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Buch ; Dissertation / Habilitation: Hippocampal involvement in configural processing and contingency awareness during contextual fear conditioning

Bäuchl, Christian

2015

Verfasserangabe	vorgelegt von Christian Bäuchl
Sprache	Englisch
Umfang	95 Blätter, Illustrationen, Diagramme, 30 cm
Erscheinungsort	Heidelberg
Erscheinungsland	Deutschland
Dokumenttyp	Buch ; Dissertation / Habilitation
Dissertation / Habilitation	Dissertation, Ruprecht-Karls-Universität zu Heidelberg, 2016
HBZ-ID	HT019072946
Datenquelle	Katalog ZB MED Medizin, Gesundheit

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2016 E 1380	bestellbar zur Ausleihe	Magazin

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Artikel ; Online: Insights from simultaneous EEG-fMRI and patient data illuminate the role of the anterior medial temporal lobe in N400 generation.

Meyer, Patric / Baeuchl, Christian / Hoppstädter, Michael

Neuropsychologia

2023 Band 193, Seite(n) 108762

Abstract: The N400, a negative event-related potential (ERP) peaking approximately 400 ms after stimulus onset, is known to reflect the processing of semantic information. While scalp recordings have contributed to understanding the psychological processes ... ...

Abstract	The N400, a negative event-related potential (ERP) peaking approximately 400 ms after stimulus onset, is known to reflect the processing of semantic information. While scalp recordings have contributed to understanding the psychological processes underlying the N400, they have been limited in identifying its neural basis. However, recent intracranial ERP recordings and fMRI studies have shed light on the crucial role of the anterior medial temporal lobe (AMTL) in semantic information processing. These findings suggest that the N400 partially represents activity in the AMTL structures. To investigate the neural underpinnings of the N400 effect, we simultaneously recorded ERPs and event-related fMRI during a semantic priming paradigm in a sample of 12 young, healthy subjects. Additionally, we collected ERPs and structural brain data from older healthy adults and patients with amnestic mild cognitive impairment (aMCI), a population characterized by neurodegenerative changes in the AMTL. In our fMRI results, we identified bilateral loci in the AMTL as the global maxima. Employing an EEG-informed fMRI analysis, we explored trial-to-trial fluctuations in semantic processing by linking single-trial N400 amplitudes to the Blood Oxygen Level Dependent (BOLD) signal. This approach provided the first direct evidence linking the N400 recorded at the scalp level to the corresponding BOLD signal in the AMTL. Consistent with these findings, patients with aMCI exhibited a diminished N400 effect compared to healthy older adults. Furthermore, voxel-based morphometry analysis revealed a correlation between the magnitude of the N400 effect and the integrity of the AMTL. By integrating data from simultaneous EEG-fMRI, and patient studies, our research advances our understanding of the neural substrate of the N400 and highlights the critical involvement of the AMTL in semantic processing.
Mesh-Begriff(e)	Humans ; Male ; Female ; Aged ; Evoked Potentials ; Electroencephalography ; Magnetic Resonance Imaging ; Temporal Lobe/diagnostic imaging ; Brain ; Semantics
Sprache	Englisch
Erscheinungsdatum	2023-12-22
Erscheinungsland	England
Dokumenttyp	Journal Article
ZDB-ID	207151-4
ISSN	1873-3514 ; 0028-3932
ISSN (online)	1873-3514
ISSN	0028-3932
DOI	10.1016/j.neuropsychologia.2023.108762
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Levodopa suppresses grid-like activity and impairs spatial learning in novel environments in healthy young adults.

Gönner, Lorenz / Baeuchl, Christian / Glöckner, Franka / Riedel, Philipp / Smolka, Michael N / Li, Shu-Chen

Cerebral cortex (New York, N.Y. : 1991)

2024 Band 33, Heft 23, Seite(n) 11247–11256

Abstract: Accumulated evidence from animal studies suggests a role for the neuromodulator dopamine in memory processes, particularly under conditions of novelty or reward. Our understanding of how dopaminergic modulation impacts spatial representations and spatial ...

Abstract	Accumulated evidence from animal studies suggests a role for the neuromodulator dopamine in memory processes, particularly under conditions of novelty or reward. Our understanding of how dopaminergic modulation impacts spatial representations and spatial memory in humans remains limited. Recent evidence suggests age-specific regulation effects of dopamine pharmacology on activity in the medial temporal lobe, a key region for spatial memory. To which degree this modulation affects spatially patterned medial temporal representations remains unclear. We reanalyzed recent data from a pharmacological dopamine challenge during functional brain imaging combined with a virtual object-location memory paradigm to assess the effect of Levodopa, a dopamine precursor, on grid-like activity in the entorhinal cortex. We found that Levodopa impaired grid cell-like representations in a sample of young adults (n = 55, age = 26-35 years) in a novel environment, accompanied by reduced spatial memory performance. We observed no such impairment when Levodopa was delivered to participants who had prior experience with the task. These results are consistent with a role of dopamine in modulating the encoding of novel spatial experiences. Our results suggest that dopamine signaling may play a larger role in shaping ongoing spatial representations than previously thought.
Mesh-Begriff(e)	Animals ; Humans ; Young Adult ; Adult ; Levodopa/pharmacology ; Spatial Learning ; Dopamine ; Entorhinal Cortex/physiology ; Spatial Memory
Chemische Substanzen	Levodopa (46627O600J) ; Dopamine (VTD58H1Z2X)
Sprache	Englisch
Erscheinungsdatum	2024-03-25
Erscheinungsland	United States
Dokumenttyp	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1077450-6
ISSN	1460-2199 ; 1047-3211
ISSN (online)	1460-2199
ISSN	1047-3211
DOI	10.1093/cercor/bhad361
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel: No evidence for a reciprocal relationship between daily self-control failures and addictive behavior in a longitudinal study.

Kräplin, Anja / Joshanloo, Mohsen / Wolff, Max / Fröhner, Juliane Hilde / Baeuchl, Christian / Krönke, Klaus-Martin / Bühringer, Gerhard / Smolka, Michael N / Goschke, Thomas

Frontiers in psychology

2024 Band 15, Seite(n) 1382483

Abstract: Introduction: We all experience occasional self-control failures (SCFs) in our daily lives, where we enact behaviors that stand in conflict with our superordinate or long-term goals. Based on the assumption that SCFs share common underlying mechanisms ... ...

Abstract	Introduction: We all experience occasional self-control failures (SCFs) in our daily lives, where we enact behaviors that stand in conflict with our superordinate or long-term goals. Based on the assumption that SCFs share common underlying mechanisms with addictive disorders, we tested the hypothesis that a generally higher susceptibility to daily SCFs predicts more addictive behavior, or vice versa. Methods: At baseline, 338 individuals (19-27 years, 59% female) from a community sample participated in multi-component assessments. These included among others (1) a clinical interview on addictive behaviors (quantity of use, frequency of use, DSM-5 criteria; Results: Controlling for age, gender, IQ, and baseline addiction level, random-intercept cross-lagged panel models revealed that participants who reported more SCFs also showed pronounced addictive behavior at the between-person level, but we found no evidence of a predictive relationship at the within-person level over time. Discussion: A higher rate of SCFs is associated with more addictive behavior, while there is no evidence of an intraindividual predictive relationship. Novel hypotheses suggested by additional exploratory results are that (1) only addiction-related SCFs in daily life are early markers of an escalation of use and thus for addictive disorders and that (2) an explicit monitoring of SCFs increases self-reflection and thereby promotes the mobilization of cognitive control in response to goal-desire conflicts.
Sprache	Englisch
Erscheinungsdatum	2024-05-01
Erscheinungsland	Switzerland
Dokumenttyp	Journal Article
ZDB-ID	2563826-9
ISSN	1664-1078
ISSN	1664-1078
DOI	10.3389/fpsyg.2024.1382483
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Dopamine differentially modulates medial temporal lobe activity and behavior during spatial navigation in young and older adults.

Baeuchl, Christian / Glöckner, Franka / Koch, Christoph / Petzold, Johannes / Schuck, Nicolas W / Smolka, Michael N / Li, Shu-Chen

NeuroImage

2023 Band 273, Seite(n) 120099

Abstract: Aging is associated with changes in spatial navigation behavior. In addition to an overall performance decline, older adults tend to rely more on proximal location cue information than on environmental boundary information during spatial navigation ... ...

Abstract	Aging is associated with changes in spatial navigation behavior. In addition to an overall performance decline, older adults tend to rely more on proximal location cue information than on environmental boundary information during spatial navigation compared to young adults. The fact that older adults are more susceptible to errors during spatial navigation might be partly attributed to deficient dopaminergic modulation of hippocampal and striatal functioning. Hence, elevating dopamine levels might differentially modulate spatial navigation and memory performance in young and older adults. In this work, we administered levodopa (L-DOPA) in a double-blind within-subject, placebo-controlled design and recorded functional neuroimaging while young and older adults performed a 3D spatial navigation task in which boundary geometry or the position of a location cue were systematically manipulated. An age by intervention interaction on the neural level revealed an upregulation of brain responses in older adults and a downregulation of responses in young adults within the medial temporal lobe (including hippocampus and parahippocampus) and brainstem, during memory retrieval. Behaviorally, L-DOPA had no effect on older adults' overall memory performance; however, older adults whose spatial memory improved under L-DOPA also showed a shift towards more boundary processing under L-DOPA. In young adults, L-DOPA induced a decline in spatial memory performance in task-naïve participants. These results are consistent with the inverted-U-shaped hypothesis of dopamine signaling and cognitive function and suggest that increasing dopamine availability improves hippocampus-dependent place learning in some older adults.
Mesh-Begriff(e)	Aged ; Humans ; Young Adult ; Dopamine ; Hippocampus/physiology ; Levodopa/pharmacology ; Spatial Memory/physiology ; Spatial Navigation/physiology ; Temporal Lobe/diagnostic imaging ; Temporal Lobe/physiology ; Double-Blind Method
Chemische Substanzen	Dopamine (VTD58H1Z2X) ; Levodopa (46627O600J)
Sprache	Englisch
Erscheinungsdatum	2023-04-08
Erscheinungsland	United States
Dokumenttyp	Journal Article ; Randomized Controlled Trial ; Research Support, Non-U.S. Gov't
ZDB-ID	1147767-2
ISSN	1095-9572 ; 1053-8119
ISSN (online)	1095-9572
ISSN	1053-8119
DOI	10.1016/j.neuroimage.2023.120099
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel: Levodopa suppresses grid-like activity and impairs spatial learning in novel environments in healthy young adults

Gönner, Lorenz / Baeuchl, Christian / Glöckner, Franka / Riedel, Philipp / Smolka, Michael N. / Li, Shu-Chen

Cerebral Cortex

2023 Band 33, Heft 23, Seite(n) 11247–11256

Titelübersetzung	Levodopa unterdrückt die gitterartige Aktivität und beeinträchtigt das räumliche Lernen in neuen Umgebungen bei gesunden jungen Erwachsenen (DeepL)
Abstract	Accumulated evidence from animal studies suggests a role for the neuromodulator dopamine in memory processes, particularly under conditions of novelty or reward. Our understanding of how dopaminergic modulation impacts spatial representations and spatial memory in humans remains limited. Recent evidence suggests age-specific regulation effects of dopamine pharmacology on activity in the medial temporal lobe, a key region for spatial memory. To which degree this modulation affects spatially patterned medial temporal representations remains unclear. We reanalyzed recent data from a pharmacological dopamine challenge during functional brain imaging combined with a virtual object-location memory paradigm to assess the effect of Levodopa, a dopamine precursor, on grid-like activity in the entorhinal cortex. We found that Levodopa impaired grid cell-like representations in a sample of young adults (n = 55, age = 26-35 years) in a novel environment, accompanied by reduced spatial memory performance. We observed no such impairment when Levodopa was delivered to participants who had prior experience with the task. These results are consistent with a role of dopamine in modulating the encoding of novel spatial experiences. Our results suggest that dopamine signaling may play a larger role in shaping ongoing spatial representations than previously thought.
Schlagwörter	Biological Neural Networks ; Biologische Neuronale Netze ; Brain ; Dopamin ; Dopamine ; Gehirn ; L-Dopa ; Levodopa ; Räumliche Navigation ; Räumliches Gedächtnis ; Spatial Memory ; Spatial Navigation ; Stimulus Novelty ; Stimulusneuheit ; Virtual Reality ; Virtuelle Realität
Sprache	Englisch
Dokumenttyp	Artikel
ZDB-ID	1077450-6
ISSN	1460-2199 ; 1047-3211
ISSN (online)	1460-2199
ISSN	1047-3211
DOI	10.1093/cercor/bhad361
Datenquelle	PSYNDEX

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Artikel ; Online: Contingency awareness as a prerequisite for differential contextual fear conditioning.

Baeuchl, Christian / Hoppstädter, Michael / Meyer, Patric / Flor, Herta

Cognitive, affective & behavioral neuroscience

2018 Band 19, Heft 4, Seite(n) 811–828

Abstract: Contingency awareness during conditioning describes the phenomenon of becoming consciously aware of the association between a conditioned stimulus (CS) and an unconditioned stimulus (US). Despite the fact that contingency awareness is necessary for ... ...

Abstract	Contingency awareness during conditioning describes the phenomenon of becoming consciously aware of the association between a conditioned stimulus (CS) and an unconditioned stimulus (US). Despite the fact that contingency awareness is necessary for associative learning in some conditioning paradigms, its role in contextual fear conditioning, a variant that uses a context-CS (CTX) instead of a cue, has not been characterized thus far. We investigated if contingency awareness is a prerequisite for contextual fear conditioning and if subjects classified as aware differ from unaware subjects on a hemodynamic, autonomic, and behavioral level. We used a computer-generated picture context as CTX and slightly painful electric stimulation as US while we recorded brain responses by functional magnetic resonance imaging (fMRI), and obtained skin conductance responses (SCR) and verbal ratings of emotional valence and arousal. SCR analyses revealed that only aware subjects became conditioned to the US-associated CTX (CTX+). Brain activity related to the CTX+ was more strongly pronounced in fear-associated areas like the insula in the aware relative to the unaware group. Finally, the hippocampus was functionally connected to the cingulate cortex and posterior medial frontal gyrus in aware subjects relative to unaware subjects. These task-related differential connectivity patterns suggest that information exchange between the hippocampus and regions involved in the expression of conditioned fear and decision uncertainty is crucial for the acquisition of contingency knowledge. This study demonstrates the importance of contingency awareness for contextual fear conditioning and points to the hippocampus as a potential mediator for contingency learning in contextual learning.
Mesh-Begriff(e)	Adult ; Association ; Awareness/physiology ; Cerebral Cortex/diagnostic imaging ; Cerebral Cortex/physiology ; Conditioning, Classical/physiology ; Connectome ; Fear/physiology ; Female ; Galvanic Skin Response/physiology ; Hippocampus/diagnostic imaging ; Hippocampus/physiology ; Humans ; Magnetic Resonance Imaging ; Male ; Young Adult
Sprache	Englisch
Erscheinungsdatum	2018-12-14
Erscheinungsland	United States
Dokumenttyp	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2029088-3
ISSN	1531-135X ; 1530-7026
ISSN (online)	1531-135X
ISSN	1530-7026
DOI	10.3758/s13415-018-00666-z
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: L-DOPA enhances neural direction signals in younger and older adults.

Koch, Christoph / Baeuchl, Christian / Glöckner, Franka / Riedel, Philipp / Petzold, Johannes / Smolka, Michael N / Li, Shu-Chen / Schuck, Nicolas W

NeuroImage

2022 Band 264, Seite(n) 119670

Abstract: Previous studies indicate a role of dopamine in spatial navigation. Although neural representations of direction are an important aspect of spatial cognition, it is not well understood whether dopamine directly affects these representations, or only ... ...

Abstract	Previous studies indicate a role of dopamine in spatial navigation. Although neural representations of direction are an important aspect of spatial cognition, it is not well understood whether dopamine directly affects these representations, or only impacts other aspects of spatial brain function. Moreover, both dopamine and spatial cognition decline sharply during age, raising the question which effect dopamine has on directional signals in the brain of older adults. To investigate these questions, we used a double-blind cross-over L-DOPA/Placebo intervention design in which 43 younger and 37 older adults navigated in a virtual spatial environment while undergoing functional magnetic resonance imaging (fMRI). We studied the effect of L-DOPA, a dopamine precursor, on fMRI activation patterns that encode spatial walking directions that have previously been shown to lose specificity with age. This was done in predefined regions of interest, including the early visual cortex, retrosplenial cortex, and hippocampus. Classification of brain activation patterns associated with different walking directions was improved across all regions following L-DOPA administration, suggesting that dopamine broadly enhances neural representations of direction. No evidence for differences between regions was found. In the hippocampus these results were found in both age groups, while in the retrosplenial cortex they were only observed in younger adults. Taken together, our study provides evidence for a link between dopamine and the specificity of neural responses during spatial navigation. SIGNIFICANCE STATEMENT: The sense of direction is an important aspect of spatial navigation, and neural representations of direction can be found throughout a large network of space-related brain regions. But what influences how well these representations track someone's true direction? Using a double-blind cross-over L-DOPA/Placebo intervention design, we find causal evidence that the neurotransmitter dopamine impacts the fidelity of direction selective neural representations in the human hippocampus and retrosplenial cortex. Interestingly, the effect of L-DOPA was either equally present or even smaller in older adults, despite the well-known age related decline of dopamine. These results provide novel insights into how dopamine shapes the neural representations that underlie spatial navigation.
Sprache	Englisch
Erscheinungsdatum	2022-10-13
Erscheinungsland	United States
Dokumenttyp	Journal Article
ZDB-ID	1147767-2
ISSN	1095-9572 ; 1053-8119
ISSN (online)	1095-9572
ISSN	1053-8119
DOI	10.1016/j.neuroimage.2022.119670
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel: Dopamine differentially modulates medial temporal lobe activity and behavior during spatial navigation in young and older adults

Baeuchl, Christian / Glöckner, Franka / Koch, Christoph / Petzold, Johannes / Schuck, Nicolas W. / Smolka, Michael N. / Li, Shu-Chen

NeuroImage

2023

Titelübersetzung	Dopamin moduliert die Aktivität des medialen Temporallappens und das Verhalten während räumlicher Navigation bei jungen und älteren Erwachsenen auf unterschiedliche Weise (DeepL)
Abstract	Aging is associated with changes in spatial navigation behavior. In addition to an overall performance decline, older adults tend to rely more on proximal location cue information than on environmental boundary information during spatial navigation compared to young adults. The fact that older adults are more susceptible to errors during spatial navigation might be partly attributed to deficient dopaminergic modulation of hippocampal and striatal functioning. Hence, elevating dopamine levels might differentially modulate spatial navigation and memory performance in young and older adults. In this work, we administered levodopa (L-DOPA) in a double-blind within-subject, placebo-controlled design and recorded functional neuroimaging while young and older adults performed a 3D spatial navigation task in which boundary geometry or the position of a location cue were systematically manipulated. An age by intervention interaction on the neural level revealed an upregulation of brain responses in older adults and a downregulation of responses in young adults within the medial temporal lobe (including hippocampus and parahippocampus) and brainstem, during memory retrieval. Behaviorally, L-DOPA had no effect on older adults' overall memory performance; however, older adults whose spatial memory improved under L-DOPA also showed a shift towards more boundary processing under L-DOPA. In young adults, L-DOPA induced a decline in spatial memory performance in task-naive participants. These results are consistent with the inverted-U-shaped hypothesis of dopamine signaling and cognitive function and suggest that increasing dopamine availability improves hippocampus-dependent place learning in some older adults.
Schlagwörter	Aging ; Altern ; Cognitive Ability ; Dopamin ; Dopamine ; Hippocampus ; Hippokampus ; Kognitive Fähigkeiten ; Räumliche Navigation ; Räumliches Gedächtnis ; Spatial Memory ; Spatial Navigation ; Striatum
Sprache	Englisch
Dokumenttyp	Artikel
ZDB-ID	1147767-2
ISSN	1095-9572 ; 1053-8119
ISSN (online)	1095-9572
ISSN	1053-8119
DOI	10.1016/j.neuroimage.2023.120099
Datenquelle	PSYNDEX

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Artikel ; Online: Interactive effects of dopamine transporter genotype and aging on resting-state functional networks.

Baeuchl, Christian / Chen, Hsiang-Yu / Su, Yu-Shiang / Hämmerer, Dorothea / Klados, Manousos A / Li, Shu-Chen

PloS one

2019 Band 14, Heft 5, Seite(n) e0215849

Abstract: Aging and dopamine modulation have both been independently shown to influence the functional connectivity of brain networks during rest. Dopamine modulation is known to decline during the course of aging. Previous evidence also shows that the dopamine ... ...

Abstract	Aging and dopamine modulation have both been independently shown to influence the functional connectivity of brain networks during rest. Dopamine modulation is known to decline during the course of aging. Previous evidence also shows that the dopamine transporter gene (DAT1) influences the re-uptake of dopamine and the anyA9 genotype of this gene is associated with higher striatal dopamine signaling. Expanding these two lines of prior research, we investigated potential interactive effects between aging and individual variations in the DAT1 gene on the modular organization of brain acvitiy during rest. The graph-theoretic metrics of modularity, betweenness centrality and participation coefficient were assessed in 41 younger (age 20-30 years) and 37 older (age 60-75 years) adults. Age differences were only observed in the participation coefficient in carriers of the anyA9 genotype of the DAT1 gene and this effect was most prominently observed in the default mode network. Furthermore, we found that individual differences in the values of the participation coefficient correlated with individual differences in fluid intelligence and a measure of executive control in the anyA9 carriers. The correlation between participation coefficient and fluid intelligence was mainly shared with age-related differences, whereas the correlation with executive control was independent of age. These findings suggest that DAT1 genotype moderates age differences in the functional integration of brain networks as well as the relation between network characteristics and cognitive abilities.
Mesh-Begriff(e)	Adult ; Aged ; Aging/genetics ; Aging/physiology ; Brain/diagnostic imaging ; Brain/metabolism ; Brain/physiology ; Brain Mapping ; Cognition ; Dopamine Plasma Membrane Transport Proteins/genetics ; Female ; Genotype ; Humans ; Magnetic Resonance Imaging ; Male ; Middle Aged ; Nerve Net/diagnostic imaging ; Nerve Net/metabolism ; Nerve Net/physiology ; Rest/physiology ; Young Adult
Chemische Substanzen	Dopamine Plasma Membrane Transport Proteins ; SLC6A3 protein, human
Sprache	Englisch
Erscheinungsdatum	2019-05-08
Erscheinungsland	United States
Dokumenttyp	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	1932-6203
ISSN (online)	1932-6203
DOI	10.1371/journal.pone.0215849
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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