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  1. Article ; Online: Women's Experience With Screening Mammography During the COVID-19 Pandemic: A Multi-Institutional Prospective Survey Study.

    Carnahan, Molly B / Sharpe, Richard E / Oluyemi, Eniola / Parra, Laura / Hippe, Daniel S / Lorans, Roxanne / Perry, Hannah / Moey, Tammy Hui Lin / Bagadiya, Neeti / Lee, Janie M

    Journal of breast imaging

    2024  Volume 4, Issue 3, Page(s) 253–262

    Abstract: Objective: Evaluate women's anxiety and experience undergoing screening mammography during the COVID-19 pandemic.: Methods: An IRB-approved anonymous survey was administered to women receiving screening mammography across six sites in the U.S. and ... ...

    Abstract Objective: Evaluate women's anxiety and experience undergoing screening mammography during the COVID-19 pandemic.
    Methods: An IRB-approved anonymous survey was administered to women receiving screening mammography across six sites in the U.S. and Singapore from October 7, 2020, to March 11, 2021. Using a 1-5 Likert scale, women rated their pre- and post-visit anxiety regarding having their mammogram during the COVID-19 pandemic, importance of observed COVID-19 precautions, and personal risk factors for breast cancer and severe COVID-19 illness. Post-visit change in anxiety was evaluated. Multivariable logistic regression was used to test associations of pre-visit anxiety with breast cancer and COVID-19 risk factors.
    Results: In total, 1086 women completed the survey. Of these, 59% (630/1061) had >1 breast cancer risk factor; 27% (282/1060) had >1 COVID-19 risk factors. Forty-two percent (445/1065) experienced pre-visit anxiety. Pre-visit anxiety was independently associated with risk factors for severe COVID-19 (OR for >2 vs 0 risk factors: 2.04, 95% confidence interval [CI]: 1.11-3.76) and breast cancer (OR for >2 vs 0 risk factors: 1.71, 95% CI: 1.17-2.50), after adjusting for age and site. Twenty-six percent (272/1065) of women reported post-visit anxiety, an absolute 16% decrease from pre-visit anxiety (95% CI: 14%-19%, P < 0.001). Provider masking (941/1075, 88%) and physical distancing (861/1085, 79%) were rated as the most important precautions.
    Conclusion: Pre-visit anxiety was associated with COVID-19 or breast cancer risk factors and declined significantly after screening mammography. Provider masking and physical distancing were rated the most important precautions implemented by imaging clinics.
    Language English
    Publishing date 2024-02-28
    Publishing country United States
    Document type Journal Article
    ISSN 2631-6129
    ISSN (online) 2631-6129
    DOI 10.1093/jbi/wbac022
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  2. Article ; Online: Use of desipramine for the treatment of overactive bladder refractory to antimuscarinic therapy.

    Hillelsohn, Joel H / Rais-Bahrami, Soroush / Bagadiya, Neeti / Kashan, Mahyar / Weiss, Gary H

    Urology journal

    2014  Volume 10, Issue 4, Page(s) 1114–1118

    Abstract: Purpose: To evaluate the use of desipramine in the treatment of overactive bladder (OAB).: Materials and methods: We retrospectively evaluated 43 patients who were treated with desipramine for OAB refractory to antimuscarinic therapy. These OAB ... ...

    Abstract Purpose: To evaluate the use of desipramine in the treatment of overactive bladder (OAB).
    Materials and methods: We retrospectively evaluated 43 patients who were treated with desipramine for OAB refractory to antimuscarinic therapy. These OAB patients were stratified by the presence or absence of bladder pain.
    Results: Forty-three patients were evaluated with a mean follow up time of 12.2 ± 4.6 months. The mean age of the patients was 71 ± 16 years. Twelve patients (28%) discontinued desipramine, 9 due to perceived lack of efficacy, 2 due to central anticholinergic side effects, and 1 due to the development of oropharyngeal sores. Patients were stratified into two subgroups based upon treatment with desipramine for OAB alone (n = 29) or OAB and bladder pain (n = 14). There was no difference between the groups in regard to sex (P = .34), prior history of radiation (P = .19), side effects (P = .16), and specifically evaluated central anti-cholinergic side effects (P = .66). There was no statistical difference in the self-reported success rate of the medication (P = .48). In the OAB plus bladder pain subgroup, 71% of patients reported improvement in their pain. Overall, 13 (30%) patients had history of prior pelvic radiation and 10 of those (77%) reported improvement with desipramine.
    Conclusion: Desipramine is a potential useful treatment for patients with OAB. In addition, it can be used in patients with OAB and bladder pain and patients with complex OAB such as OAB caused by pelvic radiation.
    MeSH term(s) Adrenergic Uptake Inhibitors/adverse effects ; Adrenergic Uptake Inhibitors/therapeutic use ; Aged ; Aged, 80 and over ; Desipramine/adverse effects ; Desipramine/therapeutic use ; Drug Resistance ; Female ; Humans ; Male ; Middle Aged ; Muscarinic Antagonists/therapeutic use ; Off-Label Use ; Pain/complications ; Pain/drug therapy ; Radiation Injuries/complications ; Radiation Injuries/drug therapy ; Retrospective Studies ; Urinary Bladder/radiation effects ; Urinary Bladder, Overactive/complications ; Urinary Bladder, Overactive/drug therapy
    Chemical Substances Adrenergic Uptake Inhibitors ; Muscarinic Antagonists ; Desipramine (TG537D343B)
    Language English
    Publishing date 2014-01-04
    Publishing country Iran
    Document type Journal Article
    ZDB-ID 2251940-3
    ISSN 1735-546X ; 1735-1308
    ISSN (online) 1735-546X
    ISSN 1735-1308
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  3. Article ; Online: Outcomes of Preoperative MRI-Guided Needle Localization of Nonpalpable Mammographically Occult Breast Lesions.

    Gao, Yiming / Bagadiya, Neeti R / Jardon, Meghan L / Heller, Samantha L / Melsaether, Amy N / Toth, Hildegard B / Moy, Linda

    AJR. American journal of roentgenology

    2016  Volume 207, Issue 3, Page(s) 676–684

    Abstract: Objective: MRI-guided needle localization allows access to MRI-detected mammographically occult breast lesions that are not amenable to MRI-guided biopsy. The purpose of this study was to examine the safety and outcomes of MRI-guided needle localization. ...

    Abstract Objective: MRI-guided needle localization allows access to MRI-detected mammographically occult breast lesions that are not amenable to MRI-guided biopsy. The purpose of this study was to examine the safety and outcomes of MRI-guided needle localization.
    Materials and methods: Ninety-nine consecutive breast lesions that underwent preoperative MRI-guided needle localization were identified. Clinical indications for breast MRI, reasons for performing MRI-guided needle localization, and surgical pathology results were recorded. Lesion characteristics, procedure time, and complications were assessed.
    Results: Of 99 lesions, 60 (60.6%) were in a location inaccessible for MRI biopsy, necessitating MRI-guided needle localization. Histologic evaluation revealed 38 (38.4%) carcinomas, 31 (31.3%) high-risk lesions, and 30 (30.3%) benign lesions. Carcinoma was more likely to be found in women with known cancer (31/61 [50.8%]; p = 0.003) than in women undergoing imaging for high-risk screening (2/18 [11.1%]) or problem solving (6/20 [30%]). Masses (p = 0.013) and foci (p < 0.001) were more likely to be malignant than were lesions with nonmass enhancement. Foci were significantly more often malignant compared with all other lesion types (9/10 [90%]; p < 0.001). The mean (± SD) procedure time was 32.9 ± 9.39 minutes. All lesions were occult on specimen radiographs. There were no procedure-related complications.
    Conclusion: The positive predictive value of MRI-guided needle localization (38.4%) is comparable to that of mammography- and tomosynthesis-guided localizations and is highest in women with a known diagnosis of cancer. It is highly accurate in targeting small enhancing lesions, thereby improving surgical management. MRI-guided needle localization is a safe, accurate, and time-efficient procedure.
    MeSH term(s) Adult ; Aged ; Aged, 80 and over ; Biopsy, Needle/methods ; Breast Neoplasms/pathology ; Female ; Humans ; Image-Guided Biopsy/methods ; Magnetic Resonance Imaging ; Mammography ; Middle Aged ; Predictive Value of Tests ; Retrospective Studies
    Language English
    Publishing date 2016-09
    Publishing country United States
    Document type Journal Article
    ZDB-ID 82076-3
    ISSN 1546-3141 ; 0361-803X ; 0092-5381
    ISSN (online) 1546-3141
    ISSN 0361-803X ; 0092-5381
    DOI 10.2214/AJR.15.15913
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  4. Article: Is Proton Therapy a "Pro" for Breast Cancer? A Comparison of Proton vs. Non-proton Radiotherapy Using the National Cancer Database.

    Chowdhary, Mudit / Lee, Anna / Gao, Sarah / Wang, Dian / Barry, Parul N / Diaz, Roberto / Bagadiya, Neeti R / Park, Henry S / Yu, James B / Wilson, Lynn D / Moran, Meena S / Higgins, Susan A / Knowlton, Christin A / Patel, Kirtesh R

    Frontiers in oncology

    2019  Volume 8, Page(s) 678

    Abstract: Background: ...

    Abstract Background:
    Language English
    Publishing date 2019-01-14
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2649216-7
    ISSN 2234-943X
    ISSN 2234-943X
    DOI 10.3389/fonc.2018.00678
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  5. Article ; Online: Feasibility analysis of early temporal kinetics as a surrogate marker for breast tumor type, grade, and aggressiveness.

    Heacock, Laura / Lewin, Alana A / Gao, Yiming / Babb, James S / Heller, Samantha L / Melsaether, Amy N / Bagadiya, Neeti / Kim, Sungheon G / Moy, Linda

    Journal of magnetic resonance imaging : JMRI

    2017  Volume 47, Issue 6, Page(s) 1692–1700

    Abstract: Background: Screening breast MRI has been shown to preferentially detect high-grade ductal carcinoma in situ (DCIS) and invasive carcinoma, likely due to increased angiogenesis resulting in early initial uptake of contrast. As interest grows in ... ...

    Abstract Background: Screening breast MRI has been shown to preferentially detect high-grade ductal carcinoma in situ (DCIS) and invasive carcinoma, likely due to increased angiogenesis resulting in early initial uptake of contrast. As interest grows in abbreviated screening breast MRI (AB-MRI), markers of early contrast washin that can predict tumor grade and potential aggressiveness are of clinical interest.
    Purpose: To evaluate the feasibility of using the initial enhancement ratio (IER) as a surrogate marker for tumor grade, hormone receptor status, and prognostic markers, as an initial step to being incorporated into AB-MRI.
    Study type: Retrospective.
    Subjects: In all, 162 women (mean 55.0 years, range 32.8-87.7 years) with 187 malignancies imaged January 2012-November 2015.
    Field strength/sequence: Images were acquired at 3.0T with a T
    Assessment: Subjects underwent dynamic contrast-enhanced breast MRI with a 7-channel breast coil. IER (% signal increase over baseline at the first postcontrast acquisition) was assessed and correlated with background parenchymal enhancement, washout curves, stage, and final pathology.
    Statistical tests: Chi-square test, Spearman rank correlation, Mann-Whitney U-tests, Bland-Altman analysis, and receiver operating characteristic curve analysis.
    Results: IER was higher for invasive cancer than for DCIS (R1/R2, P < 0.001). IER increased with tumor grade (R1: r = 0.56, P < 0.001, R2: r = 0.50, P < 0.001), as ki-67 increased (R1: r = 0.35, P < 0.001; R2 r = 0.35, P < 0.001), and for node-positive disease (R1/R2, P = 0.001). IER was higher for human epidermal growth factor receptor two-positive and triple negative cancers than for estrogen receptor-positive / progesterone receptor-positive tumors (R1 P < 0.001-0.002; R2 P = 0.0.001-0.011). IER had higher sensitivity (80.6% vs. 75.5%) and specificity (55.8% vs. 48.1%) than washout curves for positive nodes, higher specificity (48.1% vs. 36.5%) and positive predictive value (70.2% vs. 66.7%) for high ki-67, and excellent interobserver agreement (intraclass correlation coefficient = 0.82).
    Data conclusion: IER, a measurement of early contrast washin, is associated with higher-grade malignancies and tumor aggressiveness and might be potentially incorporated into an AB-MRI protocol.
    Level of evidence: 3 Technical Efficacy: Stage 2 J. Magn. Reson. Imaging 2018;47:1692-1700.
    MeSH term(s) Adult ; Aged ; Aged, 80 and over ; Biomarkers, Tumor/metabolism ; Biopsy ; Breast Neoplasms/diagnostic imaging ; Feasibility Studies ; Female ; Humans ; Image Processing, Computer-Assisted ; Kinetics ; Middle Aged ; Neoplasm Invasiveness ; Neovascularization, Pathologic ; Reproducibility of Results ; Retrospective Studies ; Sensitivity and Specificity
    Chemical Substances Biomarkers, Tumor
    Language English
    Publishing date 2017-11-27
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 1146614-5
    ISSN 1522-2586 ; 1053-1807
    ISSN (online) 1522-2586
    ISSN 1053-1807
    DOI 10.1002/jmri.25897
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    Zs.A 3648: Show issues Location:
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  6. Article ; Online: Masked pneumothorax: risk of valveless trocar systems.

    Hillelsohn, Joel H / Friedlander, Justin I / Bagadiya, Neeti / Okhunov, Zhamshid / Kashan, Mahyar / Schwartzur, Mikhail / Kavoussi, Louis

    The Journal of urology

    2013  Volume 189, Issue 3, Page(s) 955–959

    Abstract: Purpose: Unlike traditional valved trocars, the valveless trocar maintains pneumoperitoneum during laparoscopy by forming a CO(2) curtain at the proximal end of the trocar. This gas barrier instantaneously maintains exact intraperitoneal pressure that ... ...

    Abstract Purpose: Unlike traditional valved trocars, the valveless trocar maintains pneumoperitoneum during laparoscopy by forming a CO(2) curtain at the proximal end of the trocar. This gas barrier instantaneously maintains exact intraperitoneal pressure that yields to the transient physiological changes seen with breathing. Due to this different mechanism of action, pneumothorax development may be masked by the valveless trocar system.
    Materials and methods: We retrospectively reviewed 850 transperitoneal laparoscopic kidney and adrenal surgeries in which a valveless trocar system was used to determine any record of pneumothorax detected intraoperatively or postoperatively. A patient with pneumothorax was considered a case and anesthetic parameters were reviewed. A matched control group was generated from patients treated with transperitoneal laparoscopic kidney and adrenal surgery using the valveless trocar with no complications.
    Results: Pneumothorax was diagnosed in 10 patients (1.2%). Two cases were the result of intentional excision of the diaphragm, which were repaired intraoperatively, while 8 were not recognized until the postoperative period. Five of the patients (63%) with unintentional pneumothorax required chest tube placement for a mean of 2.4 days. The remaining 3 patients (37%) were treated conservatively and followed with serial chest x-rays. The only anesthetic variable that was significantly different between the groups was Δ end tidal CO(2) with greater fluctuations in end tidal CO(2) in the pneumothorax group than in controls (p = 0.03).
    Conclusions: Pneumothorax is a rare complication of laparoscopic urological surgery that is usually recognized intraoperatively through physiological changes. Valveless trocar systems mask these findings and can delay identification until the postoperative period.
    MeSH term(s) Equipment Design ; Equipment Failure ; Female ; Humans ; Iatrogenic Disease ; Laparoscopy/adverse effects ; Male ; Middle Aged ; Pneumothorax/etiology ; Retrospective Studies ; Surgical Instruments/adverse effects
    Language English
    Publishing date 2013-03
    Publishing country United States
    Document type Comparative Study ; Journal Article
    ZDB-ID 3176-8
    ISSN 1527-3792 ; 0022-5347
    ISSN (online) 1527-3792
    ISSN 0022-5347
    DOI 10.1016/j.juro.2012.08.244
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