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  1. Article ; Online: Microglia form satellites with different neuronal subtypes in the adult murine central nervous system.

    Bakina, Olga / Kettenmann, Helmut / Nolte, Christiane

    Journal of neuroscience research

    2022  Volume 100, Issue 4, Page(s) 1105–1122

    Abstract: Microglia are the innate immune cells of the central nervous system (CNS). In the adult uncompromised CNS, they have a highly ramified morphology and continuously extend and retract their processes. A subpopulation of microglial cells forms close soma-to- ...

    Abstract Microglia are the innate immune cells of the central nervous system (CNS). In the adult uncompromised CNS, they have a highly ramified morphology and continuously extend and retract their processes. A subpopulation of microglial cells forms close soma-to-soma contacts with neurons and have been termed satellite microglia, yet the role of such interaction is largely unknown. Here, we analyzed the distribution of satellite microglia in different areas of the CNS of adult male mice applying transgenic- and immunolabeling of neuronal subtypes and microglia followed by three-dimensional imaging analysis. We quantified satellite microglia associated with GABAergic and glutamatergic neurons in the somatosensory cortex, striatum, and thalamus; with dopaminergic and serotonergic neurons in the basal forebrain and raphe nucleus, respectively; and with cerebellar Purkinje cell neurons. Satellite microglia in the retina were assessed qualitatively. Microglia form satellites with all neuronal subtypes studied, whereas a preference for a specific neuron subtype was not found. The occurrence and frequency of satellite microglia is determined by the histo-architectural organization of the brain area and the densities of neuronal somata therein.
    MeSH term(s) Animals ; Brain ; Male ; Mice ; Microglia/physiology ; Neurons/physiology
    Language English
    Publishing date 2022-02-25
    Publishing country United States
    Document type Journal Article
    ZDB-ID 195324-2
    ISSN 1097-4547 ; 0360-4012
    ISSN (online) 1097-4547
    ISSN 0360-4012
    DOI 10.1002/jnr.25026
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1232: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (1.OG)
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  2. Article ; Online: New PMMA-Based Hydroxyapatite/ZnFe

    Bakina, Olga / Svarovskaya, Natalia / Ivanova, Ludmila / Glazkova, Elena / Rodkevich, Nikolay / Evstigneev, Vladyslav / Evstigneev, Maxim / Mosunov, Andrey / Lerner, Marat

    Biomimetics (Basel, Switzerland)

    2023  Volume 8, Issue 6

    Abstract: Polymethylmethacrylate (PMMA) is the most commonly used bone void filler in orthopedic surgery. However, the biocompatibility and radiopacity of PMMA are insufficient for such applications. In addition to insufficient biocompatibility, the microbial ... ...

    Abstract Polymethylmethacrylate (PMMA) is the most commonly used bone void filler in orthopedic surgery. However, the biocompatibility and radiopacity of PMMA are insufficient for such applications. In addition to insufficient biocompatibility, the microbial infection of medical implants is one of the frequent causes of failure in bone reconstruction. In the present work, the preparation of a novel PMMA-based hydroxyapatite/ZnFe
    Language English
    Publishing date 2023-10-14
    Publishing country Switzerland
    Document type Journal Article
    ISSN 2313-7673
    ISSN (online) 2313-7673
    DOI 10.3390/biomimetics8060488
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  3. Article ; Online: Drug-eluting biodegradable metals and metal-ceramic composites

    Sharipova, Aliya / Bakina, Olga / Lozhkomoev, Aleksandr / Lerner, Marat / Gutmanas, Elazar / Sosnik, Alejandro

    2023  

    Abstract: Biodegradable metals emerged as promising temporary bone implants. The integration of local drug delivery (LDD) can prevent biomaterial-centered infections that are difficult to treat. LDD is achieved by drug-eluting coatings or porous implants where the ...

    Abstract Biodegradable metals emerged as promising temporary bone implants. The integration of local drug delivery (LDD) can prevent biomaterial-centered infections that are difficult to treat. LDD is achieved by drug-eluting coatings or porous implants where the drug is impregnated after implant fabrication because the high temperatures used during conventional production processes would result in their thermal decomposition. This work reports on the production and characterization of vancomycin hydrochloride (VH)-loaded Fe and Fe-iron oxide (Fe2O3) composites (Fe-Fe2O3) by a cold sintering technique. We use focused ion beam milling for the first time to investigate the drug-metal interface. We investigate the mechanical and degradation properties of VH-free and VH-loaded Fe and Fe-Fe2O3. Results show very high mechanical strength of drug-eluting Fe and Fe-Fe2O3 composites (up to than 780 MPa under compression, exceeding the maximum strength of cancellous bone more than three times) accompanied by a delayed drug release. Then, we confirm the good antimicrobial activity against Staphylococcus aureus and cell compatibility with the murine embryonic fibroblast cell line NIH/3T3 in vitro. Overall results confirm the promise of drug-eluting metals and metal-ceramic composites for LDD in bone.

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    Keywords Biodegradable metals ; Cold sintering ; Drug-eluting metal-ceramics ; Drug-eluting metals ; Fe-Fe2-O3 ; Local drug delivery
    Subject code 660
    Language English
    Publishing country de
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article: Fabrication of strong bioresorbable composites from electroexplosive Fe-Fe

    Lozhkomoev, A S / Kazantsev, S O / Bakina, O V / Pervikov, A V / Sharipova, A F / Chymaevskii, A V / Lerner, M I

    Heliyon

    2022  Volume 8, Issue 9, Page(s) e10663

    Abstract: Bulk samples with high mechanical strength reaching 1000 MPa were obtained from electroexplosive Fe- ... ...

    Abstract Bulk samples with high mechanical strength reaching 1000 MPa were obtained from electroexplosive Fe-Fe
    Language English
    Publishing date 2022-09-16
    Publishing country England
    Document type Journal Article
    ZDB-ID 2835763-2
    ISSN 2405-8440
    ISSN 2405-8440
    DOI 10.1016/j.heliyon.2022.e10663
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  5. Article ; Online: A single-cell RNA labeling strategy for measuring stress response upon tissue dissociation.

    Neuschulz, Anika / Bakina, Olga / Badillo-Lisakowski, Victor / Olivares-Chauvet, Pedro / Conrad, Thomas / Gotthardt, Michael / Kettenmann, Helmut / Junker, Jan Philipp

    Molecular systems biology

    2022  Volume 19, Issue 2, Page(s) e11147

    Abstract: Tissue dissociation, a crucial step in single-cell sample preparation, can alter the transcriptional state of a sample through the intrinsic cellular stress response. Here we demonstrate a general approach for measuring transcriptional response during ... ...

    Abstract Tissue dissociation, a crucial step in single-cell sample preparation, can alter the transcriptional state of a sample through the intrinsic cellular stress response. Here we demonstrate a general approach for measuring transcriptional response during sample preparation. In our method, transcripts made during dissociation are labeled for later identification upon sequencing. We found general as well as cell-type-specific dissociation response programs in zebrafish larvae, and we observed sample-to-sample variation in the dissociation response of mouse cardiomyocytes despite well-controlled experimental conditions. Finally, we showed that dissociation of the mouse hippocampus can lead to the artificial activation of microglia. In summary, our approach facilitates experimental optimization of dissociation procedures as well as computational removal of transcriptional perturbation response.
    MeSH term(s) Mice ; Animals ; RNA ; Transcriptome ; Zebrafish/genetics ; Sequence Analysis, RNA/methods ; Microglia ; Single-Cell Analysis ; Gene Expression Profiling/methods
    Chemical Substances RNA (63231-63-0)
    Language English
    Publishing date 2022-12-27
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2193510-5
    ISSN 1744-4292 ; 1744-4292
    ISSN (online) 1744-4292
    ISSN 1744-4292
    DOI 10.15252/msb.202211147
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Fabrication of strong bioresorbable composites from electroexplosive Fe-Fe3O4 nanoparticles by isostatic pressing followed by vacuum sintering

    Lozhkomoev, A.S. / Kazantsev, S.O. / Bakina, O.V. / Pervikov, A.V. / Sharipova, A.F. / Chymaevskii, A.V. / Lerner, M.I.

    Heliyon. 2022 Sept., v. 8, no. 9 p.e10663-

    2022  

    Abstract: Bulk samples with high mechanical strength reaching 1000 MPa were obtained from electroexplosive Fe-Fe₃O₄ nanoparticles containing 81 wt. % Fe. Maximum strength is achieved by consolidation of the nanoparticles by isostatic pressing followed by vacuum ... ...

    Abstract Bulk samples with high mechanical strength reaching 1000 MPa were obtained from electroexplosive Fe-Fe₃O₄ nanoparticles containing 81 wt. % Fe. Maximum strength is achieved by consolidation of the nanoparticles by isostatic pressing followed by vacuum sintering at 700 °C. A further increase in the sintering temperature leads to the formation of large pores with a size of up to 5 μm and an intense interaction of Fe and Fe₃O₄ with the formation of FeO leading to the embrittlement of the samples and a decrease in their strength. The degradation rate of Fe- Fe₃O₄ samples in NaCl (0.9% wt.) and Hank's solution is 7 times higher than that of samples obtained by sintering an electroexplosive Fe nanopowder under the same conditions.
    Keywords nanoparticles ; strength (mechanics) ; temperature ; Fe-Fe3O4 nanopowders ; Electrical explosion of wire ; Bioresorbable composites ; Sintering ; Corrosion ; Strength
    Language English
    Dates of publication 2022-09
    Publishing place Elsevier Ltd
    Document type Article ; Online
    Note Use and reproduction
    ZDB-ID 2835763-2
    ISSN 2405-8440
    ISSN 2405-8440
    DOI 10.1016/j.heliyon.2022.e10663
    Database NAL-Catalogue (AGRICOLA)

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  7. Article ; Online: Synthesis of novel hierarchical micro/nanostructures AlOOH/AlFe and their application for As(V) removal.

    Svarovskaya, Natalia / Bakina, Olga / Glazkova, Elena / Rodkevich, Nikolay / Lerner, Marat / Vornakova, Ekaterina / Chzhou, Valeria / Naumova, Liudmila

    Environmental science and pollution research international

    2021  Volume 29, Issue 1, Page(s) 1246–1258

    Abstract: Hierarchical micro/nanostructured composites, which contain iron and/or its (hydr)oxides, demonstrate high rate and capacity of arsenic adsorption. The main objective of this paper is the use of novel low toxicity AlOOH/AlFe hierarchical micro/ ... ...

    Abstract Hierarchical micro/nanostructured composites, which contain iron and/or its (hydr)oxides, demonstrate high rate and capacity of arsenic adsorption. The main objective of this paper is the use of novel low toxicity AlOOH/AlFe hierarchical micro/nanostructures for arsenic removal. AlOOH/AlFe composite was obtained by simple water oxidation in mild conditions using AlFe bimetallic nanopowder as a precursor. AlFe bimetallic nanopowder was produced by electrical explosive of two twisted wires in argon atmosphere. The productivity of the electrical explosion assembly was 50 g/h, with the consumption of the electrical energy was 75 kW·h/kg. AlFe bimetallic nanoparticles were chemically active and interacted with water at 60 °C. This nanocomposite AlOOH/AlFe is low cost and adsorbs more than 200 mg/g As(V) from its aqueous solution. AlOOH/AlFe composite has flower-like morphology and specific surface area 247.1 m
    MeSH term(s) Adsorption ; Aluminum Hydroxide ; Aluminum Oxide ; Arsenic/analysis ; Hydrogen-Ion Concentration ; Kinetics ; Nanocomposites ; Water Pollutants, Chemical/analysis ; Water Purification
    Chemical Substances Water Pollutants, Chemical ; Aluminum Hydroxide (5QB0T2IUN0) ; aluminum oxide hydroxide (63957-70-0) ; Aluminum Oxide (LMI26O6933) ; Arsenic (N712M78A8G)
    Language English
    Publishing date 2021-08-05
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1178791-0
    ISSN 1614-7499 ; 0944-1344
    ISSN (online) 1614-7499
    ISSN 0944-1344
    DOI 10.1007/s11356-021-15612-9
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    In stock of ZB MED Bonn / Germany

    Z 5915: Show issues

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  8. Article: Synthesis and antibacterial activity of cellulose acetate sheets modified with flower-shaped AlOOH/Ag

    Bakina, O. V / Glazkova, E. A / Lozhkomoev, A. S / Svarovskaya, N. V / Rodkevich, N. G / Lerner, M. I

    Cellulose. 2020 July, v. 27, no. 11

    2020  

    Abstract: Modified cellulose acetate antibacterial material was obtained by immobilizing Al/Ag nanoparticles on fabric fibres in water and subsequent hydrolysis of this nanoparticles under mild reaction condition. AlOOH/Ag self-assembled flower-shaped ... ...

    Abstract Modified cellulose acetate antibacterial material was obtained by immobilizing Al/Ag nanoparticles on fabric fibres in water and subsequent hydrolysis of this nanoparticles under mild reaction condition. AlOOH/Ag self-assembled flower-shaped nanostructures consist of AlOOH nanoplates and Ag inclusions. The AlOOH nanosheets size is of 150–300 nm, thickness is 5–7 nm. The silver inclusions were from 5 to 30 nm in size. Flower-shaped AlOOH/Ag nanostructures change the charge of fibres and stabilize Ag nanoparticles against agglomeration. The positive charge of the modified fibres improves the bacteria adsorption due to electrostatic interaction. The antibacterial activity of the nanoparticles and modified material arise due to the slow Ag⁺ migration into the medium from stabilized Ag nanoparticles. The nanoparticles and modified cellulose acetate sheets were characterized by transmission and scanning electron microscopy, energy dispersive X-ray spectroscopy, X-ray diffraction analysis, FTIR spectroscopy. The release of silver ions to the medium remains low for 70 h with AlOOH/Ag@CA reducing all the tested bacterial strains below the limit of detection (10² CFU/mL) within 3 h for Escherichia coli and 6 h for MRSA due to local effects of silver on adsorbed bacteria. The antibacterial activity of modified cellulose acetate fabric allows this method of modification to be exploited to produce materials for biomedical applications.
    Keywords Escherichia coli ; Fourier transform infrared spectroscopy ; X-ray diffraction ; adsorption ; antibacterial properties ; antibiotics ; cellulose ; cellulose acetate ; detection limit ; electrostatic interactions ; energy-dispersive X-ray analysis ; fabrics ; hydrolysis ; methicillin-resistant Staphylococcus aureus ; nanosheets ; nanosilver ; silver
    Language English
    Dates of publication 2020-07
    Size p. 6663-6676.
    Publishing place Springer Netherlands
    Document type Article
    Note NAL-AP-2-clean
    ZDB-ID 1496831-9
    ISSN 1572-882X ; 0969-0239
    ISSN (online) 1572-882X
    ISSN 0969-0239
    DOI 10.1007/s10570-020-03250-2
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  9. Article ; Online: Hierarchical γ-alumina: From Pure Phase to Nanocomposites.

    Svarovskaya, Natalia / Glazkova, Elena / Bakina, Olga / Kazantsev, Sergey / Lozhkomoev, Aleksandr / Lerner, Marat

    Recent patents on nanotechnology

    2019  Volume 14, Issue 2, Page(s) 92–101

    Abstract: Recent advances in nanotechnology make it possible to create nanomaterials based on γ-alumina with novel hierarchical structure and physicochemical properties. Hierarchical γ-alumina can be synthesized using chemical or physical methods. The ... ...

    Abstract Recent advances in nanotechnology make it possible to create nanomaterials based on γ-alumina with novel hierarchical structure and physicochemical properties. Hierarchical γ-alumina can be synthesized using chemical or physical methods. The nanostructures based on γ-alumina exhibit unique properties, which are utilized in the design of efficient applications. These superior properties are often due to their hierarchical organizations from the nanosize scale to the macroscopic level. The present review is devoted to the contemporary state of the studies on the methods to produce hierarchical γ-alumina. We tried to summarize herein the literature data on the methods of synthesis of hierarchical γ-AlOOH and γ-Al2O3 with controlled morphology and the application of these methods for the synthesis of hierarchical γ-AlOOH and γ-Al2O3 nanocomposites.
    Language English
    Publishing date 2019-12-15
    Publishing country United Arab Emirates
    Document type Journal Article
    ISSN 2212-4020
    ISSN (online) 2212-4020
    DOI 10.2174/1872210514666191213150838
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  10. Article: MEK inhibitor trametinib attenuates neuroinflammation and cognitive deficits following traumatic brain injury in mice.

    Huang, Yimin / Li, Qing / Tian, Hao / Yao, Xiaolong / Bakina, Olga / Zhang, Huaqiu / Lei, Ting / Hu, Feng

    American journal of translational research

    2020  Volume 12, Issue 10, Page(s) 6351–6365

    Abstract: Microglia-mediated neuroinflammation is one of the hallmark pathological features following traumatic brain injury (TBI) that contributes to aggravated brain damage and cognitive deficits. These pathologies require novel effective treatments to improve ... ...

    Abstract Microglia-mediated neuroinflammation is one of the hallmark pathological features following traumatic brain injury (TBI) that contributes to aggravated brain damage and cognitive deficits. These pathologies require novel effective treatments to improve prognosis. Trametinib, a mitogen-activated protein kinase inhibitor approved by the Food and Drug Administration in treating various malignant tumors, has been shown to exert anti-inflammatory effects. The present study demonstrated that TBI mice treated with trametinib exhibited improved cognitive function. Trametinib treatment rescued oligodendrocytes and decreased infiltrating microglial density in the TBI area. Furthermore, this study revealed that ameliorated lipopolysaccharides (LPS) induced inflammatory reaction in microglial cells. Besides, trametinib attenuated inflammation factors expression during the early stages of TBI. In addition, trametinib inhibited LPS-induced microglial chemotactic activity. In conclusion, the results indicate that trametinib efficiently suppresses microglia-induced neuroinflammation and improves cognitive function of TBI mice, providing a potential therapy strategy for TBI patients.
    Language English
    Publishing date 2020-10-15
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2471058-1
    ISSN 1943-8141
    ISSN 1943-8141
    Database MEDical Literature Analysis and Retrieval System OnLINE

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