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  1. Article ; Online: Impact of an implanted neuroprosthesis on community ambulation in incomplete SCI.

    Lombardo, Lisa M / Kobetic, Rudolf / Pinault, Gilles / Foglyano, Kevin M / Bailey, Stephanie N / Selkirk, Stephen / Triolo, Ronald J

    The journal of spinal cord medicine

    2017  Volume 41, Issue 2, Page(s) 165–173

    Abstract: Objective: Test the effect of a multi-joint control with implanted electrical stimulation on walking after spinal cord injury (SCI).: Design: Single subject research design with repeated measures.: Setting: Hospital-based biomechanics laboratory ... ...

    Abstract Objective: Test the effect of a multi-joint control with implanted electrical stimulation on walking after spinal cord injury (SCI).
    Design: Single subject research design with repeated measures.
    Setting: Hospital-based biomechanics laboratory and user assessment of community use.
    Participants: Female with C6 AIS C SCI 30 years post injury.
    Interventions: Lower extremity muscle activation with an implanted pulse generator and gait training.
    Outcome measures: Walking speed, maximum distance, oxygen consumption, upper extremity (UE) forces, kinematics and self-assessment of technology.
    Results: Short distance walking speed at one-year follow up with or without stimulation was not significantly different from baseline. However, average walking speed was significantly faster (0.22 m/s) with stimulation over longer distances than volitional walking (0.12 m/s). In addition, there was a 413% increase in walking distance from 95 m volitionally to 488 m with stimulation while oxygen consumption and maximum upper extremity forces decreased by 22 and 16%, respectively. Stimulation also produced significant (P ≤ 0.001) improvements in peak hip and knee flexion, ankle angle at foot off and at mid-swing.
    Conclusion: An implanted neuroprosthesis enabled a subject with incomplete SCI to walk longer distances with improved hip and knee flexion and ankle dorsiflexion resulting in decreased oxygen consumption and UE support. Further research is required to determine the robustness, generalizability and functional implications of implanted neuroprostheses for community ambulation after incomplete SCI.
    MeSH term(s) Electric Stimulation Therapy/instrumentation ; Female ; Gait ; Hip Joint ; Humans ; Knee Joint ; Middle Aged ; Prostheses and Implants ; Range of Motion, Articular ; Spinal Cord Injuries/rehabilitation ; Walking/physiology
    Language English
    Publishing date 2017-02-03
    Publishing country England
    Document type Journal Article ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 1223949-5
    ISSN 2045-7723 ; 1079-0268
    ISSN (online) 2045-7723
    ISSN 1079-0268
    DOI 10.1080/10790268.2016.1275448
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2416: Show issues Location:
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    ab Jg. 2022: Lesesaal (EG)

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  2. Article ; Online: A preliminary comparison of myoelectric and cyclic control of an implanted neuroprosthesis to modulate gait speed in incomplete SCI.

    Lombardo, Lisa M / Bailey, Stephanie N / Foglyano, Kevin M / Miller, Michael E / Pinault, Gilles / Triolo, Ronald J

    The journal of spinal cord medicine

    2014  Volume 38, Issue 1, Page(s) 115–122

    Abstract: Objective: Explore whether electromyography (EMG) control of electrical stimulation for walking after incomplete spinal cord injury (SCI) can affect ability to modulate speed and alter gait spatial-temporal parameters compared to cyclic repetition of ... ...

    Abstract Objective: Explore whether electromyography (EMG) control of electrical stimulation for walking after incomplete spinal cord injury (SCI) can affect ability to modulate speed and alter gait spatial-temporal parameters compared to cyclic repetition of pre-programmed stimulation.
    Design: Single case study with subject acting as own concurrent control. Setting Hospital-based biomechanics laboratory.
    Participants: Single subject with C6 AIS D SCI using an implanted neuroprosthesis for walking. Interventions Lower extremity muscle activation via an implanted system with two different control methods: (1) pre-programmed pattern of stimulation, and (2) EMG-controlled stimulation based on signals from the gastrocnemius and quadriceps.
    Outcome measures: Gait speed, distance, and subjective rating of difficulty during 2-minute walks. Range of walking speeds and associated cadences, stride lengths, stride times, and double support times during quantitative gait analysis.
    Results: EMG control resulted in statistically significant increases in both walking speed and distance (P < 0.001) over cyclic stimulation during 2-minute walks. Maximum walking speed with EMG control (0.48 m/second) was significantly (P < 0.001) faster than the fastest automatic pattern (0.39 m/second), with increased cadence and decreased stride and double support times (P < 0.000) but no change in stride length (z = -0.085; P = 0.932). The slowest walking with EMG control (0.25 m/second) was virtually indistinguishable from the slowest with automatic cycling (z = -0.239; P = 0.811).
    Conclusion: EMG control can increase the ability to modulate comfortable walking speed over pre-programmed cyclic stimulation. While control methods did not differ at the lowest speed, EMG-triggered stimulation allowed significantly faster walking than cyclic stimulation. The expanded range of available walking speeds could permit users to better avoid obstacles and naturally adapt to various environments. Further research is required to definitively determine the robustness, generalizability, and functional implications of these results.
    MeSH term(s) Adult ; Electromyography ; Gait ; Humans ; Male ; Neural Prostheses/adverse effects ; Spinal Cord Injuries/rehabilitation ; Spinal Cord Injuries/surgery ; Spinal Cord Stimulation/adverse effects ; Spinal Cord Stimulation/instrumentation ; Spinal Cord Stimulation/methods
    Language English
    Publishing date 2014-09-22
    Publishing country England
    Document type Case Reports ; Comparative Study ; Journal Article ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 1223949-5
    ISSN 2045-7723 ; 1079-0268
    ISSN (online) 2045-7723
    ISSN 1079-0268
    DOI 10.1179/2045772314Y.0000000262
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2416: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  3. Article ; Online: Contralaterally controlled neuromuscular electrical stimulation for recovery of ankle dorsiflexion: a pilot randomized controlled trial in patients with chronic post-stroke hemiplegia.

    Knutson, Jayme S / Hansen, Kristine / Nagy, Jennifer / Bailey, Stephanie N / Gunzler, Douglas D / Sheffler, Lynne R / Chae, John

    American journal of physical medicine & rehabilitation

    2013  Volume 92, Issue 8, Page(s) 656–665

    Abstract: Objective: The aim of this study was to compare the effects of contralaterally controlled neuromuscular electrical stimulation (CCNMES) vs. cyclic neuromuscular electrical stimulation (NMES) on lower extremity impairment, functional ambulation, and gait ...

    Abstract Objective: The aim of this study was to compare the effects of contralaterally controlled neuromuscular electrical stimulation (CCNMES) vs. cyclic neuromuscular electrical stimulation (NMES) on lower extremity impairment, functional ambulation, and gait characteristics.
    Design: Twenty-six survivors of stroke with chronic (≥6 mos) foot drop during ambulation were randomly assigned to 6 wks of CCNMES or cyclic NMES. Both groups had ten sessions per week of self-administered home application of either CCNMES or cyclic NMES plus two sessions per week of gait training with a physical therapist. Primary outcomes included lower extremity Fugl-Meyer score, modified Emory Functional Ambulation Profile, and gait velocity. Assessments were made at pretreatment and posttreatment and at 1 and 3 mos after treatment.
    Results: There were no significant differences between the groups in the outcome trajectories for any of the measures. With data from both groups pooled, there were significant but modest and sustained improvements in the Fugl-Meyer score and the modified Emory Functional Ambulation Profile but not in gait velocity.
    Conclusions: The results support the hypothesis that gait training combined with either CCNMES or cyclic NMES reduces lower extremity impairment and functional ambulation but do not support the hypothesis that CCNMES is more effective than cyclic NMES in patients with chronic post-stroke hemiplegia.
    MeSH term(s) Adult ; Aged ; Ankle/physiopathology ; Electric Stimulation Therapy/methods ; Female ; Gait/physiology ; Hemiplegia/etiology ; Hemiplegia/physiopathology ; Hemiplegia/therapy ; Humans ; Male ; Middle Aged ; Motor Activity/physiology ; Pilot Projects ; Range of Motion, Articular/physiology ; Recovery of Function/physiology ; Stroke/complications ; Stroke/physiopathology ; Stroke/therapy ; Treatment Outcome
    Language English
    Publishing date 2013-07-17
    Publishing country United States
    Document type Journal Article ; Randomized Controlled Trial ; Research Support, N.I.H., Extramural
    ZDB-ID 219390-5
    ISSN 1537-7385 ; 0002-9491 ; 0894-9115
    ISSN (online) 1537-7385
    ISSN 0002-9491 ; 0894-9115
    DOI 10.1097/PHM.0b013e31829b4c16
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Molecular imaging of the translocator protein (TSPO) in a pre-clinical model of breast cancer.

    Wyatt, Shelby K / Manning, H Charles / Bai, Mingfeng / Bailey, Stephanie N / Gallant, Pascal / Ma, Guobin / McIntosh, Laura / Bornhop, Darryl J

    Molecular imaging and biology

    2009  Volume 12, Issue 3, Page(s) 349–358

    Abstract: Purpose: To quantitatively evaluate the utility of a translocator protein (TSPO)-targeted near-infrared (NIR) probe (NIR-conPK11195) for in vivo molecular imaging of TSPO in breast cancer.: Procedures: NIR-conPK11195 uptake and TSPO-specificity were ... ...

    Abstract Purpose: To quantitatively evaluate the utility of a translocator protein (TSPO)-targeted near-infrared (NIR) probe (NIR-conPK11195) for in vivo molecular imaging of TSPO in breast cancer.
    Procedures: NIR-conPK11195 uptake and TSPO-specificity were validated in TSPO-expressing human breast adenocarcinoma cells (MDA-MB-231). In vivo NIR-conPK11195 biodistribution and accumulation were quantitatively evaluated in athymic nude mice bearing MDA-MB-231 xenografts.
    Results: Fluorescence micrographs illustrated intracellular labeling of MDA-MB-231 cells by NIR-conPK11195. Quantitative uptake and competition assays demonstrated dose-dependent (p < 0.001) and TSPO-specific (p < 0.001) NIR-conPK11195 uptake. In vivo, NIR-conPK11195 preferentially labeled MDA-MB-231 tumors with an 11-fold (p < 0.001) and 7-fold (p < 0.001) contrast enhancement over normal tissue and unconjugated NIR dye, respectively.
    Conclusions: NIR-conPK11195 appears to be a promising TSPO-targeted molecular imaging agent for visualization and quantification of breast cancer cells in vivo. This research represents the first study to demonstrate the feasibility of TSPO imaging as an alternative breast cancer imaging approach.
    MeSH term(s) Animals ; Breast Neoplasms/diagnosis ; Breast Neoplasms/pathology ; Cell Line, Tumor ; Cell Survival ; Female ; Mice ; Mice, Inbred BALB C ; Microscopy, Fluorescence ; Models, Biological ; Molecular Imaging/methods ; Molecular Probes/chemistry ; Molecular Probes/pharmacokinetics ; Receptors, GABA/metabolism ; Spectroscopy, Near-Infrared ; Time Factors ; Tissue Distribution ; Whole Body Imaging
    Chemical Substances Molecular Probes ; Receptors, GABA ; TSPO protein, human
    Language English
    Publishing date 2009-12-01
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 2079160-4
    ISSN 1860-2002 ; 1536-1632
    ISSN (online) 1860-2002
    ISSN 1536-1632
    DOI 10.1007/s11307-009-0270-8
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6468: Show issues Location:
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  5. Article ; Online: Standing after spinal cord injury with four-contact nerve-cuff electrodes for quadriceps stimulation.

    Fisher, Lee E / Miller, Michael E / Bailey, Stephanie N / Davis, John A / Anderson, James S / Rhode, Lori / Tyler, Dustin J / Triolo, Ronald J

    IEEE transactions on neural systems and rehabilitation engineering : a publication of the IEEE Engineering in Medicine and Biology Society

    2008  Volume 16, Issue 5, Page(s) 473–478

    Abstract: This paper describes the performance of a 16-channel implanted neuroprosthesis for standing and transfers after spinal cord injury including four-contact nerve-cuff electrodes stimulating the femoral nerve for knee extension. Responses of the nerve-cuffs ...

    Abstract This paper describes the performance of a 16-channel implanted neuroprosthesis for standing and transfers after spinal cord injury including four-contact nerve-cuff electrodes stimulating the femoral nerve for knee extension. Responses of the nerve-cuffs were stable and standing times increased by 600% over time-matched values with a similar eight-channel neuroprosthesis utilizing muscle-based electrodes on vastus lateralis for knee extension.
    MeSH term(s) Electric Stimulation Therapy/instrumentation ; Electrodes, Implanted ; Equipment Design ; Equipment Failure Analysis ; Humans ; Knee Joint/innervation ; Knee Joint/physiopathology ; Male ; Middle Aged ; Muscle Contraction ; Muscle, Skeletal/innervation ; Muscle, Skeletal/physiopathology ; Paraplegia/physiopathology ; Paraplegia/rehabilitation ; Posture ; Prostheses and Implants ; Spinal Cord Injuries/physiopathology ; Spinal Cord Injuries/rehabilitation ; Therapy, Computer-Assisted/instrumentation ; Treatment Outcome
    Language English
    Publishing date 2008-10
    Publishing country United States
    Document type Case Reports ; Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 1166307-8
    ISSN 1558-0210 ; 1063-6528 ; 1534-4320
    ISSN (online) 1558-0210
    ISSN 1063-6528 ; 1534-4320
    DOI 10.1109/TNSRE.2008.2003390
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4726: Show issues Location:
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