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  1. Article ; Online: Carcinogenic mechanisms of virus-associated lymphoma.

    Zhang, Ying / Guo, Wei / Zhan, Zhumei / Bai, Ou

    Frontiers in immunology

    2024  Volume 15, Page(s) 1361009

    Abstract: The development of lymphoma is a complex multistep process that integrates numerous experimental findings and clinical data that have not yet yielded a definitive explanation. Studies of oncogenic viruses can help to deepen insight into the pathogenesis ... ...

    Abstract The development of lymphoma is a complex multistep process that integrates numerous experimental findings and clinical data that have not yet yielded a definitive explanation. Studies of oncogenic viruses can help to deepen insight into the pathogenesis of lymphoma, and identifying associations between lymphoma and viruses that are established and unidentified should lead to cellular and pharmacologically targeted antiviral strategies for treating malignant lymphoma. This review focuses on the pathogenesis of lymphomas associated with hepatitis B and C, Epstein-Barr, and human immunodeficiency viruses as well as Kaposi sarcoma-associated herpesvirus
    MeSH term(s) Humans ; Lymphoma/etiology ; Oncogenic Viruses ; Herpesvirus 8, Human
    Language English
    Publishing date 2024-02-28
    Publishing country Switzerland
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2024.1361009
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Advances in the treatment of relapsed/refractory marginal zone lymphoma.

    Wang, Haotian / Wan, Xin / Zhang, Ying / Guo, Jing / Bai, Ou

    Frontiers in oncology

    2024  Volume 14, Page(s) 1327309

    Abstract: Marginal zone lymphoma (MZL) is the second most common subtype of inert B-cell non-Hodgkin's lymphoma, accounting for 5-15% of non-Hodgkin's lymphoma cases. Patients with MZL have a long survival period, with a median survival of >10 years, and patients ... ...

    Abstract Marginal zone lymphoma (MZL) is the second most common subtype of inert B-cell non-Hodgkin's lymphoma, accounting for 5-15% of non-Hodgkin's lymphoma cases. Patients with MZL have a long survival period, with a median survival of >10 years, and patients treated with a combination of anti-CD20 monoclonal antibody can achieve an overall effective rate of 81%. However, 20% of patients with MZL show relapse or experience disease progression within 2 years, with a median survival of only 3-5 years. Currently, the treatment options for patients with relapsed/refractory (R/R) MZL are limited, underscoring the pressing need for novel therapeutic drugs. The advent of novel anti-CD20 monoclonal antibodies, small molecule kinase inhibitors, immunomodulators, and other therapeutic strategies has ushered in a new era in the treatment of R/R MZL. Our objective is to summarize the existing treatment strategies, including immunotherapy and the emergent targeted therapies, and to evaluate their effectiveness and safety in the management of R/R MZL. By doing so, we aim to provide a clear understanding of the therapeutic landscape for R/R MZL, and to guide future research directions toward improving the prognosis and quality of life for patients afflicted with this challenging disease.
    Language English
    Publishing date 2024-01-25
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2649216-7
    ISSN 2234-943X
    ISSN 2234-943X
    DOI 10.3389/fonc.2024.1327309
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Mechanism of action and therapeutic targeting of CD30 molecule in lymphomas.

    Li, Zhaoxia / Guo, Wei / Bai, Ou

    Frontiers in oncology

    2023  Volume 13, Page(s) 1301437

    Abstract: At present, the treatment of lymphoma has entered the era of precision medicine, and CD30, as a transmembrane protein, has become an important marker to help the diagnosis and formulation of treatment plans for lymphomas. This protein is widely expressed ...

    Abstract At present, the treatment of lymphoma has entered the era of precision medicine, and CD30, as a transmembrane protein, has become an important marker to help the diagnosis and formulation of treatment plans for lymphomas. This protein is widely expressed in various types of lymphomas and can play a role through nuclear factor-κB (NF-κB), mitogen-activated protein kinase (MAPK), and other pathways, and ultimately lead to the up-regulation of CD30 expression to give tumor cells a survival advantage. Brentuximab vedotin (BV), as an antibody-drug conjugate (ADC) targeting CD30, is one of the first new drugs to significantly improve survival in patients with CD30+lymphomas. However, the biological function of CD30 has not been fully elucidated. Therefore, this review highlights the CD30-mediated tumor-promoting mechanisms and the molecular factors that regulate CD30 expression. We hope that a better understanding of CD30 biology will provide new insights into clinical treatment and improve the survival and quality of life of lymphoma patients.
    Language English
    Publishing date 2023-12-22
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2649216-7
    ISSN 2234-943X
    ISSN 2234-943X
    DOI 10.3389/fonc.2023.1301437
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: HBV-associated DLBCL of poor prognosis: advance in pathogenesis, immunity and therapy.

    Wan, Xin / Young, Ken H / Bai, Ou

    Frontiers in immunology

    2023  Volume 14, Page(s) 1216610

    Abstract: Advanced studies have shown a biological correlation between hepatitis B virus (HBV) and B-cell lymphoma, especially diffuse large B-cell lymphoma (DLBCL). Patients with DLBCL infected with HBV (HBV-associated DLBCL) are clinically characterized by an ... ...

    Abstract Advanced studies have shown a biological correlation between hepatitis B virus (HBV) and B-cell lymphoma, especially diffuse large B-cell lymphoma (DLBCL). Patients with DLBCL infected with HBV (HBV-associated DLBCL) are clinically characterized by an advanced clinical stage, poor response to front-line immunochemotherapy regimens, and worse clinical prognosis. HBV-associated DLBCL often exhibits abnormal activation of the nuclear factor kappa B pathway as well as mutations in oncogenes, including
    MeSH term(s) Humans ; Hepatitis B virus ; Prognosis ; Treatment Outcome ; Hepatitis B/drug therapy ; Lymphoma, Large B-Cell, Diffuse/pathology
    Language English
    Publishing date 2023-07-07
    Publishing country Switzerland
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2023.1216610
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Second primary malignancies in non-Hodgkin lymphoma: epidemiology and risk factors.

    Zhan, Zhumei / Guo, Wei / Wan, Xin / Bai, Ou

    Annals of hematology

    2023  Volume 102, Issue 2, Page(s) 249–259

    Abstract: With the advancements in therapeutics for non-Hodgkin lymphoma (NHL), the long-term survival of patients with NHL has markedly increased. Second primary malignancies (SPMs) have become an increasingly relevant long-term concern for NHL survivors. The ... ...

    Abstract With the advancements in therapeutics for non-Hodgkin lymphoma (NHL), the long-term survival of patients with NHL has markedly increased. Second primary malignancies (SPMs) have become an increasingly relevant long-term concern for NHL survivors. The etiology of SPMs is multifactorial and involves multiple steps. Germline alterations, immune dysregulation, and clonal hematopoiesis contribute to the accumulation of intrinsic adverse factors, and external factors such as lifestyle; exposure to infectious factors; and late effects of radiotherapy, chemotherapy, high-dose therapy, and autologous hematopoietic stem cell transplantation further increase SPM risk. Therapy-related myeloid neoplasms (t-MNs) are a devastating complication of cytotoxic chemotherapeutic agents. However, as targeted therapies begin to replace cytotoxic chemotherapy, the incidence of t-MNs is likely to decline, particularly for indolent B-cell NHL.
    MeSH term(s) Humans ; Neoplasms, Second Primary/epidemiology ; Neoplasms, Second Primary/etiology ; Lymphoma, Non-Hodgkin/therapy ; Lymphoma, Non-Hodgkin/drug therapy ; Lymphoma, B-Cell/complications ; Risk Factors ; Hematopoietic Stem Cell Transplantation/adverse effects
    Language English
    Publishing date 2023-01-09
    Publishing country Germany
    Document type Journal Article ; Review
    ZDB-ID 1064950-5
    ISSN 1432-0584 ; 0939-5555 ; 0945-8077
    ISSN (online) 1432-0584
    ISSN 0939-5555 ; 0945-8077
    DOI 10.1007/s00277-023-05095-8
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Uh III Zs.181: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  6. Article ; Online: Operando Decoding of Surface Chemical and Thermal Events in Photoelectrocatalysis via a Lab-Around-Microfiber Sensor.

    Huang, Yunyun / Mou, Caini / Liang, Jiaxuan / Wan, Jiaxin / Chen, Pengwei / Guan, Bai-Ou

    Advanced science (Weinheim, Baden-Wurttemberg, Germany)

    2024  , Page(s) e2310264

    Abstract: Operando decoding of the key parameters of photo-electric catalysis provides reliable information for catalytic effect evaluation and catalytic mechanism exploration. However, to capture the details of surface-localized and rapid chemical and thermal ... ...

    Abstract Operando decoding of the key parameters of photo-electric catalysis provides reliable information for catalytic effect evaluation and catalytic mechanism exploration. However, to capture the details of surface-localized and rapid chemical and thermal events at the nanoscale in real-time is highly challenging. A promising approach based on a lab-around-microfiber sensor capable of simulating photo-electric catalytic reactions on the surface of optical fibers as well as monitoring reactant concentration changes and catalytic heat generation processes is demonstrated. Due to the penetration depth of submicron size and the fast response ability of the evanescent field, the lab-around-microfiber sensor overcame the difficulty of reading instantaneous surface parameters in the submicron range. This sensor operando dismantled the changes in reactant concentration and temperature on the catalyst surface induced by light and voltage, respectively. It also decoded the impact of catalyst composition on the adsorption efficiency and catalytic efficiency across various wavelengths and determined the synchronized occurrence of pollutant degradation and catalytic thermal effects. Stable correlations between the real-time parameters and catalytic activities are obtained, helping to provide a basic understanding of the catalytic process and mechanism. This approach fills an important gap in the current monitoring methods of catalytic processes and heat production.
    Language English
    Publishing date 2024-04-30
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2808093-2
    ISSN 2198-3844 ; 2198-3844
    ISSN (online) 2198-3844
    ISSN 2198-3844
    DOI 10.1002/advs.202310264
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Dysregulation of FBW7 in malignant lymphoproliferative disorders.

    Wan, Xin / Guo, Wei / Zhan, Zhumei / Bai, Ou

    Frontiers in oncology

    2022  Volume 12, Page(s) 988138

    Abstract: The ubiquitin-proteasome system (UPS) is involved in various aspects of cell processes, including cell proliferation, differentiation, and cell cycle progression. F-box and WD repeat domain-containing protein 7 (FBW7), as a key component of UPS proteins ... ...

    Abstract The ubiquitin-proteasome system (UPS) is involved in various aspects of cell processes, including cell proliferation, differentiation, and cell cycle progression. F-box and WD repeat domain-containing protein 7 (FBW7), as a key component of UPS proteins and a critical tumor suppressor in human cancers, controls proteasome-mediated degradation by ubiquitinating oncoproteins such as c-Myc, Mcl-1, cyclin E, and Notch. It also plays a role in the development of various cancers, including solid and hematological malignancies, such as T-cell acute lymphoblastic leukemia, diffuse large B-cell lymphoma, and multiple myeloma. This comprehensive review emphasizes the functions, substrates, and expression of FBW7 in malignant lymphoproliferative disorders.
    Language English
    Publishing date 2022-11-09
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2649216-7
    ISSN 2234-943X
    ISSN 2234-943X
    DOI 10.3389/fonc.2022.988138
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Improvement in resolution of fiber-laser photoacoustic tomography based on a virtual-point concept

    Xue Bai / Xu Li / Jun Ma / Bai-Ou Guan

    Visual Computing for Industry, Biomedicine, and Art, Vol 4, Iss 1, Pp 1-

    2021  Volume 7

    Abstract: Abstract In this study, a virtual-point concept was introduced into fiber-laser photoacoustic tomography to improve the elevational image resolution. The flexible fiber laser was bent into an arc shape to conform to the ultrasound wavefront, which formed ...

    Abstract Abstract In this study, a virtual-point concept was introduced into fiber-laser photoacoustic tomography to improve the elevational image resolution. The flexible fiber laser was bent into an arc shape to conform to the ultrasound wavefront, which formed an ultrasound focus at the center of the arc. The synthetic aperture focusing technique was utilized to reconstruct the images; as a result, the elevational resolution particularly within the out-of-focus region was considerably improved compared to the resolution of an image retrieved by multiplexing the PA time-resolved signals with sound velocity. The all-optical fiber-laser photoacoustic tomography system with a high spatial resolution has potential for various applications, including biomedical research and preclinical/clinical diagnosis.
    Keywords Photoacoustic tomography ; Fiber laser ; Virtual point ; Synthetic aperture focusing ; Drawing. Design. Illustration ; NC1-1940 ; Computer applications to medicine. Medical informatics ; R858-859.7 ; Computer software ; QA76.75-76.765
    Subject code 621
    Language English
    Publishing date 2021-02-01T00:00:00Z
    Publisher SpringerOpen
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Article ; Online: Clinical features and prognosis of double primary malignant neoplasms in patients with non-hodgkin lymphoma.

    Zhan, Zhumei / Guo, Wei / Li, Jia / Wan, Xin / Guo, Jing / Bai, Ou

    Discover. Oncology

    2023  Volume 14, Issue 1, Page(s) 54

    Abstract: To investigate the clinical features, survival, and prognostic factors of patients with double primary malignant neoplasms (DPMNs) comprising non-Hodgkin lymphoma (NHL) and malignant solid tumors. Of the 2352 patients diagnosed with NHL, 105 (4.46%) ... ...

    Abstract To investigate the clinical features, survival, and prognostic factors of patients with double primary malignant neoplasms (DPMNs) comprising non-Hodgkin lymphoma (NHL) and malignant solid tumors. Of the 2352 patients diagnosed with NHL, 105 (4.46%) patients were diagnosed with DPMNs, 42 (40.0%) had NHL first (the NHL-first group) and 63 (60.0%) had solid tumor first (the ST-first group). Females were more frequent in the ST-first group, and the interval time between the two tumors was longer. More NHLs in early stages and originating from extranodal sites were observed in the NHL-first group. Male, age ≥ 55 years at diagnosis of the first tumor, interval time <60 months, NHL diagnosed first, NHL arising from an extranodal site, DPMNs without breast cancer, and no surgery for the first primary tumor were associated with poorer overall survival (OS). Interval time <60 months and NHL diagnosed first were independent risk factors that affected the prognosis of patients with DPMNs. Therefore, careful monitoring and follow-up are especially important for these patients. 50.5% (53/105) of patients with DPMNs did not receive chemotherapy or radiotherapy prior to the diagnosis of the second tumor. We further compared the baseline characteristics of diffuse large B-cell lymphoma(DLBCL) patients with and without solid tumors, the former had a higher proportion of extranodal DLBCL, suggesting that extranodal DLBCL is more likely to develop solid tumors than nodal DLBCL.
    Language English
    Publishing date 2023-05-03
    Publishing country United States
    Document type Journal Article
    ISSN 2730-6011
    ISSN (online) 2730-6011
    DOI 10.1007/s12672-023-00667-6
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Compact optical fiber photoacoustic gas sensor with integrated multi-pass cell.

    Fan, Enbo / Liu, Haojie / Wang, Chao / Ma, Jun / Guan, Bai-Ou

    Photoacoustics

    2023  Volume 32, Page(s) 100524

    Abstract: Optical fiber acoustic sensors with miniature size and high sensitivity are attractive to develop compact photoacoustic spectroscopy. Here, a compact photoacoustic gas sensor was demonstrated by utilizing a diaphragm-based fiber-optic Fabry-Perot cavity ... ...

    Abstract Optical fiber acoustic sensors with miniature size and high sensitivity are attractive to develop compact photoacoustic spectroscopy. Here, a compact photoacoustic gas sensor was demonstrated by utilizing a diaphragm-based fiber-optic Fabry-Perot cavity as both the acoustic sensor and the multipass cell. A nanoscale graphite film was used as the flexible diaphragm to increase the acoustic sensitivity of the Fabry-Perot cavity and the cavity inner surface was coated with highly-reflective Au film to form a multipass cell for amplification of the photoacoustic signal. With a laser power of 20 mW at 1532.8 nm, the sensor demonstrated a low detection limit of ∼ 50 ppb for C
    Language English
    Publishing date 2023-06-20
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2716706-9
    ISSN 2213-5979
    ISSN 2213-5979
    DOI 10.1016/j.pacs.2023.100524
    Database MEDical Literature Analysis and Retrieval System OnLINE

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