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Article ; Online: Deciphering Multi-target Pharmacological Mechanism of

Shahzadi, Aqsa / Ashfaq, Usman Ali / Khurshid, Mohsin / Nisar, Muhammad Atif / Syed, Asad / Bahkali, Ali H

2024 Volume 30, Issue 4, Page(s) 295–309

Abstract: Background: Urolithiasis is a prevalent condition with significant morbidity and economic implications. The economic burden associated with urolithiasis primarily stems from medical expenses. Previous literature suggests that herbal plants, including !## ...

Abstract	Background: Urolithiasis is a prevalent condition with significant morbidity and economic implications. The economic burden associated with urolithiasis primarily stems from medical expenses. Previous literature suggests that herbal plants, including Objective: In this research, we employed network pharmacology and molecular docking to examine the active compounds and biological mechanisms of Methods: Active constituents were obtained from previous studies and the IMPPAT database, with their targets predicted using Swiss target prediction. Kidney stone-associated genes were collected from DisGeNET and GeneCards. The active constituent-target-pathway network was constructed using Cytoscape, and the target protein-protein interaction network was generated using the STRING database. Gene enrichment analysis of Results: The findings revealed that Conclusion: These findings provide insight into the anti-kidney stone effects of
MeSH term(s)	Cucurbita/chemistry ; Molecular Docking Simulation ; Kidney Calculi/drug therapy ; Seeds/chemistry ; Humans ; Network Pharmacology
Language	English
Publishing date	2024-01-26
Publishing country	United Arab Emirates
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1304236-1
ISSN	1873-4286 ; 1381-6128
ISSN (online)	1873-4286
ISSN	1381-6128
DOI	10.2174/0113816128271781231104151155
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Article ; Online: Evaluation of gases emission and enzyme dynamics in sheep manure compost occupying with peach shell biochar.

Liu, Hong / Awasthi, Mukesh Kumar / Zhang, Zengqiang / Syed, Asad / Bahkali, Ali H

Environmental pollution (Barking, Essex : 1987)

2024 Volume 351, Page(s) 124065

Abstract: The effect of peach shell biochar (PSB) amendment on sheep manure (SM) composting was investigated. Five different ratios of PSB were applied (0%, 2.5%, 5%, 7.5%, and 10% PSB), and named T1 to T5, and run 50 days of composting experiment. It was found ... ...

Abstract	The effect of peach shell biochar (PSB) amendment on sheep manure (SM) composting was investigated. Five different ratios of PSB were applied (0%, 2.5%, 5%, 7.5%, and 10% PSB), and named T1 to T5, and run 50 days of composting experiment. It was found that PSB (especially 7.5% and 10%) could improve the compost environment, regulate the activity of microorganisms and related enzymes, and promote the decomposition of compost. 7.5% and 10% PSB advanced the heap into the thermophilic stage and increased the maximum temperature, while also increasing the germination index by 1.40 and 1.39 times compared to control. Importantly, 10% PSB effectively retained more than 60% of carbon and 55% of nitrogen by inhibiting the excess release of NH
Language	English
Publishing date	2024-04-30
Publishing country	England
Document type	Journal Article
ZDB-ID	280652-6
ISSN	1873-6424 ; 0013-9327 ; 0269-7491
ISSN (online)	1873-6424
ISSN	0013-9327 ; 0269-7491
DOI	10.1016/j.envpol.2024.124065
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Article: Efficacy of Gold Nanoparticles against Drug-Resistant Nosocomial Fungal Pathogens and Their Extracellular Enzymes: Resistance Profiling towards Established Antifungal Agents.

Almansob, Abobakr / Bahkali, Ali H / Ameen, Fuad

Nanomaterials (Basel, Switzerland)

2022 Volume 12, Issue 5

Abstract: Drug resistance of filamentous fungi to the commonly used antifungal agents is a major concern in medicine. Therefore, an effective approach to treat several opportunistic fungal infections is the need of the hour. ...

Abstract	Drug resistance of filamentous fungi to the commonly used antifungal agents is a major concern in medicine. Therefore, an effective approach to treat several opportunistic fungal infections is the need of the hour.
Language	English
Publishing date	2022-02-28
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662255-5
ISSN	2079-4991
ISSN	2079-4991
DOI	10.3390/nano12050814
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Article ; Online: The efficient solution to decline the greenhouses emission and enrich the bacterial community during pig manure composting: Regulating the particle size of cornstalk

Ren, Xiuna / Jiao, Minna / Zhang, Zengqiang / Syed, Asad / Bahkali, Ali H.

Bioresource Technology. 2023 Nov., v. 387 p.129596-

2023

Abstract: In present study, four lengths of chopped cornstalks were amended with pig manure respectively for 100 days aerobic fermentation, which aimed to evaluate the impact of different length of agricultural solid wastes on gaseous emission and dominating ... ...

Abstract	In present study, four lengths of chopped cornstalks were amended with pig manure respectively for 100 days aerobic fermentation, which aimed to evaluate the impact of different length of agricultural solid wastes on gaseous emission and dominating bacterial community succession and connection. The result revealed that the maximum ammonia volatilization was observed in 5 cm of straw samples attributed to the prominent mineralization, which was opposite to the emission of CH₄ and N₂O. As for global warming potential, the minimum value was detected in 5 cm of straw samples, which decreased by 5.03–24.75% compared with other samples. Additionally, the strongest correlation and complexity of bacterial community could be detected in 5 cm of straw treatment, representing the most vigorous bacterial metabolic ability could be recorded by optimizing the microbial habitat. Therefore, in order to decline the greenhouse effect in livestock manure composting, the 5 cm of corn straw was recommended.
Keywords	ammonia ; bacterial communities ; corn stover ; corn straw ; fermentation ; gas emissions ; greenhouse effect ; habitats ; mineralization ; particle size ; pig manure ; volatilization ; Cornstalk ; Different particle size ; Greenhouse gas emission ; Global warming potential ; Bacterial community succession
Language	English
Dates of publication	2023-11
Publishing place	Elsevier Ltd
Document type	Article ; Online
ZDB-ID	1065195-0
ISSN	1873-2976 ; 0960-8524
ISSN (online)	1873-2976
ISSN	0960-8524
DOI	10.1016/j.biortech.2023.129596
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Article: Improved visible-light driven photocatalysis of a novel heterostructure by the decoration of CuS on Ag2MoO4 nanorod: Synthesis, characterization, elucidation of photocatalytic mechanism and anti-microbial application

Syed, Asad / Elgorban, Abdallah M. / Bahkali, Ali H.

Colloids and surfaces. 2021 Nov. 20, v. 629

2021

Abstract: The novel heterostructured CuS/Ag₂MoO₄ nanocomposite (NCs) was prepared via sono-chemical precipitation method and characterized by UV–vis diffuse reflectance spectroscopy, XPS, SEM, HR-TEM, FT-IR, PL, Raman, EIS, ESR, N₂ adsorption and desorption, EDAX ... ...

Abstract	The novel heterostructured CuS/Ag₂MoO₄ nanocomposite (NCs) was prepared via sono-chemical precipitation method and characterized by UV–vis diffuse reflectance spectroscopy, XPS, SEM, HR-TEM, FT-IR, PL, Raman, EIS, ESR, N₂ adsorption and desorption, EDAX and ESR. The photodegradation performance of the prepared particle was evaluated by investigating the visible light degradation of MB dye. When compared to pristine CuS and Ag₂MoO₄ nanoparticles (NPs), the CuS/Ag₂MoO₄ NCs shows good photocatalytic activity where about 90.5% of MB was degraded in 200 min. The activity of the NCs (0.009 min⁻¹) was 2.25 times greater than CuS (0.004 min⁻¹) and Ag₂MoO₄ (0.004 min⁻¹). The enhanced photodegradation by CuS/Ag₂MoO₄ was attributed to the heterojunction formation between CuS and Ag₂MoO₄, whereas the inner electric field generated gradually decrease the electron-hole recombination thereby enhancing the dye molecules adsorption on the photocatalytic surface. The main oxidative species was superoxide radical and hydroxyl radical where it is confirmed by radical scavenging experiments. The NCs exhibited excellent anti-microbial activity against B. subtilis and E. coli.
Keywords	Escherichia coli ; adsorption ; antimicrobial properties ; desorption ; dyes ; electric field ; hydroxyl radicals ; light ; nanocomposites ; nanorods ; photocatalysis ; photolysis ; reflectance spectroscopy ; superoxide anion
Language	English
Dates of publication	2021-1120
Publishing place	Elsevier B.V.
Document type	Article
ZDB-ID	1500517-3
ISSN	0927-7757
ISSN	0927-7757
DOI	10.1016/j.colsurfa.2021.127371
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Article ; Online: Metal-tolerant and siderophore producing Pseudomonas fluorescence and Trichoderma spp. improved the growth, biochemical features and yield attributes of chickpea by lowering Cd uptake.

Syed, Asad / Elgorban, Abdallah M / Bahkali, Ali H / Eswaramoorthy, Rajalakshmanan / Iqbal, Rana Khalid / Danish, Subhan

Scientific reports

2023 Volume 13, Issue 1, Page(s) 4471

Abstract: Industrialization and human urbanization have led to an increase in heavy metal (HM) pollution which often cause negative/toxic effect on agricultural crops. The soil-HMs cannot be degraded biologically however, microbe-mediated detoxification of toxic ... ...

Abstract	Industrialization and human urbanization have led to an increase in heavy metal (HM) pollution which often cause negative/toxic effect on agricultural crops. The soil-HMs cannot be degraded biologically however, microbe-mediated detoxification of toxic HMs into lesser toxic forms are reported. Considering the potentiality of HMs-tolerant soil microbes in metal detoxification, Pseudomonas fluorescence PGPR-7 and Trichoderma sp. T-4 were recovered from HM-affected areas. Under both normal and cadmium stress, the ability of both microorganisms to produce different plant hormones and biologically active enzymes was examined. Strains PGPR-7 and T-4 tolerated cadmium (Cd) an up-to 1800 and 2000 µg mL
MeSH term(s)	Humans ; Cicer ; Cadmium/metabolism ; Pseudomonas/metabolism ; Trichoderma/metabolism ; Siderophores/metabolism ; Fluorescence ; Metals, Heavy/metabolism ; Soil/chemistry ; Soil Pollutants/metabolism ; Plant Roots/metabolism ; Biodegradation, Environmental
Chemical Substances	Cadmium (00BH33GNGH) ; Siderophores ; Metals, Heavy ; Soil ; Soil Pollutants
Language	English
Publishing date	2023-03-18
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-023-31330-3
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Article ; Online: Facile green synthesis of novel tantalum doped tungsten trioxide for photocatalytic degradation: Correlation with COMSOL simulation.

Maryam, Iqra / Iqbal, Tahir / Syed, Asad / Bahkali, Ali H / Tehseen, Aqsa / Afsheen, Sumera / Sultan, Muhammad Shehzad

Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy

2024 Volume 314, Page(s) 124191

Abstract: The facilegreen synthesis techniqueis becoming more and more important, and it has been proposed as a potential substitute for chemical techniques. The current study describes a low-cost, environmentally friendly method for producing tungsten trioxide ( ... ...

Abstract	The facilegreen synthesis techniqueis becoming more and more important, and it has been proposed as a potential substitute for chemical techniques. The current study describes a low-cost, environmentally friendly method for producing tungsten trioxide (WO
Language	English
Publishing date	2024-03-26
Publishing country	England
Document type	Journal Article
ZDB-ID	210413-1
ISSN	1873-3557 ; 0370-8322 ; 0584-8539 ; 1386-1425
ISSN (online)	1873-3557
ISSN	0370-8322 ; 0584-8539 ; 1386-1425
DOI	10.1016/j.saa.2024.124191
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Article ; Online: Assessing phytotoxicity and cyto-genotoxicity of two insecticides using a battery of in-vitro biological assays.

Shahid, Mohammad / Zeyad, Mohammad Tarique / Syed, Asad / Bahkali, Ali H / Pichtel, John / Verma, Meenakshi

Mutation research. Genetic toxicology and environmental mutagenesis

2023 Volume 891, Page(s) 503688

Abstract: Intensive use of chemical pesticides in agriculture poses environmental risks and may have negative impacts on agricultural productivity. The potential phytotoxicity of two chemical pesticides, chlorpyrifos (CPS) and fensulfothion (FSN), were evaluated ... ...

Abstract	Intensive use of chemical pesticides in agriculture poses environmental risks and may have negative impacts on agricultural productivity. The potential phytotoxicity of two chemical pesticides, chlorpyrifos (CPS) and fensulfothion (FSN), were evaluated using Cicer arietinum and Allium cepa as model crops. Different concentrations (0-100 μgmL
MeSH term(s)	Insecticides/toxicity ; Reactive Oxygen Species/metabolism ; Hydrogen Peroxide/pharmacology ; Antioxidants/pharmacology ; Pesticides/toxicity ; Onions ; Chlorpyrifos/metabolism ; Chlorpyrifos/pharmacology ; DNA Damage ; Soil ; Plant Roots
Chemical Substances	Insecticides ; Reactive Oxygen Species ; Hydrogen Peroxide (BBX060AN9V) ; Antioxidants ; Pesticides ; Chlorpyrifos (JCS58I644W) ; Soil
Language	English
Publishing date	2023-08-30
Publishing country	Netherlands
Document type	Journal Article
ISSN	1879-3592
ISSN (online)	1879-3592
DOI	10.1016/j.mrgentox.2023.503688
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Article ; Online: The efficient solution to decline the greenhouses emission and enrich the bacterial community during pig manure composting: Regulating the particle size of cornstalk.

Ren, Xiuna / Jiao, Minna / Zhang, Zengqiang / Syed, Asad / Bahkali, Ali H

Bioresource technology

2023 Volume 387, Page(s) 129596

Abstract	In present study, four lengths of chopped cornstalks were amended with pig manure respectively for 100 days aerobic fermentation, which aimed to evaluate the impact of different length of agricultural solid wastes on gaseous emission and dominating bacterial community succession and connection. The result revealed that the maximum ammonia volatilization was observed in 5 cm of straw samples attributed to the prominent mineralization, which was opposite to the emission of CH
MeSH term(s)	Swine ; Animals ; Composting ; Manure ; Particle Size ; Soil ; Gases ; Bacteria ; Nitrogen
Chemical Substances	Manure ; Soil ; Gases ; Nitrogen (N762921K75)
Language	English
Publishing date	2023-08-02
Publishing country	England
Document type	Journal Article
ZDB-ID	1065195-0
ISSN	1873-2976 ; 0960-8524
ISSN (online)	1873-2976
ISSN	0960-8524
DOI	10.1016/j.biortech.2023.129596
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Article ; Online: Microbial dynamics and nitrogen retention during sheep manure composting employing peach shell biochar

Liu, Hong / Awasthi, Mukesh Kumar / Zhang, Zengqiang / Syed, Asad / Bahkali, Ali H. / Sindhu, Raveendran / Verma, Meenakshi

Bioresource Technology. 2023 Oct., v. 386 p.129555-

2023

Abstract: In this study, the effects of peach shell biochar (PSB) and microbial agent (EM) amendment on nitrogen conservation and bacterial dynamics during sheep manure (SM) composting were examined. Six treatments were performed including T1 (control with no ... ...

Abstract	In this study, the effects of peach shell biochar (PSB) and microbial agent (EM) amendment on nitrogen conservation and bacterial dynamics during sheep manure (SM) composting were examined. Six treatments were performed including T1 (control with no addition), T2 (EM), T3 (EM + 2.5 %PSB), T4 (EM + 5 %PSB), T5 (EM + 7.5 %PSB), and T6 (EM + 10 %PSB). The results showed that the additives amendment reduced NH₃ emissions by 6.12%∼32.88% and N₂O emissions by 10.96%∼19.76%, while increased total Kjeldahl nitrogen (TKN) content by 8.15–9.13 g/kg. Meanwhile, Firmicutes were the dominant flora in the thermophilic stages, while Proteobacteria, Actinobacteriota, and Bacteroidota were the dominant flora in the maturation stages. The abundance of Bacteroidota and Actinobacteriota were increased by 17.49%∼32.51% and 2.31%∼12.60%, respectively, which can accelerate the degradable organic materials decomposition. Additionally, redundancy analysis showed that Proteobacteria, Actinobacteriota, and Bacteroidota were positively correlated with NO₃⁻-N, TKN, and N₂O, but a negative correlation with NH₃ and NH₄⁺-N. Finally, results confirmed that (EM + 10 %PSB) additives were more effective to reduce nitrogen loss and improve bacterial dynamics.
Keywords	Firmicutes ; Proteobacteria ; biochar ; flora ; nitrogen ; nitrogen retention ; peaches ; sheep manure ; technology ; total Kjeldahl nitrogen ; Organic materials ; Microbial agent ; Bacterial dynamics ; Nitrogen conservation
Language	English
Dates of publication	2023-10
Publishing place	Elsevier Ltd
Document type	Article ; Online
ZDB-ID	1065195-0
ISSN	1873-2976 ; 0960-8524
ISSN (online)	1873-2976
ISSN	0960-8524
DOI	10.1016/j.biortech.2023.129555
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