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  1. Article: Regulatory role of peroxynitrite in advanced glycation end products mediated diabetic cardiovascular complications.

    Bala, Asis

    World journal of diabetes

    2024  Volume 15, Issue 3, Page(s) 572–574

    Abstract: The Advanced Glycation End Products (AGE) binding with its receptor can increase reactive oxygen species (ROS) generation through specific signaling mediators. The effect of superoxide ( ... ...

    Abstract The Advanced Glycation End Products (AGE) binding with its receptor can increase reactive oxygen species (ROS) generation through specific signaling mediators. The effect of superoxide (O
    Language English
    Publishing date 2024-03-25
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2583471-X
    ISSN 1948-9358
    ISSN 1948-9358
    DOI 10.4239/wjd.v15.i3.572
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  2. Article ; Online: A need for clinical trial: re-purposing the Monoamine Oxidase Inhibitors (MAO-I) for rheumatoid arthritis (RA).

    Bala, Asis

    Inflammopharmacology

    2023  Volume 31, Issue 6, Page(s) 3367–3370

    Abstract: There is a group of enzymes called monoamine oxidase(s) (MAOs) that help with the oxidation of amines found in both our diet and our bodies. Currently, monoamine oxidase inhibitors (MAO-Is) are utilized to manage conditions like depression, Parkinson's ... ...

    Abstract There is a group of enzymes called monoamine oxidase(s) (MAOs) that help with the oxidation of amines found in both our diet and our bodies. Currently, monoamine oxidase inhibitors (MAO-Is) are utilized to manage conditions like depression, Parkinson's disease, and other psychiatric disorders. Rheumatoid arthritis (RA) is an auto-immune disease that has been linked to negative changes in mental health, such as depression. When depression co-occurs with RA, it can further worsen the outcome of the disease. Inhibiting monoamine oxidases could potentially treat RA by improving its pathological markers. Using existing pre-clinical and clinical data on safety and toxicity makes drug re-purposing advantageous. Hence, the pre-clinical validation of MAO-I's effectiveness in managing RA requires urgent regulatory intervention to commence clinical trials. Back in 1983, a clinical case report put forward the idea of repurposing MAO-I for RA treatment. Although MAO-I had been used for depression, it was observed to have a significant reduction in joint pain and stiffness. However, no significant clinical research has been conducted on this matter since then. In this commentary article, we provide a summary of the pre-clinical data that is currently available. The main focus of our discussion is on the significance of clinical trials for MAO-I, repurposing it for RA, and using it for the simultaneous management of depression and RA.
    MeSH term(s) Humans ; Monoamine Oxidase Inhibitors/pharmacology ; Monoamine Oxidase Inhibitors/therapeutic use ; Monoamine Oxidase/therapeutic use ; Parkinson Disease/drug therapy ; Arthritis, Rheumatoid/drug therapy ; Autoimmune Diseases/drug therapy
    Chemical Substances Monoamine Oxidase Inhibitors ; Monoamine Oxidase (EC 1.4.3.4)
    Language English
    Publishing date 2023-08-09
    Publishing country Switzerland
    Document type Case Reports ; Letter
    ZDB-ID 1080058-x
    ISSN 1568-5608 ; 0925-4692
    ISSN (online) 1568-5608
    ISSN 0925-4692
    DOI 10.1007/s10787-023-01310-0
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3274: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
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  3. Article ; Online: Importance of protein kinase C (PKC) in phosphorylation of AMP-activated protein kinase (AMPK) in endocrine control.

    Bala, Asis

    Endocrine

    2023  Volume 83, Issue 3, Page(s) 828

    MeSH term(s) Protein Kinase C/metabolism ; AMP-Activated Protein Kinases/metabolism ; Phosphorylation ; Protein Serine-Threonine Kinases/metabolism ; Signal Transduction/physiology
    Chemical Substances Protein Kinase C (EC 2.7.11.13) ; AMP-Activated Protein Kinases (EC 2.7.11.31) ; Protein Serine-Threonine Kinases (EC 2.7.11.1)
    Language English
    Publishing date 2023-10-21
    Publishing country United States
    Document type Letter
    ZDB-ID 1194484-5
    ISSN 1559-0100 ; 1355-008X ; 0969-711X
    ISSN (online) 1559-0100
    ISSN 1355-008X ; 0969-711X
    DOI 10.1007/s12020-023-03576-4
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3884: Show issues Location:
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  4. Article ; Online: Letter to the Editor from Bala and Dayal: "Safety and Efficacy of Denosumab in Children With Osteogenesis Imperfecta - the First Prospective Comparative Study".

    Bala, Anju / Dayal, Devi

    The Journal of clinical endocrinology and metabolism

    2024  

    Language English
    Publishing date 2024-05-07
    Publishing country United States
    Document type Journal Article
    ZDB-ID 3029-6
    ISSN 1945-7197 ; 0021-972X
    ISSN (online) 1945-7197
    ISSN 0021-972X
    DOI 10.1210/clinem/dgae305
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    In stock of ZB MED Cologne/Königswinter

    Uh III Zs.134: Show issues Location:
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  5. Article ; Online: Enhanced stability of triple-halide perovskites CsPbI

    Bala, Anu / Kumar, Vijay

    Physical chemistry chemical physics : PCCP

    2023  Volume 25, Issue 34, Page(s) 22989–23000

    Abstract: Doping of chloride in mixed iodide-bromide perovskites has been shown experimentally to suppress the photo-induced halide-ion segregation and enhance the stability of triple-halide perovskites (THP). However, a fundamental understanding of the effects of ...

    Abstract Doping of chloride in mixed iodide-bromide perovskites has been shown experimentally to suppress the photo-induced halide-ion segregation and enhance the stability of triple-halide perovskites (THP). However, a fundamental understanding of the effects of Cl doping is yet to be achieved especially when the doping concentration is low. Here we report the results of a state-of-the-art
    Language English
    Publishing date 2023-08-30
    Publishing country England
    Document type Journal Article
    ZDB-ID 1476244-4
    ISSN 1463-9084 ; 1463-9076
    ISSN (online) 1463-9084
    ISSN 1463-9076
    DOI 10.1039/d3cp02476h
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  6. Article ; Online: The impact of depressive symptomology, rumination and objective memory performance on subjective cognitive complaints.

    Szyszkowska, Joanna / Bala, Aleksandra

    International journal of psychophysiology : official journal of the International Organization of Psychophysiology

    2023  Volume 190, Page(s) 1–7

    Abstract: Introduction: Cognitive impairment in depression can present as subjective or objective, but the intensity of the former is higher and is not correlated with the deficits measured in neuropsychological tests. We hypothesised that rumination would be ... ...

    Abstract Introduction: Cognitive impairment in depression can present as subjective or objective, but the intensity of the former is higher and is not correlated with the deficits measured in neuropsychological tests. We hypothesised that rumination would be associated with subjective cognitive impairment.
    Methods: The study was performed through the online PsyToolkit platform. It included 168 healthy people and 93 people with depression. To examine memory, a recognition-type task was used with emotionally charged words as the stimulus. Depression symptoms were measured using the Beck Depression Inventory-II, subjective cognitive impairment with the Perceived Deficits Questionnaire-20, and intensity of rumination with the Polish Questionnaire of Rumination.
    Results: MDD patients had significantly higher levels of depression symptoms, rumination, and subjective cognitive deficits than the control group. In the memory task, the MDD group had a higher error rate than the control group. In hierarchical regression analysis, depression and rumination were found to be significant predictors of subjective cognitive impairment, whereas objective memory performance was not. Exploratory analyses revealed that rumination mediates the association between depression and subjective cognitive complaints.
    Conclusion: Cognitive problems are common in depression and affect the quality of life. The results suggest that patients with depression have higher levels of rumination and subjective memory impairment, and that there is no direct link between subjective and objective cognitive decline. The findings may have implications for the development of effective treatment strategies for depression and cognitive impairment.
    MeSH term(s) Humans ; Quality of Life ; Cognition ; Cognitive Dysfunction/complications ; Cognition Disorders ; Memory Disorders/psychology ; Neuropsychological Tests ; Depression/diagnosis
    Language English
    Publishing date 2023-06-02
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 605645-3
    ISSN 1872-7697 ; 0167-8760
    ISSN (online) 1872-7697
    ISSN 0167-8760
    DOI 10.1016/j.ijpsycho.2023.05.351
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1925: Show issues Location:
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  7. Article ; Online: Green synthesis of AgNPs using Delonix regia bark for potential catalytic and antioxidant applications.

    Bala, Anu / Rani, Gita

    Microscopy research and technique

    2023  Volume 86, Issue 8, Page(s) 911–922

    Abstract: Nanoparticle synthesis from plant resources has recently gained significant impact due to its low cost, simple equipment requirements, and ease of availability. In this work, DR-AgNPs were synthesized using bark extract of Delonix regia (D. regia) plant ... ...

    Abstract Nanoparticle synthesis from plant resources has recently gained significant impact due to its low cost, simple equipment requirements, and ease of availability. In this work, DR-AgNPs were synthesized using bark extract of Delonix regia (D. regia) plant under microwave irradiation. The formation of DR-AgNPs has been confirmed with UV-Vis, XRD, FTIR, FESEM, HRTEM, EDS, DLS, and zeta potential analysis. Catalytic and antioxidant activities were tested on synthesized spherical nanoparticles with a size range of 10-48 nm. The effects of pH and catalyst dosage on the methylene blue (MB) dye degradation were carried out. It was observed from the treatment results that 95% MB dye degradation efficiency was achieved within 4 min with a degradation rate constant of 0.772 min
    MeSH term(s) Antioxidants/pharmacology ; Metal Nanoparticles/chemistry ; Methylene Blue/analysis ; Methylene Blue/chemistry ; Plant Bark/chemistry ; Silver/pharmacology ; Plant Extracts/chemistry ; Fabaceae ; Anti-Bacterial Agents/pharmacology
    Chemical Substances Antioxidants ; Methylene Blue (T42P99266K) ; Silver (3M4G523W1G) ; Plant Extracts ; Anti-Bacterial Agents
    Language English
    Publishing date 2023-03-04
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1099714-3
    ISSN 1097-0029 ; 1059-910X
    ISSN (online) 1097-0029
    ISSN 1059-910X
    DOI 10.1002/jemt.24310
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2251: Show issues Location:
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  8. Article ; Online: Zebrafish in understanding molecular pathophysiology, disease modeling, and developing effective treatments for Rett syndrome.

    Pramanik, Subrata / Bala, Asis / Pradhan, Ajay

    The journal of gene medicine

    2024  Volume 26, Issue 2, Page(s) e3677

    Abstract: Rett syndrome (RTT) is a rare but dreadful X-linked genetic disease that mainly affects young girls. It is a neurological disease that affects nerve cell development and function, resulting in severe motor and intellectual disabilities. To date, no cure ... ...

    Abstract Rett syndrome (RTT) is a rare but dreadful X-linked genetic disease that mainly affects young girls. It is a neurological disease that affects nerve cell development and function, resulting in severe motor and intellectual disabilities. To date, no cure is available for treating this disease. In 90% of the cases, RTT is caused by a mutation in methyl-CpG-binding protein 2 (MECP2), a transcription factor involved in the repression and activation of transcription. MECP2 is known to regulate several target genes and is involved in different physiological functions. Mouse models exhibit a broad range of phenotypes in recapitulating human RTT symptoms; however, understanding the disease mechanisms remains incomplete, and many potential RTT treatments developed in mouse models have not shown translational effectiveness in human trials. Recent data hint that the zebrafish model emulates similar disrupted neurological functions following mutation of the mecp2 gene. This suggests that zebrafish can be used to understand the onset and progression of RTT pathophysiology and develop a possible cure. In this review, we elaborate on the molecular basis of RTT pathophysiology in humans and model organisms, including rodents and zebrafish, focusing on the zebrafish model to understand the molecular pathophysiology and the development of therapeutic strategies for RTT. Finally, we propose a rational treatment strategy, including antisense oligonucleotides, small interfering RNA technology and induced pluripotent stem cell-derived cell therapy.
    MeSH term(s) Mice ; Animals ; Female ; Humans ; Rett Syndrome/genetics ; Rett Syndrome/therapy ; Zebrafish/genetics ; Gene Expression Regulation ; Intellectual Disability ; Mutation
    Language English
    Publishing date 2024-02-21
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 1458024-x
    ISSN 1521-2254 ; 1099-498X
    ISSN (online) 1521-2254
    ISSN 1099-498X
    DOI 10.1002/jgm.3677
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    Zs.A 5423: Show issues Location:
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  9. Article ; Online: Effectiveness of various organic peels in facial rejuvenation and treatment of sensitive skin

    Dogiparthi SN / Mohan S / Bala A / Jenson J

    Journal of Medical and Scientific Research, Vol 11, Iss 4, Pp 310-

    2023  Volume 314

    Abstract: The problems with adverse effects of conventional treatments for a range of dermatological conditions have led scientists to search for new compounds of therapeutic value. Efforts have included the evaluation of natural products such as manuka honey, ... ...

    Abstract The problems with adverse effects of conventional treatments for a range of dermatological conditions have led scientists to search for new compounds of therapeutic value. Efforts have included the evaluation of natural products such as manuka honey, black olives, citrus extracts , pumpkin enzyme extracts for example, has been scientifically recognized for its anti-microbial and skin rejuvenation properties and is now used clinically as a part of medi-facials or as basic low strength peels for skin rejuvenation and for those with sensitive skin. We evaluated the effects of various organic peels on sixty patients over a period of six months by using a grading scale for following skin characteristics post peel procedure; smoothness, firmness, even coloration, normal texture and absence of active skin infections. The overall score in current study was showed that the effectiveness of mandelic peel was more when compared with other organic peels which showed significant difference (p value 0.033).
    Keywords sensitive skin ; organic peels ; medifacials ; black olive ; manuka honey ; pumpkin peel ; citrus peel ; chemical peels ; Medicine (General) ; R5-920
    Subject code 571
    Language English
    Publishing date 2023-12-01T00:00:00Z
    Publisher KIMS Foundation and Research Center
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Article: Navigating Social Waters: Understanding Theory-of-Mind Challenges in Patients with Mesial Temporal Lobe Epilepsy.

    Bala, Aleksandra / Olejnik, Agnieszka / Mojżeszek, Maria / Rysz, Andrzej / Kunert, Przemysław

    Journal of clinical medicine

    2024  Volume 13, Issue 5

    Abstract: Background: ...

    Abstract Background:
    Language English
    Publishing date 2024-02-29
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm13051410
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