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  1. Article ; Online: Sensory Ganglionopathy.

    Ng, Yi Shiau / Baker, Mark R

    The New England journal of medicine

    2021  Volume 384, Issue 2, Page(s) 192

    MeSH term(s) Ganglia, Autonomic ; Humans ; Peripheral Nervous System Diseases
    Language English
    Publishing date 2021-01-26
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 207154-x
    ISSN 1533-4406 ; 0028-4793
    ISSN (online) 1533-4406
    ISSN 0028-4793
    DOI 10.1056/NEJMc2033783
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  2. Article ; Online: Cathodal Transcranial Direct Current Stimulation for Treatment of Rasmussen Encephalitis.

    Bangel, Katrin A / Pang, Ki / Baker, Mark R

    Neurology

    2022  Volume 100, Issue 10, Page(s) 484–485

    MeSH term(s) Humans ; Transcranial Direct Current Stimulation ; Encephalitis/therapy ; Inflammation
    Language English
    Publishing date 2022-12-02
    Publishing country United States
    Document type Journal Article
    ZDB-ID 207147-2
    ISSN 1526-632X ; 0028-3878
    ISSN (online) 1526-632X
    ISSN 0028-3878
    DOI 10.1212/WNL.0000000000201644
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  3. Article ; Online: Twitchy about fasciculation.

    Baker, Mark R / Williams, Timothy L

    Practical neurology

    2020  Volume 20, Issue 3, Page(s) 260–261

    MeSH term(s) Fasciculation/classification ; Fasciculation/diagnosis ; Humans ; Neurology/classification ; Teaching Rounds/classification ; Terminology as Topic
    Language English
    Publishing date 2020-01-23
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2170881-2
    ISSN 1474-7766 ; 1474-7758
    ISSN (online) 1474-7766
    ISSN 1474-7758
    DOI 10.1136/practneurol-2019-002469
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  4. Article ; Online: Excitability in amyotrophic lateral sclerosis: What goes up must come down.

    Bashford, James / Baker, Mark R

    Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology

    2020  Volume 131, Issue 11, Page(s) 2617–2620

    MeSH term(s) Action Potentials/physiology ; Amyotrophic Lateral Sclerosis/physiopathology ; Humans ; Motor Neurons/physiology
    Language English
    Publishing date 2020-08-29
    Publishing country Netherlands
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1463630-x
    ISSN 1872-8952 ; 0921-884X ; 1388-2457
    ISSN (online) 1872-8952
    ISSN 0921-884X ; 1388-2457
    DOI 10.1016/j.clinph.2020.08.009
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  5. Article ; Online: The phenomenon of Lhermitte.

    Williams, Timothy L / Bates, David / Baker, Mark R

    Practical neurology

    2021  Volume 21, Issue 3, Page(s) 246–248

    Language English
    Publishing date 2021-04-13
    Publishing country England
    Document type Journal Article
    ZDB-ID 2170881-2
    ISSN 1474-7766 ; 1474-7758
    ISSN (online) 1474-7766
    ISSN 1474-7758
    DOI 10.1136/practneurol-2020-002918
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  6. Article ; Online: Recovery of neurophysiological measures in post-COVID fatigue: a 12-month longitudinal follow-up study.

    Maffitt, Natalie J / Germann, Maria / Baker, Anne M E / Baker, Mark R / Baker, Stuart N / Soteropoulos, Demetris S

    Scientific reports

    2024  Volume 14, Issue 1, Page(s) 8874

    Abstract: One of the major consequences of the COVID-19 pandemic has been the significant incidence of persistent fatigue following resolution of an acute infection (i.e. post-COVID fatigue). We have shown previously that, in comparison to healthy controls, those ... ...

    Abstract One of the major consequences of the COVID-19 pandemic has been the significant incidence of persistent fatigue following resolution of an acute infection (i.e. post-COVID fatigue). We have shown previously that, in comparison to healthy controls, those suffering from post-COVID fatigue exhibit changes in muscle physiology, cortical circuitry, and autonomic function. Whether these changes preceded infection, potentially predisposing people to developing post-COVID fatigue, or whether the changes were a consequence of infection was unclear. Here we present results of a 12-month longitudinal study of 18 participants from the same cohort of post-COVID fatigue sufferers to investigate these correlates of fatigue over time. We report improvements in self-perception of the impact of fatigue via questionnaires, as well as significant improvements in objective measures of peripheral muscle fatigue and autonomic function, bringing them closer to healthy controls. Additionally, we found reductions in muscle twitch tension rise times, becoming faster than controls, suggesting that the improvement in muscle fatigability might be due to a process of adaptation rather than simply a return to baseline function.
    MeSH term(s) Humans ; Follow-Up Studies ; Longitudinal Studies ; COVID-19 ; Pandemics ; Fasciculation
    Language English
    Publishing date 2024-04-17
    Publishing country England
    Document type Journal Article
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-024-59232-y
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  7. Article ; Online: In-House Intraoperative Monitoring in Neurosurgery in England - Benefits and Challenges.

    Paranathala, Menaka Pasangy / Jaiser, Stephan / Hussain, Mohammed Akbar / Mirallave-Pescador, Ana / Cowie, Christopher J A / Baker, Mark R / Holliman, Damian / Fry, Charles Alexander

    Journal of medical systems

    2024  Volume 48, Issue 1, Page(s) 24

    Abstract: Background: Intraoperative neurophysiological monitoring (IOM) is a valuable adjunct for neurosurgical operative techniques, and has been shown to improve clinical outcomes in cranial and spinal surgery. It is not necessarily provided by NHS hospitals ... ...

    Abstract Background: Intraoperative neurophysiological monitoring (IOM) is a valuable adjunct for neurosurgical operative techniques, and has been shown to improve clinical outcomes in cranial and spinal surgery. It is not necessarily provided by NHS hospitals so may be outsourced to private companies, which are expensive and at cost to the NHS trusts. We discuss the benefits and challenges of developing an in-house service.
    Methods: We surveyed NHS neurosurgical departments across England regarding their expenditure on IOM over the period January 2018 - December 2022 on cranial neurosurgery and spinal surgery. Out of 24 units, all responded to our Freedom of Information requests and 21 provided data. The standard NHS England salary of NHS staff who would normally be involved in IOM, including physiologists and doctors, was also compiled for comparison.
    Results: The total spend on outsourced IOM, across the units who responded, was over £8 million in total for the four years. The annual total increased, between 2018 and 2022, from £1.1 to £3.5 million. The highest single unit yearly spend was £568,462. This is in addition to salaries for staff in neurophysiology departments. The mean NHS salaries for staff is also presented.
    Conclusion: IOM is valuable in surgical decision-making, planning, and technique, having been shown to lead to fewer patient complications and shorter length of stay. Current demand for IOM outstrips the internal NHS provision in many trusts across England, leading to outsourcing to private companies. This is at significant cost to the NHS. Although there is a learning curve, there are many benefits to in-house provision, such as stable working relationships, consistent methods, training of the future IOM workforce, and reduced long-term costs, which planned expansion of NHS services may provide.
    MeSH term(s) Humans ; Neurosurgery ; Monitoring, Intraoperative ; England ; Health Expenditures ; Hospitals
    Language English
    Publishing date 2024-02-22
    Publishing country United States
    Document type Journal Article
    ZDB-ID 423488-1
    ISSN 1573-689X ; 0148-5598
    ISSN (online) 1573-689X
    ISSN 0148-5598
    DOI 10.1007/s10916-024-02041-7
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  8. Article ; Online: ALS--dying forward, backward or outward?

    Baker, Mark R

    Nature reviews. Neurology

    2014  Volume 10, Issue 11, Page(s) 660

    MeSH term(s) Amyotrophic Lateral Sclerosis/metabolism ; Axonal Transport/physiology ; Cerebral Cortex/metabolism ; DNA-Binding Proteins/metabolism ; Humans ; Models, Neurological ; Synaptic Transmission/physiology
    Chemical Substances DNA-Binding Proteins
    Language English
    Publishing date 2014-09-23
    Publishing country England
    Document type Letter ; Comment
    ZDB-ID 2491514-2
    ISSN 1759-4766 ; 1759-4758
    ISSN (online) 1759-4766
    ISSN 1759-4758
    DOI 10.1038/nrneurol.2013.221-c1
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    Zs.A 6257: Show issues Location:
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  9. Article ; Online: Minimum Electromyographic Burst Duration in Healthy Controls: Implications for Electrodiagnosis in Movement Disorders.

    Collins, Alexis F / Brown, Steven T R / Baker, Mark R

    Movement disorders clinical practice

    2020  Volume 7, Issue 7, Page(s) 827–833

    Abstract: Background: Electromyogram (EMG) burst duration can provide additional diagnostic information when investigating hyperkinetic movement disorders, particularly when a functional movement disorder is suspected. It is generally accepted that EMG bursts <50  ...

    Abstract Background: Electromyogram (EMG) burst duration can provide additional diagnostic information when investigating hyperkinetic movement disorders, particularly when a functional movement disorder is suspected. It is generally accepted that EMG bursts <50 milliseconds are pathological.
    Objective: To reassess minimum physiological EMG burst duration.
    Methods: Surface EMG was recorded from face, trunk, and limb muscles in controls (n = 60; ages 19-85). Participants were instructed to generate the briefest possible ballistic movements involving each muscle (40 repetitions) or, in muscles spanning joints, to generate rapid rhythmic alternating movements (20-30 seconds), or both.
    Results: We found no effect of age on EMG burst duration. However, EMG burst duration varied significantly between body regions. Rhythmic EMG bursts were shorter than ballistic bursts but only significantly so for lower limbs (
    Conclusion: We present normal reference data for minimum EMG burst duration, which may assist clinical interpretation when investigating hyperkinetic movement disorders.
    Language English
    Publishing date 2020-08-26
    Publishing country United States
    Document type Journal Article
    ISSN 2330-1619
    ISSN (online) 2330-1619
    DOI 10.1002/mdc3.13044
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  10. Article ; Online: Botulinum Toxin: An Update on Pharmacology and Newer Products in Development.

    Choudhury, Supriyo / Baker, Mark R / Chatterjee, Suparna / Kumar, Hrishikesh

    Toxins

    2021  Volume 13, Issue 1

    Abstract: Since its introduction as a treatment for strabismus, botulinum toxin (BoNT) has had a phenomenal journey and is now recommended as first-line treatment for focal dystonia, despite short-term clinical benefits and the risks of adverse effects. To cater ... ...

    Abstract Since its introduction as a treatment for strabismus, botulinum toxin (BoNT) has had a phenomenal journey and is now recommended as first-line treatment for focal dystonia, despite short-term clinical benefits and the risks of adverse effects. To cater for the high demand across various medical specialties, at least six US Food and Drug Administration (FDA)-approved formulations of BoNT are currently available for diverse labelled indications. The toxo-pharmacological properties of these formulations are not uniform and thus should not be used interchangeably. Synthetic BoNTs and BoNTs from non-clostridial sources are not far from clinical use. Moreover, the study of mutations in naturally occurring toxins has led to modulation in the toxo-pharmacokinetic properties of BoNTs, including the duration and potency. We present an overview of the toxo-pharmacology of conventional and novel BoNT preparations, including those awaiting imminent translation from the laboratory to the clinic.
    MeSH term(s) Bacterial Toxins/pharmacology ; Bacterial Toxins/therapeutic use ; Botulinum Toxins/chemistry ; Botulinum Toxins/pharmacology ; Botulinum Toxins/therapeutic use ; Drug Compounding ; Drug Development ; Drug Prescriptions ; Humans ; Nervous System Diseases/drug therapy ; Neuromuscular Agents/pharmacology ; Neuromuscular Agents/therapeutic use ; Neuromuscular Junction/drug effects ; Recombinant Proteins/pharmacology ; Recombinant Proteins/therapeutic use
    Chemical Substances Bacterial Toxins ; Neuromuscular Agents ; Recombinant Proteins ; Botulinum Toxins (EC 3.4.24.69)
    Language English
    Publishing date 2021-01-14
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2518395-3
    ISSN 2072-6651 ; 2072-6651
    ISSN (online) 2072-6651
    ISSN 2072-6651
    DOI 10.3390/toxins13010058
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