Article ; Online: Recent Advances in Delivery of Peptide and Protein Therapeutics to the Brain.
The Journal of pharmacology and experimental therapeutics
2024 Volume 388, Issue 1, Page(s) 54–66
Abstract: The classes of neuropharmaceuticals known as proteins and peptides serve as diagnostic tools and are involved in specific communication in the peripheral and central nervous systems. However, due to tight junctions resembling epithelial cells found in ... ...
| Abstract | The classes of neuropharmaceuticals known as proteins and peptides serve as diagnostic tools and are involved in specific communication in the peripheral and central nervous systems. However, due to tight junctions resembling epithelial cells found in the blood-brain barrier (BBB) in vivo, they are typically excluded from transport from the blood to the brain. The drugs having molecular weight of less than 400 Dalton are able to cross the BBB via lipid-mediated free diffusion. However, large molecule therapeutics are devoid of these characteristics. As an alternative, these substances may be carried via chimeric peptide drug delivery systems, and assist in transcytosis through BBB with the aid of linker strategies. With their recent developments, several forms of nanoparticles, including poly (ethylene glycol)-poly( |
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| MeSH term(s) | Brain/metabolism ; Blood-Brain Barrier/metabolism ; Drug Delivery Systems/methods ; Peptides/metabolism ; Nanoparticles/chemistry ; Lipids | |||||
| Chemical Substances | Peptides ; Lipids | |||||
| Language | English | |||||
| Publishing date | 2024-01-02 | |||||
| Publishing country | United States | |||||
| Document type | Journal Article ; Review | |||||
| ZDB-ID | 3106-9 | |||||
| ISSN | 1521-0103 ; 0022-3565 | |||||
| ISSN (online) | 1521-0103 | |||||
| ISSN | 0022-3565 | |||||
| DOI | 10.1124/jpet.123.001690 | |||||
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| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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