Article ; Online: High-flow nasal oxygenation versus standard oxygenation for gastrointestinal endoscopy with sedation. The prospective multicentre randomised controlled ODEPHI study protocol.
2020 Volume 10, Issue 2, Page(s) e034701
Abstract: Introduction: Hypoxaemia is a major complication during gastrointestinal endoscopy (GIE) procedures (upper/lower) when performed under deep sedation in the procedure room. Standard oxygen therapy (SOT) is used to prevent hypoxaemia. Data suggest that ... ...
| Abstract | Introduction: Hypoxaemia is a major complication during gastrointestinal endoscopy (GIE) procedures (upper/lower) when performed under deep sedation in the procedure room. Standard oxygen therapy (SOT) is used to prevent hypoxaemia. Data suggest that risk factors for hypoxaemia under deep sedation during GIE are obstructive sleep apnoea syndrome, a body mass index above 30 kg/m², high blood pressure, diabetes, heart disease, age over 60 years old, high American Society of Anesthesiologists physical status class and the association of upper and lower GIE. High-flow nasal oxygenation (HFNO) may potentially improve oxygenation during GIE under deep sedation. We hypothesised that HFNO could decrease the incidence of hypoxaemia in comparison with SOT. Methods and analysis: The ODEPHI (High-flow nasal Ethics and dissemination: This study has been approved by the ethics committee (CPP Sud Est Paris V, France), and patients are included after informed consent. The results will be submitted for publication in peer-reviewed journals. As provided for by French law, patients participating in the study are informed that they have the possibility to ask the investigators, once the study is completed, to be informed of the overall results of the study. Thus, a summary of the results will be sent by post to the participants on request. Trial registration number: ClinicalTrials.gov Registry (NCT03829293). |
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| MeSH term(s) | Administration, Intranasal ; Anesthesia/adverse effects ; Endoscopy, Gastrointestinal/adverse effects ; France ; Humans ; Hypoxia/etiology ; Hypoxia/prevention & control ; Multicenter Studies as Topic ; Oxygen/administration & dosage ; Prospective Studies ; Randomized Controlled Trials as Topic ; Reference Standards |
| Chemical Substances | Oxygen (S88TT14065) |
| Language | English |
| Publishing date | 2020-02-18 |
| Publishing country | England |
| Document type | Clinical Trial Protocol ; Journal Article ; Research Support, Non-U.S. Gov't |
| ZDB-ID | 2599832-8 |
| ISSN | 2044-6055 ; 2044-6055 |
| ISSN (online) | 2044-6055 |
| ISSN | 2044-6055 |
| DOI | 10.1136/bmjopen-2019-034701 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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