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Article ; Online: Social determinants of health, health disparities, and adiposity.

Baez, Andrew S / Ortiz-Whittingham, Lola R / Tarfa, Hannatu / Osei Baah, Foster / Thompson, Keitra / Baumer, Yvonne / Powell-Wiley, Tiffany M

Progress in cardiovascular diseases

2023 Volume 78, Page(s) 17–26

Abstract: Social determinants of health (SDoH), or the socioeconomic, environmental, and psychosocial conditions in which individuals spend their daily lives, substantially influence obesity as a cardiovascular disease (CVD) risk factor. The coronavirus disease ... ...

Abstract	Social determinants of health (SDoH), or the socioeconomic, environmental, and psychosocial conditions in which individuals spend their daily lives, substantially influence obesity as a cardiovascular disease (CVD) risk factor. The coronavirus disease 2019 (COVID-19) pandemic highlighted the converging epidemics of obesity, CVD, and social inequities globally. Obesity and CVD serve as independent risk factors for COVID-19 severity and lower-resourced populations most impacted by adverse SDoH have the highest COVID-19 mortality rates. Better understanding the interplay between social and biologic factors that contribute to obesity-related CVD disparities are important to equitably address obesity across populations. Despite efforts to investigate SDoH and their biologic effects as drivers of health disparities, the connections between SDoH and obesity remain incompletely understood. This review aims to highlight the relationships between socioeconomic, environmental, and psychosocial factors and obesity. We also present potential biologic factors that may play a role in the biology of adversity, or link SDoH to adiposity and poor adipo-cardiology outcomes. Finally, we provide evidence for multi-level obesity interventions targeting multiple aspects of SDoH. Throughout, we emphasize areas for future research to tailor health equity-promoting interventions across populations to reduce obesity and obesity-related CVD disparities.
MeSH term(s)	Humans ; Adiposity ; Social Determinants of Health ; COVID-19/epidemiology ; Obesity/diagnosis ; Obesity/epidemiology ; Cardiovascular Diseases/diagnosis ; Cardiovascular Diseases/epidemiology ; Cardiovascular Diseases/prevention & control
Language	English
Publishing date	2023-05-11
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	209312-1
ISSN	1873-1740 ; 1532-8643 ; 0033-0620
ISSN (online)	1873-1740 ; 1532-8643
ISSN	0033-0620
DOI	10.1016/j.pcad.2023.04.011
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Article ; Online: Neighborhood socioeconomic deprivation and individual-level socioeconomic status are associated with dopamine-mediated changes to monocyte subset CCR2 expression via a cAMP-dependent pathway.

Baumer, Yvonne / Pita, Mario A / Turner, Briana S / Baez, Andrew S / Ortiz-Whittingham, Lola R / Gutierrez-Huerta, Cristhian A / Neally, Sam J / Farmer, Nicole / Mitchell, Valerie M / Collins, Billy S / Powell-Wiley, Tiffany M

Brain, behavior, & immunity - health

2023 Volume 30, Page(s) 100640

Abstract: Social determinants of health (SDoH) include socioeconomic, environmental, and psychological factors that impact health. Neighborhood socioeconomic deprivation (NSD) and low individual-level socioeconomic status (SES) are SDoH that associate with ... ...

Abstract	Social determinants of health (SDoH) include socioeconomic, environmental, and psychological factors that impact health. Neighborhood socioeconomic deprivation (NSD) and low individual-level socioeconomic status (SES) are SDoH that associate with incident heart failure, stroke, and cardiovascular mortality, but the underlying biological mechanisms are not well understood. Previous research has demonstrated an association between NSD, in particular, and key components of the neural-hematopoietic-axis including amygdala activity as a marker of chronic stress, bone marrow activity, and arterial inflammation. Our study further characterizes the role of NSD and SES as potential sources of chronic stress related to downstream immunological factors in this stress-associated biologic pathway. We investigated how NSD, SES, and catecholamine levels (as proxy for sympathetic nervous system activation) may influence monocytes which are known to play a significant role in atherogenesis. First, in an
Language	English
Publishing date	2023-05-14
Publishing country	United States
Document type	Journal Article
ISSN	2666-3546
ISSN (online)	2666-3546
DOI	10.1016/j.bbih.2023.100640
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Article ; Online: By what molecular mechanisms do social determinants impact cardiometabolic risk?

Baumer, Yvonne / Pita, Mario A / Baez, Andrew S / Ortiz-Whittingham, Lola R / Cintron, Manuel A / Rose, Rebecca R / Gray, Veronica C / Osei Baah, Foster / Powell-Wiley, Tiffany M

Clinical science (London, England : 1979)

2023 Volume 137, Issue 6, Page(s) 469–494

Abstract: While it is well known from numerous epidemiologic investigations that social determinants (socioeconomic, environmental, and psychosocial factors exposed to over the life-course) can dramatically impact cardiovascular health, the molecular mechanisms by ...

Abstract	While it is well known from numerous epidemiologic investigations that social determinants (socioeconomic, environmental, and psychosocial factors exposed to over the life-course) can dramatically impact cardiovascular health, the molecular mechanisms by which social determinants lead to poor cardiometabolic outcomes are not well understood. This review comprehensively summarizes a variety of current topics surrounding the biological effects of adverse social determinants (i.e., the biology of adversity), linking translational and laboratory studies with epidemiologic findings. With a strong focus on the biological effects of chronic stress, we highlight an array of studies on molecular and immunological signaling in the context of social determinants of health (SDoH). The main topics covered include biomarkers of sympathetic nervous system and hypothalamic-pituitary-adrenal axis activation, and the role of inflammation in the biology of adversity focusing on glucocorticoid resistance and key inflammatory cytokines linked to psychosocial and environmental stressors (PSES). We then further discuss the effect of SDoH on immune cell distribution and characterization by subset, receptor expression, and function. Lastly, we describe epigenetic regulation of the chronic stress response and effects of SDoH on telomere length and aging. Ultimately, we highlight critical knowledge gaps for future research as we strive to develop more targeted interventions that account for SDoH to improve cardiometabolic health for at-risk, vulnerable populations.
MeSH term(s)	Humans ; Social Determinants of Health ; Hypothalamo-Hypophyseal System ; Epigenesis, Genetic ; Pituitary-Adrenal System ; Cardiovascular Diseases/epidemiology ; Cardiovascular Diseases/etiology
Language	English
Publishing date	2023-03-24
Publishing country	England
Document type	Review ; Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	206835-7
ISSN	1470-8736 ; 0301-0538 ; 0009-0360 ; 0143-5221
ISSN (online)	1470-8736
ISSN	0301-0538 ; 0009-0360 ; 0143-5221
DOI	10.1042/CS20220304
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Article ; Online: Associations between neighborhood socioeconomic deprivation, IFNγ, and high-density lipoprotein particle size: Data from the Washington, D.C. cardiovascular health and needs assessment.

Ortiz-Whittingham, Lola R / Baumer, Yvonne / Pang, Alina P S / Sampson, Maureen / Baez, Andrew S / Rose, Rebecca R / Noonan, Sarah H / Mendez-Silva, Joanna / Collins, Billy S / Mitchell, Valerie M / Cintron, Manuel A / Farmer, Nicole / Remaley, Alan T / Corley, Michael J / Powell-Wiley, Tiffany M

Psychoneuroendocrinology

2023 Volume 157, Page(s) 106346

Abstract: Introduction: Neighborhood socioeconomic deprivation is associated with increased cardiovascular risk factors, including inflammation. Inflammation plays an important role in modifying the cardioprotective function of high-density lipoprotein (HDL). ... ...

Abstract	Introduction: Neighborhood socioeconomic deprivation is associated with increased cardiovascular risk factors, including inflammation. Inflammation plays an important role in modifying the cardioprotective function of high-density lipoprotein (HDL). Moreover, recent studies suggest that very high HDL is associated with adverse cardiovascular disease (CVD) outcomes. Thus, we sought to explore the relationships between neighborhood socioeconomic deprivation as a marker of chronic stress, inflammation, proprotein convertase subtilisin/kexin type 9 (PCSK9) (a core component of the HDL proteome), HDL characterisitcs, and biological aging as a predictor of CVD and all-cause mortality. Methods: Sixty African American subjects were recruited to the NIH Clinical Center as part of a community-based participatory research-designed observational study. Neighborhood deprivation index (NDI), a marker of neighborhood socioeconomic deprivation, was measured using US Census data. HDL characteristics (cholesterol, particle number, size, subspecies) were determined from NMR lipoprotein profiling, and plasma cytokines (IL-1β, IL-6, IL-8, TNFα, IFNγ) were measured using an ELISA-based multiplex technique. Epigenetic clock biomarkers of aging were measured using DNA methylation data obtained from participants' buffy coat samples. We used linear regression modeling adjusted for atherosclerotic cardiovascular disease (ASCVD) risk score, body mass index (BMI), and lipid-lowering medication use to investigate relationships of interest. Results: NDI directly associated with large HDL particle count (H7P) and IFNγ and trended toward significance with HDL-C and PCSK9. IFNγ and PCSK9 then directly associated with H7P. H7P also directly associated with higher DNA methylation phenotypic age (PhenoAge). Conclusion: We highlight associations between neighborhood socioeconomic deprivation, IFNγ, PCSK9, HDL subspecies, and epigenetic biomarkers of aging. Taken together, our findings suggest indirect pathways linking neighborhood deprivation-related stress and inflammation to HDL and immune epigenetic changes. Moreover, these results add to recent work showing the pathogenicity of high HDL levels and underscore the need to understand how chronic stress-related inflammation and lipoprotein subspecies relate to CVD risk across diverse populations.
MeSH term(s)	Humans ; Proprotein Convertase 9/metabolism ; Cardiovascular Diseases ; District of Columbia ; Needs Assessment ; Particle Size ; Lipoproteins, HDL/metabolism ; Lipoproteins ; Biomarkers ; Inflammation/complications ; Socioeconomic Factors
Chemical Substances	PCSK9 protein, human (EC 3.4.21.-) ; Proprotein Convertase 9 (EC 3.4.21.-) ; Lipoproteins, HDL ; Lipoproteins ; Biomarkers
Language	English
Publishing date	2023-08-09
Publishing country	England
Document type	Observational Study ; Journal Article ; Research Support, N.I.H., Intramural ; Research Support, N.I.H., Extramural
ZDB-ID	197636-9
ISSN	1873-3360 ; 0306-4530
ISSN (online)	1873-3360
ISSN	0306-4530
DOI	10.1016/j.psyneuen.2023.106346
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Article ; Online: Social Determinants of Cardiovascular Disease.

Powell-Wiley, Tiffany M / Baumer, Yvonne / Baah, Foster Osei / Baez, Andrew S / Farmer, Nicole / Mahlobo, Christa T / Pita, Mario A / Potharaju, Kameswari A / Tamura, Kosuke / Wallen, Gwenyth R

Circulation research

2022 Volume 130, Issue 5, Page(s) 782–799

Abstract: Social determinants of health (SDoH), which encompass the economic, social, environmental, and psychosocial factors that influence health, play a significant role in the development of cardiovascular disease (CVD) risk factors as well as CVD morbidity ... ...

Abstract	Social determinants of health (SDoH), which encompass the economic, social, environmental, and psychosocial factors that influence health, play a significant role in the development of cardiovascular disease (CVD) risk factors as well as CVD morbidity and mortality. The COVID-19 pandemic and the current social justice movement sparked by the death of George Floyd have laid bare long-existing health inequities in our society driven by SDoH. Despite a recent focus on these structural drivers of health disparities, the impact of SDoH on cardiovascular health and CVD outcomes remains understudied and incompletely understood. To further investigate the mechanisms connecting SDoH and CVD, and ultimately design targeted and effective interventions, it is important to foster interdisciplinary efforts that incorporate translational, epidemiological, and clinical research in examining SDoH-CVD relationships. This review aims to facilitate research coordination and intervention development by providing an evidence-based framework for SDoH rooted in the lived experiences of marginalized populations. Our framework highlights critical structural/socioeconomic, environmental, and psychosocial factors most strongly associated with CVD and explores several of the underlying biologic mechanisms connecting SDoH to CVD pathogenesis, including excess stress hormones, inflammation, immune cell function, and cellular aging. We present landmark studies and recent findings about SDoH in our framework, with careful consideration of the constructs and measures utilized. Finally, we provide a roadmap for future SDoH research focused on individual, clinical, and policy approaches directed towards developing multilevel community-engaged interventions to promote cardiovascular health.
MeSH term(s)	Cardiovascular Diseases/epidemiology ; Health Equity/statistics & numerical data ; Humans ; Social Determinants of Health/statistics & numerical data
Language	English
Publishing date	2022-03-03
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	80100-8
ISSN	1524-4571 ; 0009-7330 ; 0931-6876
ISSN (online)	1524-4571
ISSN	0009-7330 ; 0931-6876
DOI	10.1161/CIRCRESAHA.121.319811
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Article: Social Determinants modulate NK cell activity via obesity, LDL, and DUSP1 signaling.

Baumer, Yvonne / Singh, Komudi / Baez, Andrew S / Gutierrez-Huerta, Christian A / Chen, Long / Igboko, Muna / Turner, Briana S / Yeboah, Josette A / Reger, Robert N / Ortiz-Whittingham, Lola R / Bleck, Christopher K E / Mitchell, Valerie M / Collins, Billy S / Pirooznia, Mehdi / Dagur, Pradeep K / Allan, David S J / Muallem-Schwartz, Daniella / Childs, Richard W / Powell-Wiley, Tiffany M

bioRxiv : the preprint server for biology

2023

Abstract: Adverse social determinants of health (aSDoH) are associated with obesity and related comorbidities like diabetes, cardiovascular disease, and cancer. Obesity is also associated with natural killer cell (NK) dysregulation, suggesting a potential ... ...

Abstract	Adverse social determinants of health (aSDoH) are associated with obesity and related comorbidities like diabetes, cardiovascular disease, and cancer. Obesity is also associated with natural killer cell (NK) dysregulation, suggesting a potential mechanistic link. Therefore, we measured NK phenotypes and function in a cohort of African-American (AA) women from resource-limited neighborhoods. Obesity was associated with reduced NK cytotoxicity and a shift towards a regulatory phenotype.
Language	English
Publishing date	2023-09-15
Publishing country	United States
Document type	Preprint
DOI	10.1101/2023.09.12.556825
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Article ; Online: Inflammation-induced iron transport and metabolism by brain microglia.

McCarthy, Ryan C / Sosa, Jose Carlo / Gardeck, Andrew M / Baez, Andrew S / Lee, Chih-Hao / Wessling-Resnick, Marianne

The Journal of biological chemistry

2018 Volume 293, Issue 20, Page(s) 7853–7863

Abstract: Microglia are immune cells of the central nervous system and are implicated in brain inflammation. However, how brain microglia modulate transport and metabolism of the essential metal iron in response to pro- and anti-inflammatory environmental cues is ... ...

Abstract	Microglia are immune cells of the central nervous system and are implicated in brain inflammation. However, how brain microglia modulate transport and metabolism of the essential metal iron in response to pro- and anti-inflammatory environmental cues is unclear. Here, we characterized uptake of transferrin (Tf)-bound iron (TBI) and non-Tf-bound iron (NTBI) by immortalized microglial (IMG) cells. We found that these cells preferentially take up NTBI in response to the proinflammatory stimulus lipopolysaccharide (LPS) or β-amyloid (Aβ). In contrast, the anti-inflammatory cytokine interleukin 4 (IL-4) promoted TBI uptake. Concordant with these functional data, levels of the Tf receptor (TfR) in IMG cells were up-regulated in response to IL-4, whereas divalent metal transporter-1 (DMT1) and ferritin levels increased in response to LPS or Aβ. Similar changes in expression were confirmed in isolated primary adult mouse microglia treated with pro- or anti-inflammatory inducers. LPS-induced changes in IMG cell iron metabolism were accompanied by notable metabolic changes, including increased glycolysis and decreased oxidative respiration. Under these conditions, the extracellular acidification rate was increased, compatible with changes in the cellular microenvironment that would support the pH-dependent function of DMT1. Moreover, LPS increased heme oxygenase-1 (HO1) expression in IMG cells, and iron released because of HO1 activity increased the intracellular labile free-iron pool. Together, this evidence indicates that brain microglia preferentially acquire iron from Tf or from non-Tf sources, depending on their polarization state; that NTBI uptake is enhanced by the proinflammatory response; and that under these conditions microglia sequester both extra- and intracellular iron.
MeSH term(s)	Amyloid beta-Peptides/pharmacology ; Animals ; Brain/metabolism ; Brain/pathology ; Cation Transport Proteins/genetics ; Cation Transport Proteins/metabolism ; Cell Line, Transformed ; Cellular Microenvironment ; Ferritins/genetics ; Ferritins/metabolism ; Gene Expression Regulation ; Glycolysis/drug effects ; Glycolysis/genetics ; Heme Oxygenase-1/genetics ; Heme Oxygenase-1/metabolism ; Hydrogen-Ion Concentration ; Inflammation ; Ion Transport ; Iron/metabolism ; Lipopolysaccharides/pharmacology ; Membrane Proteins/genetics ; Membrane Proteins/metabolism ; Mice ; Microglia/drug effects ; Microglia/metabolism ; Microglia/pathology ; Oxidative Phosphorylation/drug effects ; Primary Cell Culture ; Receptors, Transferrin/genetics ; Receptors, Transferrin/metabolism ; Signal Transduction ; Transferrin/genetics ; Transferrin/metabolism
Chemical Substances	Amyloid beta-Peptides ; Cation Transport Proteins ; Lipopolysaccharides ; Membrane Proteins ; Receptors, Transferrin ; Transferrin ; solute carrier family 11- (proton-coupled divalent metal ion transporters), member 2 ; Ferritins (9007-73-2) ; Iron (E1UOL152H7) ; Heme Oxygenase-1 (EC 1.14.14.18) ; Hmox1 protein, mouse (EC 1.14.14.18)
Language	English
Publishing date	2018-04-02
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	2997-x
ISSN	1083-351X ; 0021-9258
ISSN (online)	1083-351X
ISSN	0021-9258
DOI	10.1074/jbc.RA118.001949
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Article ; Online: Customizing Place-Tailored Messaging Using a Multilevel Approach: Pilot Study of the Step It Up Physical Activity Mobile App Tailored to Neighborhood Environment.

Vijayakumar, Nithya P / Neally, Sam J / Potharaju, Kameswari A / Curlin, Kaveri / Troendle, James F / Collins, Billy S / Mitchell, Valerie M / Tamura, Kosuke / Ayers, Colby / Pita, Mario A / Tarfa, Hannatu A / Thompson, Keitra / Osei Baah, Foster / Baez, Andrew S / Ortiz-Whittingham, Lola R / Wills Gallagher, Jennifer / McCoy, Regina / Heist, Michael / Gutierrez-Huerta, Cristhian A /

Turner, Briana S / Baumer, Yvonne / Farmer, Nicole / Wallen, Gwenyth R / Dodge, Tonya / Powell-Wiley, Tiffany M

Circulation. Cardiovascular quality and outcomes

2022 Volume 15, Issue 11, Page(s) e009328

MeSH term(s)	Humans ; Mobile Applications ; Pilot Projects ; Residence Characteristics ; Exercise
Language	English
Publishing date	2022-11-15
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Intramural
ZDB-ID	2483197-9
ISSN	1941-7705 ; 1941-7713
ISSN (online)	1941-7705
ISSN	1941-7713
DOI	10.1161/CIRCOUTCOMES.122.009328
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