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  1. AU="Baharia, Rajendra Kumar"
  2. AU="Muñoz, José M."
  3. AU="Singh, Satbir"
  4. AU="Matsuda, Hitoki"
  5. AU="Hobbs, Sarah Jane"
  6. AU="Visuttijai, Kittichate"
  7. AU="Madanitsa, Mwayi"
  8. AU="Delguste, Catherine"
  9. AU="Di Lonardo, Antonio"
  10. AU="Tsimberidou, Apostolia-Maria"
  11. AU="Beutner, Dirk"
  12. AU=Qiu Liying
  13. AU=Nishimura Gen AU=Nishimura Gen
  14. AU="Würz, Andrea"
  15. AU="Herrero, Ane Olazabal"
  16. AU="Tian, Qing-Shan"
  17. AU="Neff, Thomas B"
  18. AU="Chen, Yuyang"
  19. AU="Marija Trenkić-Božinović"
  20. AU="Aminifar, Mina"
  21. AU="Mascarenhas, Joana D P"
  22. AU="Pochet, Stéphanie"
  23. AU="Wittman, Hannah"
  24. AU="Sgolastra, Federica"
  25. AU="Kim, Dennis H"
  26. AU="Thai, Linh Duy"
  27. AU=Walker Scott C
  28. AU="Sheridan, Katherine"
  29. AU="Brown, Sharlie B"
  30. AU=Walker Kathleen
  31. AU="Miller, Donald G"
  32. AU="Sendino, O"
  33. AU="Rao, Arya"
  34. AU="Wong, Gary K W"

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  1. Artikel: Economic burden estimation associated with dengue and chikungunya in Gujarat, India.

    Kaur, Jaspreet / Yadav, Chander Prakash / Chauhan, Naresh Muljibhai / Baharia, Rajendra Kumar

    Journal of family medicine and primary care

    2022  Band 11, Heft 9, Seite(n) 5393–5403

    Abstract: Background: Dengue and chikungunya have been emerging as major vector-borne diseases. The global burden of the diseases is rising as a public health problem. The complexity of disease is governed by multiple constraints including only symptomatic ... ...

    Abstract Background: Dengue and chikungunya have been emerging as major vector-borne diseases. The global burden of the diseases is rising as a public health problem. The complexity of disease is governed by multiple constraints including only symptomatic treatment and inflicts heavy social and economic burden on society. The present study is designed to assess the economic burden of dengue and chikungunya infection by calculating cost per patient in Gujarat, India.
    Methods: A total of 210 patients were enrolled in the study from Ahmedabad and Kheda district of Gujarat from May 2018 to December 2019 of which 150 had dengue and 60 chikungunya infections, subject to the willingness of participation in the survey. Information on wage loss days, cost associated with medicines, diagnosis, special food and travel cost, etc., for the calculation of the direct and indirect costs associated with dengue and chikungunya were collected from these participants using a structured questionnaire. Informed consent was taken before including any participant in the study.
    Results: In the dengue sample, 86 were males (57.3%) and the rest were females, and in the chikungunya sample, 31 were males (51.7%) and the rest females. The median age of the participants with dengue and chikungunya was 18 (p25 to p75: 8 to 26) and 30 (p25 to p75: 21 to 45) years respectively. Median family income was recorded as Rs 15,000 (p25 to p75: 9000 to 25500) and Rs 12,000 (p25 to p75: 9000 to 18500) for the dengue and chikungunya cases, respectively. The average duration of the illness was observed to be higher in chikungunya (median days (P25 to p75): 15 (7-45)) than dengue (median days (P25 to p75): 10 (5-15)). The median indirect cost in the case of dengue was Rs 1,931 (p25 to p75: 300 to 4500) while Rs 2,550 (p25 to p75: 0 to 5250) was observed for chikungunya cases. Two types of direct cost, namely, direct cost related to medical expenses and direct cost related to other expenses were calculated. Direct cost related to medical expenses was observed to be higher in dengue (Md (P25 to p75): Rs 2,450 (400-5000)) than chikungunya (Md (P25 to p75): Rs 1,500 (150-5200)) while indirect cost related to other expenses were comparable between dengue (Md (P25 to p75): Rs 1,575 (1300-2600)) and chikungunya (Md (P25 to p75): Rs 1500 (850-2850)). The average total cost for one dengue episode was estimated to be Rs 6,860 (3700-12525) whereas it was Rs 7,000 (2550-14000) for one episode of Chikungunya.
    Conclusions: Overall, patients have to bear high costs while suffering from dengue and chikungunya infections. Furthermore, the duration of illness while suffering from viral diseases also contributes to the substantial economic burden. Improved knowledge about the impact of the cost and the economic burden associated with dengue and chikungunya will help policymakers allocate and appropriate resources accordingly.
    Sprache Englisch
    Erscheinungsdatum 2022-10-14
    Erscheinungsland India
    Dokumenttyp Journal Article
    ZDB-ID 2735275-4
    ISSN 2278-7135 ; 2249-4863
    ISSN (online) 2278-7135
    ISSN 2249-4863
    DOI 10.4103/jfmpc.jfmpc_694_21
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel: Four decades of epidemiological data reveal trajectories towards malaria elimination in Kheda district (Gujarat), western part of India.

    Baharia, Rajendra Kumar / Yadav, Chander Prakash / Sharma, Amit

    BMJ global health

    2021  Band 6, Heft 12

    Abstract: Background: Malaria is a main public health problem in India and was so particularly in the state of Gujarat in the western part of the country. This study assesses the effects of various interventions on malaria cases using data from the last 33 years ( ...

    Abstract Background: Malaria is a main public health problem in India and was so particularly in the state of Gujarat in the western part of the country. This study assesses the effects of various interventions on malaria cases using data from the last 33 years (1987-2019).
    Methods: Here we have analysed 33 years of malaria epidemiological data from a malaria clinic in Kheda district in Gujarat. The data were digitised yearly and monthly, age-wise and gender-wise, and descriptive analysis was performed to assess the effects of several interventions on malaria burden.
    Results: During 1987-2019, our clinic diagnosed 5466
    Interpretation: Introduction of revised drug policy and improved surveillance technique (rapid diagnosis kits) have strengthened the diagnosis and treatment of malaria in the district. Use of pyrethroid in indoor residual insecticide spray has also strengthened vector control. Among the various interventions used, long-lasting insecticide nets and introduction of artemisinin-based combination therapy have played significant roles in controlling malaria cases. A more drastic decline in
    Mesh-Begriff(e) Epidemics ; Humans ; India/epidemiology ; Malaria/epidemiology ; Malaria/prevention & control ; Plasmodium vivax
    Sprache Englisch
    Erscheinungsdatum 2021-12-08
    Erscheinungsland England
    Dokumenttyp Journal Article
    ISSN 2059-7908
    ISSN 2059-7908
    DOI 10.1136/bmjgh-2021-005815
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  3. Artikel: Enhancing healthcare access and malaria management via mobile clinics and phone call services in Nuh district of Haryana, India.

    Rahi, Manju / Nazmeen, Aarifa / Kumar, Sanjeev / Yadav, Chander Prakash / Kumar, Gaurav / Mittal, Peeyush / Joy, Sam / Sharma, Sachin / Baharia, Rajendra Kumar / Bhati, Gaurav / Goel, Pawan / Sharma, Amit

    Journal of vector borne diseases

    2024  

    Abstract: Background objectives: Malaria remains a complex challenge in India due to its diverse epidemiology, multi-ethnic population, and multiplicity of malaria vectors. While progress has been made in reducing malaria nationally, persistent pockets hinder ... ...

    Abstract Background objectives: Malaria remains a complex challenge in India due to its diverse epidemiology, multi-ethnic population, and multiplicity of malaria vectors. While progress has been made in reducing malaria nationally, persistent pockets hinder elimination efforts. These challenges include hidden reservoirs, inadequate healthcare, suboptimal surveillance, non-compliance, and subclinical infections. Shortage of grassroot level and primary care health staff, transportation issues and general inaccessibility and unavailability of healthcare services are additional challenges.
    Methods: Mobile healthcare vans have been tried and found useful in enhancing healthcare availability in several health conditions in different settings. Nuh (Mewat) district in Haryana is a malaria endemic region; it is indeed one of the districts included by NITI Aayog in the Aspirational Districts Programme (ADP) a government initiative that focuses on rapidly transforming and developing the most underdeveloped districts in India. With an aim to improve the health care seeking behavior of malaria endemic community of selected villages of Nuh district, we carried out a study to using interventions in two villages of Nuh district like mobile malaria clinics and toll-free telephone services in enhancing healthcare access.
    Results: We found that the Sangel village had higher literacy rates (60.6%) as compared to 39.4% in Naushera. Similarly, the unemployment rate was higher for Naushera. The mobile malaria clinic was deployed from December 2019 to July 2020 and a total of 269 phone calls were received from both the villages. A similar number of rapid tests and microscopy smears were examined and all were negative for malaria. The febrile patients were referred to the nearest healthcare facility.
    Interpretation conclusion: The study shows that the community is open to using these healthcare interventions and these initiatives of mobile malaria clinics and toll-free telephone services can bridge healthcare gaps, especially in malaria-endemic regions, aligning with India's malaria elimination and equitable healthcare access goals.
    Sprache Englisch
    Erscheinungsdatum 2024-02-21
    Erscheinungsland India
    Dokumenttyp Journal Article
    ZDB-ID 2161218-3
    ISSN 0972-9062
    ISSN 0972-9062
    DOI 10.4103/JVBD.JVBD_163_23
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  4. Artikel ; Online: Small-scale field evaluation of the entomological efficacy and the residual activity of Fludora

    Kamaraju, Raghavendra / Pant, Chandra Shekhar / Uragayala, Sreehari / Baharia, Rajendra Kumar / Srivastava, Harish Chandra / Yadav, Rajpal S

    Tropical medicine & international health : TM & IH

    2021  Band 26, Heft 4, Seite(n) 469–477

    Abstract: Objectives: To evaluate the entomological efficacy and the residual activity of indoor residual spraying with Fludora: Methods: In three study villages, suitable households were randomly allocated to five treatments: Fludora: Results: The ratios ... ...

    Abstract Objectives: To evaluate the entomological efficacy and the residual activity of indoor residual spraying with Fludora
    Methods: In three study villages, suitable households were randomly allocated to five treatments: Fludora
    Results: The ratios of applied to target doses of insecticides were within 0.84 to 1.4, showing a good spray quality. The cone bioassays revealed residual action lasting 7 months for all insecticides without significant differences in mortality between different surfaces treated nor between the four treatment arms (P > 0.05). Considering all entomological parameters such as indoor resting density, excito-repellency, blood-feeding inhibition and delayed mortality, the overall efficacy of Fludora
    Conclusions: Fludora
    Mesh-Begriff(e) Animals ; Anopheles/drug effects ; Biological Assay ; Culicidae/drug effects ; Family Characteristics ; Guanidines/pharmacology ; Humans ; Insecticide Resistance ; Insecticides/pharmacology ; Malaria/prevention & control ; Malaria/transmission ; Mosquito Control/methods ; Mosquito Vectors/drug effects ; Neonicotinoids/pharmacology ; Nitriles/pharmacology ; Pyrethrins/pharmacology ; Thiazoles/pharmacology
    Chemische Substanzen Guanidines ; Insecticides ; Neonicotinoids ; Nitriles ; Pyrethrins ; Thiazoles ; decamethrin (2JTS8R821G) ; clothianidin (2V9906ABKQ)
    Sprache Englisch
    Erscheinungsdatum 2021-01-25
    Erscheinungsland England
    Dokumenttyp Evaluation Study ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1314080-2
    ISSN 1365-3156 ; 1360-2276
    ISSN (online) 1365-3156
    ISSN 1360-2276
    DOI 10.1111/tmi.13549
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  5. Artikel ; Online: Overlaying COVID-19 mitigation plans on malaria control infrastructures.

    Rahi, Manju / Baharia, Rajendra Kumar / Das, Payal / Chhibber-Goel, Jyoti / Sharma, Amit

    Transactions of the Royal Society of Tropical Medicine and Hygiene

    2020  Band 115, Heft 1, Seite(n) 6–8

    Abstract: To counter the coronavirus disease 2019 (COVID-19) pandemic, each country must design sustainable control plans given the inherent disparities in wealth and healthcare systems. Most malaria-endemic countries run well-entrenched malaria control programs ... ...

    Abstract To counter the coronavirus disease 2019 (COVID-19) pandemic, each country must design sustainable control plans given the inherent disparities in wealth and healthcare systems. Most malaria-endemic countries run well-entrenched malaria control programs via their established frameworks for diagnosis, case management, treatment and overall surveillance. We propose that the malaria control infrastructures can be partially co-opted for launching sustainable COVID-19 mitigation plans.
    Mesh-Begriff(e) COVID-19/epidemiology ; COVID-19/prevention & control ; Delivery of Health Care ; Endemic Diseases ; Government Programs ; Health Planning ; Humans ; Malaria/prevention & control ; Pandemics ; SARS-CoV-2
    Schlagwörter covid19
    Sprache Englisch
    Erscheinungsdatum 2020-10-12
    Erscheinungsland England
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 441375-1
    ISSN 1878-3503 ; 0035-9203
    ISSN (online) 1878-3503
    ISSN 0035-9203
    DOI 10.1093/trstmh/traa108
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  6. Artikel ; Online: A randomised controlled trial to compare the efficacy, safety, and tolerability of low dose, short course primaquine in adults with uncomplicated P. vivax malaria in two hospitals in India.

    Ahmad, Sundus Shafat / Verma, Reena / Commons, Robert J / Nitika / Singh-Phulgenda, Sauman / Chhajed, Rutuja / Bharti, Praveen K / Behera, Beauty / Naser, Syed Mohammad / Pal, Salil Kumar / Ranjit, Parinita Halder / Baharia, Rajendra Kumar / Solanki, Bhavin / Upadhyay, K J / Guerin, Philippe J / Sharma, Amit / Price, Ric N / Rahi, Manju / Thriemer, Kamala

    Trials

    2024  Band 25, Heft 1, Seite(n) 154

    Abstract: Background: Plasmodium vivax remains a major challenge for malaria control and elimination due to its ability to cause relapsing illness. To prevent relapses the Indian National Center for Vector Borne Diseases Control (NCVBDC) recommends treatment with ...

    Abstract Background: Plasmodium vivax remains a major challenge for malaria control and elimination due to its ability to cause relapsing illness. To prevent relapses the Indian National Center for Vector Borne Diseases Control (NCVBDC) recommends treatment with primaquine at a dose of 0.25 mg/kg/day provided over 14 days. Shorter treatment courses may improve adherence and treatment effectiveness.
    Methods: This is a hospital-based, randomised, controlled, open-label trial in two centres in India. Patients above the age of 16 years, with uncomplicated vivax malaria, G6PD activity of ≥ 30% of the adjusted male median (AMM) and haemoglobin levels ≥ 8 g/dL will be recruited into the study and randomised in a 1:1 ratio to receive standard schizonticidal treatment plus 7-day primaquine at 0.50 mg/kg/day or standard care with schizonticidal treatment plus 14-day primaquine at 0.25 mg/kg/day. Patients will be followed up for 6 months. The primary endpoint is the incidence risk of any P. vivax parasitaemia at 6 months. Safety outcomes include the incidence risk of severe anaemia (haemoglobin < 8 g/dL), the risk of blood transfusion, a > 25% fall in haemoglobin and an acute drop in haemoglobin of > 5 g/dL during primaquine treatment.
    Discussion: This study will evaluate the efficacy and safety of a 7-day primaquine regimen compared to the standard 14-day regimen in India. Results from this trial are likely to directly inform national treatment guidelines.
    Trial registration: Trial is registered on CTRI portal, Registration No: CTRI/2022/12/048283.
    Mesh-Begriff(e) Adolescent ; Adult ; Humans ; Male ; Antimalarials/adverse effects ; Antimalarials/therapeutic use ; Hemoglobins ; India ; Malaria, Vivax/diagnosis ; Malaria, Vivax/drug therapy ; Malaria, Vivax/prevention & control ; Primaquine/adverse effects ; Primaquine/therapeutic use ; Recurrence ; Multicenter Studies as Topic ; Randomized Controlled Trials as Topic
    Chemische Substanzen Antimalarials ; Hemoglobins ; Primaquine (MVR3634GX1)
    Sprache Englisch
    Erscheinungsdatum 2024-02-29
    Erscheinungsland England
    Dokumenttyp Clinical Trial Protocol ; Journal Article
    ZDB-ID 2040523-6
    ISSN 1745-6215 ; 1468-6694 ; 1745-6215
    ISSN (online) 1745-6215
    ISSN 1468-6694 ; 1745-6215
    DOI 10.1186/s13063-024-07987-0
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  7. Artikel: Overlaying COVID-19 mitigation plans on malaria control infrastructures

    Rahi, Manju / Baharia, Rajendra Kumar / Das, Payal / Chhibber-Goel, Jyoti / Sharma, Amit

    Trans. R. Soc. Trop. Med. Hyg

    Abstract: To counter the coronavirus disease 2019 (COVID-19) pandemic, each country must design sustainable control plans given the inherent disparities in wealth and healthcare systems. Most malaria-endemic countries run well-entrenched malaria control programs ... ...

    Abstract To counter the coronavirus disease 2019 (COVID-19) pandemic, each country must design sustainable control plans given the inherent disparities in wealth and healthcare systems. Most malaria-endemic countries run well-entrenched malaria control programs via their established frameworks for diagnosis, case management, treatment and overall surveillance. We propose that the malaria control infrastructures can be partially co-opted for launching sustainable COVID-19 mitigation plans.
    Schlagwörter covid19
    Verlag WHO
    Dokumenttyp Artikel
    Anmerkung WHO #Covidence: #845729
    Datenquelle COVID19

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  8. Artikel ; Online: Overlaying COVID-19 mitigation plans on malaria control infrastructures

    Rahi, Manju / Baharia, Rajendra Kumar / Das, Payal / Chhibber-Goel, Jyoti / Sharma, Amit

    Transactions of The Royal Society of Tropical Medicine and Hygiene ; ISSN 0035-9203 1878-3503

    2020  

    Abstract: Abstract To counter the coronavirus disease 2019 (COVID-19) pandemic, each country must design sustainable control plans given the inherent disparities in wealth and healthcare systems. Most malaria-endemic countries run well-entrenched malaria control ... ...

    Abstract Abstract To counter the coronavirus disease 2019 (COVID-19) pandemic, each country must design sustainable control plans given the inherent disparities in wealth and healthcare systems. Most malaria-endemic countries run well-entrenched malaria control programs via their established frameworks for diagnosis, case management, treatment and overall surveillance. We propose that the malaria control infrastructures can be partially co-opted for launching sustainable COVID-19 mitigation plans.
    Schlagwörter Public Health, Environmental and Occupational Health ; Parasitology ; Infectious Diseases ; General Medicine ; covid19
    Sprache Englisch
    Verlag Oxford University Press (OUP)
    Erscheinungsland uk
    Dokumenttyp Artikel ; Online
    DOI 10.1093/trstmh/traa108
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  9. Artikel: Molecular, biochemical characterization and assessment of immunogenic potential of cofactor-independent phosphoglycerate mutase against Leishmania donovani: a step towards exploring novel vaccine candidate

    TANDON, RATI / CHANDRA, SHARAT / BAHARIA, RAJENDRA KUMAR / MISRA, PRAGYA / DAS, SANCHITA / RAWAT, KEERTI / SIDDIQI, MOHAMMAD IMRAN / SUNDAR, SHYAM / DUBE, ANURADHA

    Parasitology. 2018 Apr., v. 145, no. 4

    2018  

    Abstract: Despite immense efforts, vaccine against visceral leishmaniasis has yet not been developed. Earlier our proteomic study revealed a novel protein, cofactor-independent phoshoglycerate mutase (LdiPGAM), an important enzyme in glucose metabolism, in T ... ...

    Abstract Despite immense efforts, vaccine against visceral leishmaniasis has yet not been developed. Earlier our proteomic study revealed a novel protein, cofactor-independent phoshoglycerate mutase (LdiPGAM), an important enzyme in glucose metabolism, in T helper cells type 1 (Th1) stimulatory region of soluble Leishmania donovani antigen. In this study, LdiPGAM was biochemically and molecularly characterized and evaluated for its immunogenicity and prophylactic efficacy against L. donovani. Immunogenicity of recombinant LdiPGAM (rLdiPGAM) was initially assessed in naïve hamsters immunized with it by analysing mRNA expression of inducible nitric oxide (NO) synthase (iNOS) and other Th1/T helper cells type 2 cytokines, which revealed an upregulation of Th1 cytokines along with iNOS. Immunogenicity of rLdiPGAM was further evaluated in lymphocytes of treated Leishmania-infected hamsters and peripheral blood mononuclear cells of Leishmania patients in clinical remission by various parameters, viz. lymphoproliferation assay and NO production (hamsters and patients) and levels of various cytokines (patients). rLdiPGAM induced remarkable Lymphoproliferative response and NO production in treated Leishmania-infected hamsters as well as in patients and increase in interferon gamma (IFN-γ), interleukin-12 (IL-12p40) responses in Leishmania patients in clinical remission. Vaccination with rLdiPGAM exerted considerable prophylactic efficacy (73%) supported by increase in mRNA expression of iNOS, IFN-γ and IL-12p40 with decrease in transforming growth factor beta and interleukin-10. Above results indicate the importance of rLdiPGAM protein as a potential vaccine candidate against visceral leishmaniasis.
    Schlagwörter CD4-positive T-lymphocytes ; Leishmania donovani ; antigens ; gene expression ; gene expression regulation ; glucose ; hamsters ; immunogenicity ; inducible nitric oxide synthase ; interferon-gamma ; interleukin-10 ; interleukin-12 ; metabolism ; nitric oxide ; patients ; proteomics ; remission ; transforming growth factor beta ; vaccination ; vaccines ; visceral leishmaniasis
    Sprache Englisch
    Erscheinungsverlauf 2018-04
    Umfang p. 508-526.
    Erscheinungsort Cambridge University Press
    Dokumenttyp Artikel
    ZDB-ID 207627-5
    ISSN 1469-8161 ; 0031-1820
    ISSN (online) 1469-8161
    ISSN 0031-1820
    DOI 10.1017/S0031182017001160
    Datenquelle NAL Katalog (AGRICOLA)

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  10. Artikel ; Online: Vaccination coverage and breakthrough infections of COVID-19 during the second wave among staff of selected medical institutions in India.

    Rahi, Manju / Yadav, Chander Prakash / Ahmad, Sundus Shafat / Nitika / Das, Payal / Sharma, Shweta / Baharia, Rajendra Kumar / Bhattacharya, Debdutta / Deshmukh, Pradeep / Dhatrak, Amey / Dogra, Sandeep / Eapen, Alex / Goel, Pawan / Faizi, Nafis / Khan, Siraj A / Kochar, Sanjay Kumar / Kochar, Aditya / Kumar, Ashwani / Mundra, Anuj /
    Narang, Rahul / Narain, Kanwar / Pandey, Krishna / Pati, Sanghamitra / Raghav, Pankaja / Ranjha, Ritesh / Shah, Salman / Singh, Kuldeep / Singh, Piyoosh Kumar / Singh, Raj Kumar / Kuttiatt, Vijesh Shreedhar / Soni, Ravinder / Sreehari, Uragayala / Malhotra, Sumit / Sharma, Amit

    PLOS global public health

    2023  Band 3, Heft 4, Seite(n) e0000946

    Abstract: India experienced the second wave of SARS-CoV-2 infection from April 3 to June 10, 2021. During the second wave, Delta variant B.1617.2 emerged as the predominant strain, spiking cases from 12.5 million to 29.3 million (cumulative) by the end of the ... ...

    Abstract India experienced the second wave of SARS-CoV-2 infection from April 3 to June 10, 2021. During the second wave, Delta variant B.1617.2 emerged as the predominant strain, spiking cases from 12.5 million to 29.3 million (cumulative) by the end of the surge in India. Vaccines against COVID-19 are a potent tool to control and end the pandemic in addition to other control measures. India rolled out its vaccination programme on January 16, 2021, initially with two vaccines that were given emergency authorization-Covaxin (BBV152) and Covishield (ChAdOx1 nCoV- 19). Vaccination was initially started for the elderly (60+) and front-line workers and then gradually opened to different age groups. The second wave hit when vaccination was picking up pace in India. There were instances of vaccinated people (fully and partially) getting infected, and reinfections were also reported. We undertook a survey of staff (front line health care workers and supporting) of 15 medical colleges and research institutes across India to assess the vaccination coverage, incidence of breakthrough infections, and reinfections among them from June 2 to July 10, 2021. A total of 1876 staff participated, and 1484 forms were selected for analysis after removing duplicates and erroneous entries (n = 392). We found that among the respondents at the time of response, 17.6% were unvaccinated, 19.8% were partially vaccinated (received the first dose), and 62.5% were fully vaccinated (received both doses). Incidence of breakthrough infections was 8.7% among the 801 individuals (70/801) tested at least 14 days after the 2nd dose of vaccine. Eight participants reported reinfection in the overall infected group and reinfection incidence rate was 5.1%. Out of (N = 349) infected individuals 243 (69.6%) were unvaccinated and 106 (30.3%) were vaccinated. Our findings reveal the protective effect of vaccination and its role as an essential tool in the struggle against this pandemic.
    Sprache Englisch
    Erscheinungsdatum 2023-04-07
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ISSN 2767-3375
    ISSN (online) 2767-3375
    DOI 10.1371/journal.pgph.0000946
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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