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  1. Article ; Online: Lymphadenectomy in the Management of Gynecologic Cancer.

    Bakkum-Gamez, Jamie N

    Clinical obstetrics and gynecology

    2020  Volume 62, Issue 4, Page(s) 749–755

    Abstract: Among nearly all gynecologic cancers, knowing whether the cancer has metastasized to lymph nodes impacts the ultimate management of the cancer. Lymph node status assists in cancer staging, prognostication, guidance of surgical intervention and adjuvant ... ...

    Abstract Among nearly all gynecologic cancers, knowing whether the cancer has metastasized to lymph nodes impacts the ultimate management of the cancer. Lymph node status assists in cancer staging, prognostication, guidance of surgical intervention and adjuvant therapy, and removal of positive lymph nodes may be therapeutic in some cancers. Surgical staging through lymph node removal and pathologist assessment is standard of care for most gynecologic cancers. This section reviews the anatomic lymphatic drainage patterns of each gynecologic organ and the evolution and current practice of surgical lymph node assessment along the spectrum of gynecologic cancers.
    MeSH term(s) Female ; Genital Neoplasms, Female/surgery ; Humans ; Lymph Node Excision/methods ; Lymphatic Metastasis/diagnosis ; Neoplasm Staging/methods
    Language English
    Publishing date 2020-04-06
    Publishing country United States
    Document type Journal Article
    ZDB-ID 391207-3
    ISSN 1532-5520 ; 0009-9201
    ISSN (online) 1532-5520
    ISSN 0009-9201
    DOI 10.1097/GRF.0000000000000481
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Sugammadex and urinary retention after hysterectomy: A propensity-matched cohort study.

    De Lima Laporta Miranda, Mariana L / Ochs Kinney, Michelle A / Bakkum-Gamez, Jamie N / Schroeder, Darrell R / Sprung, Juraj / Weingarten, Toby N

    Biomolecules & biomedicine

    2024  Volume 24, Issue 2, Page(s) 395–400

    Abstract: Postoperative urinary retention (POUR) is a well-known complication after gynecologic surgery. Our objective was to investigate whether the choice of pharmacologic agent for reversing neuromuscular blockade at the end of a hysterectomy is a risk factor ... ...

    Abstract Postoperative urinary retention (POUR) is a well-known complication after gynecologic surgery. Our objective was to investigate whether the choice of pharmacologic agent for reversing neuromuscular blockade at the end of a hysterectomy is a risk factor for POUR. Among adult patients undergoing hysterectomy with general anesthesia from 2012 to 2017, those who received aminosteroid nondepolarizing neuromuscular agents followed by pharmacologic reversal were identified, and electronic health records were reviewed. The cohort was dichotomized into two groups by reversal agent: 1) sugammadex and 2) neostigmine with glycopyrrolate. The primary outcome, POUR, was defined as unplanned postoperative bladder recatheterization. A propensity-adjusted analysis was performed to investigate the association between POUR and reversal agent by using inverse probability of treatment weighting to adjust for potential confounders. We identified 1,974 patients, of whom 1,586 (80.3%) received neostigmine-glycopyrrolate and 388 (19.7%) received sugammadex for reversal of neuromuscular blockade. The frequency of POUR was 24.8% (393/1,586) after reversal with neostigmine-glycopyrrolate and 18.3% (71/388) with sugammadex. Results from the propensity-adjusted analysis showed that sugammadex was associated with a lower POUR risk than neostigmine-glycopyrrolate (odds ratio 0.53, 95% confidence interval [CI] 0.37 - 0.76, P < 0.001). A post hoc analysis of sugammadex recipients who received glycopyrrolate for another indication showed a higher POUR risk than among those who did not receive glycopyrrolate (odds ratio 1.86, 95% CI 1.07 - 3.22, P = 0.03). Use of sugammadex to reverse aminosteroid neuromuscular blocking agents is associated with decreased risk of POUR after hysterectomy. A potential mechanism is the omission of glycopyrrolate, which is coadministered with neostigmine to mitigate unwanted cholinergic effects.
    MeSH term(s) Adult ; Humans ; Female ; Sugammadex/therapeutic use ; Neostigmine/adverse effects ; Glycopyrrolate/pharmacology ; Cohort Studies ; Urinary Retention/chemically induced ; Neuromuscular Nondepolarizing Agents/adverse effects ; Postoperative Complications/chemically induced ; Hysterectomy
    Chemical Substances Sugammadex (361LPM2T56) ; Neostigmine (3982TWQ96G) ; Glycopyrrolate (V92SO9WP2I) ; Neuromuscular Nondepolarizing Agents
    Language English
    Publishing date 2024-03-11
    Publishing country Bosnia and Herzegovina
    Document type Journal Article
    ISSN 2831-090X
    ISSN (online) 2831-090X
    DOI 10.17305/bb.2023.9569
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Refining the Definition of Low-Risk Endometrial Cancer: Improving Value.

    Bakkum-Gamez, Jamie N

    Gynecologic oncology

    2016  Volume 141, Issue 2, Page(s) 189–190

    Language English
    Publishing date 2016
    Publishing country United States
    Document type Editorial
    ZDB-ID 801461-9
    ISSN 1095-6859 ; 0090-8258
    ISSN (online) 1095-6859
    ISSN 0090-8258
    DOI 10.1016/j.ygyno.2016.04.009
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  4. Article ; Online: Retained Products of Conception After Cesarean Section and Occult Placenta Accreta.

    Schoolmeester, J Kenneth / Bakkum-Gamez, Jamie N

    Mayo Clinic proceedings

    2020  Volume 95, Issue 11, Page(s) 2462–2463

    MeSH term(s) Adult ; Cesarean Section/adverse effects ; Female ; Humans ; Hysteroscopy ; Placenta Accreta/diagnosis ; Placenta Accreta/diagnostic imaging ; Placenta Accreta/pathology ; Placenta, Retained/diagnosis ; Placenta, Retained/diagnostic imaging ; Placenta, Retained/pathology ; Pregnancy ; Ultrasonography ; Ultrasonography, Prenatal
    Language English
    Publishing date 2020-10-10
    Publishing country England
    Document type Case Reports ; Journal Article
    ZDB-ID 124027-4
    ISSN 1942-5546 ; 0025-6196
    ISSN (online) 1942-5546
    ISSN 0025-6196
    DOI 10.1016/j.mayocp.2020.08.046
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Repurposing the vaginal tampon for endometrial cancer detection.

    Bakkum-Gamez, Jamie N

    Biomarkers in medicine

    2015  Volume 9, Issue 8, Page(s) 715–717

    MeSH term(s) Biomarkers, Tumor/genetics ; DNA, Neoplasm/analysis ; Early Detection of Cancer/methods ; Early Detection of Cancer/trends ; Endometrial Neoplasms/diagnosis ; Endometrial Neoplasms/genetics ; Female ; Genetic Testing/methods ; Genetic Testing/trends ; Humans ; Menstrual Hygiene Products ; Reproducibility of Results ; Sensitivity and Specificity
    Chemical Substances Biomarkers, Tumor ; DNA, Neoplasm
    Language English
    Publishing date 2015
    Publishing country England
    Document type Editorial
    ZDB-ID 2481014-9
    ISSN 1752-0371 ; 1752-0363
    ISSN (online) 1752-0371
    ISSN 1752-0363
    DOI 10.2217/BMM.15.44
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Preventing Ovarian Cancer in High-risk Women: One Surgery at a Time.

    Swanson, Casey L / Bakkum-Gamez, Jamie N

    Clinical obstetrics and gynecology

    2019  Volume 63, Issue 1, Page(s) 64–73

    Abstract: Eleven genes have been identified that increase the lifetime risk of developing ovarian cancer. The cumulative cancer risk of ovarian cancer varies with the mutation type and age. Ovarian cancer risk management options include surgical risk reduction ... ...

    Abstract Eleven genes have been identified that increase the lifetime risk of developing ovarian cancer. The cumulative cancer risk of ovarian cancer varies with the mutation type and age. Ovarian cancer risk management options include surgical risk reduction with salpingo-oophorectomy and a newer step-wise approach with interval salpingectomy and delayed oophorectomy. Women should be counseled on the pros and cons of hysterectomy in the setting of reducing the risk of other cancers; eliminating the risk of endometrial cancer in Lynch Syndrome, potential risk of serous/serous-like endometrial cancer in BRCA1 carriers, and elimination of progestogen therapy that may increase breast cancer risk.
    MeSH term(s) Adult ; Aged ; Breast Neoplasms/genetics ; Breast Neoplasms/prevention & control ; Carcinoma, Ovarian Epithelial/genetics ; Carcinoma, Ovarian Epithelial/mortality ; Carcinoma, Ovarian Epithelial/prevention & control ; Decision Making ; Endometrial Neoplasms/genetics ; Endometrial Neoplasms/prevention & control ; Female ; Genes, BRCA1 ; Genes, BRCA2 ; Humans ; Lynch Syndrome II/complications ; Lynch Syndrome II/genetics ; Lynch Syndrome II/surgery ; Middle Aged ; Ovarian Neoplasms/genetics ; Ovarian Neoplasms/mortality ; Ovarian Neoplasms/prevention & control ; Prophylactic Surgical Procedures/methods ; Risk Assessment ; Salpingo-oophorectomy
    Language English
    Publishing date 2019-12-10
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 391207-3
    ISSN 1532-5520 ; 0009-9201
    ISSN (online) 1532-5520
    ISSN 0009-9201
    DOI 10.1097/GRF.0000000000000499
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Quality improvement in gynecologic oncology: Current successes and future promise.

    Kumar, Amanika / Nesbitt, Katherine M / Bakkum-Gamez, Jamie N

    Gynecologic oncology

    2019  Volume 152, Issue 3, Page(s) 486–491

    Abstract: Quality improvement in healthcare has accelerated over the past two decades, including in gynecologic oncology. Improvements have been made on a practice, institution, system and national scale, and efforts have focused on improving safety, efficiency, ... ...

    Abstract Quality improvement in healthcare has accelerated over the past two decades, including in gynecologic oncology. Improvements have been made on a practice, institution, system and national scale, and efforts have focused on improving safety, efficiency, and cost of care. Gynecologic oncology practitioners ought to engage in this work to improve patient outcomes, comply with federal regulation, and continue to meet required educational requirements of training programs. In gynecologic oncology there are already many examples of successful quality improvement initiatives that have resulted in improved patient care, including the implementation of enhanced recovery after surgery programs, reduction in blood transfusion, and increases in guideline adherent cancer care. Quality improvement methodology is born out of industrial engineering and includes Six Sigma and Lean; both are frameworks for implementing quality improvement as a process and can be adopted in healthcare settings to achieve the desired outcomes. Six Sigma is a system that aims to have a 99.9997% defect free process, and uses the DMAIC (Define-Measure-Analyze-Improve-Control) framework to guide stakeholders in their work. Lean is a concept aimed at reducing waste in process. Regardless of methodology used, the most important aspect of successful quality improvement is the use of change-management theory to achieve stakeholder buy-in and institutional participation. The physician champion is a key element to this. Finally, once a project has been completed, successfully or not, it is important to disseminate the experience. This will allow for adoption and replication in other institutions. It also can serve as a mechanism for academic recognition and advancement. Quality improvement is an important and growing field in medicine, and has an important role in the future of gynecologic oncology.
    MeSH term(s) Female ; Forecasting ; Genital Neoplasms, Female/therapy ; Gynecology/methods ; Gynecology/standards ; Gynecology/trends ; Humans ; Medical Oncology/methods ; Medical Oncology/standards ; Medical Oncology/trends ; Quality Improvement
    Language English
    Publishing date 2019-03-14
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 801461-9
    ISSN 1095-6859 ; 0090-8258
    ISSN (online) 1095-6859
    ISSN 0090-8258
    DOI 10.1016/j.ygyno.2018.10.046
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Cost-effectiveness analysis of margin-controlled surgery for vulvar Paget's disease.

    Bruce, Kelly H / Moriarty, James P / Borah, Bijan J / Dholakia, Ruchita / Lohman, Mary E / Brewer, Jerry D / Vidal, Nahid Y / Bakkum-Gamez, Jamie N / Cliby, William A

    Gynecologic oncology reports

    2024  Volume 52, Page(s) 101339

    Abstract: Objectives: To determine the cost of two surgical treatment approaches for vulvar Paget's disease and model the cost-effectiveness considering differences in recurrence and reoperation over time.: Methods: We assessed cost-effectiveness between ... ...

    Abstract Objectives: To determine the cost of two surgical treatment approaches for vulvar Paget's disease and model the cost-effectiveness considering differences in recurrence and reoperation over time.
    Methods: We assessed cost-effectiveness between excision guided by Mohs micrographic surgery (MMS-E) and traditional wide local excision (WLE). We examined billing data from patients with vulvar Paget's disease who underwent MMS-E (cases, n = 24, 2018-2022) or WLE (controls, n = 64, 1990-2020). We created typical treatment bundles incorporating physician-administered services and facility costs standardized to Medicare reimbursements in 2022 United States Dollars (USD). The primary measure of effectiveness was disease-free years of life. A secondary analysis estimated quality-adjusted life years (QALY). A Markov model simulated treatment pathways over a 10-year time horizon. Transition probabilities were based on institutional recurrence rates (3-year RR 6.7 % for MMS-E vs 34.1 % for WLE). We used a willingness-to-pay threshold of 100,000 USD per QALY.
    Results: The cost of a single surgical episode was 34,664 USD for MMS-E and 14,969 USD for WLE. In the setting of lower recurrence rates with MMS-E, the incremental cost was 12,789 USD per disease-free year gained. A secondary analysis incorporating QALY showed an incremental cost of 72,820 USD per QALY.
    Conclusions: MMS-E appears to be a cost-effective treatment for vulvar Paget's disease compared to historic standard of care. Our ability to estimate quality of life gained by avoiding disease recurrence was limited by scant data for this rare condition; thus, future studies incorporating health utility values are needed to facilitate a more comprehensive analysis.
    Language English
    Publishing date 2024-02-22
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2818505-5
    ISSN 2352-5789
    ISSN 2352-5789
    DOI 10.1016/j.gore.2024.101339
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  9. Article ; Online: Opportunistic salpingectomy to decrease the mortality from ovarian cancer: Can we expand the pool of eligible patients?

    Bakkum-Gamez, Jamie N / Cliby, William A

    Surgery

    2018  Volume 164, Issue 5, Page(s) 935–936

    MeSH term(s) Carcinoma, Ovarian Epithelial/mortality ; Carcinoma, Ovarian Epithelial/prevention & control ; Carcinoma, Ovarian Epithelial/surgery ; Elective Surgical Procedures/methods ; Female ; Humans ; Ovarian Neoplasms/mortality ; Ovarian Neoplasms/prevention & control ; Ovarian Neoplasms/surgery ; Patient Selection ; Prophylactic Surgical Procedures/methods ; Risk Reduction Behavior ; Salpingectomy/methods ; Survival Rate ; Treatment Outcome
    Language English
    Publishing date 2018-06-24
    Publishing country United States
    Document type Editorial
    ZDB-ID 202467-6
    ISSN 1532-7361 ; 0039-6060
    ISSN (online) 1532-7361
    ISSN 0039-6060
    DOI 10.1016/j.surg.2018.05.004
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: The 2020 SGO Annual Meeting Report.

    Kim, Kenneth H / Moore, Kathleen N / Arend, Rebecca C / Bakkum-Gamez, Jamie N / Westin, Shannon N

    Gynecologic oncology

    2020  Volume 158, Issue 1, Page(s) 12–15

    MeSH term(s) Female ; Genital Neoplasms, Female/therapy ; Humans ; Randomized Controlled Trials as Topic
    Language English
    Publishing date 2020-05-30
    Publishing country United States
    Document type Congress
    ZDB-ID 801461-9
    ISSN 1095-6859 ; 0090-8258
    ISSN (online) 1095-6859
    ISSN 0090-8258
    DOI 10.1016/j.ygyno.2020.05.031
    Database MEDical Literature Analysis and Retrieval System OnLINE

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