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Article ; Online: Systematic review with meta-analysis: Steatosis severity and subclinical atherosclerosis in metabolic dysfunction-associated steatotic liver disease.

Jamalinia, Mohamad / Zare, Fatemeh / Noorizadeh, Kiarash / Bagheri Lankarani, Kamran

2024 Volume 59, Issue 4, Page(s) 445–458

Abstract: Background: Metabolic dysfunction-associated steatotic liver disease (MASLD) is a prevalent liver condition recognised as an independent risk factor for cardiovascular disease (CVD). However, there is ongoing debate regarding the effective strategy for ... ...

Abstract	Background: Metabolic dysfunction-associated steatotic liver disease (MASLD) is a prevalent liver condition recognised as an independent risk factor for cardiovascular disease (CVD). However, there is ongoing debate regarding the effective strategy for cardiovascular risk assessment in MASLD. Aim: To investigate the relationship between liver imaging, specifically focusing on the severity of steatosis and subclinical atherosclerosis. Methods: We conducted a thorough search across four databases, from 1950 to April 2023, to identify eligible studies employing imaging to explore the relationship between different degrees of steatosis and subclinical atherosclerosis among MASLD. Additionally, we conducted a quality assessment using the Newcastle Ottawa Scale, performed a meta-analysis employing the DerSimonian-Liard random-effects model, and conducted subgroup analyses for validation. Results: In total, 19 studies, encompassing 147,411 middle-aged individuals without previous CVD (74.94% male; mean age 45.53 years [SD 10.69]; mean BMI 24.3 kg/m Conclusions: Even mild steatosis is associated with CVD risk, and steatosis severity further intensifies this association. These findings suggest that liver fat quantification enhances CVD risk stratification in patients with MASLD.
MeSH term(s)	Female ; Humans ; Male ; Middle Aged ; Atherosclerosis/complications ; Atherosclerosis/diagnosis ; Cardiovascular Diseases ; Fatty Liver/complications ; Metabolic Diseases
Language	English
Publishing date	2024-01-07
Publishing country	England
Document type	Journal Article ; Meta-Analysis ; Systematic Review
ZDB-ID	639012-2
ISSN	1365-2036 ; 0269-2813 ; 0953-0673
ISSN (online)	1365-2036
ISSN	0269-2813 ; 0953-0673
DOI	10.1111/apt.17869
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Article ; Online: The Potential Role of Autophagy in Progression of Liver Fibrosis in Chronic Hepatitis B Patients Receiving Antiviral Treatment: A Brief Report.

Bagheri Lankarani, Kamran / Sadidoost, Atefeh / Fattahi, Mohammadreza / Amirizadeh Fard, Saeid / Mokarram, Pooneh

Iranian journal of medical sciences

2024 Volume 49, Issue 3, Page(s) 196–200

Abstract: Despite antiviral treatment, some patients with chronic hepatitis B (CHB) progress to cirrhosis. Enhancement of autophagy was implicated in the proliferation of hepatitis B in hepatocytes. This study aimed to evaluate the potential role of autophagy in ... ...

Abstract	Despite antiviral treatment, some patients with chronic hepatitis B (CHB) progress to cirrhosis. Enhancement of autophagy was implicated in the proliferation of hepatitis B in hepatocytes. This study aimed to evaluate the potential role of autophagy in the progression of liver fibrosis in patients receiving antiviral treatments and having completely inhibited viral replication. This descriptive-analytical study was designed and conducted in 2020 at Mottahhari Hepatitis Clinic affiliated with Shiraz University of Medical Science (Shiraz, Iran). Patients who were on anti-hepatitis B nucleotide treatments for at least two years, and those who were not cirrhotic at baseline but later progressed to cirrhosis were identified to be included in the case group. Besides, for the control group, patients on the nucleotide regimens who did not have cirrhosis at baseline or during follow-up were randomly selected. Ultimately, 16 cases and 14 controls were included in the study. Data were analyzed using SPSS software, and P<0.05 was considered statistically significant. Serum Beclin-1 and LC3 levels were compared between the two groups using enzyme-linked immunosorbent assays. The
MeSH term(s)	Humans ; Hepatitis B, Chronic/complications ; Hepatitis B, Chronic/drug therapy ; Antiviral Agents/pharmacology ; Antiviral Agents/therapeutic use ; Beclin-1 ; Liver Cirrhosis/complications ; Liver Cirrhosis/drug therapy ; Nucleotides/therapeutic use ; Autophagy
Chemical Substances	Antiviral Agents ; Beclin-1 ; Nucleotides
Language	English
Publishing date	2024-03-01
Publishing country	Iran
Document type	Journal Article
ZDB-ID	603872-4
ISSN	1735-3688 ; 0253-0716
ISSN (online)	1735-3688
ISSN	0253-0716
DOI	10.30476/ijms.2023.96588.2813
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Article ; Online: Factors contributing to the burnout of the faculties of a medical university in Iran: A cross-sectional study.

Ghahramani, Sulmaz / Moghadami, Mohsen / Omidifar, Navid / Tabatabaei, Seyed Mohamad Mehdi / Sayari, Mohammad / Bagheri Lankarani, Kamran

Brain and behavior

2024 Volume 14, Issue 1, Page(s) e3384

Abstract: Background and aims: Faculty members confront a variety of obstacles over time, the most recent of which is the coronavirus disease 2019 pandemic, which may increase their vulnerability to burnout (BO). This study aims to examine BO in medical school ... ...

Abstract	Background and aims: Faculty members confront a variety of obstacles over time, the most recent of which is the coronavirus disease 2019 pandemic, which may increase their vulnerability to burnout (BO). This study aims to examine BO in medical school faculties, as well as the factors that lead to BO and well-being in them. Methods: This cross-sectional study was conducted in 2021 using online questionnaires completed by 222 faculty members of a medical university in Iran. The Maslach Burnout Inventory-Human Services Survey (MBI-HSS) and the Well-being index (WBI) were used. Additionally, we gathered individual-level profiles (demographic, well-being) and occupational information (job profile, attitude toward work). Results: A total of 60 (27%) faculties reported having high BO, and 112 (50.5%) reported having low well-being. Being female (odds ratio, OR = 2.69), having time to spend with the family (OR = .26), the intent of turnover (OR = 8.65), job recommendation to the offspring (OR = .26), and experiencing violence last year (OR = 2.97) were some of the individual-level factors and job-related attitudes associated with a higher BO. In the neural network for BO, the most important variables were the intention of turnover, followed by adequate family time. Conclusion: One third of the responding faculty reported severe BO, and BO was found to be significantly associated with lower well-being. The increased levels of BO and a decreased experience of well-being were both associated with a higher intention of turnover. According to the study, it is important to pay attention to both clinical and nonclinical field faculty members, female faculty members, those who have a high workload, and members who have experienced violence in the workplace. By acknowledging the unique challenges and experiences faced by these individuals, tailored measures can be developed to address their specific concerns and foster a supportive and inclusive environment.
MeSH term(s)	Humans ; Female ; Male ; Cross-Sectional Studies ; Iran/epidemiology ; Universities ; Job Satisfaction ; Burnout, Professional/epidemiology ; Surveys and Questionnaires ; Faculty ; Psychological Tests ; Self Report
Language	English
Publishing date	2024-02-20
Publishing country	United States
Document type	Journal Article
ZDB-ID	2623587-0
ISSN	2162-3279 ; 2162-3279
ISSN (online)	2162-3279
ISSN	2162-3279
DOI	10.1002/brb3.3384
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Article ; Online: The Global Road Traffic Death Rate and Human Development Index from 2000 to 2019: A Trend Analysis.

Sayari, Mohammad / Rahmanian Haghighi, Mohammad Reza / Bagheri Lankarani, Kamran / Ghahramani, Sulmaz / Honarvar, Behnam

Archives of Iranian medicine

2024 Volume 27, Issue 3, Page(s) 113–121

Abstract: Background: Numerous studies on the association between the human development index (HDI) and road traffic death rate (RTDR) merely focus on developed countries, not reflecting the relationship between the HDI components and RTDR in a time-trend ... ...

Abstract	Background: Numerous studies on the association between the human development index (HDI) and road traffic death rate (RTDR) merely focus on developed countries, not reflecting the relationship between the HDI components and RTDR in a time-trend analysis. Accordingly, this study analyzes the trends of RTDR and their association with the HDI and its components from 2000 to 2019. Methods: The RTDR data of 154 countries were imported into the unconditional latent growth model (LGM) to assess the RTDR trends. The impact of the HDI and its components (viz., education, income, and life expectancy [LE viz]) on the trajectory of RTDR was also evaluated using the conditional LGM. Results: The results of the unconditional LGM indicated an overall decreasing trend in RTDR. The conditional LGM results revealed the negative effect of the HDI and its components on the model parameters. The findings of random forests indicated that education and LE were the most crucial variables. Conclusion: Overall, this study emphasizes the significance of HDI and its components, particularly education and LE, in lowering the number of traffic fatalities. In this sense, improving formal education and LE could be one of the main policies that policymakers could consider to reduce RTDR.
MeSH term(s)	Humans ; Accidents, Traffic/mortality ; Accidents, Traffic/statistics & numerical data ; Life Expectancy/trends ; Global Health ; Human Development ; Educational Status
Language	English
Publishing date	2024-03-01
Publishing country	Iran
Document type	Journal Article
ZDB-ID	2204979-4
ISSN	1735-3947 ; 1029-2977
ISSN (online)	1735-3947
ISSN	1029-2977
DOI	10.34172/aim.2024.18
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Article ; Online: Sociodemographic characteristics, riding behavior and motorcycle crash involvement: a structural equation modeling approach.

Naderpour, Sara / Heydari, Seyed Taghi / Bagheri Lankarani, Kamran / Motevalian, Seyed Abbas

Journal of injury & violence research

2023 Volume 15, Issue 1

Abstract: Background: The increasing rate of traffic crashes involving motorcyclists have turned into a public health and road safety concern. Furthermore, riding behaviors and their precedent factors have been identified as potential determinants for assessing, ... ...

Abstract	Background: The increasing rate of traffic crashes involving motorcyclists have turned into a public health and road safety concern. Furthermore, riding behaviors and their precedent factors have been identified as potential determinants for assessing, intervening, and preventing traffic injuries of motorists. This study aimed to identify the effects of a set of demographic and motorcycle-related variables as potential predictors on collision through riding behavior components. Methods: The study sample was 1,611 motorcyclists who were selected through time-location sampling method from three cities in Iran. They responded a Motorcycle Rider Behavior Questionnaire (MRBQ) and a general questionnaire including sociodemographic and riding-related items. The chosen method to analyze the data was Structural Equation Modeling (SEM) through Lavaan package version 0.6-8 of R software version 4.1.0. Results: All participants were male (100%) with a mean age of 28.1(SD=8.5) years. About 24.4% of riders experienced at least one crash during the last year and the majority of riders did not hold a motorcycle license (80.1%). The SEM model showed that riding license (0.06) and frequency of riding (0.09) had a direct effect on crash involvement. Some latent variables including speed violation (0.13), stunts (0.11) and traffic violation (0.07) had positive effects and safety violation (-0.07) had a negative effect on crash history. There were indirect effects between age and history of crash mediated by speed violation (-0.04), stunts (-0.04), traffic violation (-0.02) and safety violation (0.01). Also, the indirect effects of riding frequency on crash involvement were mediated by speed violation (0.01), traffic violation (0.006) and safety violation (-0.01). Conclusions: This study's main finding is that age and riding frequency are the main variables indirectly affecting crash involvement. Therefore, periodic training courses for younger riders is essential in order to decreasing crash involvements.
Language	English
Publishing date	2023-01-02
Publishing country	Iran
Document type	Journal Article
ZDB-ID	2573562-7
ISSN	2008-4072 ; 2008-4072
ISSN (online)	2008-4072
ISSN	2008-4072
DOI	10.5249/jivr.v15i1.1784
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Article ; Online: The cost of illness analysis of inflammatory bowel disease.

Pakdin, Majid / Zarei, Leila / Bagheri Lankarani, Kamran / Ghahramani, Sulmaz

BMC gastroenterology

2023 Volume 23, Issue 1, Page(s) 21

Abstract: Background: Inflammatory bowel disease (IBD) is a chronic inflammatory condition involving individuals across all age groups. Recent data suggests the increase in the prevalence of IBD and the surge in applying the biologic drugs in which both change ... ...

Abstract	Background: Inflammatory bowel disease (IBD) is a chronic inflammatory condition involving individuals across all age groups. Recent data suggests the increase in the prevalence of IBD and the surge in applying the biologic drugs in which both change the cost of IBD in recent years. Comprehensive assessment of direct and indirect cost profiles associated with IBD in our area is scarce. This study aimed to determine the economic burden of IBD in Iran from a societal perspective, using cost diaries. Methods: Patients available on clinic registry and hospital information system (HIS), who were diagnosed with IBD, were invited to take part in this study. Demographic and clinical data, the healthcare resource utilization or cost items, absenteeism for the patients and their caregivers were obtained. The cost of the used resources were derived from national tariffs. The data regarding premature mortality in IBD patients was extracted from HIS. Productivity loss was estimated based on the human capital method. Then, cost date were calculated as mean annual costs per patient. Results: The cost diaries were obtained from 240 subjects (Ulcerative colitis: n = 168, Crohn's disease, n = 72). The mean annual costs per patient were 1077 US$ (95% CI 900-1253), and 1608 (95% CI 1256, 1960) for the patients with ulcerative colitis and Crohn's disease, respectively. Of the total costs, 58% and 63% were in terms of the indirect costs for the patients with ulcerative colitis and Crohn's disease, respectively. The cost of illness for country was found to be 22,331,079 US$ and 15,183,678 US$ for patients with ulcerative colitis and Crohn's disease, respectively. Highest nationwide economic burden of IBD was found for patients older than 40 years were estimated to be 8,198,519 US$ and 7,120,891 US$, for ulcerative colitis and Crohn's disease, respectively. Conclusion: The medication was found to be the greatest contributor of direct medical costs. Productivity loss in terms of long-term disability and premature mortality were major components of IBD's economic burden in Iran.
MeSH term(s)	Humans ; Colitis, Ulcerative/drug therapy ; Crohn Disease/epidemiology ; Crohn Disease/drug therapy ; Inflammatory Bowel Diseases/epidemiology ; Health Care Costs ; Cost of Illness
Language	English
Publishing date	2023-01-19
Publishing country	England
Document type	Journal Article
ZDB-ID	2041351-8
ISSN	1471-230X ; 1471-230X
ISSN (online)	1471-230X
ISSN	1471-230X
DOI	10.1186/s12876-023-02648-z
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Article ; Online: Methodological and reporting quality of qualitative evidence in the field of lower limb orthoses: a systematic review.

Shahabi, Saeed / Bagheri Lankarani, Kamran / Hoseeinabadi, Mostafa / Heydari, Seyed Taghi

Assistive technology : the official journal of RESNA

2023 Volume 35, Issue 6, Page(s) 532–550

Abstract: This study aimed to assess the methodological and reporting quality of qualitative studies conducted in the field of lower limb orthoses (LLOs). The following electronic databases were searched from inception to 2022: PubMed, Scopus, ProQuest, WoS, ... ...

Abstract	This study aimed to assess the methodological and reporting quality of qualitative studies conducted in the field of lower limb orthoses (LLOs). The following electronic databases were searched from inception to 2022: PubMed, Scopus, ProQuest, WoS, Embase, the Cochrane Central Register of Controlled Trials, and RehabData. Two authors independently screened and selected the potential studies. The methodological quality of included studies was assessed using the Critical Appraisal Skills Programs qualitative checklist. In addition, the reporting quality of included studies was assessed using the Standards for Reporting Qualitative Research (SRQR) tool. The mean methodological quality score of included studies was 8 (from min = 2 to max = 9.5), and most of the studies had a score of more than 7.5. However, SRQR findings revealed that the overall reporting quality of included studies was not desirable in that the mean score was about 15.44 (from min = 6 to max = 19.5) out of 21. In total, the methodological quality of qualitative studies published in the field of LLOs was moderate. Further, the adherence of these studies to available reporting guidelines was unsatisfactory. As a result, when designing, performing, and reporting qualitative investigations, authors should pay more attention to these criteria.
MeSH term(s)	Humans ; Qualitative Research ; Reference Standards
Language	English
Publishing date	2023-05-02
Publishing country	United States
Document type	Systematic Review ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1014913-2
ISSN	1949-3614 ; 1040-0435
ISSN (online)	1949-3614
ISSN	1040-0435
DOI	10.1080/10400435.2023.2199056
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Article: Endoscopy during COVID-19 Pandemic.

Sadeghi, Anahita / Bagheri Lankarani, Kamran

Middle East journal of digestive diseases

2020 Volume 12, Issue 3, Page(s) 217–219

Keywords	covid19
Language	English
Publishing date	2020-10-01
Publishing country	Iran
Document type	Editorial
ZDB-ID	2623796-9
ISSN	2008-5249 ; 2008-5230
ISSN (online)	2008-5249
ISSN	2008-5230
DOI	10.34172/mejdd.2020.186
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Article ; Online: The association of patient-reported social determinants of health and hospitalization rate: A scoping review.

Ardekani, Ali / Fereidooni, Reza / Heydari, Seyed Taghi / Ghahramani, Sulmaz / Shahabi, Saeed / Bagheri Lankarani, Kamran

Health science reports

2023 Volume 6, Issue 2, Page(s) e1124

Abstract: Introduction: The interplay between social determinants of health (SDOH) and hospitalization is significant as targeted interventions can improve the social status of the individuals. This interrelation has been historically overlooked in health care. ... ...

Abstract	Introduction: The interplay between social determinants of health (SDOH) and hospitalization is significant as targeted interventions can improve the social status of the individuals. This interrelation has been historically overlooked in health care. In the present study, we reviewed studies in which the association between patient-reported social risks and hospitalization rate was assessed. Method: We performed a scoping literature review of articles published until September 1, 2022 without time limit. We searched PubMed, Embase, Web of Science, Scopus, and Google Scholar to find relevant studies using terms representing "social determinants of health" and "hospitalization." Forward and backward reference checking was done for the included studies. All studies that used patient-reported data as a proxy of social risks to determine the association between social risks and hospitalization rates were included. The screening and data extraction processes were done independently by two authors. In case of disagreement, senior authors were consulted. Results: Our search process retrieved a total of 14,852 records. After the duplicate removal and screening process, eight studies met the eligibility criteria, all of which were published from 2020 to 2022. The sample size of the studies ranged from 226 to 56,155 participants. All eight studies investigated the impact of food security on hospitalization, and six investigated economic status. In three studies, latent class analysis was applied to divide participants based on their social risks. Seven studies found a statistically significant association between social risks and hospitalization rates. Conclusion: Individuals with social risk factors are more susceptible to hospitalization. There is a need for a paradigm shift to meet these needs and reduce the number of preventable hospitalizations.
Language	English
Publishing date	2023-02-22
Publishing country	United States
Document type	Journal Article
ISSN	2398-8835
ISSN (online)	2398-8835
DOI	10.1002/hsr2.1124
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Article ; Online: Double burden of vulnerability for refugees: conceptualization and policy solutions for financial protection in Iran using systems thinking approach.

Shahabi, Saeed / Etemadi, Manal / Hedayati, Maryam / Bagheri Lankarani, Kamran / Jakovljevic, Mihajlo

Health research policy and systems

2023 Volume 21, Issue 1, Page(s) 94

Abstract: Introduction: Iran is host to one of the world's largest and longest-standing refugee populations. Although Iran has initiated a basic health insurance scheme for refugees throughout the country since September 2015, the population coverage of this ... ...

Abstract	Introduction: Iran is host to one of the world's largest and longest-standing refugee populations. Although Iran has initiated a basic health insurance scheme for refugees throughout the country since September 2015, the population coverage of this scheme is very low, and various factors have caused a significant percentage of refugees to still lack insurance coverage and often face financial hardships when receiving health services. In response, this study aimed to understand barriers to insurance coverage among refugees in Iran and propose effective policies that can address persistent gaps in financial protection. Methods: This qualitative study was conducted in two phases. First, a review of policy documents and interviews with participants were conducted to investigate the common barriers and facilitators of effective insurance coverage for refugees in Iran. Then, a systems thinking approach was applied to visualize the common variables and interactions on the path to achieving financial protection for refugees. Results: Findings showed that various factors, such as (1) household-based premium for refugees, (2) considering a waiting time to be eligible for insurance benefits, (3) determining high premiums for non-vulnerable groups and (4) a deep difference between the health services tariffs of the public and private service delivery sectors in Iran, have caused the coverage of health insurance for non-vulnerable refugees to be challenging. Furthermore, some policy solutions were found to improve the health insurance coverage of refugees in Iran. These included removing household size from premium calculations, lowering current premium rates and getting monthly premiums from non-vulnerable refugees. Conclusions: A number of factors have caused health insurance coverage to be inaccessible for refugees, especially non-vulnerable refugees in Iran. Therefore, it is necessary to adopt effective policies to improve the health financing for the refugee with the aim of ensuring financial protection, taking into account the different actors and the interactions between them.
MeSH term(s)	Humans ; Concept Formation ; Iran ; Policy ; Refugees ; Systems Analysis
Language	English
Publishing date	2023-09-11
Publishing country	England
Document type	Journal Article
ZDB-ID	2101196-5
ISSN	1478-4505 ; 1478-4505
ISSN (online)	1478-4505
ISSN	1478-4505
DOI	10.1186/s12961-023-01041-2
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