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  1. Article ; Online: Noncanonical function of folate through folate receptor 1 during neural tube formation.

    Balashova, Olga A / Panoutsopoulos, Alexios A / Visina, Olesya / Selhub, Jacob / Knoepfler, Paul S / Borodinsky, Laura N

    Nature communications

    2024  Volume 15, Issue 1, Page(s) 1642

    Abstract: Folate supplementation reduces the occurrence of neural tube defects (NTDs), birth defects consisting in the failure of the neural tube to form and close. The mechanisms underlying NTDs and their prevention by folate remain unclear. Here we show that ... ...

    Abstract Folate supplementation reduces the occurrence of neural tube defects (NTDs), birth defects consisting in the failure of the neural tube to form and close. The mechanisms underlying NTDs and their prevention by folate remain unclear. Here we show that folate receptor 1 (FOLR1) is necessary for the formation of neural tube-like structures in human-cell derived neural organoids. FOLR1 knockdown in neural organoids and in Xenopus laevis embryos leads to NTDs that are rescued by pteroate, a folate precursor that is unable to participate in metabolism. We demonstrate that FOLR1 interacts with and opposes the function of CD2-associated protein, molecule essential for apical endocytosis and turnover of C-cadherin in neural plate cells. In addition, folates increase Ca
    MeSH term(s) Humans ; Folic Acid/metabolism ; Neural Tube/metabolism ; Folate Receptor 1/genetics ; Folate Receptor 1/metabolism ; Neural Tube Defects/genetics ; Neural Tube Defects/metabolism ; Neural Plate/metabolism
    Chemical Substances Folic Acid (935E97BOY8) ; Folate Receptor 1 ; FOLR1 protein, human
    Language English
    Publishing date 2024-02-22
    Publishing country England
    Document type Journal Article
    ZDB-ID 2553671-0
    ISSN 2041-1723 ; 2041-1723
    ISSN (online) 2041-1723
    ISSN 2041-1723
    DOI 10.1038/s41467-024-45775-1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Non-canonical Hedgehog signaling regulates spinal cord and muscle regeneration in

    Hamilton, Andrew M / Balashova, Olga A / Borodinsky, Laura N

    eLife

    2021  Volume 10

    Abstract: Inducing regeneration in injured spinal cord represents one of modern medicine's greatest challenges. Research from a variety of model organisms indicates that Hedgehog (Hh) signaling may be a useful target to drive regeneration. However, the mechanisms ... ...

    Abstract Inducing regeneration in injured spinal cord represents one of modern medicine's greatest challenges. Research from a variety of model organisms indicates that Hedgehog (Hh) signaling may be a useful target to drive regeneration. However, the mechanisms of Hh signaling-mediated tissue regeneration remain unclear. Here, we examined Hh signaling during post-amputation tail regeneration in
    MeSH term(s) Animals ; Female ; Hedgehog Proteins/genetics ; Hedgehog Proteins/metabolism ; Larva/genetics ; Larva/physiology ; Muscles/physiology ; Regeneration/genetics ; Regeneration/physiology ; Signal Transduction/genetics ; Signal Transduction/physiology ; Spinal Cord Regeneration/genetics ; Spinal Cord Regeneration/physiology ; Xenopus laevis/genetics ; Xenopus laevis/physiology
    Chemical Substances Hedgehog Proteins
    Language English
    Publishing date 2021-05-06
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 2687154-3
    ISSN 2050-084X ; 2050-084X
    ISSN (online) 2050-084X
    ISSN 2050-084X
    DOI 10.7554/eLife.61804
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Calcium dynamics at the neural cell primary cilium regulate Hedgehog signaling-dependent neurogenesis in the embryonic neural tube.

    Shim, Sangwoo / Goyal, Raman / Panoutsopoulos, Alexios A / Balashova, Olga A / Lee, David / Borodinsky, Laura N

    Proceedings of the National Academy of Sciences of the United States of America

    2023  Volume 120, Issue 23, Page(s) e2220037120

    Abstract: The balance between neural stem cell proliferation and neuronal differentiation is paramount for the appropriate development of the nervous system. Sonic hedgehog (Shh) is known to sequentially promote cell proliferation and specification of neuronal ... ...

    Abstract The balance between neural stem cell proliferation and neuronal differentiation is paramount for the appropriate development of the nervous system. Sonic hedgehog (Shh) is known to sequentially promote cell proliferation and specification of neuronal phenotypes, but the signaling mechanisms responsible for the developmental switch from mitogenic to neurogenic have remained unclear. Here, we show that Shh enhances Ca
    MeSH term(s) Calcium/metabolism ; Cell Differentiation ; Cilia/metabolism ; Hedgehog Proteins/metabolism ; Neural Tube/metabolism ; Neurogenesis/physiology ; Xenopus laevis ; Animals ; Xenopus Proteins
    Chemical Substances Calcium (SY7Q814VUP) ; Hedgehog Proteins ; Shh protein, Xenopus ; Xenopus Proteins
    Language English
    Publishing date 2023-05-30
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 209104-5
    ISSN 1091-6490 ; 0027-8424
    ISSN (online) 1091-6490
    ISSN 0027-8424
    DOI 10.1073/pnas.2220037120
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1148: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  4. Article: Non-canonical function of folate/folate receptor 1 during neural tube formation.

    Balashova, Olga A / Panoutsopoulos, Alexios A / Visina, Olesya / Selhub, Jacob / Knoepfler, Paul S / Borodinsky, Laura N

    bioRxiv : the preprint server for biology

    2023  

    Abstract: Folate supplementation reduces the occurrence of neural tube defects, one of the most common and serious birth defects, consisting in the failure of the neural tube to form and close early in pregnancy. The mechanisms underlying neural tube defects and ... ...

    Abstract Folate supplementation reduces the occurrence of neural tube defects, one of the most common and serious birth defects, consisting in the failure of the neural tube to form and close early in pregnancy. The mechanisms underlying neural tube defects and folate action during neural tube formation remain unclear. Here we show that folate receptor 1 (FOLR1) is necessary for the formation of neural tube-like structures in human-cell derived neural organoids. Knockdown of FOLR1 in human neural organoids as well as in the
    Language English
    Publishing date 2023-07-21
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2023.07.19.549718
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Folate action in nervous system development and disease.

    Balashova, Olga A / Visina, Olesya / Borodinsky, Laura N

    Developmental neurobiology

    2018  Volume 78, Issue 4, Page(s) 391–402

    Abstract: The vitamin folic acid has been recognized as a crucial environmental factor for nervous system development. From the early fetal stages of the formation of the presumptive spinal cord and brain to the maturation and maintenance of the nervous system ... ...

    Abstract The vitamin folic acid has been recognized as a crucial environmental factor for nervous system development. From the early fetal stages of the formation of the presumptive spinal cord and brain to the maturation and maintenance of the nervous system during infancy and childhood, folate levels and its supplementation have been considered influential in the clinical outcome of infants and children affected by neurological diseases. Despite the vast epidemiological information recorded on folate function and neural tube defects, neural development and neurodegenerative diseases, the mechanisms of folate action in the developing neural tissue have remained elusive. Here we compiled studies that argue for a unique role for folate in nervous system development and function and its consequences to neural disease and repair. © 2018 Wiley Periodicals, Inc. Develop Neurobiol 78: 391-402, 2018.
    MeSH term(s) Animals ; Folic Acid/metabolism ; Humans ; Nervous System/growth & development ; Nervous System/metabolism ; Nervous System Diseases/etiology ; Nervous System Diseases/metabolism
    Chemical Substances Folic Acid (935E97BOY8)
    Language English
    Publishing date 2018-02-06
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S. ; Review
    ZDB-ID 2256184-5
    ISSN 1932-846X ; 1097-4695 ; 1932-8451 ; 0022-3034
    ISSN (online) 1932-846X ; 1097-4695
    ISSN 1932-8451 ; 0022-3034
    DOI 10.1002/dneu.22579
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 853: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  6. Article ; Online: Folate receptor 1 is necessary for neural plate cell apical constriction during

    Balashova, Olga A / Visina, Olesya / Borodinsky, Laura N

    Development (Cambridge, England)

    2017  Volume 144, Issue 8, Page(s) 1518–1530

    Abstract: Folate supplementation prevents up to 70% of neural tube defects (NTDs), which result from a failure of neural tube closure during embryogenesis. The elucidation of the mechanisms underlying folate action has been challenging. This study ... ...

    Abstract Folate supplementation prevents up to 70% of neural tube defects (NTDs), which result from a failure of neural tube closure during embryogenesis. The elucidation of the mechanisms underlying folate action has been challenging. This study introduces
    MeSH term(s) Animals ; Cadherins/metabolism ; Cell Polarity/drug effects ; Cell Shape/drug effects ; Embryo, Nonmammalian/cytology ; Embryo, Nonmammalian/metabolism ; Endocytosis/drug effects ; Female ; Folate Receptor 1/genetics ; Folate Receptor 1/metabolism ; Gene Expression Regulation, Developmental/drug effects ; Gene Knockdown Techniques ; Gene Targeting ; Humans ; Morpholinos/pharmacology ; Neural Plate/cytology ; Neural Plate/metabolism ; Neural Tube/cytology ; Neural Tube/embryology ; Neural Tube/metabolism ; Neurulation/drug effects ; Organogenesis/drug effects ; Xenopus Proteins/genetics ; Xenopus Proteins/metabolism ; Xenopus laevis/embryology ; Xenopus laevis/metabolism
    Chemical Substances Cadherins ; Folate Receptor 1 ; Morpholinos ; Xenopus Proteins
    Language English
    Publishing date 2017--15
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 90607-4
    ISSN 1477-9129 ; 0950-1991
    ISSN (online) 1477-9129
    ISSN 0950-1991
    DOI 10.1242/dev.137315
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Ub I Zs.183: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)
    Zs.MG 91: Show issues

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  7. Article ; Online: Spatiotemporal integration of developmental cues in neural development.

    Borodinsky, Laura N / Belgacem, Yesser H / Swapna, Immani / Visina, Olesya / Balashova, Olga A / Sequerra, Eduardo B / Tu, Michelle K / Levin, Jacqueline B / Spencer, Kira A / Castro, Patricio A / Hamilton, Andrew M / Shim, Sangwoo

    Developmental neurobiology

    2015  Volume 75, Issue 4, Page(s) 349–359

    Abstract: Nervous system development relies on the generation of neurons, their differentiation and establishment of synaptic connections. These events exhibit remarkable plasticity and are regulated by many developmental cues. Here, we review the mechanisms of ... ...

    Abstract Nervous system development relies on the generation of neurons, their differentiation and establishment of synaptic connections. These events exhibit remarkable plasticity and are regulated by many developmental cues. Here, we review the mechanisms of three classes of these cues: morphogenetic proteins, electrical activity, and the environment. We focus on second messenger dynamics and their role as integrators of the action of diverse cues, enabling plasticity in the process of neural development.
    MeSH term(s) Animals ; Cell Differentiation ; Cues ; Humans ; Nervous System/cytology ; Nervous System/embryology ; Nervous System/growth & development ; Neural Stem Cells/physiology ; Neurogenesis/physiology ; Neurons/physiology
    Language English
    Publishing date 2015-04
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S. ; Review
    ZDB-ID 2256184-5
    ISSN 1932-846X ; 1097-4695 ; 1932-8451 ; 0022-3034
    ISSN (online) 1932-846X ; 1097-4695
    ISSN 1932-8451 ; 0022-3034
    DOI 10.1002/dneu.22254
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 853: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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