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Article ; Online: Venous Thromboembolism and Chronic Thromboembolic Pulmonary Hypertension: Novel Clinical Insights.

Sagris, Marios / Bakoyiannis, Christos

2022 Volume 28, Issue 10, Page(s) 769–770

MeSH term(s)	Chronic Disease ; Humans ; Hypertension, Pulmonary/drug therapy ; Pulmonary Embolism/drug therapy ; Venous Thromboembolism/drug therapy
Language	English
Publishing date	2022-06-27
Publishing country	United Arab Emirates
Document type	Editorial
ZDB-ID	1304236-1
ISSN	1873-4286 ; 1381-6128
ISSN (online)	1873-4286
ISSN	1381-6128
DOI	10.2174/138161282810220511124302
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Article ; Online: Contemporary Management of Deep Vein Thrombosis, Pulmonary Embolism and Chronic Thromboembolic Pulmonary Hypertension.

Sagris, Marios / Kokkinidis, Damianos G / Bakoyiannis, Christos

Current pharmaceutical design

2022 Volume 28, Issue 7, Page(s) 511

MeSH term(s)	Humans ; Hypertension, Pulmonary/drug therapy ; Pulmonary Embolism/drug therapy ; Venous Thrombosis/drug therapy
Language	English
Publishing date	2022-04-05
Publishing country	United Arab Emirates
Document type	Editorial
ZDB-ID	1304236-1
ISSN	1873-4286 ; 1381-6128
ISSN (online)	1873-4286
ISSN	1381-6128
DOI	10.2174/138161282807220221103233
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Article: Inflammation, anti-inflammatory agents, and the role of colchicine in carotid artery stenosis.

Chlorogiannis, David-Dimitris / Pargaonkar, Sumant / Papanagiotou, Panagiotis / Bakogiannis, Nikolaos C / Bakoyiannis, Christos / Kokkinidis, Damianos G

VASA. Zeitschrift fur Gefasskrankheiten

2023 Volume 53, Issue 1, Page(s) 4–12

Abstract: Cardiovascular disease is a major cause of morbidity and mortality worldwide. In the last few years, the role of inflammation and inflammatory modulatory medications is investigated for the optimal treatment of coronary artery disease. It can be ... ...

Abstract	Cardiovascular disease is a major cause of morbidity and mortality worldwide. In the last few years, the role of inflammation and inflammatory modulatory medications is investigated for the optimal treatment of coronary artery disease. It can be hypothesized that since inflammation is also involved in carotid artery stenosis development and progression, the same class of medication could be useful. Our objective with this review is to present the available evidence, published studies and promising ongoing trials on the role of anti-inflammatory medications - with a special emphasis on the most commonly used drug of this class: colchicine - in patients with carotid artery stenosis.
MeSH term(s)	Humans ; Colchicine/adverse effects ; Carotid Stenosis/complications ; Carotid Stenosis/diagnostic imaging ; Carotid Stenosis/drug therapy ; Anti-Inflammatory Agents/adverse effects ; Inflammation/drug therapy ; Coronary Artery Disease
Chemical Substances	Colchicine (SML2Y3J35T) ; Anti-Inflammatory Agents
Language	English
Publishing date	2023-12-11
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	120977-2
ISSN	1664-2872 ; 0301-1526
ISSN (online)	1664-2872
ISSN	0301-1526
DOI	10.1024/0301-1526/a001104
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Article ; Online: Management of Post-thrombotic Syndrome: A Comprehensive Review.

Chaitidis, Nikolaos / Kokkinidis, Damianos G / Papadopoulou, Zoi / Hasemaki, Natasha / Attaran, Robert / Bakoyiannis, Christos

Current pharmaceutical design

2022 Volume 28, Issue 7, Page(s) 550–559

Abstract: Background: Post-thrombotic syndrome (PTS) is the most common long-term complication of acute deep venous thrombosis (DVT). The cumulative incidence of PTS in the first two years after the first acute DVT diagnosis approximates 25%.: Objective: This ... ...

Abstract	Background: Post-thrombotic syndrome (PTS) is the most common long-term complication of acute deep venous thrombosis (DVT). The cumulative incidence of PTS in the first two years after the first acute DVT diagnosis approximates 25%. Objective: This study aims to summarize the most recent updates and provide a comprehensive review of the current management of PTS. Methods: We searched MEDLINE/PMC/NCBI Bookshelf (PubMed), Cochrane, Embase, Scopus, ClinicalTrials, and OpenGrey databases for relevant articles in English published from the establishment of each separate database until February 9, 2021. Conclusion: PTS constitutes the most frequent long-term complication of lower limb deep venous thrombosis (DVT). Lifestyle changes and compression treatment represent an integral part of PTS management and have a clear benefit to offer in PTS patients. Pharmacological treatment with phlebotonic and non-phlebotonic medications, such as micronized purified flavonoid fraction (MMPF) and sulodexide, respectively, may have a more central and significant role in PTS management than previously thought. The introduction of percutaneous transluminal venoplasty (PTV) and stenting has again raised our expectations with the field, along with new concerns and considerations. There is a growing number of studies that report promising results on patientoriented outcomes on PTS patients who were treated with PTV and stenting. Moreover, hybrid (endovascular/ surgical) interventions may also represent a safe and efficacious treatment option for a subset of patients with PTS. Patient selection criteria for endovascular and hybrid interventional treatment should be carefully set and standardized. Post-operative care after venoplasty is an important field of future research with potential clinical impact. Management of deep and superficial reflux remains controversial. Hopefully, future prospective studies shall provide more robust evidence on the management of PTS.
MeSH term(s)	Humans ; Postthrombotic Syndrome/complications ; Postthrombotic Syndrome/therapy ; Prospective Studies ; Risk Factors ; Stents/adverse effects ; Treatment Outcome ; Venous Thrombosis/drug therapy
Language	English
Publishing date	2022-01-31
Publishing country	United Arab Emirates
Document type	Journal Article ; Review
ZDB-ID	1304236-1
ISSN	1873-4286 ; 1381-6128
ISSN (online)	1873-4286
ISSN	1381-6128
DOI	10.2174/1381612828666220131094655
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Article ; Online: Obesity and Peripheral Artery Disease: Current Evidence and Controversies.

Lempesis, Ioannis G / Varrias, Dimitrios / Sagris, Marios / Attaran, Robert R / Altin, Elissa S / Bakoyiannis, Christos / Palaiodimos, Leonidas / Dalamaga, Maria / Kokkinidis, Damianos G

Current obesity reports

2023 Volume 12, Issue 3, Page(s) 264–279

Abstract: Purpose of review: Obesity is a significant public health problem and a major risk factor for the development and progression of atherosclerosis and its cardiovascular manifestations. Lower extremity peripheral artery disease (PAD) affects 3%-10% of the ...

Abstract	Purpose of review: Obesity is a significant public health problem and a major risk factor for the development and progression of atherosclerosis and its cardiovascular manifestations. Lower extremity peripheral artery disease (PAD) affects 3%-10% of the Western population and, if left untreated, can lead to devastating outcomes with both an increased risk of morbidity and mortality. Interestingly, the association between obesity and PAD remains debatable. Whereas it is well known that PAD and obesity frequently overlap in the same patients, many studies have demonstrated a negative association between obesity and PAD and a protective effect of obesity on disease development and progression, a phenomenon described as the "obesity paradox." Possible mechanisms for this paradox may include genetic background, as assessed by mendelian randomization studies, adipose tissue dysfunction, and body fat distribution rather than adiposity, while other factors, such as sex, ethnicity, sarcopenia in the elderly population, or aggressive treatment of co-existing metabolic conditions in individuals with obesity compared to those with normal weight, could have some impact as well. Recent rindings: Few reviews and meta-analyses examining systematically the relationship between obesity and PAD exist. The impact of PAD development due to the presence of obesity remains largely controversial. However, the most current evidence, backed by a recent meta-analysis, suggests a potential protective role of a higher body mass index on PAD-related complications and mortality. In this review, we discuss the association between obesity and PAD development, progression, and management, and the potential pathophysiologic mechanisms linking the two diseases.
MeSH term(s)	Aged ; Humans ; Obesity/epidemiology ; Peripheral Arterial Disease/complications ; Peripheral Arterial Disease/epidemiology ; Risk Factors ; Adiposity ; Body Fat Distribution ; Body Mass Index
Language	English
Publishing date	2023-05-27
Publishing country	United States
Document type	Journal Article ; Review
ISSN	2162-4968
ISSN (online)	2162-4968
DOI	10.1007/s13679-023-00510-7
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Article ; Online: Treatment of chronic venous disorder: A comprehensive review.

Chaitidis, Nikolaos / Kokkinidis, Damianos G / Papadopoulou, Zoi / Kyriazopoulou, Maria / Schizas, Dimitrios / Bakoyiannis, Christos

Dermatologic therapy

2021 Volume 35, Issue 2, Page(s) e15238

Abstract: Chronic venous disorder (CVD) is highly prevalent vascular disorder affecting up to 45% of the general population, with clinical manifestations ranging from teleangiectasias to venous leg ulcers (VLUs). We examined the currently available data in order ... ...

Abstract	Chronic venous disorder (CVD) is highly prevalent vascular disorder affecting up to 45% of the general population, with clinical manifestations ranging from teleangiectasias to venous leg ulcers (VLUs). We examined the currently available data in order to provide an updated, comprehensive review on treatment options of CVD. We searched MEDLINE, Cochrane, Scopus, EMBASE, ClinicalTrials, and OpenGrey databases for relevant articles in English published until November 2020. Compression treatment is the mainstay of conservative treatment. Pharmacological treatment can provide significant symptomatic relief and hence it should be considered as part of conservative treatment. Transcutaneous Lacer treatment (TCL) is a safe and effective alternative option to sclerotherapy for treatment of C1 stage. High ligation and stripping (HL/S), ultrasound-guided foam sclerotherapy (UGFS), endovenous thermal ablation (EVTA) systems and non thermal non tumescent ablation (NTNT) systems are safe and efficacious first-line options for treatment of saphenous insufficiency. Interventional treatment of co-existing incompetent perforator veins (IPVs) is not supported by contemporary evidence. Regarding deep venous insufficiency (DVI), treatment of symptomatic femoroiliocaval occlusive venous disease refractory to conservative treatment with percutaneous transluminal venoplasty stenting has produced encouraging results.
MeSH term(s)	Humans ; Laser Therapy/methods ; Saphenous Vein/surgery ; Sclerotherapy/methods ; Treatment Outcome ; Varicose Veins/surgery ; Venous Insufficiency/surgery
Language	English
Publishing date	2021-12-13
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	1354801-3
ISSN	1529-8019 ; 1396-0296
ISSN (online)	1529-8019
ISSN	1396-0296
DOI	10.1111/dth.15238
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Zs.A 5181: Show issues

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Article ; Online: Advances in treatment of chronic thromboembolic pulmonary hypertension.

Tzoumas, Andreas / Peppas, Spyridon / Sagris, Marios / Papanastasiou, Christos A / Barakakis, Paraschos Archontakis / Bakoyiannis, Christos / Taleb, Adam / Kokkinidis, Damianos G / Giannakoulas, George

Thrombosis research

2022 Volume 212, Page(s) 30–37

Abstract: Chronic Thromboembolic Pulmonary Hypertension (CTEPH) is a progressive pulmonary vascular disease which can lead to right heart failure and death, if left untreated. CTEPH is caused by persistent obstruction of large, middle-sized, or distal pulmonary ... ...

Abstract	Chronic Thromboembolic Pulmonary Hypertension (CTEPH) is a progressive pulmonary vascular disease which can lead to right heart failure and death, if left untreated. CTEPH is caused by persistent obstruction of large, middle-sized, or distal pulmonary arteries due to limited thromboembolic resolution in the pulmonary vascular arterial tree. Every patient with CTEPH should undergo evaluation for Pulmonary Endarterectomy (PEA) after referral to institutions with an experienced multidisciplinary CTEPH team. Although management of distal thromboembolic lesions with PEA remains a challenge due to their difficult accessibility, limited distal CTEPH is not considered an absolute contraindication for PEA, as more expertise surgical teams operate on them successfully. Furthermore, in up to 30-50% of patients who undergo PEA, curative treatment is not achieved due to incomplete thrombi removal or extensive pulmonary microvascular disease. Medical therapies that target the underlying pulmonary microvascular disease can offer symptomatic and hemodynamic benefits, although they do not deal with the core mechanism of the disease which is the removal of thromboembolic material from pulmonary vasculature. Recent research has provided evidence suggesting balloon pulmonary angioplasty (BPA) is a reasonable treatment option for inoperable CTEPH and recurrent/persistent pulmonary hypertension after PEA. Advancements in diagnostic modalities and refinements of BPA technique have decreased the complication rate and increased its beneficial effects in hemodynamics, symptoms, right ventricular function and long-term survival. Ongoing trials and future prospective cohorts will provide evidence regarding the optimal selection of patients and lesions prone to BPA treatment along with hybrid therapeutic strategies combining pharmacological therapy, PEA and BPA, which can potentially change the standard of care in CTEPH.
MeSH term(s)	Chronic Disease ; Endarterectomy/adverse effects ; Endarterectomy/methods ; Humans ; Hypertension, Pulmonary/diagnosis ; Hypertension, Pulmonary/etiology ; Hypertension, Pulmonary/therapy ; Pulmonary Artery ; Pulmonary Embolism/complications ; Pulmonary Embolism/diagnosis ; Pulmonary Embolism/therapy
Language	English
Publishing date	2022-02-12
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	121852-9
ISSN	1879-2472 ; 0049-3848
ISSN (online)	1879-2472
ISSN	0049-3848
DOI	10.1016/j.thromres.2022.02.003
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Article ; Online: Differences between Lower Extremity Arterial Occlusion vs. Stenosis and Predictors of Successful Endovascular Interventions.

Kokkinidis, Damianos G / Schizas, Dimitrios / Pargaonkar, Sumant / Karamanis, Dimitrios / Mylonas, Konstantinos S / Hasemaki, Natasha / Palaiodimos, Leonidas / Varrias, Dimitrios / Tzavellas, Georgios / Siasos, Gerasimos / Klonaris, Christos / Kharawala, Amrin / Chlorogiannis, David-Dimitris / Georgopoulos, Sotirios / Bakoyiannis, Christos

Medicina (Kaunas, Lithuania)

2023 Volume 59, Issue 11

Abstract: Background and Objectives: ...

Abstract	Background and Objectives:
MeSH term(s)	Humans ; Constriction, Pathologic/surgery ; Treatment Outcome ; Lower Extremity/blood supply ; Peripheral Arterial Disease/surgery ; Arterial Occlusive Diseases/surgery ; Endovascular Procedures ; Aspirin/therapeutic use ; Neoplasms ; Chronic Disease ; Retrospective Studies ; Risk Factors
Chemical Substances	Aspirin (R16CO5Y76E)
Language	English
Publishing date	2023-11-17
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2188113-3
ISSN	1648-9144 ; 1010-660X
ISSN (online)	1648-9144
ISSN	1010-660X
DOI	10.3390/medicina59112029
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Article ; Online: Repeat Coronary Artery Bypass Grafting: A Meta-Analysis of Off-Pump versus On-Pump Techniques in a Large Cohort of Patients.

Tzoumas, Andreas / Giannopoulos, Stefanos / Kakargias, Fotis / Kokkinidis, Damianos G / Giannakoulas, George / Faillace, Robert T / Bakoyiannis, Christos / Doulamis, Ilias P / Avgerinos, Dimitrios V

Heart, lung & circulation

2021 Volume 30, Issue 9, Page(s) 1281–1291

Abstract: Background: Redo coronary artery bypass grafting (CABG) can be performed with either the off-pump (OPCAB) or the on-pump (ONCAB) technique.: Method: Following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA), this meta- ... ...

Abstract	Background: Redo coronary artery bypass grafting (CABG) can be performed with either the off-pump (OPCAB) or the on-pump (ONCAB) technique. Method: Following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA), this meta-analysis compared the safety and efficacy of OPCAB versus ONCAB redo CABG. Results: Twenty-three (23) eligible studies were included (OPCAB, n=2,085; ONCAB, n=3,245). Off-pump CABG significantly reduced the risk of perioperative death (defined as in-hospital or 30-day death rate), myocardial infarction, atrial fibrillation, and acute kidney injury. The two treatment approaches were comparable regarding 30-day stroke and late all-cause mortality. Conclusions: Off-pump redo CABG resulted in lower perioperative death and periprocedural complication rates. No difference was observed in perioperative stroke rates and long-term survival between the two techniques.
MeSH term(s)	Atrial Fibrillation/surgery ; Cohort Studies ; Coronary Artery Bypass ; Coronary Artery Bypass, Off-Pump ; Humans ; Stroke/epidemiology ; Stroke/etiology ; Treatment Outcome
Language	English
Publishing date	2021-03-31
Publishing country	Australia
Document type	Journal Article ; Meta-Analysis ; Review
ZDB-ID	2020980-0
ISSN	1444-2892 ; 1443-9506
ISSN (online)	1444-2892
ISSN	1443-9506
DOI	10.1016/j.hlc.2021.02.015
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Article ; Online: Revascularization approaches in patients with radiation-induced carotid stenosis: an updated systematic review and meta-analysis.

Tzoumas, Andreas / Xenos, Dimitrios / Giannopoulos, Stefanos / Sagris, Marios / Kokkinidis, Damianos G / Bakoyiannis, Christos / Schizas, Dimitrios

Kardiologia polska

2021 Volume 79, Issue 6, Page(s) 645–653

Abstract: Background: Ionizing radiation remains a well-known risk factor of carotid artery stenosis. The survival rates of head and neck cancer patients undergoing radiotherapy have risen owing to medical advancements in the field. As a consequence, the ... ...

Abstract	Background: Ionizing radiation remains a well-known risk factor of carotid artery stenosis. The survival rates of head and neck cancer patients undergoing radiotherapy have risen owing to medical advancements in the field. As a consequence, the incidence of carotid artery stenosis in these high-risk patients has increased. Aims: In this study we sought to compare the outcomes of carotid endarterectomy (CEA) vs carotid artery stenting (CAS) for radiation-induced carotid artery stenosis. Methods: This study was performed according to the Preferred Reporting Items for Systematic reviews and Meta-Analyses guidelines. Eligible studies were identified through a comprehensive search of PubMed, Scopus and Cochrane Central until July 2020. A random-effects model meta-analysis was conducted, and odds ratios (ORs) were calculated. The I-square statistic was used to assess for heterogeneity. Results: Seven studies and 201 patients were included. Periprocedural stroke, myocardial infarction (MI), and death rates were similar between the two revascularization approaches. However, the risk for cranial nerve (CN) injury was higher in the CEA group (OR, 7.40; 95% CI, 1.58-34.59; I2 = 0%). Analysis revealed no significant difference in terms of long-term mortality (OR, 0.41; 95% CI, 0.14-1.16; I2 = 0%) and restenosis rates (OR, 0.69; 95% CI, 0.29-1.66; I2 = 0%) between CEA and CAS after a mean follow-up of 40.5 months. Conclusions: CAS and CEA appear to have a similar safety and efficacy profile in patients with radiation-induced carotid artery stenosis. Patients treated with CEA have a higher risk for periprocedural CN injuries. Future prospective studies are warranted to validate these results.
Language	English
Publishing date	2021-05-20
Publishing country	Poland
Document type	Journal Article
ZDB-ID	411492-9
ISSN	1897-4279 ; 0022-9032
ISSN (online)	1897-4279
ISSN	0022-9032
DOI	10.33963/KP.15956
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