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Article: Self‐Aeration of Supercritical Water Flow Rushing Down Artificial Vegetated Stepped Chutes

Wang, Hang / Bai, Zhongtian / Bai, Ruidi / Liu, Shanjun

Water resources research. 2022 July, v. 58, no. 7

2022

Abstract: Vegetation flow is commonly studied for subcritical flow motions, while in supercritical flow, the presence of vegetation often leads to enhancement of flow self‐aeration, which would in turn alter the flow hydraulics and water‐plant interaction. This ... ...

Abstract	Vegetation flow is commonly studied for subcritical flow motions, while in supercritical flow, the presence of vegetation often leads to enhancement of flow self‐aeration, which would in turn alter the flow hydraulics and water‐plant interaction. This paper presents an experimental investigation of aerated water flow cascading down a vegetated stepped chute. The 21.8° sloping chute is equipped with a 12‐m‐long uniformly stepped invert section. The 0.12‐m‐high steps have grate‐shaped rough top surface covered by 0.07‐m‐high flexible artificial plants, and three vegetation densities are tested in skimming flows, in addition to the reference cases of smooth steps and rough steps covered by bare grate only. The air‐water flow properties and free‐surface fluctuations are systematically measured from the upstream clear‐water region to the downstream fully developed aerated region. The experiment results demonstrate that, compared to a man‐made concrete stepped chute, the presence of vegetation cover on the steps reduces the overall self‐aeration and unsteady fluctuating motions of the flow, while it enhances the dissipation of the flow kinetic energy. The present finding also suggests that the modification to flow aeration and energy loss in the vegetated flow over macrostep‐shaped roughness is dependent on the flow regime which is primarily determined by the flow rate for a given slope and step‐induced macroroughness height.
Keywords	aeration ; concrete ; fluid mechanics ; kinetic energy ; plant-water relations ; research ; roughness ; vegetation cover ; water ; water flow
Language	English
Dates of publication	2022-07
Publishing place	John Wiley & Sons, Ltd
Document type	Article
Note	JOURNAL ARTICLE
ZDB-ID	5564-5
ISSN	1944-7973 ; 0043-1397
ISSN (online)	1944-7973
ISSN	0043-1397
DOI	10.1029/2021WR031719
Database	NAL-Catalogue (AGRICOLA)

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Article: Air‐Water Mixing in Vegetated Supercritical Flow: Effects of Vegetation Roughness and Water Temperature on Flow Self‐Aeration

Bai, Ruidi / Bai, Zhongtian / Wang, Hang / Liu, Shanjun

Water resources research. 2022 Feb., v. 58, no. 2

2022

Abstract: Vegetated flow is rarely investigated for supercritical flow regime, in which self‐aeration occurs and modifies the flow dynamics, energy dissipation, and mass transfer between the water body and ambient air environment. In this study, natural river ... ...

Abstract	Vegetated flow is rarely investigated for supercritical flow regime, in which self‐aeration occurs and modifies the flow dynamics, energy dissipation, and mass transfer between the water body and ambient air environment. In this study, natural river water was used at two flow rates in combination with six bottom vegetation conditions to investigate the air‐water flow development in an 18‐m‐long sloping chute. The vegetation configurations included two artificial turfs with different grass lengths and three flexible plant covers with different canopy densities, in addition to a reference case of smooth solid boundary, providing flow resistance and turbulent disturbance with different orders of equivalent roughness heights. Physical measurements were focused on the air concentration, free‐surface splashing, turbulent velocity, bubble count frequency, and bubble size distributions from the upstream non‐aerated flow to the far‐field fully developed aeration region. Compared to the velocity developing to uniform equilibrium shortly downstream the inception of aeration, the flow self‐aeration reached air‐concentration equilibrium at further downstream positions, while the bubble count and air‐water interfacial area kept increasing. The vegetation roughness conditions affected the inception location, equivalent bubble rise velocity, superfacial splashing height, velocity gradient, and maximum bubble count near the free surface, whereas the equilibrium air concentration in the fully developed region depended only upon the slope. The vegetation type influenced the percentage of submillimetre bubbles. Little differences were shown in the air‐water flow characteristics by repeating the summer experiments in winter with a 25.5°C drop in water temperature, despite the variation in fluid viscosity thus the Reynolds number under identical discharge.
Keywords	Reynolds number ; aeration ; air ; canopy ; energy ; flow resistance ; grasses ; hydrodynamics ; mass transfer ; research ; river water ; roughness ; summer ; surface water ; vegetation types ; viscosity ; water temperature ; winter
Language	English
Dates of publication	2022-02
Publishing place	John Wiley & Sons, Ltd
Document type	Article
Note	JOURNAL ARTICLE
ZDB-ID	5564-5
ISSN	1944-7973 ; 0043-1397
ISSN (online)	1944-7973
ISSN	0043-1397
DOI	10.1029/2021WR031692
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Dynamic variations of the gastric microbiota: Key therapeutic points in the reversal of Correa's cascade.

Xi, Jiahui / Li, Yonghong / Zhang, Hui / Bai, Zhongtian

International journal of cancer

2022 Volume 152, Issue 6, Page(s) 1069–1084

Abstract: Correa's cascade is a dynamic process in the development of intestinal-type gastric cancer (GC), and its pathological features, gastric microbiota and interactions between microorganisms and their hosts vary at different developmental stages. The ... ...

Abstract	Correa's cascade is a dynamic process in the development of intestinal-type gastric cancer (GC), and its pathological features, gastric microbiota and interactions between microorganisms and their hosts vary at different developmental stages. The characteristics of cells, tissues and gastric microbiota before or after key therapeutic points are critical for monitoring malignant transformation and early tumour reversal. This review summarises the pathological features of gastric mucosa, characteristics of gastric microbiota, specific microbial markers, microbe-microbe interactions and microbe-host interactions at different stages in Correa's cascade. The markers related to each Correa's cascade point were analysed in detail. We attempted to identify key therapeutic points for early cancer reversal and provide a novel approach to reduce the incidence of GC and improve precise treatment.
MeSH term(s)	Humans ; Stomach Neoplasms/epidemiology ; Gastric Mucosa/pathology ; Cell Transformation, Neoplastic/pathology
Language	English
Publishing date	2022-09-08
Publishing country	United States
Document type	Journal Article ; Review ; Research Support, Non-U.S. Gov't
ZDB-ID	218257-9
ISSN	1097-0215 ; 0020-7136
ISSN (online)	1097-0215
ISSN	0020-7136
DOI	10.1002/ijc.34264
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Article ; Online: Advances in the Application of Apoptotic Proteins and Alternative Splicing in Tumor Therapy: A Narrative Review.

He, Jin / Qiu, Weitao / Li, Yonghong / Wei, Chaojun / Bai, Zhongtian / Jia, Jing / Cai, Hui

Iranian journal of public health

2023 Volume 52, Issue 7, Page(s) 1311–1319

Abstract: An apoptosis-resistant state determined by apoptotic protein expression is commonly seen in the initiation, progression, and treatment failure stages of human cancer, and anti-tumor drugs targeting apoptotic proteins have been increasingly developed over ...

Abstract	An apoptosis-resistant state determined by apoptotic protein expression is commonly seen in the initiation, progression, and treatment failure stages of human cancer, and anti-tumor drugs targeting apoptotic proteins have been increasingly developed over the past three decades. However, the frequently alternative splicing of apoptotic proteins diminished the ability of targeting drugs to bind to apoptotic proteins and, consequently, limit the drug efficacy. Currently, accumulating evidence has demonstrated that many alternative splicing events have been associated to apoptosis resistance in different cancers. Therefore, the intervention targeting alternative splicing for regulating tumor cell apoptosis is expected to become a new strategy and new direction of antitumor therapy. Here, we present well established alternative splicing events that occur in different apoptosis-related genes and their modification by several approaches with cancer therapeutic purposes.
Language	English
Publishing date	2023-08-12
Publishing country	Iran
Document type	Journal Article ; Review
ISSN	2251-6093 ; 0304-4556
ISSN (online)	2251-6093
ISSN	0304-4556
DOI	10.18502/ijph.v52i7.13233
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Article: MicroRNA polymorphism: A target for diagnosis and prognosis of hepatocellular carcinoma?

Ma, Ruixia / Zhao, Maomao / Zou, Xin / Zhou, Jianye / Bai, Zhongtian

Oncology letters

2021 Volume 21, Issue 4, Page(s) 324

Abstract: Hepatocellular carcinoma (HCC) is a life-threatening cancer of the digestive system, with complex pathogenesis affected by a broad spectrum of genetic and epigenetic factors. Among several factors, microRNAs (miRNAs), which are considered regulators of ... ...

Abstract	Hepatocellular carcinoma (HCC) is a life-threatening cancer of the digestive system, with complex pathogenesis affected by a broad spectrum of genetic and epigenetic factors. Among several factors, microRNAs (miRNAs), which are considered regulators of the post-transcriptional gene expression, play important roles in determining the malignant phenotype of HCC. In recent years, the advances in molecular genetics have resulted in the characterization of complex genetic factors and in the identification of epigenetic mechanisms of diseases. Accumulating data have suggested that miRNA polymorphisms are involved in tumorigenesis and prognosis, suggesting that the miRNAs may serve as a target for HCC with regard to pathogenesis and prognosis. In the present review, a comprehensive and detailed literature search was conducted and the role of miRNA polymorphisms in the pathogenesis and prognosis of HCC is summarized. The data proposed the use of miRNAs as targets for the diagnosis and treatment of HCC.
Language	English
Publishing date	2021-02-24
Publishing country	Greece
Document type	Journal Article ; Review
ZDB-ID	2573196-8
ISSN	1792-1082 ; 1792-1074
ISSN (online)	1792-1082
ISSN	1792-1074
DOI	10.3892/ol.2021.12586
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Article ; Online: FOXP3 and SQSTM1/P62 correlate with prognosis and immune infiltration in hepatocellular carcinoma.

Liu, Shuohui / Zhang, Honglong / Yan, Jun / Zhu, Jun / Bai, Zhongtian / Li, Xun

Pathology, research and practice

2022 Volume 242, Page(s) 154292

Abstract: Background: Hepatocellular carcinoma (HCC) is one of the most common highly malignant tumours worldwide. FOXP3 and SQSTM1/P62 have been shown to be abnormally expressed in tumour cells, but their function in different tumours remains controversial. The ... ...

Abstract	Background: Hepatocellular carcinoma (HCC) is one of the most common highly malignant tumours worldwide. FOXP3 and SQSTM1/P62 have been shown to be abnormally expressed in tumour cells, but their function in different tumours remains controversial. The present study was designed to evaluate the expression of FOXP3 and P62 in HCC and their prognostic value as well as their relationship with immune infiltration in HCC patients. Methods: The Gene Expression Omnibus (GEO) database and TNMplot.com platform were used to analyse the expression of FOXP3 and P62. The Cancer Genome Atlas (TCGA) database and Kaplan-Meier plotter were used to assess the impacts of FOXP3 and P62 on clinical prognosis. In addition, TCGA database was also used to examine the correlation between the expression of FOXP3 and P62 and tumour immune infiltration using the CIBERSORT algorithm. Finally, immunohistochemistry (IHC) was used to determine expression levels of FOXP3 and P62 in 89 HCC and adjacent normal liver tissues, and their effects on clinicopathological features and prognosis were verified. Results: FOXP3 expression was downregulated in HCC tissues, while P62 expression was upregulated. FOXP3 underexpression and P62 overexpression were closely related to decreased overall survival (OS) in HCC patients. Additionally, the abnormal expression of FOXP3 and P62 was closely related to the infiltration levels of 12 types of immune cells, including regulatory T cells (Tregs), M2 macrophages, M0 macrophages, and CD8 T cells. Notably, in the validation model, abnormal FOXP3 and P62 expression was significantly associated with adverse clinicopathological factors in HCC patients, including elevated α-fetoprotein (AFP) levels, poor tumour differentiation, and increased Ki67 levels. Furthermore, low FOXP3 and high P62 expression were independent risk factors for predicting OS prognosis in HCC patients. Conclusion: FOXP3 and P62 have been shown to be important prognostic factors in HCC patients and are associated with immune cell infiltration in HCC. These findings suggest that FOXP3 and P62 may be valuable prognostic biomarkers and potential therapeutic targets for HCC treatment.
MeSH term(s)	Humans ; Carcinoma, Hepatocellular ; Sequestosome-1 Protein ; Liver Neoplasms ; Prognosis ; Forkhead Transcription Factors ; Biomarkers, Tumor
Chemical Substances	Sequestosome-1 Protein ; Forkhead Transcription Factors ; Biomarkers, Tumor ; SQSTM1 protein, human ; FOXP3 protein, human
Language	English
Publishing date	2022-12-26
Publishing country	Germany
Document type	Journal Article
ZDB-ID	391889-0
ISSN	1618-0631 ; 0344-0338
ISSN (online)	1618-0631
ISSN	0344-0338
DOI	10.1016/j.prp.2022.154292
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Article ; Online: Estimation and sensitivity analysis of a COVID-19 model considering the use of face mask and vaccination.

Bai, Zhongtian / Ma, Zhihui / Jing, Libaihe / Li, Yonghong / Wang, Shufan / Wang, Bin-Guo / Wu, Yan / Han, Xiaotao

Scientific reports

2023 Volume 13, Issue 1, Page(s) 6434

Abstract: To model the COVID-19 infection and develop effective control measures, this paper proposes an SEIR-type epidemic model considering the impact of face-mask wearing and vaccination. Firstly, the effective reproduction number and the threshold conditions ... ...

Abstract	To model the COVID-19 infection and develop effective control measures, this paper proposes an SEIR-type epidemic model considering the impact of face-mask wearing and vaccination. Firstly, the effective reproduction number and the threshold conditions are obtained. Secondly, based on the data of South Korea from January 20, 2022 to March 21, 2022, the model parameters are estimated. Finally, a sensitivity analysis and the numerical study are conducted. The results show that the face-mask wearing is associated with [Formula: see text] and [Formula: see text] reductions in the numbers of cumulative cases and newly confirmed cases, respectively, after a period of 60 days, when the face mask wearing rate increases by [Formula: see text]. Furthermore, the vaccination rate is associated with [Formula: see text] and [Formula: see text] reductions in the numbers of cumulative cases and the newly confirmed cases, respectively, after the same period of 60 days when the vaccination rate is increased by [Formula: see text]. A combined measure involving face-mask wearing and vaccination may be more effective and reasonable in preventing and controlling this infection. It is also suggested that disease control departments should strongly recommended the wearing of face masks s as well as vaccination to prevent the unvaccinated people from becoming infected.
MeSH term(s)	Humans ; COVID-19/epidemiology ; COVID-19/prevention & control ; Masks ; Epidemics ; Vaccination ; Basic Reproduction Number
Language	English
Publishing date	2023-04-20
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-023-33499-z
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Article ; Online: (2E)-1-(2,4,6-Trimethoxyphenyl)-3-(4-chlorophenyl)prop-2-en-1-one, a Chalcone Derivative, Promotes Apoptosis by Suppressing RAS-ERK and AKT/FOXO3a Pathways in Hepatocellular Carcinoma Cells.

Zhang, Meigui / Li, Jing / Ma, Ruixia / Xi, Jiahui / Xi, Lili / Zhang, Baoxin / Tian, Jing / Bai, Zhongtian

Chemistry & biodiversity

2023 Volume 20, Issue 7, Page(s) e202300050

Abstract: Background: Liver cancer is an extremely common cancer with the highest mortality rate and poor prognosis. Owing to their low systemic toxicity and few side effects, natural compounds may provide better therapeutic effects for patients. (2E)-1-(2,4,6- ... ...

Abstract	Background: Liver cancer is an extremely common cancer with the highest mortality rate and poor prognosis. Owing to their low systemic toxicity and few side effects, natural compounds may provide better therapeutic effects for patients. (2E)-1-(2,4,6-trimethoxyphenyl)-3-(4-chlorophenyl)prop-2-en-1-one (TMOCC), a chalcone derivative, exhibits cytotoxicity towards many tumor cells. However, the anticancer mechanism of TMOCC has not been elucidated in human hepatocellular carcinoma (HCC). Methods: Cell Counting Kit-8 and colony formation assays were used to evaluate the effects of TMOCC on viability and proliferation. Mitochondrial transmembrane potential and flow cytometry assays were used to detect apoptosis. The expression levels of proteins related to apoptosis, the RAS-ERK and AKT/FOXO3a signaling pathways were assessed using western blot. Potential targets of TMOCC were detected using molecular docking analysis. Results: TMOCC inhibited viability and proliferation, and induced the loss of mitochondrial transmembrane potential, apoptosis and DNA double-strand breaks in both HCC cells. The RAS-ERK and AKT/FOXO3a signaling pathways were suppressed by TMOCC. Finally, ERK1, PARP-1, and BAX were identified as potential targets of TMOCC. Conclusion: Taken together, our results show that TMOCC promotes apoptosis by suppressing the RAS-ERK and AKT/FOXO3a signaling pathways. TMOCC may be a potential multi-target compound that is effective against liver cancer.
MeSH term(s)	Humans ; Carcinoma, Hepatocellular/pathology ; Liver Neoplasms/pathology ; Proto-Oncogene Proteins c-akt/metabolism ; Chalcones/pharmacology ; Chalcones/therapeutic use ; Chalcone/pharmacology ; Molecular Docking Simulation ; Apoptosis ; Cell Line, Tumor ; Cell Proliferation
Chemical Substances	Proto-Oncogene Proteins c-akt (EC 2.7.11.1) ; Chalcones ; Chalcone (5S5A2Q39HX)
Language	English
Publishing date	2023-06-29
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2139001-0
ISSN	1612-1880 ; 1612-1872
ISSN (online)	1612-1880
ISSN	1612-1872
DOI	10.1002/cbdv.202300050
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Article ; Online: Research progress of dCTP pyrophosphatase 1 regulating nucleotide metabolism and phenotype of tumor cells

LI Jing, ZHANG Mei-gui, BAI Zhong-tian

Jichu yixue yu linchuang, Vol 41, Iss 11, Pp 1666-

2021 Volume 1670

Abstract: Deoxycytidine triphosphate pyrophosphatase 1(dCTP pyrophosphatase 1, DCTPP1) is a newly discovered pyrophosphatase targeting deoxycytidine triphosphate (dCTP). It regulates cytosine metabolism by not only hydrolyzing conventional and modified dCTP, but ... ...

Abstract	Deoxycytidine triphosphate pyrophosphatase 1(dCTP pyrophosphatase 1, DCTPP1) is a newly discovered pyrophosphatase targeting deoxycytidine triphosphate (dCTP). It regulates cytosine metabolism by not only hydrolyzing conventional and modified dCTP, but also participating in the steady-state regulation of other pyrimidine nucleotides. In the process of tumor cells, the high expression of DCTPP1 is facilitate to stabilize the balance of deoxynucleoside triphosphate pool (dNTP pool),methylation of the genome, and maintainance of stability of the tumor cell genome. Besides, DCTPP1 promotes malignant phenotypes such as tumor cell proliferation and metastasis through different signal pathways, and it is related to tumor drug resistance and poor clinical prognosis. DCTPP1 may become a “star” target for the development of anti-tumor drugs. In-depth research on its regulatory mechanism is expected to provide a new strategy for the development of targeted inhibitors of tumor nucleotide metabolism.
Keywords	deoxycytidine triphosphate pyrophosphatase 1(dctpp1)\|deoxynucleoside triphosphate pool(dntp pool)\|nucleotide metabolism\|antitumor ; Medicine ; R
Language	Chinese
Publishing date	2021-11-01T00:00:00Z
Publisher	Institute of Basic Medical Sciences and Peking Union Medical College Hospital, Chinese Academy of Medical Sciences / Peking Union Medical College.
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: NRP1 is a Prognostic Factor and Promotes the Growth and Migration of Cells in Intrahepatic Cholangiocarcinoma.

Wu, Yong-Na / He, Li-Hong / Bai, Zhong-Tian / Li, Xun

Cancer management and research

2020 Volume 12, Page(s) 7021–7032

Abstract: Background: Neuropilin-1 (NRP-1) participates in cancer cell proliferation and metastasis as a multifunctional co-receptor by interacting with multiple signaling pathways. However, few studies have addressed the precise function and prognosis analysis ... ...

Abstract	Background: Neuropilin-1 (NRP-1) participates in cancer cell proliferation and metastasis as a multifunctional co-receptor by interacting with multiple signaling pathways. However, few studies have addressed the precise function and prognosis analysis of NRP1 in intrahepatic cholangiocarcinoma (ICC). We aimed to study the correlations between NRP1 and clinicopathological characteristics and NRP1 effect on ICC cell line functions. Methods: NRP1 mRNA and its protein levels in human ICC tissues and cell lines were detected by IHC, qRT-PCR, and WB method. Transwell, wound healing, and CCK-8 assays were performed to verify the effects of NRP1 knockdown and overexpression on cell migration and proliferation capability. Results: NRP1 proteins and mRNA levels increased in ICC tissues compared to those in paired adjacent non-tumor tissues. High NRP1 expression of ICC tissues was related to poor prognosis. NRP1 expression level was expected to be an independent prognosticator for overall survival and cumulative tumor recurrence, and was closely related to tumor number ( Conclusion: As an oncogene, NRP1 may function as a candidate target and prognostic biomarker of value for ICC therapy.
Language	English
Publishing date	2020-08-07
Publishing country	New Zealand
Document type	Journal Article
ZDB-ID	2508013-1
ISSN	1179-1322
ISSN	1179-1322
DOI	10.2147/CMAR.S260091
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