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  1. Article ; Online: DWT-Based Image Fusion Technique in Matlab

    Balakrishna T. / Hannan Md. Abdul / Nimishka G. / Subba reddy Gv.

    E3S Web of Conferences, Vol 391, p

    Identifying the most effective method

    2023  Volume 01076

    Abstract: Images have some information that can be perceived by the value or intensity of pixel colors or through their visual appearance, used in medical imaging which is used for medical management to generate a visual representation of the inside functioning of ...

    Abstract Images have some information that can be perceived by the value or intensity of pixel colors or through their visual appearance, used in medical imaging which is used for medical management to generate a visual representation of the inside functioning of the human body. CT and MRI go through medical imaging techniques that provide valuable information to treat medical conditions. The fused image gives a complete analysis of a patient’s body by revealing the internal structure with comprehensive information through computer processing. In previous research, this process of fusing two images was approached using a specified DWT technique. In this paper, we demonstrate the best image fusion method for a DWT technique so that it can provide a fused image with significant detail. Image fusion can be implemented using Discrete Wavelet Transform techniques, which include nine combinations of Mean-Max-Min fusion methods. The analysis to derive the best fusion method and implementation of the image fusion method using the DWT technique is done using Matlab programming.
    Keywords Environmental sciences ; GE1-350
    Subject code 006
    Language English
    Publishing date 2023-01-01T00:00:00Z
    Publisher EDP Sciences
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article ; Online: Assessment of Potential Clinical Role for Exome Sequencing in Schizophrenia.

    Balakrishna, Thivia / Curtis, David

    Schizophrenia bulletin

    2019  Volume 46, Issue 2, Page(s) 328–335

    Abstract: Background: There is increasing evidence that certain genetic variants increase the risk of schizophrenia and other neurodevelopmental disorders. Exome sequencing has been shown to have a high diagnostic yield for developmental disability and testing ... ...

    Abstract Background: There is increasing evidence that certain genetic variants increase the risk of schizophrenia and other neurodevelopmental disorders. Exome sequencing has been shown to have a high diagnostic yield for developmental disability and testing for copy number variants has been advocated for schizophrenia. The diagnostic yield for exome sequencing in schizophrenia is unknown.
    Method: A sample of 591 exome-sequenced schizophrenia cases and their parents were screened for disruptive and damaging variants in autosomal genes listed in the Genomics England panels for intellectual disability and other neurological disorders.
    Results: Previously reported disruptive de novo variants were noted in SETD1A, POGZ, SCN2A, and ZMYND11. Although the loss of function of ZMYND11 is a recognized cause of intellectual disability, it has not previously been noted as a risk factor for schizophrenia. A damaging de novo variant of uncertain significance was noted in NRXN1. A previously reported homozygous damaging variant in BLM is predicted to cause Bloom syndrome in 1 case and 1 case was homozygous for a damaging variant in MCPH1, a result of uncertain significance. There were more than 400 disruptive and damaging variants in the target genes in cases but similar numbers were seen among untransmitted parental alleles and none appeared to be clinically significant.
    Conclusions: The diagnostic yield from exome sequencing in schizophrenia is low. Disruptive and damaging variants seen in known neuropsychiatric genes should not be automatically assumed to have an etiological role if observed in a patient with schizophrenia.
    MeSH term(s) Female ; Genetic Predisposition to Disease/genetics ; Humans ; Male ; Parents ; Schizophrenia/diagnosis ; Schizophrenia/genetics ; Exome Sequencing
    Language English
    Publishing date 2019-05-20
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 439173-1
    ISSN 1745-1701 ; 0586-7614
    ISSN (online) 1745-1701
    ISSN 0586-7614
    DOI 10.1093/schbul/sbz057
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Formulation of rizatriptan benzoate fast dissolving buccal films by emulsion evaporation technique.

    Vidyadhara, Suryadevara / Sasidhar, Reddyvallam Lankapalli / Balakrishna, Thalamanchi / Vardhan, Malapolu Santha

    International journal of pharmaceutical investigation

    2015  Volume 5, Issue 2, Page(s) 101–106

    Abstract: Aim: The present study deals with the formulation of fast dissolving films of Rizatriptan benzoate that is used for the treatment of Migraine. The concept of fast-dissolving drug delivery emerged from the desire to provide patient with more conventional ...

    Abstract Aim: The present study deals with the formulation of fast dissolving films of Rizatriptan benzoate that is used for the treatment of Migraine. The concept of fast-dissolving drug delivery emerged from the desire to provide patient with more conventional means of taking their medication.
    Materials and methods: In the present research work, various trials were carried out using film forming agents such as maltodextrin, gum karaya and xanthan gum to prepare an ideal film. Emulsion evaporation method was used for the preparation of films. The prepared films were evaluated for weight uniformity, drug content, film thickness, folding endurance, dispersion test and curling. The in vitro dissolution studies were carried out using simulated salivary fluid (pH 6.8 phosphate buffer).
    Results: About 97% of the drug was found to be released from the film within 10 min that is a desirable character for fast absorption. The drug excipient interaction studies carried out by differential scanning calorimetry analysis and Fourier transform infrared studies revealed that there were no major interactions between the drugs and excipients used for the preparation of films.
    Conclusion: Fast dissolving films of Rizatriptan benzoate prepared by emulsion evaporation technique were found to be suitable for eliciting better therapeutic effect in the treatment of migraine.
    Language English
    Publishing date 2015-03-27
    Publishing country India
    Document type Journal Article
    ISSN 2230-973X
    ISSN 2230-973X
    DOI 10.4103/2230-973X.153387
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Formulation and Evaluation of Controlled Release Floating Microballoons of Stavudine.

    Vidyadhara, Suryadevara / Sasidhar, Reddyvalam Lankapalli / Balakrishna, Talamanchi / Balaji, Boyapati / Amrutha, Ravi

    Scientia pharmaceutica

    2015  Volume 83, Issue 4, Page(s) 671–682

    Abstract: The aim of this study was to formulate and evaluate stavudine floating microballoons for controlled drug release. Initially, the drug-loaded low-density granular pellets were prepared with hydroxypropyl methylcellulose E5 grade and by using isopropyl ... ...

    Abstract The aim of this study was to formulate and evaluate stavudine floating microballoons for controlled drug release. Initially, the drug-loaded low-density granular pellets were prepared with hydroxypropyl methylcellulose E5 grade and by using isopropyl alcohol as a granulating fluid. Further, the low-density granular pellets were subjected to microencapsulation by an emulsion evaporation technique using ethyl cellulose 7 cps and Eudragit S 100 as coating polymers and 1% w/v polyethylene glycol 400 as aqueous phase. The prepared microballoons were characterized for their particle size analysis, angle of repose, and compressibility index. The in vitro release studies were performed in 0.1 N HCl as medium. The prepared microballoons were free-flowing and spherical in shape. From all the formulations, F5E and F5F can be considered as promising controlled release floating microballoons of stavudine providing first-order release over a period of 12 hours, with a minimum floating lag time of 1 minute. It was found that the ratio of the drug & polymer, stirring speed, and concentration of surfactant were the most significant variables which influenced the size of the stavudine microballoons under the applied experimental conditions.
    Language English
    Publishing date 2015-06-09
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 206865-5
    ISSN 2218-0532 ; 0036-8709
    ISSN (online) 2218-0532
    ISSN 0036-8709
    DOI 10.3797/scipharm.1501-07
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1126: Show issues Location:
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    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
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  5. Article: Development and evaluation of diltiazem hydrochloride controlled-release pellets by fluid bed coating process.

    Prasad, Mikkilineni Bhanu / Vidyadhara, Suryadevara / Sasidhar, Reddyvalam Lankapalli C / Balakrishna, Talamanchi / Trilochani, Pavuluri

    Journal of advanced pharmaceutical technology & research

    2013  Volume 4, Issue 2, Page(s) 101–107

    Abstract: The aim of the present study was to develop controlled-release pellets of diltiazem HCl with ethyl cellulose and hydroxylpropyl methylcellulose phthalate as the release rate retarding polymers by fluid bed coating technique. The prepared pellets were ... ...

    Abstract The aim of the present study was to develop controlled-release pellets of diltiazem HCl with ethyl cellulose and hydroxylpropyl methylcellulose phthalate as the release rate retarding polymers by fluid bed coating technique. The prepared pellets were evaluated for drug content, particle size, subjected to Scanning Electron Microscopy (SEM) and Differential Scanning Calori metry (DSC), and evaluated for in vitro release. Stability studies were carried out on the optimized formulations for a period of 3 months. The drug content was in the range of 97%-101%. The mean particle size of the drug-loaded pellets was in the range 700-785 μm. The drug release rate decreased as the concentration of ethyl cellulose increased in the pellet formulations. Among the prepared formulations, FDL10 and FDL11 showed 80% drug release in 16 h, matching with USP dissolution test 6 for diltiazem HCl extended-release capsules. SEM photographs confirmed that the prepared formulations were spherical in nature with a smooth surface. The compatibility between drug and polymers in the drug-loaded pellets was confirmed by DSC studies. Stability studies indicated that the pellets were stable.
    Language English
    Publishing date 2013-03-28
    Publishing country India
    Document type Journal Article
    ISSN 2231-4040
    ISSN 2231-4040
    DOI 10.4103/2231-4040.111526
    Database MEDical Literature Analysis and Retrieval System OnLINE

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