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Article ; Online: Survival analysis and identification of prognostic factors in colorectal liver metastasis after liver resection.

Plúa-Muñiz, Katherine / Bailón-Cuadrado, Martín / Pérez-Saborido, Baltasar / Pacheco-Sánchez, David / Pinto, Pilar / Asensio-Díaz, Enrique

Cirugia espanola

2022 Volume 101, Issue 3, Page(s) 160–169

Abstract: Introduction: Liver resection is the only curative treatment for colorectal liver metastasis. The identification of predictive factors leads to personalize patient management to enhance their long-term outcomes. This population-based study aimed to ... ...

Abstract	Introduction: Liver resection is the only curative treatment for colorectal liver metastasis. The identification of predictive factors leads to personalize patient management to enhance their long-term outcomes. This population-based study aimed to characterize factors associated with, and survival impact of patients who received hepatectomy for colorectal liver metastasis. Methods: A retrospective cohort study of all the hepatectomies for colorectal liver metastasis performed at third-level hospital of Spain (2010-2018) was conducted. The Kaplan-Meier method was used for survival analyses. Multivariable Cox and regression models were used to determine prognostic factors associated with overall survival. Results: The 5-year overall survival and disease-free survival were 42 and 33%, respectively. Survival analysis showed that metastasis features (number, largest size, distribution, and extrahepatic disease) and postsurgical factors (transfusion, major complications, and positive margin resection), as well as non-mutated KRAS, showed a significant association with survival. Otherwise, on multivariate analysis, only 5 independent risk factors were identified: major size metastasis >4 cm, RAS mutation, positive margin resection, intraoperative transfusion, and major complications. Conclusions: According to our findings, major size metastasis >4 cm, intraoperative transfusion, and major postoperative complications continue to be traditional prognostic factors. Meanwhile, the KRAS biomarker has a powerful impact as a survival prognostic factor.
MeSH term(s)	Humans ; Prognosis ; Hepatectomy/methods ; Retrospective Studies ; Proto-Oncogene Proteins p21(ras) ; Liver Neoplasms/secondary ; Survival Analysis ; Colorectal Neoplasms/surgery
Chemical Substances	Proto-Oncogene Proteins p21(ras) (EC 3.6.5.2)
Language	English
Publishing date	2022-09-12
Publishing country	Spain
Document type	Journal Article
ISSN	2173-5077
ISSN (online)	2173-5077
DOI	10.1016/j.cireng.2022.09.023
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Article: A liver abscess secondary to a toothpick: a rare complication of accidental foreign body ingestion.

Pérez Saborido, Baltasar / Bailón Cuadrado, Martín / Velasco López, Rosalía

Revista espanola de enfermedades digestivas : organo oficial de la Sociedad Espanola de Patologia Digestiva

2018 Volume 111, Issue 2, Page(s) 167–168

Abstract: Perforation of the gastrointestinal tract caused by the ingested foreign bodies and subsequent hepatic abscess formation is uncommon. Early diagnosis is difficult and the treatment is mainly surgical. ...

Abstract	Perforation of the gastrointestinal tract caused by the ingested foreign bodies and subsequent hepatic abscess formation is uncommon. Early diagnosis is difficult and the treatment is mainly surgical.
MeSH term(s)	Female ; Foreign Bodies/complications ; Foreign Bodies/diagnostic imaging ; Humans ; Liver Abscess/diagnostic imaging ; Liver Abscess/etiology ; Middle Aged ; Pyloric Antrum/diagnostic imaging ; Pyloric Antrum/injuries ; Tomography, X-Ray Computed
Language	English
Publishing date	2018-12-10
Publishing country	Spain
Document type	Case Reports ; Letter
ZDB-ID	1070381-0
ISSN	1130-0108 ; 0212-7512
ISSN	1130-0108 ; 0212-7512
DOI	10.17235/reed.2018.5860/2018
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Article ; Online: Anastomotic recurrence 13 years after curative resection for rectal cancer.

Bailón-Cuadrado, Martín / Blanco-Álvarez, José I / Rodríguez-López, Mario

Medicina clinica

2017 Volume 149, Issue 1, Page(s) 43–44

Title translation	Recidiva en la anastomosis 13 años después de cirugía curativa para cáncer de recto.
MeSH term(s)	Adenocarcinoma/diagnosis ; Adenocarcinoma/surgery ; Anastomosis, Surgical ; Humans ; Male ; Middle Aged ; Neoplasm Recurrence, Local/diagnosis ; Rectal Neoplasms/diagnosis ; Rectal Neoplasms/surgery ; Rectum/surgery
Language	Spanish
Publishing date	2017-02-27
Publishing country	Spain
Document type	Case Reports ; Letter
ZDB-ID	411607-0
ISSN	1578-8989 ; 0025-7753
ISSN (online)	1578-8989
ISSN	0025-7753
DOI	10.1016/j.medcli.2017.01.009
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Article: Cervicothoracic abscess secondary to transesophageal ultrasound-guided fine needle aspiration.

Tejero-Pintor, Francisco J / Blanco-Álvarez, José I / Bailón-Cuadrado, Martín / Rodríguez-López, Mario

Gastroenterologia y hepatologia

2018 Volume 42, Issue 1, Page(s) 35–36

Title translation	Absceso cervicotorácico secundario a punción con aguja fina guiada por ecografía endoscópica transesofágica.
MeSH term(s)	Abscess/etiology ; Abscess/microbiology ; Abscess/therapy ; Adenocarcinoma/diagnosis ; Adenocarcinoma/pathology ; Adenocarcinoma/therapy ; Anti-Bacterial Agents/therapeutic use ; Chemoradiotherapy ; Combined Modality Therapy ; Drainage ; Endoscopic Ultrasound-Guided Fine Needle Aspiration/adverse effects ; Esophagoscopy/adverse effects ; Esophagoscopy/methods ; Humans ; Lung Neoplasms/diagnosis ; Lung Neoplasms/pathology ; Lung Neoplasms/therapy ; Male ; Meropenem/therapeutic use ; Middle Aged ; Neck/diagnostic imaging ; Smoking/adverse effects ; Streptococcal Infections/etiology ; Streptococcal Infections/microbiology ; Streptococcal Infections/therapy ; Streptococcus anginosus/isolation & purification ; Subcutaneous Tissue ; Superior Vena Cava Syndrome/etiology ; Superior Vena Cava Syndrome/therapy ; Thoracic Diseases/etiology ; Thoracic Diseases/microbiology ; Thoracic Diseases/therapy ; Tomography, X-Ray Computed
Chemical Substances	Anti-Bacterial Agents ; Meropenem (FV9J3JU8B1)
Language	Spanish
Publishing date	2018-03-05
Publishing country	Spain
Document type	Journal Article
ZDB-ID	632502-6
ISSN	0210-5705
ISSN	0210-5705
DOI	10.1016/j.gastrohep.2018.01.010
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Article: Type V biliary cyst with cystolithiasis.

Bailón Cuadrado, Martín / Pinto Fuentes, Pilar / Pacheco Sánchez, David / Escudero Caro, Trinidad

Revista espanola de enfermedades digestivas : organo oficial de la Sociedad Espanola de Patologia Digestiva

2018 Volume 110, Issue 7, Page(s) 462–463

Abstract: We present the case of a 40-year-old female who presented to the General Surgery clinic due to a single episode of abdominal pain which required a visit to the Emergency Department. The patient had undergone surgery during childhood due to the suspicion ... ...

Abstract	We present the case of a 40-year-old female who presented to the General Surgery clinic due to a single episode of abdominal pain which required a visit to the Emergency Department. The patient had undergone surgery during childhood due to the suspicion of a hepatic hydatid cyst. However, an intraoperative cholangiography identified a small, non-complicated biliary cyst. Therefore, a hepatic resection was not performed. The patient did not undergo follow-up of the lesion.
MeSH term(s)	Adult ; Bile Duct Diseases/complications ; Bile Duct Diseases/diagnostic imaging ; Cysts/complications ; Cysts/diagnostic imaging ; Female ; Humans ; Lithiasis/complications ; Lithiasis/diagnostic imaging
Language	English
Publishing date	2018-04-17
Publishing country	Spain
Document type	Case Reports ; Journal Article
ZDB-ID	1070381-0
ISSN	1130-0108 ; 0212-7512
ISSN	1130-0108 ; 0212-7512
DOI	10.17235/reed.2018.5477/2018
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Article: Impaired immune reaction and increased lactate and C-reactive protein for early prediction of severe morbidity and pancreatic fistula after pancreatoduodenectomy.

Rodriguez-Lopez, Mario / Tejero-Pintor, Francisco J / Bailon-Cuadrado, Martin / Barrera-Rebollo, Asterio / Perez-Saborido, Baltasar / Pacheco-Sanchez, David

Hepatobiliary & pancreatic diseases international : HBPD INT

2019 Volume 19, Issue 1, Page(s) 58–67

Abstract: Background: Prediction of complications after pancreatoduodenectomy (PD) remains of interest. Blood parameters and biomarkers during first and second postoperative days (POD1, POD2) may be early indicators of complications.: Methods: This case- ... ...

Abstract	Background: Prediction of complications after pancreatoduodenectomy (PD) remains of interest. Blood parameters and biomarkers during first and second postoperative days (POD1, POD2) may be early indicators of complications. Methods: This case-control study included 50 patients. Baseline, POD1 and POD2 values of leukocytes, neutrophils, lymphocytes, platelets, hemoglobin, C-reactive protein (CRP), procalcitonin and arterial lactate were compared between individuals presenting Clavien ≥ III morbidity, pancreatic fistula (PF) or clinically relevant PF (CRPF) and those without these morbidities. Common variables reaching significance were further analyzed in order to calculate a predictive score. Results: Severe morbidity, PF and CRPF rates were 28.0%, 26.0% and 14.0%, respectively. Patients with severe morbidity had lower leukocytes on POD2 (P = 0.04). Patients with PF presented higher CRP on POD2 (P = 0.001), higher lactate on POD1 (P = 0.007) and POD2 (P = 0.008), and lower lymphocytes on POD1 (P = 0.007) and POD2 (P = 0.008). Patients with CRPF had lower leukocytes and neutrophils on POD1 (P = 0.048, P = 0.038), lower lymphocytes on POD1 (P = 0.001) and POD2 (P = 0.003), and higher CRP on POD2 (P = 0.001). Baseline parameters and procalcitonin obtained no statistical associations. Score was defined according to lymphocytes on POD1 < 650/µL and CRP on POD2 ≥ 250 mg/L allocating patients in 3 risk categories. PF and CRPF rates were statistically higher as risk category increased (P<0.001). Receiver operating characteristic curves and Hosmer-Lemeshow tests showed a good accuracy. Conclusions: Impaired immunological reaction during early postoperative period (lower leukocytes and, particularly, lymphocytes) in response to surgical aggression would favor complications after PD. Likewise, acidosis (higher arterial lactate) could behave as risk factor of PF. An elevated CRP on POD2 is also an early biomarker of PF. Our novel score based on postoperative lymphocyte count and CRP seems reliable for early prediction of PF.
MeSH term(s)	Aged ; C-Reactive Protein/analysis ; Case-Control Studies ; Female ; Humans ; Lactates/blood ; Male ; Middle Aged ; Morbidity ; Pancreatic Fistula/etiology ; Pancreatic Fistula/immunology ; Pancreaticoduodenectomy/adverse effects
Chemical Substances	Lactates ; C-Reactive Protein (9007-41-4)
Language	English
Publishing date	2019-05-20
Publishing country	Singapore
Document type	Journal Article ; Observational Study
ZDB-ID	2241386-8
ISSN	1499-3872
ISSN	1499-3872
DOI	10.1016/j.hbpd.2019.05.003
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Article ; Online: A new dimensional-reducing variable obtained from original inflammatory scores is highly associated to morbidity after curative surgery for colorectal cancer.

Bailon-Cuadrado, Martin / Perez-Saborido, Baltasar / Sanchez-Gonzalez, Javier / Rodriguez-Lopez, Mario / Mayo-Iscar, Agustin / Pacheco-Sanchez, David

International journal of colorectal disease

2018 Volume 33, Issue 9, Page(s) 1225–1234

Abstract: Purpose: Several scores have been developed to define the inflammatory status of oncological patients. We suspect they share iterative information. Our hypothesis is that we may summarise their information into one or two new variables which will be ... ...

Abstract	Purpose: Several scores have been developed to define the inflammatory status of oncological patients. We suspect they share iterative information. Our hypothesis is that we may summarise their information into one or two new variables which will be independent. This will help us to predict, more accurately, which patients are at an increased risk of suffering postoperative complications after curative surgery for CRC. Methods: Observational prospective study with those patients undergoing curative surgery for CRC between September 2015 and February 2017. We analysed the influence of inflammatory scores (PNI, GPS, NLR, PLR) on postoperative morbidity (overall and severe complications, anastomotic leakage and reoperation). Results: Finally, 168 patients were analysed. We checked these four original scores are interrelated among them. Using a complex and innovative statistical method, we created two new independent variables (resultant A and resultant B) which resume the information coming from them. One of these two new variables (resultant A) was statistically associated to overall complications (OR, 2.239; 95% CI, 1.541-3.253; p = 0.0001), severe complications (OR, 1.773; 95% CI, 1.129-2.785; p = 0.013), anastomotic leakage (OR, 3.208; 95% CI, 1.416-7.268; p = 0.005) and reoperation (OR, 2.349; 95% CI, 1.281-4.305; p = 0.006). Conclusions: We evinced the four original scores we used share redundant information. We created two new independent new variables which resume their information. In our sample of patients, one of these variables turned out to be a great predictive factor for the four complications we analysed.
MeSH term(s)	Aged ; Anastomotic Leak/etiology ; Biomarkers/blood ; Blood Platelets ; C-Reactive Protein/metabolism ; Colectomy/adverse effects ; Colorectal Neoplasms/complications ; Colorectal Neoplasms/diagnosis ; Colorectal Neoplasms/surgery ; Decision Support Techniques ; Female ; Health Status ; Humans ; Inflammation/blood ; Inflammation/complications ; Inflammation/diagnosis ; Inflammation Mediators/blood ; Lymphocyte Count ; Lymphocytes ; Male ; Neutrophils ; Platelet Count ; Postoperative Complications/etiology ; Postoperative Complications/surgery ; Predictive Value of Tests ; Proctectomy/adverse effects ; Prospective Studies ; Reoperation ; Risk Assessment ; Risk Factors ; Serum Albumin, Human/metabolism ; Time Factors ; Treatment Outcome
Chemical Substances	Biomarkers ; Inflammation Mediators ; C-Reactive Protein (9007-41-4) ; Serum Albumin, Human (ZIF514RVZR)
Language	English
Publishing date	2018-06-20
Publishing country	Germany
Document type	Comparative Study ; Journal Article ; Observational Study
ZDB-ID	84975-3
ISSN	1432-1262 ; 0179-1958
ISSN (online)	1432-1262
ISSN	0179-1958
DOI	10.1007/s00384-018-3100-0
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Article: Severe morbidity after pancreatectomy is accurately predicted by preoperative pancreatic resection score (PREPARE): A prospective validation analysis from a medium-volume center.

Rodriguez-Lopez, Mario / Tejero-Pintor, Francisco J / Perez-Saborido, Baltasar / Barrera-Rebollo, Asterio / Bailon-Cuadrado, Martin / Pacheco-Sanchez, David

Hepatobiliary & pancreatic diseases international : HBPD INT

2018 Volume 17, Issue 6, Page(s) 559–565

Abstract: Background: Major morbidity in pancreatic surgery remains high. Different scores for predicting complications have been described. Preoperative pancreatic resection (PREPARE) score is based on objective preoperative variables and offers good predictive ... ...

Abstract	Background: Major morbidity in pancreatic surgery remains high. Different scores for predicting complications have been described. Preoperative pancreatic resection (PREPARE) score is based on objective preoperative variables and offers good predictive accuracy for Clavien ≥ III complications. This study aimed to validate this score and analyze other preoperative variables in a prospective study performed in a medium-volume center. Methods: A total of 50 pancreatic resections were included. Preoperative variables were registered and PREPARE was calculated. The main outcome was severe morbidity (Clavien ≥ III) up to 30 days after discharge. The secondary outcomes were length of stay (LOS) and readmission. Statistical validation was performed to compare severe morbidity rate among the scores categories. Association with other preoperative variables (not included in PREPARE) was also tested. Results: Of the 50 pancreatic resections, the severe morbidity was 34.0%, with median LOS of 11 days. Readmission rate was 25.5%. Severe morbidity rates according to PREPARE categories were 18.5% in low-risk group, 41.7% in intermediate-risk group, and 63.6% in high-risk group, respectively (P = 0.023). The accuracy was 72% (Hosmer-Lemeshow, P = 0.86). ROC curve was obtained both for PREPARE score expressed as incremental values and categorized as the three risk groups, showing an area under curve (AUC) of 0.736 (95% CI: 0.586-0.887; P = 0.007) and 0.712 (95% CI: 0.555-0.869; P = 0.015), respectively. PREPARE was significant in multivariate analysis. Median LOS was statistically higher as PREPARE category increases (9, 11 and 15 days in low-, intermediate- and high-risk groups, respectively; P = 0.009). Readmission was not associated with any variables. Conclusions: PREPARE behaves as an independent risk factor for severe morbidity after pancreatic surgery. Score validation shows good accuracy prediction. Increasing PREPARE category is also associated with longer LOS.
MeSH term(s)	Adult ; Aged ; Body Mass Index ; Female ; Humans ; Length of Stay ; Male ; Middle Aged ; Morbidity ; Pancreatectomy/adverse effects ; Pancreatic Neoplasms/pathology ; Pancreatic Neoplasms/surgery ; Patient Readmission ; Prospective Studies ; ROC Curve
Language	English
Publishing date	2018-09-26
Publishing country	Singapore
Document type	Journal Article ; Observational Study ; Validation Studies
ZDB-ID	2241386-8
ISSN	1499-3872
ISSN	1499-3872
DOI	10.1016/j.hbpd.2018.09.017
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Article ; Online: Gangrena de Fournier por Salmonella typhimurium.

Bailón Cuadrado, Martín / Sánchez González, Javier / Rodríguez López, Mario / Velasco López, Rosalía

Emergencias : revista de la Sociedad Espanola de Medicina de Emergencias

2015 Volume 27, Issue 2, Page(s) 138–139

Title translation	Fournier's Gangrene due to Salmonella typhimurium.
Language	Spanish
Publishing date	2015
Publishing country	Spain
Document type	Letter
ZDB-ID	2127173-2
ISSN	2386-5857 ; 1137-6821
ISSN (online)	2386-5857
ISSN	1137-6821
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Article ; Online: Embolismo pulmonar por fistulización de quiste hidatídico hepático a vena cava inferior.

Bailón-Cuadrado, Martín / Barrera-Rebollo, Asterio / Pérez-Saborido, Baltasar / Asensio-Díaz, Enrique

Enfermedades infecciosas y microbiologia clinica

2015 Volume 33, Issue 8, Page(s) 572

Title translation	Pulmonary embolism due to a liver hydatid cyst fistulized into the inferior cava vein.
MeSH term(s)	Albendazole/therapeutic use ; Anaphylaxis/etiology ; Anthelmintics/therapeutic use ; Blood Vessel Prosthesis Implantation ; Combined Modality Therapy ; Digestive System Fistula/etiology ; Digestive System Fistula/surgery ; Echinococcosis, Hepatic/complications ; Echinococcosis, Hepatic/diagnostic imaging ; Echinococcosis, Hepatic/drug therapy ; Echinococcosis, Hepatic/surgery ; Emergencies ; Humans ; Male ; Middle Aged ; Pulmonary Embolism/etiology ; Rupture, Spontaneous ; Vascular Fistula/etiology ; Vascular Fistula/surgery ; Vena Cava, Inferior/pathology ; Vena Cava, Inferior/surgery
Chemical Substances	Anthelmintics ; Albendazole (F4216019LN)
Language	Spanish
Publishing date	2015-10
Publishing country	Spain
Document type	Case Reports ; Letter
ZDB-ID	1070941-1
ISSN	1578-1852 ; 0213-005X
ISSN (online)	1578-1852
ISSN	0213-005X
DOI	10.1016/j.eimc.2015.02.009
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