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  1. Article ; Online: Activism contravenes consent.

    Baker, Steven K

    Journal of evaluation in clinical practice

    2023  Volume 29, Issue 6, Page(s) 880–882

    MeSH term(s) Humans ; Informed Consent ; Ethics, Medical
    Language English
    Publishing date 2023-06-04
    Publishing country England
    Document type Letter
    ZDB-ID 1327355-3
    ISSN 1365-2753 ; 1356-1294
    ISSN (online) 1365-2753
    ISSN 1356-1294
    DOI 10.1111/jep.13880
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4464: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  2. Article ; Online: Metabolites as signalling molecules.

    Baker, Steven Andrew / Rutter, Jared

    Nature reviews. Molecular cell biology

    2023  Volume 24, Issue 5, Page(s) 355–374

    Abstract: Traditional views of cellular metabolism imply that it is passively adapted to meet the demands of the cell. It is becoming increasingly clear, however, that metabolites do more than simply supply the substrates for biological processes; they also ... ...

    Abstract Traditional views of cellular metabolism imply that it is passively adapted to meet the demands of the cell. It is becoming increasingly clear, however, that metabolites do more than simply supply the substrates for biological processes; they also provide critical signals, either through effects on metabolic pathways or via modulation of other regulatory proteins. Recent investigation has also uncovered novel roles for several metabolites that expand their signalling influence to processes outside metabolism, including nutrient sensing and storage, embryonic development, cell survival and differentiation, and immune activation and cytokine secretion. Together, these studies suggest that, in contrast to the prevailing notion, the biochemistry of a cell is frequently governed by its underlying metabolism rather than vice versa. This important shift in perspective places common metabolites as key regulators of cell phenotype and behaviour. Yet the signalling metabolites, and the cognate targets and transducers through which they signal, are only beginning to be uncovered. In this Review, we discuss the emerging links between metabolism and cellular behaviour. We hope this will inspire further dissection of the mechanisms through which metabolic pathways and intermediates modulate cell function and will suggest possible drug targets for diseases linked to metabolic deregulation.
    MeSH term(s) Signal Transduction ; Metabolic Networks and Pathways ; Cell Differentiation
    Language English
    Publishing date 2023-01-12
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2031313-5
    ISSN 1471-0080 ; 1471-0072
    ISSN (online) 1471-0080
    ISSN 1471-0072
    DOI 10.1038/s41580-022-00572-w
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5446: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
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    Zs.MG 26: Show issues

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  3. Article ; Online: Case series of retinal vein occlusions showing early recovery using oral l-methylfolate.

    Baker, Steven / Baker, Dylan / Baker, Robert / Brown, Craig J

    Therapeutic advances in ophthalmology

    2024  Volume 16, Page(s) 25158414241240687

    Abstract: This case series describes the aggregate rate of recovery in five consecutive subjects (six eyes) with retinal vein occlusion (RVO) who received l-methylfolate and other ... ...

    Abstract This case series describes the aggregate rate of recovery in five consecutive subjects (six eyes) with retinal vein occlusion (RVO) who received l-methylfolate and other vitamins
    Language English
    Publishing date 2024-04-15
    Publishing country United States
    Document type Case Reports
    ISSN 2515-8414
    ISSN (online) 2515-8414
    DOI 10.1177/25158414241240687
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  4. Article ; Online: All differential on the splicing front: Host alternative splicing alters the landscape of virus-host conflict.

    Mann, Joshua T / Riley, Brent A / Baker, Steven F

    Seminars in cell & developmental biology

    2023  Volume 146, Page(s) 40–56

    Abstract: Alternative RNA splicing is a co-transcriptional process that richly increases proteome diversity, and is dynamically regulated based on cell species, lineage, and activation state. Virus infection in vertebrate hosts results in rapid host transcriptome- ... ...

    Abstract Alternative RNA splicing is a co-transcriptional process that richly increases proteome diversity, and is dynamically regulated based on cell species, lineage, and activation state. Virus infection in vertebrate hosts results in rapid host transcriptome-wide changes, and regulation of alternative splicing can direct a combinatorial effect on the host transcriptome. There has been a recent increase in genome-wide studies evaluating host alternative splicing during viral infection, which integrates well with prior knowledge on viral interactions with host splicing proteins. A critical challenge remains in linking how these individual events direct global changes, and whether alternative splicing is an overall favorable pathway for fending off or supporting viral infection. Here, we introduce the process of alternative splicing, discuss how to analyze splice regulation, and detail studies on genome-wide and splice factor changes during viral infection. We seek to highlight where the field can focus on moving forward, and how incorporation of a virus-host co-evolutionary perspective can benefit this burgeoning subject.
    MeSH term(s) Alternative Splicing/genetics ; Viruses/genetics ; Genome ; Transcriptome ; Proteome/genetics
    Chemical Substances Proteome
    Language English
    Publishing date 2023-02-02
    Publishing country England
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 1312473-0
    ISSN 1096-3634 ; 1084-9521
    ISSN (online) 1096-3634
    ISSN 1084-9521
    DOI 10.1016/j.semcdb.2023.01.013
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    Zs.A 2918: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  5. Article: An Unusual Case of Hyperhemolysis Syndrome and Delayed Hemolytic Transfusion Reaction due to Anti-Jk(a) and Anti-P1 Antibodies.

    Montgomery, Hunter / Luo, Matthew X / Baker, Steven / Lim, Ming Y

    Case reports in medicine

    2023  Volume 2023, Page(s) 5290115

    Abstract: Background: Hyperhemolysis syndrome (HS) is a severe hemolytic transfusion reaction that can cause hemoglobin and hematocrit levels to drop below pretransfusion levels, leading to severe anemia. HS most commonly occurs in patients with a pre-existing ... ...

    Abstract Background: Hyperhemolysis syndrome (HS) is a severe hemolytic transfusion reaction that can cause hemoglobin and hematocrit levels to drop below pretransfusion levels, leading to severe anemia. HS most commonly occurs in patients with a pre-existing hemoglobinopathy such as sickle cell disease (SCD) or beta-thalassemia.
    Methods: We report a case of HS, occurring in the absence of hemoglobinopathy, making the diagnosis challenging. The patient reported was also affected by a CIC-rearranged sarcoma. As part of the workup, the patient received a bone marrow biopsy for suspected hemophagocytic lymphohistiocytosis.
    Results: This provided a rare biopsy specimen to correlate reticulocytopenia with marked erythroid hyperplasia in the marrow, supporting the hypothesis of reticulocyte destruction as a contributing cause of anemia in these patients. This patient had demonstrable alloantibodies to the Jk(a) and P1 antigens as potential triggers for HS.
    Conclusions: It is vital that a diagnosis of HS be correctly made in these patients with severe anemia, as blood transfusions generally lead to worsening of their conditions.
    Language English
    Publishing date 2023-12-31
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2502642-2
    ISSN 1687-9635 ; 1687-9627
    ISSN (online) 1687-9635
    ISSN 1687-9627
    DOI 10.1155/2023/5290115
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  6. Article ; Online: Video Calls as a Replacement for Family Visits During Lockdowns in Aged Care: Interview Study With Family Members.

    Kelly, Ryan M / Xing, Yushan / Baker, Steven / Waycott, Jenny

    JMIR aging

    2023  Volume 6, Page(s) e40953

    Abstract: Background: Lockdowns have been used to prevent the spread of transmissible illnesses such as influenza, norovirus, and COVID-19 in care homes. However, lockdowns deny care home residents supplemental care and the socioemotional enrichment that comes ... ...

    Abstract Background: Lockdowns have been used to prevent the spread of transmissible illnesses such as influenza, norovirus, and COVID-19 in care homes. However, lockdowns deny care home residents supplemental care and the socioemotional enrichment that comes from seeing family members. Video calling has the potential to enable ongoing contact between residents and family members during lockdowns. However, video calls can be considered by some as a poor substitute for in-person visits. It is important to understand family members' experiences with video calling during lockdowns to ensure the effective use of this technology in the future.
    Objective: This study aimed to understand how family members use video calls to communicate with relatives living in aged care during lockdowns. We focused on experiences during the COVID-19 pandemic, which involved extensive lockdowns in aged care homes.
    Methods: We conducted semistructured interviews with 18 adults who had been using video calls with relatives living in aged care during pandemic lockdowns. The interviews focused on how participants had been using video calls, what benefits they gained from video-based interactions, and what challenges they encountered when using the technology. We analyzed the data using the 6-phase reflexive approach to thematic analysis by Braun and Clarke.
    Results: We developed 4 themes through our analysis. Theme 1 interprets video calling as a medium for the continuation of care during lockdowns. Using video calls, family members were able to provide social enrichment for residents and engaged in health monitoring to uphold residents' welfare. Theme 2 highlights how video calling extended care by supporting frequent contact, transmitting nonverbal cues that were essential for communication, and negating the need for face masks. Theme 3 interprets organizational issues such as the lack of technology and staff time as impediments to the continuation of familial care through video. Finally, theme 4 highlights the need for 2-way communication, interpreting residents' unfamiliarity with video calling and their health conditions as further barriers to the continuation of care.
    Conclusions: This study suggests that, during restrictions arising from the COVID-19 pandemic, video calls became a medium for enabling family members to continue participating in the care of their relatives. The use of video calls to continue care illustrates their value for families during times of mandatory lockdown and supports the use of video to complement face-to-face visits at other times. However, better support is needed for video calling in aged care homes. This study also revealed a need for video calling systems that are designed for the aged care context.
    Language English
    Publishing date 2023-06-12
    Publishing country Canada
    Document type Journal Article
    ISSN 2561-7605
    ISSN (online) 2561-7605
    DOI 10.2196/40953
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  7. Article: Ten questions with ….

    Baker, Steven

    Biomedical instrumentation & technology

    2015  Volume 49, Issue 3, Page(s) 155

    MeSH term(s) Biomedical Engineering ; Biomedical Technology ; Computer Security ; Humans
    Language English
    Publishing date 2015-05
    Publishing country United States
    Document type Interview
    ZDB-ID 1025474-2
    ISSN 0899-8205
    ISSN 0899-8205
    DOI 10.2345/0899-8205-49.3.155
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 898: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  8. Article ; Online: The Role of Nutrition and Forest-Bathing in the Physical Rehabilitation of Physically Inactive Patients: From the Molecular Aspects to New Nature-Inspired Techniques.

    Baker, Steven / Gilhen-Baker, Melinda / Roviello, Giovanni N

    International journal of environmental research and public health

    2022  Volume 20, Issue 1

    Abstract: Physical rehabilitation plays a fundamental role in the management of individuals with disabilities associated with age-related muscle loss or affected by catastrophic conditions such as trauma, surgery, cancer or other severe pathologies. These events ... ...

    Abstract Physical rehabilitation plays a fundamental role in the management of individuals with disabilities associated with age-related muscle loss or affected by catastrophic conditions such as trauma, surgery, cancer or other severe pathologies. These events have in common an extended period of physical inactivity. Patients who undergo prolonged bed rest often present with a number of complications; for example, muscle loss that can exacerbate existing conditions determined by sarcopenia, which in turn greatly limits physical functions. The main scope of this work is to summarize certain key strategies for the physiotherapeutic management of physically inactive patients, regardless of the reason behind their prolonged bed rest, with a particular focus on physical rehabilitation, nutrition and forest-bathing. The importance of correct nutrition in counter-acting the loss of muscle mass and consequent function is explored alongside a description of the main nutrients that are needed for muscle regeneration. From a biomolecular perspective, some specific molecular mechanisms associated with physical rehabilitation are also reported not only in the context of physical therapy, but also within nature-inspired techniques, such as forest-bathing as well as body self-healing. Combining a targeted physiotherapeutic approach with an appropriate diet as well as nature-based therapy could thus help with the recovery of bed ridden patients.
    MeSH term(s) Humans ; Sedentary Behavior ; Sarcopenia/therapy ; Diet ; Nutritional Status ; Bed Rest
    Language English
    Publishing date 2022-12-31
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2175195-X
    ISSN 1660-4601 ; 1661-7827
    ISSN (online) 1660-4601
    ISSN 1661-7827
    DOI 10.3390/ijerph20010793
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  9. Article: Dose Adjustment of Subcutaneous IgG in Chronic Inflammatory Demyelinating Polyneuropathy.

    Alsolaihim, Alanood / Baker, Steven K

    Case reports in neurology

    2020  Volume 12, Issue 1, Page(s) 73–77

    Abstract: Chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) is an immune-mediated neuropathy that is characterized by a slowly progressive sensory and motor involvement lasting at least 2 months. We present a CIDP patient on subcutaneous Ig (SCIg). ... ...

    Abstract Chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) is an immune-mediated neuropathy that is characterized by a slowly progressive sensory and motor involvement lasting at least 2 months. We present a CIDP patient on subcutaneous Ig (SCIg). Upon fine-tuning his dose from 24 to 28 g/week, this showed a dramatic improvement in both hand grip (13-25%) and dorsiflexion (73-278%). Follow-up nerve conduction studies also demonstrated significant improvements in latencies, motor amplitudes, and conduction velocities. Ongoing surveillance of CIDP patients receiving SCIg therapy is therefore necessary to ensure therapeutic optimization.
    Language English
    Publishing date 2020-02-14
    Publishing country Switzerland
    Document type Case Reports
    ZDB-ID 2505302-4
    ISSN 1662-680X
    ISSN 1662-680X
    DOI 10.1159/000505320
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  10. Article ; Online: Assessing the Effects of Physical Barriers and Hypoxia on Red Drum Movement Patterns to Develop More Effective Management Strategies

    Baker, Steven M. / Reyier, Eric A. / Ahr, Bonnie J. / Cook, Geoffrey S.

    Fishes. 2023 Mar. 23, v. 8, no. 4

    2023  

    Abstract: Human modification of coastal ecosystems often creates barriers to fish movement. Passive acoustic telemetry was used to quantify movement patterns and habitat use of red drums (Sciaenops ocellatus) within and around a complex of coastal impoundments, ... ...

    Abstract Human modification of coastal ecosystems often creates barriers to fish movement. Passive acoustic telemetry was used to quantify movement patterns and habitat use of red drums (Sciaenops ocellatus) within and around a complex of coastal impoundments, and explored how the presence of artificial structures (i.e., bollards and culverts) and a hypoxia-related mortality event impacted fish movement. Results indicated bollards impede the movement of individuals with head widths greater than the mean distance between bollards (~16.0 cm). Red drum home range area and daily distance traveled were related to water dissolved oxygen concentrations; as oxygen levels decreased, fish habitat use area decreased initially. However, continued exposure to hypoxic conditions increased fish cumulative daily distance traveled. When exposed to anoxic waters, fish daily distance traveled and rate of movement were greatly reduced. These findings suggest prolonged exposure to low dissolved oxygen in combination with artificial structures can reduce movement of red drum, increase risk of mortality, and decrease habitat connectivity. Constructing and maintaining (sediment and biofouling removal) larger culvert openings and/or using wider bollard spacing would improve water circulation in impoundments, increase habitat connectivity, and facilitate movement of large sportfish inhabiting Florida’s coastal waters.
    Keywords Sciaenops ocellatus ; acoustics ; biofouling ; culverts ; dissolved oxygen ; fish ; game fish ; habitat connectivity ; head ; home range ; humans ; hypoxia ; mortality ; oxygen ; risk ; sediments ; telemetry ; water flow ; Florida
    Language English
    Dates of publication 2023-0323
    Publishing place Multidisciplinary Digital Publishing Institute
    Document type Article ; Online
    ISSN 2410-3888
    DOI 10.3390/fishes8040171
    Database NAL-Catalogue (AGRICOLA)

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