.12.009
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  8. Artikel ; Online: Maternal cardiovascular events in autoimmune rheumatic diseases and antiphospholipid syndrome pregnancies.

    Dhital, Rashmi / Baer, Rebecca J / Bandoli, Gretchen / Guma, Monica / Poudel, Dilli R / Kalunian, Kenneth / Weisman, Michael H / Chambers, Christina

    American journal of obstetrics & gynecology MFM

    2024  Band 6, Heft 4, Seite(n) 101319

    Mesh-Begriff(e) Humans ; Antiphospholipid Syndrome/complications ; Antiphospholipid Syndrome/diagnosis ; Female ; Pregnancy ; Rheumatic Diseases/complications ; Rheumatic Diseases/diagnosis ; Autoimmune Diseases/diagnosis ; Autoimmune Diseases/complications ; Autoimmune Diseases/epidemiology ; Pregnancy Complications/epidemiology ; Pregnancy Complications/diagnosis ; Pregnancy Complications/immunology ; Adult ; Cardiovascular Diseases/epidemiology ; Pregnancy Complications, Cardiovascular/diagnosis ; Pregnancy Complications, Cardiovascular/epidemiology ; Pregnancy Complications, Cardiovascular/physiopathology
    Sprache Englisch
    Erscheinungsdatum 2024-02-29
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Letter
    ISSN 2589-9333
    ISSN (online) 2589-9333
    DOI 10.1016/j.ajogmf.2024.101319
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  9. Artikel ; Online: Racial and Ethnic Inequities in Therapeutic Hypothermia and Neonatal Hypoxic-Ischemic Encephalopathy: A Retrospective Cohort Study.

    Fall, Carolyn / Baer, Rebecca J / Jelliffe-Pawlowski, Laura / Matoba, Nana / Lee, Henry C / Chambers, Christina D / Bandoli, Gretchen

    The Journal of pediatrics

    2024  Band 269, Seite(n) 113966

    Abstract: Objective: To investigate racial inequities in the use of therapeutic hypothermia (TH) and outcomes in infants with hypoxic-ischemic encephalopathy (HIE).: Study design: We queried an administrative birth cohort of mother-baby pairs in California ... ...

    Abstract Objective: To investigate racial inequities in the use of therapeutic hypothermia (TH) and outcomes in infants with hypoxic-ischemic encephalopathy (HIE).
    Study design: We queried an administrative birth cohort of mother-baby pairs in California from 2010 through 2019 using International Classification of Diseases codes to evaluate the association between race and ethnicity and the application of TH in infants with HIE. We identified 4779 infants with HIE. Log-linear regression was used to calculate risk ratios (RR) for TH, adjusting for hospital transfer, rural location, gestational age between 35 and 37 weeks, and HIE severity. Risk of adverse infant outcome was calculated by race and ethnicity and stratified by TH.
    Results: From our identified cohort, 1338 (28.0%) neonates underwent TH. White infants were used as the reference sample, and 410 (28.4%) received TH. Black infants were significantly less likely to receive TH with 74 (20.0%) with an adjusted risk ratio (aRR) of 0.7 (95% CI 0.5-0.9). Black infants with any HIE who did not receive TH were more likely to have a hospital readmission (aRR 1.36, 95% CI 1.10-1.68) and a tracheostomy (aRR 3.07, 95% CI 1.19-7.97). Black infants with moderate/severe HIE who did not receive TH were more likely to have cerebral palsy (aRR 2.72, 95% CI 1.07-6.91).
    Conclusions: In this study cohort, Black infants with HIE were significantly less likely to receive TH. Black infants also had significantly increased risk of some adverse outcomes of HIE. Possible reasons for this inequity include systemic barriers to care and systemic bias.
    Mesh-Begriff(e) Humans ; Hypoxia-Ischemia, Brain/therapy ; Hypoxia-Ischemia, Brain/ethnology ; Hypothermia, Induced ; Infant, Newborn ; Female ; Retrospective Studies ; Male ; Healthcare Disparities/ethnology ; Healthcare Disparities/statistics & numerical data ; California ; Ethnicity
    Sprache Englisch
    Erscheinungsdatum 2024-02-16
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 3102-1
    ISSN 1097-6833 ; 0022-3476
    ISSN (online) 1097-6833
    ISSN 0022-3476
    DOI 10.1016/j.jpeds.2024.113966
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  10. Artikel ; Online: Maternal Mental Health Diagnoses and Infant Emergency Department Use, Hospitalizations, and Death.

    Abe, Naomi / Baer, Rebecca J / Jelliffe-Pawlowski, Laura / Chambers, Christina D / Bandoli, Gretchen

    Academic pediatrics

    2023  Band 24, Heft 3, Seite(n) 451–460

    Abstract: Background: The period surrounding childbirth is a uniquely vulnerable time for women and their mental health. We sought to describe the association between maternal mental health diagnoses in the year prior and after birth and infant Emergency ... ...

    Abstract Background: The period surrounding childbirth is a uniquely vulnerable time for women and their mental health. We sought to describe the association between maternal mental health diagnoses in the year prior and after birth and infant Emergency Department (ED) utilization, hospitalization, and death.
    Methods: We studied mothers who gave singleton live birth in California (2011-2017) and their infants using linked infant birth and death certificates and maternal and infant discharge records. Maternal mental health diagnoses in the year before and after birth were identified using International Classification of Diseases (ICD) codes. We abstracted infant ED visits, hospitalizations, discharge diagnoses, deaths, and causes of death. Log-linear regression was used to compare relative risks of infant outcomes between mothers with and without mental health diagnoses, adjusting for maternal variables.
    Results: Of the 3,067,069 mother-infant pairs, 85,047 (2.8%) mothers had at least one mental health diagnosis in the year before and after birth. Infants of mothers with mental health diagnoses were more likely to visit the ED (aRR 1.2, CI:1.1-1.2), have three or more ED visits (aRR 1.4, CI:1.3-1.4), be hospitalized (aRR 1.1, CI:1.04-1.1), and die (aRR 1.7, CI:1.6-1.8) in the first year of life. These infants were also more likely to be diagnosed with accidental injuries, nonaccidental trauma, and non-specific descriptive diagnosis (fussiness/fatigue/brief resolved unexplained event).
    Conclusion: This large administrative cohort study showed associations between maternal mental health diagnoses and infant acute ED visits, hospitalization, and death. This study underscores the urgent need to understand what is driving these findings and how to mitigate this risk.
    Mesh-Begriff(e) Infant ; Female ; Humans ; Cohort Studies ; Mental Health ; Mothers ; Hospitalization ; Emergency Service, Hospital
    Sprache Englisch
    Erscheinungsdatum 2023-12-14
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 2483385-X
    ISSN 1876-2867 ; 1876-2859
    ISSN (online) 1876-2867
    ISSN 1876-2859
    DOI 10.1016/j.acap.2023.11.021
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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