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  1. Article: If Theranos' Tests Had Actually Worked.

    Baird, Geoffrey S

    The journal of applied laboratory medicine

    2019  Volume 4, Issue 1, Page(s) 7–10

    MeSH term(s) Diagnostic Techniques and Procedures ; Medicine
    Language English
    Publishing date 2019-04-29
    Publishing country England
    Document type Editorial ; Comment
    ZDB-ID 2868926-4
    ISSN 2475-7241
    ISSN 2475-7241
    DOI 10.1373/jalm.2019.029355
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: The Choosing Wisely initiative and laboratory test stewardship.

    Baird, Geoffrey S

    Diagnosis (Berlin, Germany)

    2018  Volume 6, Issue 1, Page(s) 15–23

    Abstract: The United States Choosing Wisely initiative was started in 2012 by the American Board of Internal Medicine Foundation and focused on reducing medical resource overutilization. Since its inception in the US, similar efforts have arisen in at least a ... ...

    Abstract The United States Choosing Wisely initiative was started in 2012 by the American Board of Internal Medicine Foundation and focused on reducing medical resource overutilization. Since its inception in the US, similar efforts have arisen in at least a dozen countries. Strongly patient-focused, and in fact started in collaboration with the consumer magazine Consumer Reports, the effort has resulted in a collection of greater than 500 recommendations from over 80 US professional societies intended to inform both patients and doctors about medical practices whose necessity should be questioned or discussed. Targets of recommendations include practices that lack a basis in scientific evidence, practices that may be duplicative of other care already received, practices that may be harmful and practices that are simply unnecessary. While critiques have been levied against the Choosing Wisely initiative over its intent, methods and efficacy, it is clear that many of its recommendations have been adopted by large medical practices, and several positive outcomes, i.e. reductions in perceived waste, have been reported in relation to many of the recommendations, including those specifically targeting laboratory tests. The future success of Choosing Wisely will likely hinge on whether or not significantly positive and durable outcomes can be demonstrated, especially at a time where there is increasing pressure to drive down costs in medical care while concomitantly increasing quality.
    MeSH term(s) Clinical Chemistry Tests/economics ; Clinical Chemistry Tests/standards ; Humans ; Medical Overuse/prevention & control ; Physicians ; Practice Guidelines as Topic/standards ; United States
    Language English
    Publishing date 2018-09-10
    Publishing country Germany
    Document type Journal Article ; Review
    ISSN 2194-802X
    ISSN (online) 2194-802X
    DOI 10.1515/dx-2018-0045
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Pastry precautions: Poppy seed-containing products cause significant positive results in urine drug tests.

    Wilson, Rebecca J / Laha, Thomas J / Baird, Geoffrey S / Hoofnagle, Andrew N / Liao, Hsuan-Chieh

    Journal of analytical toxicology

    2023  Volume 47, Issue 7, Page(s) 644–645

    MeSH term(s) Papaver ; Morphine/urine ; Codeine/urine ; Seeds
    Chemical Substances Morphine (76I7G6D29C) ; Codeine (UX6OWY2V7J)
    Language English
    Publishing date 2023-08-09
    Publishing country England
    Document type Letter
    ZDB-ID 752391-9
    ISSN 1945-2403 ; 0146-4760
    ISSN (online) 1945-2403
    ISSN 0146-4760
    DOI 10.1093/jat/bkad054
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Benzodiazepine analysis by an improved LC-MS/MS method illustrates usage patterns in Washington State.

    Keung Chan, Ka / Moore, Andrea J / Hoofnagle, Andrew N / Baird, Geoffrey S / Liao, Hsuan-Chieh

    Clinica chimica acta; international journal of clinical chemistry

    2023  Volume 543, Page(s) 117274

    Abstract: Background: The standard approach for benzodiazepine detection often includes immunoassay followed by liquid chromatography-tandem mass spectrometry (LC-MS/MS). The illicit use of non-prescribed benzodiazepines has been trending up nationally.: ... ...

    Abstract Background: The standard approach for benzodiazepine detection often includes immunoassay followed by liquid chromatography-tandem mass spectrometry (LC-MS/MS). The illicit use of non-prescribed benzodiazepines has been trending up nationally.
    Methods: We developed and validated an improved LC-MS/MS assay for benzodiazepine detection in urine. We expanded the testing panel by adding five drugs to the previous panel of ten. We determined the prevalence of individual benzodiazepines in our patient population. Immunoassay results were compared with LC-MS/MS to evaluate assay performance.
    Results: Clonazepam and alprazolam were the most common benzodiazepines present. Etizolam and flualprazolam were also prevalent in Washington State. Compared with the LC-MS/MS assay, the immunoassay had variable cross-reactivity, which explained false negative and false positive immunoassay results. The inclusion of new drugs in the LC-MS/MS panel significantly reduced the incidence of immunoassay results interpreted as falsely positive.
    Conclusion: New illicit benzodiazepines have emerged regionally and nationally. The inclusion of novel drugs in LC-MS/MS assay was helpful in properly characterizing the epidemiology of benzodiazepine use in our patient population. This information will lead to better assay result interpretations and patient care, and our experiences provide a roadmap for other clinical laboratories looking to expand their testing menu or transition to new instrumentation.
    MeSH term(s) Humans ; Chromatography, Liquid/methods ; Tandem Mass Spectrometry/methods ; Washington ; Benzodiazepines/urine ; Clonazepam
    Chemical Substances Benzodiazepines (12794-10-4) ; Clonazepam (5PE9FDE8GB)
    Language English
    Publishing date 2023-03-17
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 80228-1
    ISSN 1873-3492 ; 0009-8981
    ISSN (online) 1873-3492
    ISSN 0009-8981
    DOI 10.1016/j.cca.2023.117274
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  5. Article ; Online: Point: the quest for clean competition in sports: are we the dopes?

    Baird, Geoffrey S

    Clinical chemistry

    2014  Volume 60, Issue 10, Page(s) 1276–1278

    MeSH term(s) Biomedical Research ; Competitive Behavior ; Doping in Sports/prevention & control ; Doping in Sports/statistics & numerical data ; Humans ; Sports/psychology ; Sports/standards ; Substance Abuse Detection/methods ; Substance Abuse Detection/statistics & numerical data
    Language English
    Publishing date 2014-07-24
    Publishing country England
    Document type Journal Article
    ZDB-ID 80102-1
    ISSN 1530-8561 ; 0009-9147
    ISSN (online) 1530-8561
    ISSN 0009-9147
    DOI 10.1373/clinchem.2014.225979
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Investigation of Fentanyl Usage in the Seattle Area.

    Reinhart, Alexandria A / Simpson, Celia / Yarid, Nicole / Haruff, Richard / Baird, Geoffrey S

    The journal of applied laboratory medicine

    2022  Volume 7, Issue 5, Page(s) 1164–1168

    Abstract: Background: Fentanyl was developed in the 1960s as an alternative to morphine, but quickly became a drug of abuse due to its potency, inexpensiveness, and ease of synthesis. One source of exposure is mixing fentanyl into other drugs of abuse (e.g., ... ...

    Abstract Background: Fentanyl was developed in the 1960s as an alternative to morphine, but quickly became a drug of abuse due to its potency, inexpensiveness, and ease of synthesis. One source of exposure is mixing fentanyl into other drugs of abuse (e.g., heroin), but users also actively seek out this potent opioid. While monitoring for pain medication compliance and office-based opioid treatment, we noticed increasing fentanyl use. We sought to investigate this increase in the local population, and see if this reflected the regional health, morbidity, and mortality statistics.
    Methods: This data review was determined not to involve "human subjects" as defined by federal regulations by the University of Washington (UW) Human Subjects Division (STUDY00014988). Local data were extracted from the laboratory information system and analyzed. Data from the King County Medical Examiner's Office derives from cases sent to the Washington State Toxicology Laboratory. The Addictions, Drug, and Alcohol Institute (ADAI) at the UW compiled data from the Washington State Department of Health, the Forensic Laboratory Services Bureau, Washington State Patrol, and the state Office of Financial Management.
    Results: We found a significant increase in fentanyl positivity in clinical LC-MS/MS assays, an increase in deaths due to fentanyl, and an increase in the fentanyl usage documented by the public health laboratory.
    Conclusions: Clinical data from community toxicology testing performed at academic medical centers can reflect trends in society at large, and as such, there may be a compelling reason to publish and use these data to inform public health approaches.
    MeSH term(s) Analgesics, Opioid ; Chromatography, Liquid ; Drug Overdose/diagnosis ; Fentanyl ; Humans ; Tandem Mass Spectrometry
    Chemical Substances Analgesics, Opioid ; Fentanyl (UF599785JZ)
    Language English
    Publishing date 2022-06-18
    Publishing country England
    Document type Journal Article
    ISSN 2576-9456
    ISSN 2576-9456
    DOI 10.1093/jalm/jfac041
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  7. Article ; Online: A Second-generation opioid LC-MS/MS assay improves laboratory workflow and capacity.

    Liao, Hsuan-Chieh / Laha, Thomas J / Baird, Geoffrey S / Chan, Ka Keung / Hoofnagle, Andrew N

    Journal of chromatography. B, Analytical technologies in the biomedical and life sciences

    2022  Volume 1210, Page(s) 123438

    Abstract: The widespread use of opioid drugs has contributed to escalating rates of addiction, overdoses, and drug-related deaths. Targeted urine drug screening plays an important role in supporting the care of patients with chronic pain or addiction. Liquid ... ...

    Abstract The widespread use of opioid drugs has contributed to escalating rates of addiction, overdoses, and drug-related deaths. Targeted urine drug screening plays an important role in supporting the care of patients with chronic pain or addiction. Liquid chromatography-tandem mass spectrometry (LC-MS/MS) can provide excellent sensitivity and specificity, and, as a result, remains the definitive choice for confirmatory urine drug testing. However, the complexities of LC-MS/MS operation present major challenges to the clinical laboratory. In this study, we leveraged upgraded instrumentation to develop and validate a simplified "dilute-and-shoot" LC-MS/MS opioid assay. By modifying the chromatographic gradient, isobaric interferences were well-resolved and eliminated. Analytical ranges were expanded by utilizing alternative mass transitions, and updated quality assurance parameters were established. Results from 204 clinical samples correlated well between the new method and a previous version. The upgraded systems provided better sensitivity, greater dynamic ranges, and the new method reduced carryover, which enabled us to eliminate extra injections and chromatogram reviews. The new method also reduced turnaround time and doubled testing capacity. These improvements could serve as a model for other laboratories approaching a similar transition in mass spectrometric instrumentation.
    MeSH term(s) Analgesics, Opioid ; Chromatography, Liquid/methods ; Humans ; Laboratories ; Tandem Mass Spectrometry/methods ; Workflow
    Chemical Substances Analgesics, Opioid
    Language English
    Publishing date 2022-08-28
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 1180823-8
    ISSN 1873-376X ; 0378-4347 ; 1570-0232 ; 1387-2273
    ISSN (online) 1873-376X
    ISSN 0378-4347 ; 1570-0232 ; 1387-2273
    DOI 10.1016/j.jchromb.2022.123438
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: A web application to support the coordination of reflexive, interpretative toxicology testing.

    Pablo, Abed / Laha, Thomas J / Breit, Nathan / Hoffman, Noah G / Hoofnagle, Andrew N / Baird, Geoffrey S / Mathias, Patrick C

    Journal of pathology informatics

    2023  Volume 14, Page(s) 100303

    Abstract: Background: Reflexive laboratory testing workflows can improve the assessment of patients receiving pain medications chronically, but complex workflows requiring pathologist input and interpretation may not be well-supported by traditional laboratory ... ...

    Abstract Background: Reflexive laboratory testing workflows can improve the assessment of patients receiving pain medications chronically, but complex workflows requiring pathologist input and interpretation may not be well-supported by traditional laboratory information systems. In this work, we describe the development of a web application that improves the efficiency of pathologists and laboratory staff in delivering actionable toxicology results.
    Method: Before designing the application, we set out to understand the entire workflow including the laboratory workflow and pathologist review. Additionally, we gathered requirements and specifications from stakeholders. Finally, to assess the performance of the implementation of the application, we surveyed stakeholders and documented the approximate amount of time that is required in each step of the workflow.
    Results: A web-based application was chosen for the ease of access for users. Relevant clinical data was routinely received and displayed in the application. The workflows in the laboratory and during the interpretation process served as the basis of the user interface. With the addition of auto-filing software, the return on investment was significant. The laboratory saved the equivalent of one full-time employee in time by automating file management and result entry.
    Discussion: Implementation of a purpose-built application to support reflex and interpretation workflows in a clinical pathology practice has led to a significant improvement in laboratory efficiency. Custom- and purpose-built applications can help reduce staff burnout, reduce transcription errors, and allow staff to focus on more critical issues around quality.
    Language English
    Publishing date 2023-02-26
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2579241-6
    ISSN 2153-3539 ; 2229-5089
    ISSN (online) 2153-3539
    ISSN 2229-5089
    DOI 10.1016/j.jpi.2023.100303
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: A Novel Discovery Platform: Aptamers for the Quantification of Human Proteins.

    Baird, Geoffrey S / Hoofnagle, Andrew N

    Clinical chemistry

    2017  Volume 63, Issue 6, Page(s) 1061–1062

    MeSH term(s) Biomarkers ; Cardiovascular Diseases ; Gene Expression Profiling ; Humans ; Proteomics
    Chemical Substances Biomarkers
    Language English
    Publishing date 2017-03-01
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 80102-1
    ISSN 1530-8561 ; 0009-9147
    ISSN (online) 1530-8561
    ISSN 0009-9147
    DOI 10.1373/clinchem.2016.265652
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Ud II Zs.171: Show issues Location:
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  10. Article: A Second-generation Opioid LC-MS/MS Assay Improves Laboratory Workflow and Capacity

    Liao, Hsuan-Chieh / Laha, Thomas J. / Baird, Geoffrey S. / Keung Chan, Ka / Hoofnagle, Andrew N.

    Journal of chromatography. 2022 Aug. 25,

    2022  

    Abstract: The widespread use of opioid drugs has contributed to escalating rates of addiction, overdoses, and drug-related deaths. Targeted urine drug screening plays an important role in supporting the care of patients with chronic pain or addiction. Liquid ... ...

    Abstract The widespread use of opioid drugs has contributed to escalating rates of addiction, overdoses, and drug-related deaths. Targeted urine drug screening plays an important role in supporting the care of patients with chronic pain or addiction. Liquid chromatography-tandem mass spectrometry (LC-MS/MS) can provide excellent sensitivity and specificity, and, as a result, remains the definitive choice for confirmatory urine drug testing. However, the complexities of LC-MS/MS operation present major challenges to the clinical laboratory. In this study, we leveraged upgraded instrumentation to develop and validate a simplified “dilute-and-shoot“ LC-MS/MS opioid assay. By modifying the chromatographic gradient, isobaric interferences were well-resolved and eliminated. Analytical ranges were expanded by utilizing alternative mass transitions, and updated quality assurance parameters were established. Results from 204 clinical samples correlated well between the new method and a previous version. The upgraded systems provided better sensitivity, greater dynamic ranges, and the new method reduced carryover, which enabled us to eliminate extra injections and chromatogram reviews. The new method also reduced turnaround time and doubled testing capacity. These improvements could serve as a model for other laboratories approaching a similar transition in mass spectrometric instrumentation.
    Keywords drugs ; instrumentation ; liquid chromatography ; models ; pain ; quality control ; tandem mass spectrometry ; urine
    Language English
    Dates of publication 2022-0825
    Publishing place Elsevier B.V.
    Document type Article
    Note Pre-press version
    ISSN 1570-0232
    DOI 10.1016/j.jchromb.2022.123438
    Database NAL-Catalogue (AGRICOLA)

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