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  1. Article: Transforaminal Endoscopic Discectomy Under General and Local Anesthesia: A Single-Center Study.

    Kerimbayev, Talgat / Kenzhegulov, Yergen / Tuigynov, Zhandos / Aleinikov, Viktor / Urunbayev, Yermek / Makhambetov, Yerbol / Pan, Andrew / Abishev, Nurzhan / Oshayev, Meirzhan / Baiskhanova, Dinara / Solodovnikov, Makar / Akshulakov, Serik

    Frontiers in surgery

    2022  Volume 9, Page(s) 873954

    Abstract: Percutaneous spinal endoscopy is used for the treatment of disorders of the lumbar spine, as it has several advantages over traditional surgical methods. The performance of percutaneous spinal endoscopy is not possible without applying anesthesia methods. ...

    Abstract Percutaneous spinal endoscopy is used for the treatment of disorders of the lumbar spine, as it has several advantages over traditional surgical methods. The performance of percutaneous spinal endoscopy is not possible without applying anesthesia methods. Two types (local and general) of anesthesia are used for percutaneous spinal endoscopy. Both, local and general anesthesia approaches contribute to safety in surgical procedures. Although it is believed that the method of local anesthesia has more benefits over general anesthesia, such as lowering the risk of postoperative neurological complications in a patient, the literature on the topic is inconclusive. The study aims to perform a comparative analysis of the two anesthesia methods using a prospective case-control design. Patients were divided into two groups: those who received local anesthesia (LA) (20 patients), and those who underwent general anesthesia (GA) (20 patients). As a result of the study, 40% of the patients experienced moderate pain and 5% of the patients experienced excruciating pain intraoperatively in the LA group. Although Visual Analog Scale and Oswestry Disability Index scores improved more rapidly in LA group, at the 12-month check-up point there was no significant difference between cases and controls. Nevertheless, there were postoperative complications such as nerve root injury in 10% of the patients; nausea, vomiting, dizziness, drowsiness in 15% of the patients in the GA group, and an insignificant or no such complications in patients of the LA group. The present study demonstrates that LA contributes to more positive short-term outcomes for patients as it facilitates nerve root damage prevention, and has no postoperative side effects on patients' well being.
    Language English
    Publishing date 2022-04-19
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2773823-1
    ISSN 2296-875X
    ISSN 2296-875X
    DOI 10.3389/fsurg.2022.873954
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Minimally Invasive Posterolateral Approach for Surgical Resection of Dumbbell Tumors of the Lumbar Spine.

    Kerimbayev, Talgat T / Tuigynov, Zhandos M / Aleinikov, Viktor G / Urunbayev, Yermek A / Kenzhegulov, Yergen N / Baiskhanova, Dinara M / Abishev, Nurzhan B / Oshayev, Meirzhan S / Solodovnikov, Makar P / Akshulakov, Serik K

    Frontiers in surgery

    2022  Volume 9, Page(s) 792922

    Abstract: Minimally invasive spine surgery (MISS) has many advantages over traditional open surgical procedures that can be conducted for the therapy of different diseases of the spine. MISS provide many prospective advantages such as, for example, small incisions, ...

    Abstract Minimally invasive spine surgery (MISS) has many advantages over traditional open surgical procedures that can be conducted for the therapy of different diseases of the spine. MISS provide many prospective advantages such as, for example, small incisions, less damage to soft tissues, early activation of patients, and a shorter postoperative hospital stay. The aim of the study was to evaluate institutional experience with Dumbbell tumors and metastatic lesions of the lumbar spine and compare it with traditional open surgical resection of this type of tumors. Fourteen patients underwent the surgery with minimally invasive posterolateral approach in experimental group, and 10 patients of the control group were operated using the traditional open surgery procedure at the Department of spinal neurosurgery and pathology of peripheral nervous system of JSC "National Center for Neurosurgery." The intraoperative neuro monitoring system (ISIS IOM System Compact, Inomed, Germany) was used in both groups. Sensory and motor evoked potentials were intraoperatively recorded. The present study was approved by the local Ethics Committee of the National Center for Neurosurgery. Patients signed informed consent before the surgical procedure. The experimental group included 14 patients, that underwent the surgery during the period from January 2020 till March 2021. And the control group included 10 patients that was operated from January 2018 to December 2019. The results of the treatment in both groups were assessed according to the generally accepted visual analog scale (VAS) and the Oswestry scales before, on the third day, and 3 months after the surgery. In experimental group, average reduction of the pain syndrome of 3.36 points (from 3 to 0 points) was observed in patients postoperatively according to the VAS 3 days, and of 4.0 points (from 2 to 0 points) 3 months after surgical procedures. Improvement by 23.86% (36-16%) was also observed using the Oswestry Disease Index (ODI) 3 days after the surgery, and then reduced to 21.00% (16-34%) in average in 3 months. All patients were revived 3 h after transfer to the specialist department. The average stay in the hospital was 6.5 (9-4) days in both groups. In control group, average reduction of the pain syndrome of 2.60 points (from 4 to 1 points) was observed postoperatively according to the VAS 3 days after the operation, and of 3.9 points (from 2 to 0 points) 3 months after the surgery. The ODI of patients was also improved by an average of 35.40% (50-20%) 3 days after the surgical procedure, and reduced to 24.20% (16-32%) in average 3 months after the surgery.
    Language English
    Publishing date 2022-02-09
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2773823-1
    ISSN 2296-875X
    ISSN 2296-875X
    DOI 10.3389/fsurg.2022.792922
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: A New Insight on the Radioprotective Potential of Epsilon-Aminocaproic Acid.

    Saliev, Timur / Baiskhanova, Dinara / Beznosko, Dmitriy / Begimbetova, Dinara / Umbayev, Bauyrzhan / Nurgozhin, Talgat / Fakhradiyev, Ildar / Tanabayev, Baimakhan / Pavalkis, Dainius

    Medicina (Kaunas, Lithuania)

    2020  Volume 56, Issue 12

    Abstract: Background and objectives: ...

    Abstract Background and objectives:
    MeSH term(s) Aminocaproic Acid ; Antifibrinolytic Agents ; Humans ; Leukocytes, Mononuclear
    Chemical Substances Antifibrinolytic Agents ; Aminocaproic Acid (U6F3787206)
    Language English
    Publishing date 2020-11-30
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2188113-3
    ISSN 1648-9144 ; 1010-660X
    ISSN (online) 1648-9144
    ISSN 1010-660X
    DOI 10.3390/medicina56120663
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Hyperthermia enhances bortezomib-induced apoptosis in human white blood cancer cells.

    Saliev, Timur / Feril, Loreto B / Begimbetova, Dinara / Baiskhanova, Dinara / Klodzinskyi, Anton / Bobrova, Xeniya / Aipov, Rassulbek / Baltabayeva, Tolkyn / Tachibana, Katsuro

    Journal of thermal biology

    2017  Volume 67, Page(s) 9–14

    Abstract: At present, the current therapeutic strategy for apoptosis induction mainly relies on the administration of pharmacological apoptotic modulators. Apart from that, apoptosis can be induced by various external stimuli such as hyperthermia, ionizing ... ...

    Abstract At present, the current therapeutic strategy for apoptosis induction mainly relies on the administration of pharmacological apoptotic modulators. Apart from that, apoptosis can be induced by various external stimuli such as hyperthermia, ionizing radiation, and electric fields. Despite advantages, both physical and pharmacological approaches bear some limitations as well. The rationale of this study was to overcome the limitations by combining hyperthermia and apoptotic modulator 'bortezomib' (Velcade). Two types of human blood cancer cell lines were utilized: human leukemic monocyte lymphoma cell U937 line and peripheral blood mononuclear cells (PMBCs) derived from the patient diagnosed with acute myeloid leukemia. Prior to apoptosis experiments, cytotoxicity tests were performed at three types of temperature regimes (40°, 42° and 44°C). We observed a gradual inhibition of cell viability correlating with an increase of temperature and drug concentration in both cell lines. However, there was no significant difference between sham group and groups of leukemic PMBCs treated by high temperature (44°C) and bortezomib. In U937 cells, combined treatment by heat shock and bortezomib led to an increase the number of cells underwent the late apoptosis stage. At the same time, similar treatment of PMBCs resulted in the stimulation of early apoptosis. Our data suggest that combination of bortezomib and hyperthermia enhances apoptosis induction in human cancer white blood cells, indicating a therapeutic potential for blood cancer therapy.
    Language English
    Publishing date 2017-07
    Publishing country England
    Document type Journal Article
    ZDB-ID 1498364-3
    ISSN 1879-0992 ; 0306-4565
    ISSN (online) 1879-0992
    ISSN 0306-4565
    DOI 10.1016/j.jtherbio.2017.04.009
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Apoptotic and genotoxic effects of low-intensity ultrasound on healthy and leukemic human peripheral mononuclear blood cells.

    Saliev, Timur / Begimbetova, Dinara / Baiskhanova, Dinara / Abetov, Danysh / Kairov, Ulykbek / Gilman, Charles P / Matkarimov, Bakhyt / Tachibana, Katsuro

    Journal of medical ultrasonics (2001)

    2017  Volume 45, Issue 1, Page(s) 31–39

    Abstract: Purpose: To scrutinize the apoptotic and genotoxic effects of low-intensity ultrasound and an ultrasound contrast agent (SonoVue; Bracco Diagnostics Inc., EU) on human peripheral mononuclear blood cells (PMBCs).: Methods: PMBCs were subjected to a ... ...

    Abstract Purpose: To scrutinize the apoptotic and genotoxic effects of low-intensity ultrasound and an ultrasound contrast agent (SonoVue; Bracco Diagnostics Inc., EU) on human peripheral mononuclear blood cells (PMBCs).
    Methods: PMBCs were subjected to a low-intensity ultrasound field (1-MHz frequency; spatial peak temporal average intensity 0.18 W/cm2) followed by analysis for apoptosis and DNA damage (single-strand breaks + double-strand breaks). The comet assay was then repeated after 2 h to examine the ability of cells to repair DNA breaks.
    Results: The results demonstrated that low-intensity ultrasound was capable of selectively inducing apoptosis in leukemic PMBCs, but not in healthy cells. The introduction of ultrasound contrast agent SonoVue resulted in an increase in apoptosis in both groups. DNA analysis after ultrasound exposure indicated that ultrasound triggered DNA damage in leukemic PMBCs (66.05 ± 13.36%), while the damage was minimal (7.01 ± 0.89%) in control PMBCs. However, both cell lines demonstrated an ability to repair DNA single- and double-strand breaks 2 h after sonication.
    Conclusions: The study demonstrated that low-intensity ultrasound selectively induced apoptosis in cancer PMBCs. Ultrasound-induced DNA damage was observed primarily in leukemic PMBCs. Nevertheless, both cell lines were able to repair ultrasound-mediated DNA strand breaks.
    MeSH term(s) Adult ; Apoptosis/radiation effects ; Cell Line/radiation effects ; Cell Line, Tumor/radiation effects ; Comet Assay ; Contrast Media/administration & dosage ; DNA Damage/radiation effects ; Healthy Volunteers ; Humans ; Leukemia/pathology ; Leukocytes, Mononuclear/radiation effects ; Male ; Phospholipids/administration & dosage ; Sulfur Hexafluoride/administration & dosage ; Ultrasonic Waves
    Chemical Substances Contrast Media ; Phospholipids ; contrast agent BR1 ; Sulfur Hexafluoride (WS7LR3I1D6)
    Language English
    Publishing date 2017-07-08
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 1396630-3
    ISSN 1613-2254 ; 0287-0592 ; 1346-4523
    ISSN (online) 1613-2254
    ISSN 0287-0592 ; 1346-4523
    DOI 10.1007/s10396-017-0805-6
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Impact of electromagnetic fields on in vitro toxicity of silver and graphene nanoparticles.

    Saliev, Timur / Baiskhanova, Dinara M / Akhmetova, Alma / Begimbetova, Dinara A / Akishev, Mars / Kulsharova, Gulsim / Molkenov, Askhat / Nurgozhin, Talgat / Alekseyeva, Tatiana / Mikhalovsky, Sergey

    Electromagnetic biology and medicine

    2018  Volume 38, Issue 1, Page(s) 21–31

    Abstract: The correlation between shape and concentration of silver nanoparticles (AgNPs), their cytotoxicity and formation of reactive oxygen species (ROS) in the presence of electromagnetic fields (EMFs) has been investigated. In addition, the bio-effects caused ...

    Abstract The correlation between shape and concentration of silver nanoparticles (AgNPs), their cytotoxicity and formation of reactive oxygen species (ROS) in the presence of electromagnetic fields (EMFs) has been investigated. In addition, the bio-effects caused by the combination of EMFs and graphene nanoparticles (GrNPs) have been also assessed. The AgNPs of three shapes (triangular, spherical and colloidal) and GrNPs were added in high concentrations to the culture of human fibroblasts and exposed to EMF of three different frequencies: 900, 2400 and 7500 MHz. The results demonstrated the dependence of the EMF-induced cytotoxicity on the shape and concentration of AgNPs. The maximal cell killing effect was observed at 900 MHz frequency for NPs of all shapes and concentrations. The highest temperature elevation was observed for GrNPs solution irradiated by EMF of 900 MHz frequency. The exposure to EMF led to significant increase of ROS formation in triangular and colloidal AgNPs solutions. However, no impact of EMF on ROS production was detected for spherical AgNPs. GrNPs demonstrated ROS-protective activity that was dependent on their concentration. Our findings indicate the feasibility to control cytotoxicity of AgNPs by means of EMFs. The effect EMF on the biological activity of AgNPs and GrNPs is reported here for the first time.
    MeSH term(s) Electromagnetic Fields ; Fibroblasts/cytology ; Fibroblasts/drug effects ; Fibroblasts/radiation effects ; Graphite/chemistry ; Graphite/toxicity ; Humans ; Metal Nanoparticles/toxicity ; Reactive Oxygen Species/metabolism ; Silver/chemistry ; Silver/toxicity ; Temperature
    Chemical Substances Reactive Oxygen Species ; Silver (3M4G523W1G) ; Graphite (7782-42-5)
    Language English
    Publishing date 2018-11-08
    Publishing country England
    Document type Journal Article
    ZDB-ID 2026727-7
    ISSN 1536-8386 ; 1061-9526
    ISSN (online) 1536-8386
    ISSN 1061-9526
    DOI 10.1080/15368378.2018.1534740
    Database MEDical Literature Analysis and Retrieval System OnLINE

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